LOCUS       NM_201645               3229 bp    mRNA    linear   ROD 24-APR-2024
DEFINITION  Mus musculus UDP glucuronosyltransferase 1 family, polypeptide A1
            (Ugt1a1), mRNA.
ACCESSION   NM_201645
VERSION     NM_201645.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3229)
  AUTHORS   Jiang,J.L., Zhou,Y.Y., Zhong,W.W., Luo,L.Y., Liu,S.Y., Xie,X.Y.,
            Mu,M.Y., Jiang,Z.G., Xue,Y., Zhang,J. and He,Y.H.
  TITLE     Uridine diphosphate glucuronosyltransferase 1A1 prevents the
            progression of liver injury
  JOURNAL   World J Gastroenterol 30 (9), 1189-1212 (2024)
   PUBMED   38577195
  REMARK    GeneRIF: Uridine diphosphate glucuronosyltransferase 1A1 prevents
            the progression of liver injury.
REFERENCE   2  (bases 1 to 3229)
  AUTHORS   Yang,X., Weber,A.A., Mennillo,E., Paszek,M., Wong,S., Le,S.,
            Teo,J.Y.A., Chang,M., Benner,C.W., Tukey,R.H. and Chen,S.
  TITLE     Oral arsenic administration to
            humanizedUDP-glucuronosyltransferase1 neonatal mice induces UGT1A1
            through a dependence on Nrf2 and PXR
  JOURNAL   J Biol Chem 299 (3), 102955 (2023)
   PUBMED   36720308
  REMARK    GeneRIF: Oral arsenic administration to
            humanizedUDP-glucuronosyltransferase1 neonatal mice induces UGT1A1
            through a dependence on Nrf2 and PXR.
REFERENCE   3  (bases 1 to 3229)
  AUTHORS   Bates,E.A., Kipp,Z.A., Martinez,G.J., Badmus,O.O.,
            Soundarapandian,M.M., Foster,D., Xu,M., Creeden,J.F., Greer,J.R.,
            Morris,A.J., Stec,D.E. and Hinds,T.D. Jr.
  TITLE     Suppressing Hepatic UGT1A1 Increases Plasma Bilirubin, Lowers
            Plasma Urobilin, Reorganizes Kinase Signaling Pathways and Lipid
            Species and Improves Fatty Liver Disease
  JOURNAL   Biomolecules 13 (2), 252 (2023)
   PUBMED   36830621
  REMARK    GeneRIF: Suppressing Hepatic UGT1A1 Increases Plasma Bilirubin,
            Lowers Plasma Urobilin, Reorganizes Kinase Signaling Pathways and
            Lipid Species and Improves Fatty Liver Disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3229)
  AUTHORS   Liu,D., Yu,Q., Li,Z., Zhang,L., Hu,M., Wang,C. and Liu,Z.
  TITLE     UGT1A1 dysfunction increases liver burden and aggravates hepatocyte
            damage caused by long-term bilirubin metabolism disorder
  JOURNAL   Biochem Pharmacol 190, 114592 (2021)
   PUBMED   33961837
  REMARK    GeneRIF: UGT1A1 dysfunction increases liver burden and aggravates
            hepatocyte damage caused by long-term bilirubin metabolism
            disorder.
REFERENCE   5  (bases 1 to 3229)
  AUTHORS   Miyauchi,Y., Kurita,A., Yamashita,R., Takamatsu,T., Ikushiro,S.,
            Mackenzie,P.I., Tanaka,Y. and Ishii,Y.
  TITLE     Hetero-oligomer formation of mouse UDP-glucuronosyltransferase
            (UGT) 2b1 and 1a1 results in the gain of glucuronidation activity
            towards morphine, an activity which is absent in homo-oligomers of
            either UGT
  JOURNAL   Biochem Biophys Res Commun 525 (2), 348-353 (2020)
   PUBMED   32093886
  REMARK    GeneRIF: Hetero-oligomer formation of mouse
            UDP-glucuronosyltransferase (UGT) 2b1 and 1a1 results in the gain
            of glucuronidation activity towards morphine, an activity which is
            absent in homo-oligomers of either UGT.
REFERENCE   6  (bases 1 to 3229)
  AUTHORS   Koiwai,O., Hasada,K., Yasui,Y., Sakai,Y., Sato,H. and Watanabe,T.
  TITLE     Isolation of cDNAs for mouse phenol and bilirubin
            UDP-glucuronosyltransferases and mapping of the mouse gene for
            phenol UDP-glucuronosyltransferase (Ugtla1) to chromosome 1 by
            restriction fragment length variations
  JOURNAL   Biochem Genet 33 (3-4), 111-122 (1995)
   PUBMED   7677729
REFERENCE   7  (bases 1 to 3229)
  AUTHORS   Nagai,F., Satoh,H., Mori,S., Sato,H., Koiwai,O., Homma,H. and
            Matsui,M.
  TITLE     Mapping of rat bilirubin UDP-glucuronosyl-transferase gene (Ugt1a1)
            to chromosome region 9q35-->q36
  JOURNAL   Cytogenet Cell Genet 69 (3-4), 185-186 (1995)
   PUBMED   7698007
REFERENCE   8  (bases 1 to 3229)
  AUTHORS   Ogawa,Y., Itoh,H., Yoshitake,Y., Inoue,M., Yoshimasa,T.,
            Serikawa,T. and Nakao,K.
  TITLE     Molecular cloning and chromosomal assignment of the mouse C-type
            natriuretic peptide (CNP) gene (Nppc): comparison with the human
            CNP gene (NPPC)
  JOURNAL   Genomics 24 (2), 383-387 (1994)
   PUBMED   7698765
REFERENCE   9  (bases 1 to 3229)
  AUTHORS   Sato,H., Sakai,Y., Koiwai,O. and Watanabe,T.
  TITLE     Mapping of the mouse bilirubin UDP-glucuronosyltransferase gene
            (Gnt-1) to chromosome 1 by restriction fragment length variations
  JOURNAL   Biochem Genet 30 (7-8), 347-352 (1992)
   PUBMED   1359870
REFERENCE   10 (bases 1 to 3229)
  AUTHORS   Miles,J.S., Moss,J.E., Taylor,B.A., Burchell,B. and Wolf,C.R.
  TITLE     Mapping genes encoding drug-metabolizing enzymes in recombinant
            inbred mice
  JOURNAL   Genomics 11 (2), 309-316 (1991)
   PUBMED   1685137
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087780.19, AA674349.1 and AI097692.1.
            
            On Apr 25, 2007 this sequence version replaced NM_201645.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY227194.1, BC093516.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-755               AC087780.19        166327-167081       c
            756-1133            AA674349.1         1-378
            1134-1565           AI097692.1         111-542
            1566-3229           AC087780.19        159038-160701       c
FEATURES             Location/Qualifiers
     source          1..3229
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 44.55 cM"
     gene            1..3229
                     /gene="Ugt1a1"
                     /gene_synonym="Gnt1; UDPGT 1-1; Udpgt-1a; UGT1A01; UgtBr1"
                     /note="UDP glucuronosyltransferase 1 family, polypeptide
                     A1"
                     /db_xref="GeneID:394436"
                     /db_xref="MGI:MGI:98898"
     exon            1..913
                     /gene="Ugt1a1"
                     /gene_synonym="Gnt1; UDPGT 1-1; Udpgt-1a; UGT1A01; UgtBr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..1651
                     /gene="Ugt1a1"
                     /gene_synonym="Gnt1; UDPGT 1-1; Udpgt-1a; UGT1A01; UgtBr1"
                     /EC_number="2.4.1.17"
                     /note="UDP-glucuronosyltransferase 1 family, member 1;
                     UDP-glucuronosyltransferase 1-1; UDPGT; UGT1*1; UGT1.1;
                     UGT1-01; UDP-glucuronosyltransferase 1A1"
                     /codon_start=1
                     /product="UDP-glucuronosyltransferase 1A1 precursor"
                     /protein_id="NP_964007.2"
                     /db_xref="CCDS:CCDS15143.1"
                     /db_xref="GeneID:394436"
                     /db_xref="MGI:MGI:98898"
                     /translation="MTVVCWSSRLLLLLPYLLLCVFGPSASHAGRLLVFPMDGSHWLS
                     MLGVIQQLQQKGHEVVVIAPEASIHIKEGSFYTLRKFPVPFQKENVTATLVELGRTAF
                     NQDSFLLRVVKIYMKVKRDSSMLLAGCSHLLHNAEFMASLEESHFDALLTDPFLPCGS
                     IVAQYLTVPTVYFLNKLPCSLDSEATQCPVPLSYVPKSLSFNSDRMNFLQRVKNVLLA
                     VSENFMCRVVYSPYGSLATEILQKEVTVQDLLSPASIWLMRSDFVKDYPRPIMPNMVF
                     IGGINCLQKKPLSQEFEAYVNASGEHGIVVFSLGSMVSEIPEKKAMEIAEALGRIPQT
                     VLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAFITHSGSHGIYEGICNGVPMVM
                     MPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHK
                     DRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIV
                     FKCCAYGCRKCFGGKGRVKKSHKSKTH"
     exon            914..1045
                     /gene="Ugt1a1"
                     /gene_synonym="Gnt1; UDPGT 1-1; Udpgt-1a; UGT1A01; UgtBr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1133
                     /gene="Ugt1a1"
                     /gene_synonym="Gnt1; UDPGT 1-1; Udpgt-1a; UGT1A01; UgtBr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1353
                     /gene="Ugt1a1"
                     /gene_synonym="Gnt1; UDPGT 1-1; Udpgt-1a; UGT1A01; UgtBr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..3229
                     /gene="Ugt1a1"
                     /gene_synonym="Gnt1; UDPGT 1-1; Udpgt-1a; UGT1A01; UgtBr1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2205..2210
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ugt1a1"
                     /gene_synonym="Gnt1; UDPGT 1-1; Udpgt-1a; UGT1A01; UgtBr1"
                     /note="hexamer: AATAAA"
     polyA_site      2225
                     /gene="Ugt1a1"
                     /gene_synonym="Gnt1; UDPGT 1-1; Udpgt-1a; UGT1A01; UgtBr1"
                     /note="major polyA site"
ORIGIN      
        1 agcttgagta gatctctggc agcatcagag agagagagat accatgactg tggtgtgctg
       61 gagctcgcgt ttgcttctgc ttcttccgta ccttctgttg tgtgtgttcg gtccctctgc
      121 atcccacgct gggaggctgt tagtgttccc tatggatgga agccactggc tgagtatgct
      181 tggagttatt cagcagctcc agcagaaggg gcacgaagtt gtggtcatag cacctgaagc
      241 ctcaatacac ataaaagaag gatcatttta cactctgagg aagttccctg tgccattcca
      301 gaaggaaaat gtgacagcta ctttggtgga acttggacgg actgccttta atcaagattc
      361 ttttctgctg cgcgtggtca aaatatatat gaaagtcaaa agggattcca gtatgctcct
      421 agctggctgc tcccacctgc tgcacaatgc cgagtttatg gcctctctgg aagaaagtca
      481 ctttgatgct ctgctgacag accctttcct tccctgtggc tccattgtgg cccagtacct
      541 gactgtgccc actgtgtact tcttgaataa attgccatgc agcctggatt cagaagctac
      601 ccaatgcccc gtcccattgt cctacgtgcc caagagtttg tctttcaact cagaccgcat
      661 gaacttccta cagcgagtga agaacgtgct cctggccgtg tcagagaact ttatgtgcag
      721 agtggtttat tccccctatg ggtcacttgc cactgaaatc ttacagaaag aagtgactgt
      781 ccaggatctt ctgagccctg catctatctg gctgatgaga agtgactttg tgaaagatta
      841 ccccaggccc atcatgccca acatggtttt tattggtggt ataaattgcc ttcagaaaaa
      901 gcccctatcc caggaatttg aagcctatgt caacgcctct ggggagcatg gcatcgttgt
      961 tttctctttg ggatccatgg tctcagagat tccggagaag aaagccatgg aaattgctga
     1021 ggctttgggc agaattcctc agacggtcct gtggcgctac accggaacta gaccatcgaa
     1081 tcttgcaaag aacacaattc ttgtcaaatg gctaccccaa aatgatctgc ttggtcatcc
     1141 aaagactcgg gcattcatca cacactctgg ctcccatggt atttatgaag gaatatgcaa
     1201 tggagttccg atggtgatga tgcccctatt tggcgatcag atggacaatg ccaagcgcat
     1261 ggaaactcgg ggagctgggg tgaccctgaa tgtccttgaa atgactgctg atgatttgga
     1321 aaatgccctt aaaactgtca tcaacaacaa gagctacaag gagaacatca tgcgcctctc
     1381 cagccttcac aaggaccgtc ctatagagcc tctggacctg gctgtgttct gggtggaata
     1441 cgtgatgagg cacaaggggg caccacacct gcgcccggcc gcccatgacc tcacctggta
     1501 tcagtaccac tccttggatg tgattggctt cctcctggcc attgtgttga cagtggtctt
     1561 cattgtcttt aaatgttgtg cctatggctg ccggaaatgc tttgggggaa aggggcgagt
     1621 gaagaaatca cacaaatcca agacccattg agaagtgggg ggaagtgaag gagaagtatt
     1681 agttcattat ctgatcagtt gaaacttgga aacaagtgtt aaatccatat tgtttttgtt
     1741 agggaaataa ttcaccatac attatacatt cagcacattt aaaaataata ataataacaa
     1801 tctaattgct ggccacaccc atcagggaag gttctagtat atgtgatgtg cttttccagt
     1861 atcttcagtc tagacaactc ttgccatctg ttggtaattt acagaaagtc tggcactctg
     1921 ctttcagtga cagccccaca gtttcccctg ctcccgccag ctgacggctt tctcccctgg
     1981 attctcagac tgccgtggcc ttctccagtg ttagtcattc ttcattgtgt tcatgcatta
     2041 tgggtggcaa gacctttgga gctttgggag aagagatgag gctgtgacac tgatggccct
     2101 gtgtttgaga taataattgt tgcttgtgcc ggaatttgat gaaaaccaaa gtatgttcta
     2161 aggcaagtac atcttctatt gtgttcccaa accaagaact tatcaataaa ttcatataaa
     2221 ttgtatcact actcttcttt tcattggtgt tatatttatt tgttgtcaaa gtatatcctc
     2281 taattgtaaa agcactacat gatcatgatg cagaacttga aaactagaac agattcacac
     2341 aggtatacat acacacaaga aaggaaccag ctgtaattac agtgctcatg aataaccatg
     2401 gctgctgcct agtttgattc tgagtcttcc aaaggtgcat tggctgatgg cttgcagcct
     2461 tgctgatgct cagcctgtga tatcactggg aagttgtgca accattaagt ggcagtctag
     2521 tgtgagaaag ctaggtctct ggaggtgttc ctttgaagga gatacaggga tagaggtacc
     2581 ttctctttct ttgttcccat actatcctga aacaagaagg ttcccggaca gtctctttga
     2641 gtattctctt atcttacaca ggtcccaaag caacataacc acatgatcag ggatgaaaag
     2701 tctatagcta gcccaaaata aacctttgct catgagttgc tacatctcag gtatttgtta
     2761 cagtaacata aagtttatta acatacctat tgttttgaca aatacacata aaacattaca
     2821 gacattctgt attagtcagt tttgcatcag cataatgaaa taaccaaagc aagtaagtta
     2881 aaagagagaa gggctgttta acttagaggt tatcttgctt tggctcagtt ctgtgagggt
     2941 aacagaaggt ggcatatcaa acaggagcat gtacatgaac aaaccatgaa ttatatcttg
     3001 aggcaggaac agggagctag agtctgggct gtcacaatcc tctttgagga agatctttaa
     3061 tgacctatgg gcattttaat aggccctacc tgaaaaaaaa agttttccct gcttctcaat
     3121 agcacacact gaagaccaag cttttatcac atggctcttt gggggcattt cagattcaag
     3181 ctatatattc tgaccaaaag ttccaaaagt tcatgtccat ttcgcaatt
//
