LOCUS       NM_139297               2847 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus UDP-glucose pyrophosphorylase 2 (Ugp2), transcript
            variant 1, mRNA.
ACCESSION   NM_139297
VERSION     NM_139297.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2847)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2847)
  AUTHORS   Wolfe,A.L., Zhou,Q., Toska,E., Galeas,J., Ku,A.A., Koche,R.P.,
            Bandyopadhyay,S., Scaltriti,M., Lebrilla,C.B., McCormick,F. and
            Kim,S.E.
  TITLE     UDP-glucose pyrophosphorylase 2, a regulator of glycogen synthesis
            and glycosylation, is critical for pancreatic cancer growth
  JOURNAL   Proc Natl Acad Sci U S A 118 (31) (2021)
   PUBMED   34330832
REFERENCE   3  (bases 1 to 2847)
  AUTHORS   Roberts,G.A.G. and Tunster,S.J.
  TITLE     Characterising the dynamics of placental glycogen stores in the
            mouse
  JOURNAL   Placenta 99, 131-140 (2020)
   PUBMED   32798765
REFERENCE   4  (bases 1 to 2847)
  AUTHORS   Ma,J., Wei,K., Liu,J., Tang,K., Zhang,H., Zhu,L., Chen,J., Li,F.,
            Xu,P., Chen,J., Liu,J., Fang,H., Tang,L., Wang,D., Zeng,L., Sun,W.,
            Xie,J., Liu,Y. and Huang,B.
  TITLE     Glycogen metabolism regulates macrophage-mediated acute
            inflammatory responses
  JOURNAL   Nat Commun 11 (1), 1769 (2020)
   PUBMED   32286295
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2847)
  AUTHORS   Eaton,M., Davies,A.H., Devine,J., Zhao,X., Simmons,D.G.,
            Mariusdottir,E., Natale,D.R.C., Matyas,J.R., Bering,E.A.,
            Workentine,M.L., Hallgrimsson,B. and Cross,J.C.
  TITLE     Complex patterns of cell growth in the placenta in normal pregnancy
            and as adaptations to maternal diet restriction
  JOURNAL   PLoS One 15 (1), e0226735 (2020)
   PUBMED   31917811
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2847)
  AUTHORS   Tunster,S.J., Tycko,B. and John,R.M.
  TITLE     The imprinted Phlda2 gene regulates extraembryonic energy stores
  JOURNAL   Mol Cell Biol 30 (1), 295-306 (2010)
   PUBMED   19884348
REFERENCE   7  (bases 1 to 2847)
  AUTHORS   Millien,G., Beane,J., Lenburg,M., Tsao,P.N., Lu,J., Spira,A. and
            Ramirez,M.I.
  TITLE     Characterization of the mid-foregut transcriptome identifies genes
            regulated during lung bud induction
  JOURNAL   Gene Expr Patterns 8 (2), 124-139 (2008)
   PUBMED   18023262
REFERENCE   8  (bases 1 to 2847)
  AUTHORS   Dequeant,M.L., Glynn,E., Gaudenz,K., Wahl,M., Chen,J., Mushegian,A.
            and Pourquie,O.
  TITLE     A complex oscillating network of signaling genes underlies the
            mouse segmentation clock
  JOURNAL   Science 314 (5805), 1595-1598 (2006)
   PUBMED   17095659
REFERENCE   9  (bases 1 to 2847)
  AUTHORS   Ramsdell,C.M., Thames,E.L., Weston,J.L. and Dewey,M.J.
  TITLE     Development of a deer mouse whole-genome radiation hybrid panel and
            comparative mapping of Mus chromosome 11 loci
  JOURNAL   Mamm Genome 17 (1), 37-48 (2006)
   PUBMED   16416089
REFERENCE   10 (bases 1 to 2847)
  AUTHORS   Fuchs,S., Resch,K., Thiel,C., Ulbrich,M., Platzer,M., Jockusch,H.
            and Schmitt-John,T.
  TITLE     Comparative transcription map of the wobbler critical region on
            mouse chromosome 11 and the homologous region on human chromosome
            2p13-14
  JOURNAL   BMC Genet 3, 14 (2002)
   PUBMED   12174196
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY729023.1, AK033445.1, BQ033764.1 and AL833772.8.
            
            On Mar 15, 2014 this sequence version replaced NM_139297.5.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033445.1, BC061208.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               BY729023.1         200-353
            155-2381            AK033445.1         2-2228
            2382-2382           BQ033764.1         466-466             c
            2383-2827           AK033445.1         2230-2674
            2828-2847           AL833772.8         29739-29758         c
FEATURES             Location/Qualifiers
     source          1..2847
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 13.89 cM"
     gene            1..2847
                     /gene="Ugp2"
                     /gene_synonym="UDPGP; UGPase"
                     /note="UDP-glucose pyrophosphorylase 2"
                     /db_xref="GeneID:216558"
                     /db_xref="MGI:MGI:2183447"
     exon            1..443
                     /gene="Ugp2"
                     /gene_synonym="UDPGP; UGPase"
                     /inference="alignment:Splign:2.1.0"
     CDS             425..1951
                     /gene="Ugp2"
                     /gene_synonym="UDPGP; UGPase"
                     /EC_number="2.7.7.9"
                     /note="isoform 1 is encoded by transcript variant 1;
                     UTP--glucose-1-phosphate uridylyltransferase;
                     uridindiphosphoglucosepyrophosphorylase 2"
                     /codon_start=1
                     /product="UTP--glucose-1-phosphate uridylyltransferase
                     isoform 1"
                     /protein_id="NP_647458.1"
                     /db_xref="CCDS:CCDS24464.1"
                     /db_xref="GeneID:216558"
                     /db_xref="MGI:MGI:2183447"
                     /translation="MSRFVQDLSKAMSQDGASQFQEVILQELELSVKKELEKILTTAA
                     SHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRPPEDSIQPYEKIKARGLPDNIS
                     SVLNKLVVVKLNGGLGTSMGCKGPKSLIGVRNENTFLDLTVQQIEHLNKTYNTDVPLV
                     LMNSFNTDEDTKKILQKYNHCRVKIYTFNQSRYPRINKESLLPIAKDVSYSGENTEAW
                     YPPGHGDIYASFYNSGLLDTFIEEGKEYIFVSNIDNLGATVDLYILNHLMNPPNGKRC
                     EFVMEVTNKTRADVKGGTLTQYEGKLRLVEIAQVPKAHVDEFKSVSKFKIFNTNNLWI
                     SLGAVKRLQEQNAIDMEIIVNPKTLDGGLNVIQLETAVGAAIKSFENSLGINVPRSRF
                     LPVKTTSDLLLVMSNLYSLNAGSLTMSEKREFPTVPLVKLGSSFTKVQDYLRRFESIP
                     DMLELDHLTVSGDVTFGKNVSLKGTVIIIANHGDRIDIPPGAVLENKIVSGNLRILDH
                     "
     exon            444..571
                     /gene="Ugp2"
                     /gene_synonym="UDPGP; UGPase"
                     /inference="alignment:Splign:2.1.0"
     exon            572..679
                     /gene="Ugp2"
                     /gene_synonym="UDPGP; UGPase"
                     /inference="alignment:Splign:2.1.0"
     exon            680..865
                     /gene="Ugp2"
                     /gene_synonym="UDPGP; UGPase"
                     /inference="alignment:Splign:2.1.0"
     exon            866..999
                     /gene="Ugp2"
                     /gene_synonym="UDPGP; UGPase"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1297
                     /gene="Ugp2"
                     /gene_synonym="UDPGP; UGPase"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1495
                     /gene="Ugp2"
                     /gene_synonym="UDPGP; UGPase"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1738
                     /gene="Ugp2"
                     /gene_synonym="UDPGP; UGPase"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..1843
                     /gene="Ugp2"
                     /gene_synonym="UDPGP; UGPase"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..2847
                     /gene="Ugp2"
                     /gene_synonym="UDPGP; UGPase"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2283..2288
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ugp2"
                     /gene_synonym="UDPGP; UGPase"
                     /note="hexamer: AATAAA"
     polyA_site      2300
                     /gene="Ugp2"
                     /gene_synonym="UDPGP; UGPase"
                     /note="major polyA site"
     regulatory      2813..2818
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ugp2"
                     /gene_synonym="UDPGP; UGPase"
                     /note="hexamer: AATATA"
     polyA_site      2835
                     /gene="Ugp2"
                     /gene_synonym="UDPGP; UGPase"
ORIGIN      
        1 gctggacggc cgccggcgag gggcctcggg gtgcggccgg gggcctgcgg cagtcctgcc
       61 ctagagggcg tggagaccgg agggcggtga agcggctcta ggtccgcctc tccattgatg
      121 aaatttaagt tcgtctggtt ttaccttttc cggagtctcc agtcgtcccc tgttggtgtc
      181 gggatcgctg agtagcctgg agttccctcc caagctgagt cggtcccacc aagttttccg
      241 tcttcaggat ttttcttttt aaagactagt tttgattttt tttccccccg aattcttctt
      301 taagtagtta aacatcggag gagaaagaac acttcggttg cagggaaggg agagagacct
      361 tccttacaac gtagattcta gaaattgaaa attataagcc agattatttt aataagatcc
      421 taaaatgtcg agatttgtac aagatcttag caaagctatg tctcaagatg gtgcttctca
      481 gttccaagag gtcattctcc aagaactaga attatctgtg aagaaagaat tagaaaaaat
      541 acttaccaca gcagcctcac atgagtttga gcacactaaa aaagatcttg atggatttcg
      601 gaagctattt catagatttt tgcaagaaaa gggaccgtct gtggactggg gtaaaatcca
      661 gagacctcca gaagattcga ttcaacccta tgaaaagata aaagccagag gcttgcctga
      721 taacatatct tctgtgttga acaagttggt ggtagtgaaa ctcaatggtg gtttgggaac
      781 cagcatgggc tgcaaaggcc ctaaaagtct gattggtgta agaaatgaga acaccttttt
      841 ggatctaact gttcagcaaa ttgaacattt gaacaaaacc tataatacag atgttcctct
      901 cgttttaatg aattctttta acacggatga agataccaaa aaaatactcc agaagtacaa
      961 tcactgtcgt gtgaaaatct acaccttcaa tcaaagcagg tacccgagga tcaataagga
     1021 atctctactt cctatagcaa aggatgtgtc ttattcaggg gaaaatactg aagcttggta
     1081 ccctccaggg catggagata tctatgctag tttctacaat tctggcttgc tcgatacctt
     1141 tatagaagaa ggcaaagagt atatttttgt gtctaacata gataatctgg gtgccacagt
     1201 ggatctttat attcttaatc acctgatgaa cccacccaat gggaagcgct gtgagtttgt
     1261 catggaagtc acaaacaaaa cacgagcaga tgttaagggt gggacactca ctcagtatga
     1321 aggcaaactg agactggtgg aaatcgctca agtgcccaaa gcacacgttg atgagttcaa
     1381 gtctgtgtca aaatttaaaa tatttaacac aaacaaccta tggatttctc ttggagcagt
     1441 taaaagactt caggaacaga atgccattga catggaaatc attgtgaatc caaagacatt
     1501 ggatggaggc ctgaatgtaa ttcagttaga aactgcagtt ggagctgcaa ttaaaagttt
     1561 cgagaattct ttaggtatta atgttccaag gagtcgtttt ctgcctgtga aaaccacatc
     1621 agatctcttg cttgtgatgt caaacctcta tagccttaac gcaggatctc tgaccatgag
     1681 tgaaaagcgt gaattcccta cagtgccctt ggttaaatta ggcagttctt ttaccaaggt
     1741 tcaagattat ctaagaaggt ttgaaagtat acccgatatg ctggaactgg accacctcac
     1801 tgtttcagga gatgtgacat ttggaaaaaa tgtttcacta aagggaacag ttattattat
     1861 tgcaaatcat ggtgacagaa ttgacatccc cccaggagcc gtgttagaga acaagattgt
     1921 atctggaaac cttcggatcc tggatcactg aaataagcac tttcagatac actttctact
     1981 aattatgggc taaagagttt cttataataa aatatcctct aagattataa aataagcagg
     2041 tactttattt actatgttgt actctgcagt gttgattttt taaagtagtt ttctgcaatg
     2101 agcttttagt ctaaggaaag catagatgaa gcaatacttt ccttctttga tgaaaagcct
     2161 agaaattagt tcctcttaaa gtgcaatatt acttaacctc agaatcgggc cagttctgta
     2221 gatcctcaag agaagcttca gtgactgtcc ctttgaattg cctccgattt caaaaataaa
     2281 taaataaatc tacacgttta cttttgctgt ctagtgctca ctcttgtgaa atgcagaaaa
     2341 agtcaagtac tcttgctcca acataaacag gaaggtttgt tcttgcagtt ttatcactag
     2401 ccagtccagg attttttttt tttttctgat tttcatttct aagactatta aacatagttg
     2461 acactagaac taaacttgac agtatttagt gttcatctgg ttctagacct gggatacctg
     2521 ccgtgctgta cacatttcat caaactgttt gcccagagga aggaaggggt gagcaggtca
     2581 aagtagagca tgtcttttac atccttgttt cctgcagctc tctgttgggg gaggggatat
     2641 catgtcatta gaagttacct ctcattacag cttcagttct taacactctg ttgccactca
     2701 gaaatactga taacctttgc aatcaggtcc actggtggtt agatgtgtgc ctttctagcc
     2761 aagaaatatt tccagttctt ccatatttgt tttgaaaagg ctgtgtgttt aaaatatact
     2821 gtaccattga aaaaagttgc cttttaa
//
