LOCUS       NM_198899               9045 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus UDP-glucose glycoprotein glucosyltransferase 1
            (Uggt1), mRNA.
ACCESSION   NM_198899 XM_129854
VERSION     NM_198899.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9045)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 9045)
  AUTHORS   Cho,J., Tsugawa,Y. and Imai,T.
  TITLE     R1526 residue in arginine/proinsulin binding domain of UGGT1 is
            involved in proinsulin binding
  JOURNAL   Biochem Biophys Res Commun 615, 131-135 (2022)
   PUBMED   35613513
  REMARK    GeneRIF: R1526 residue in arginine/proinsulin binding domain of
            UGGT1 is involved in proinsulin binding.
REFERENCE   3  (bases 1 to 9045)
  AUTHORS   Cho,J., Hiramoto,M., Masaike,Y., Sakamoto,S., Imai,Y., Imai,Y.,
            Handa,H. and Imai,T.
  TITLE     UGGT1 retains proinsulin in the endoplasmic reticulum in an
            arginine dependent manner
  JOURNAL   Biochem Biophys Res Commun 527 (3), 668-675 (2020)
   PUBMED   32423812
  REMARK    GeneRIF: UGGT1 retains proinsulin in the endoplasmic reticulum in
            an arginine dependent manner.
REFERENCE   4  (bases 1 to 9045)
  AUTHORS   Huang,P.N., Jheng,J.R., Arnold,J.J., Wang,J.R., Cameron,C.E. and
            Shih,S.R.
  TITLE     UGGT1 enhances enterovirus 71 pathogenicity by promoting viral RNA
            synthesis and viral replication
  JOURNAL   PLoS Pathog 13 (5), e1006375 (2017)
   PUBMED   28545059
  REMARK    GeneRIF: Increased UGGT1 levels elevated viral growth rates, while
            viral pathogenicity was observed to be lower in heterozygous
            knockout mice (Uggt1 +/- mice). These findings provide important
            insight on the role of UPR and host UGGT1 in regulating RNA virus
            replication and pathogenicity.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9045)
  AUTHORS   Bockor,L., Bortolussi,G., Vodret,S., Iaconcig,A., Jasprova,J.,
            Zelenka,J., Vitek,L., Tiribelli,C. and Muro,A.F.
  TITLE     Modulation of bilirubin neurotoxicity by the Abcb1 transporter in
            the Ugt1-/- lethal mouse model of neonatal hyperbilirubinemia
  JOURNAL   Hum Mol Genet 26 (1), 145-157 (2017)
   PUBMED   28025333
  REMARK    GeneRIF: Loss of UGT1 expression is associated with neonatal
            hyperbilirubinemia.
REFERENCE   6  (bases 1 to 9045)
  AUTHORS   Labunskyy,V.M., Ferguson,A.D., Fomenko,D.E., Chelliah,Y.,
            Hatfield,D.L. and Gladyshev,V.N.
  TITLE     A novel cysteine-rich domain of Sep15 mediates the interaction with
            UDP-glucose:glycoprotein glucosyltransferase
  JOURNAL   J Biol Chem 280 (45), 37839-37845 (2005)
   PUBMED   16129668
  REMARK    GeneRIF: The cysteine-rich domain of Sep15 exclusively mediates
            protein-protein interactions with UDP-glucose:glycoprotein
            glucosyltransferase.
REFERENCE   7  (bases 1 to 9045)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 9045)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 9045)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 9045)
  AUTHORS   Korotkov,K.V., Kumaraswamy,E., Zhou,Y., Hatfield,D.L. and
            Gladyshev,V.N.
  TITLE     Association between the 15-kDa selenoprotein and
            UDP-glucose:glycoprotein glucosyltransferase in the endoplasmic
            reticulum of mammalian cells
  JOURNAL   J Biol Chem 276 (18), 15330-15336 (2001)
   PUBMED   11278576
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK639915.1, BC062936.1, CD808359.1, AK044321.1, AK134231.1,
            AK162491.1 and AI877337.1.
            
            On May 13, 2009 this sequence version replaced NM_198899.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062936.1, SRR10223970.227.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                CK639915.1         1-53
            54-3421             BC062936.1         1-3368
            3422-3925           CD808359.1         185-688
            3926-5569           BC062936.1         3873-5516
            5570-6845           AK044321.1         169-1444
            6846-6899           AK134231.1         249-302
            6900-8392           AK134231.1         304-1796
            8393-9027           AK162491.1         852-1486
            9028-9045           AI877337.1         227-244
FEATURES             Location/Qualifiers
     source          1..9045
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 15.15 cM"
     gene            1..9045
                     /gene="Uggt1"
                     /gene_synonym="0910001L17Rik; A930007H10Rik;
                     C820010P03Rik; GT; Ugcgl1; UGT1"
                     /note="UDP-glucose glycoprotein glucosyltransferase 1"
                     /db_xref="GeneID:320011"
                     /db_xref="MGI:MGI:2443162"
     exon            1..233
                     /gene="Uggt1"
                     /gene_synonym="0910001L17Rik; A930007H10Rik;
                     C820010P03Rik; GT; Ugcgl1; UGT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..4831
                     /gene="Uggt1"
                     /gene_synonym="0910001L17Rik; A930007H10Rik;
                     C820010P03Rik; GT; Ugcgl1; UGT1"
                     /note="UDP-glucose ceramide glucosyltransferase-like 1;
                     UDP-glucose:glycoprotein glucosyltransferase;
                     UDP--Glc:glycoprotein glucosyltransferase"
                     /codon_start=1
                     /product="UDP-glucose:glycoprotein glucosyltransferase 1
                     precursor"
                     /protein_id="NP_942602.2"
                     /db_xref="CCDS:CCDS48238.1"
                     /db_xref="GeneID:320011"
                     /db_xref="MGI:MGI:2443162"
                     /translation="MCSRGDANTADAAAARRVTGLRYNMRLLIALALPCLFSLAEANS
                     KAITTSLTTKWFSAPLLLEASEFLAEDSQEKFWSFVEATQNIGSSDHHDTDHSYYDAV
                     LEAAFRFLSPLQQNLLKFCLSLRSYSASIQAFQQIAVDEPPPEGCKSFLSVHGKQTCD
                     LDTLESLLLTAADRPKPLLFKGDHRYPSSNPESPVVILYSEIGHEEFSNIHHQLISKS
                     NEGKINYVFRHYISNPSKEPVYLSGYGVELAIKSTEYKAKDDTQVKGTEVNATVIGES
                     DPIDEVQGFLFGKLRELYPALEGQLKEFRKHLVESTNEMAPLKVWQLQDLSFQTAARI
                     LAASGALSLVVMKDISQNFPTKARAITKTAVSAQLRAEVEENQKYFKGTIGLQPGDSA
                     LFINGLHIDLDTQDIFSLFDTLRNEARVMEGLHRLGIEGLSLHNILKLNIQPSETDYA
                     VDIRSPAISWVNNLEVDSRYNSWPSSLQELLRPTFPGVIRQIRKNLHNMVFIIDPVHE
                     TTAELISIAEMFLSNHIPLRIGFIFVVNDSEDVDGMQDAGVAVLRAYNYVAQEVDGYH
                     AFQTLTQIYNKVRTGETVKVEHVVSVLEKKYPYVEVNSILGIDSAYDQNRKEARGYYE
                     QTGVGPLPVVLFNGMPFEKEQLDPDELETITMHKILETTTFFQRAVYLGELSHDQDVV
                     EYIMNQPNVVPRINSRILTAKREYLDLTASNNFYVDDFARFSALDSRGKTAAIANSMN
                     YLTKKGMSSKEIYDDSFIRPVTFWIVGDFDSPSGRQLLYDAIKHQKTSNNVRISMINN
                     PSQEISDSSTPIFRAIWAALQTQASSSAKNFITKMAKEETAEALAAGVDIAEFSVGGM
                     DVSLFKEVFESSRMDFILSHALYCRDVLKLKKGQRVVISNGRIIGPLEDNELFNQDDF
                     HLLENIILKTSGQKIKSHIQQLRVEEDVASDLVMKVDALLSAQPKGEARIEYQFFEDK
                     HSAIKLKPKEGETYYDVVAVVDPVTREAQRLAPLLLVLTQLINMNLRVFMNCQSKLSD
                     MPLKSFYRYVLEPEISFTADSSFAKGPIAKFLDMPQSPLFTLNLNTPESWMVESVRTP
                     YDLDNIYLEEVDSIVAAEYELEYLLLEGHCYDITTGQPPRGLQFTLGTSANPTIVDTI
                     VMANLGYFQLKANPGAWILRLRKGRSDDIYRIYSHDGTDSPPDANDVVVILNNFKSKI
                     IKVKVQKKADMANEDLLSDGTNENESGFWDSFKWGFSGQKAEEVKQDKDDIINIFSVA
                     SGHLYERFLRIMMLSVLKNTKTPVKFWFLKNYLSPTFKEFIPYMAKKYNFQYELVQYK
                     WPRWLHQQTEKQRIIWGYKILFLDVLFPLVVDKFLFVDADQIVRTDLKELRDFNLDGA
                     PYGYTPFCDSRREMDGYRFWKSGYWASHLAGRKYHISALYVVDLKKFRKIAAGDRLRG
                     QYQGLSQDPNSLSNLDQDLPNNMIHQVPIKSLPQEWLWCETWCDDASKKRAKTIDLCN
                     NPMTKEPKLEAAVRIVPEWQDYDQEIKQLQTLFQEEKELGTLHTEETQEGSQKHEEL"
     exon            234..369
                     /gene="Uggt1"
                     /gene_synonym="0910001L17Rik; A930007H10Rik;
                     C820010P03Rik; GT; Ugcgl1; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            370..452
                     /gene="Uggt1"
                     /gene_synonym="0910001L17Rik; A930007H10Rik;
                     C820010P03Rik; GT; Ugcgl1; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            453..583
                     /gene="Uggt1"
                     /gene_synonym="0910001L17Rik; A930007H10Rik;
                     C820010P03Rik; GT; Ugcgl1; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            584..696
                     /gene="Uggt1"
                     /gene_synonym="0910001L17Rik; A930007H10Rik;
                     C820010P03Rik; GT; Ugcgl1; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            697..871
                     /gene="Uggt1"
                     /gene_synonym="0910001L17Rik; A930007H10Rik;
                     C820010P03Rik; GT; Ugcgl1; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            872..968
                     /gene="Uggt1"
                     /gene_synonym="0910001L17Rik; A930007H10Rik;
                     C820010P03Rik; GT; Ugcgl1; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1047
                     /gene="Uggt1"
                     /gene_synonym="0910001L17Rik; A930007H10Rik;
                     C820010P03Rik; GT; Ugcgl1; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1148
                     /gene="Uggt1"
                     /gene_synonym="0910001L17Rik; A930007H10Rik;
                     C820010P03Rik; GT; Ugcgl1; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1248
                     /gene="Uggt1"
                     /gene_synonym="0910001L17Rik; A930007H10Rik;
                     C820010P03Rik; GT; Ugcgl1; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1309
                     /gene="Uggt1"
                     /gene_synonym="0910001L17Rik; A930007H10Rik;
                     C820010P03Rik; GT; Ugcgl1; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1401
                     /gene="Uggt1"
                     /gene_synonym="0910001L17Rik; A930007H10Rik;
                     C820010P03Rik; GT; Ugcgl1; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1552
                     /gene="Uggt1"
                     /gene_synonym="0910001L17Rik; A930007H10Rik;
                     C820010P03Rik; GT; Ugcgl1; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1672
                     /gene="Uggt1"
                     /gene_synonym="0910001L17Rik; A930007H10Rik;
                     C820010P03Rik; GT; Ugcgl1; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1758
                     /gene="Uggt1"
                     /gene_synonym="0910001L17Rik; A930007H10Rik;
                     C820010P03Rik; GT; Ugcgl1; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1894
                     /gene="Uggt1"
                     /gene_synonym="0910001L17Rik; A930007H10Rik;
                     C820010P03Rik; GT; Ugcgl1; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..2026
                     /gene="Uggt1"
                     /gene_synonym="0910001L17Rik; A930007H10Rik;
                     C820010P03Rik; GT; Ugcgl1; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2191
                     /gene="Uggt1"
                     /gene_synonym="0910001L17Rik; A930007H10Rik;
                     C820010P03Rik; GT; Ugcgl1; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..2312
                     /gene="Uggt1"
                     /gene_synonym="0910001L17Rik; A930007H10Rik;
                     C820010P03Rik; GT; Ugcgl1; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2313..2411
                     /gene="Uggt1"
                     /gene_synonym="0910001L17Rik; A930007H10Rik;
                     C820010P03Rik; GT; Ugcgl1; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2412..2435
                     /gene="Uggt1"
                     /gene_synonym="0910001L17Rik; A930007H10Rik;
                     C820010P03Rik; GT; Ugcgl1; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2436..2530
                     /gene="Uggt1"
                     /gene_synonym="0910001L17Rik; A930007H10Rik;
                     C820010P03Rik; GT; Ugcgl1; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2531..2737
                     /gene="Uggt1"
                     /gene_synonym="0910001L17Rik; A930007H10Rik;
                     C820010P03Rik; GT; Ugcgl1; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2738..2869
                     /gene="Uggt1"
                     /gene_synonym="0910001L17Rik; A930007H10Rik;
                     C820010P03Rik; GT; Ugcgl1; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2870..3000
                     /gene="Uggt1"
                     /gene_synonym="0910001L17Rik; A930007H10Rik;
                     C820010P03Rik; GT; Ugcgl1; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            3001..3096
                     /gene="Uggt1"
                     /gene_synonym="0910001L17Rik; A930007H10Rik;
                     C820010P03Rik; GT; Ugcgl1; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            3097..3199
                     /gene="Uggt1"
                     /gene_synonym="0910001L17Rik; A930007H10Rik;
                     C820010P03Rik; GT; Ugcgl1; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            3200..3279
                     /gene="Uggt1"
                     /gene_synonym="0910001L17Rik; A930007H10Rik;
                     C820010P03Rik; GT; Ugcgl1; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            3280..3469
                     /gene="Uggt1"
                     /gene_synonym="0910001L17Rik; A930007H10Rik;
                     C820010P03Rik; GT; Ugcgl1; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            3470..3628
                     /gene="Uggt1"
                     /gene_synonym="0910001L17Rik; A930007H10Rik;
                     C820010P03Rik; GT; Ugcgl1; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            3629..3714
                     /gene="Uggt1"
                     /gene_synonym="0910001L17Rik; A930007H10Rik;
                     C820010P03Rik; GT; Ugcgl1; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            3715..3799
                     /gene="Uggt1"
                     /gene_synonym="0910001L17Rik; A930007H10Rik;
                     C820010P03Rik; GT; Ugcgl1; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            3800..3888
                     /gene="Uggt1"
                     /gene_synonym="0910001L17Rik; A930007H10Rik;
                     C820010P03Rik; GT; Ugcgl1; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            3889..3990
                     /gene="Uggt1"
                     /gene_synonym="0910001L17Rik; A930007H10Rik;
                     C820010P03Rik; GT; Ugcgl1; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            3991..4075
                     /gene="Uggt1"
                     /gene_synonym="0910001L17Rik; A930007H10Rik;
                     C820010P03Rik; GT; Ugcgl1; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            4076..4258
                     /gene="Uggt1"
                     /gene_synonym="0910001L17Rik; A930007H10Rik;
                     C820010P03Rik; GT; Ugcgl1; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            4259..4419
                     /gene="Uggt1"
                     /gene_synonym="0910001L17Rik; A930007H10Rik;
                     C820010P03Rik; GT; Ugcgl1; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            4420..4534
                     /gene="Uggt1"
                     /gene_synonym="0910001L17Rik; A930007H10Rik;
                     C820010P03Rik; GT; Ugcgl1; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            4535..4651
                     /gene="Uggt1"
                     /gene_synonym="0910001L17Rik; A930007H10Rik;
                     C820010P03Rik; GT; Ugcgl1; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            4652..4805
                     /gene="Uggt1"
                     /gene_synonym="0910001L17Rik; A930007H10Rik;
                     C820010P03Rik; GT; Ugcgl1; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            4806..9029
                     /gene="Uggt1"
                     /gene_synonym="0910001L17Rik; A930007H10Rik;
                     C820010P03Rik; GT; Ugcgl1; UGT1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      5575
                     /gene="Uggt1"
                     /gene_synonym="0910001L17Rik; A930007H10Rik;
                     C820010P03Rik; GT; Ugcgl1; UGT1"
                     /note="major polyA site"
     regulatory      9006..9011
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Uggt1"
                     /gene_synonym="0910001L17Rik; A930007H10Rik;
                     C820010P03Rik; GT; Ugcgl1; UGT1"
                     /note="hexamer: AATAAA"
     polyA_site      9029
                     /gene="Uggt1"
                     /gene_synonym="0910001L17Rik; A930007H10Rik;
                     C820010P03Rik; GT; Ugcgl1; UGT1"
ORIGIN      
        1 ggaagtgcag gggcagctgg caactgggtt attgctttga gaaaccggct tgtgaggagc
       61 ggcgggaaag gcgcgtgtcg gcttctcact ggcgcagcct ccccggcgat cgccgctgct
      121 ccgccctgcc caggcgtcgt tgcagacacc ggagtggacg aagcgcggcc cgggcatgtg
      181 cagccggggg gatgcgaaca ctgcggatgc cgcggctgcg cggcgggtga cagggctccg
      241 ttacaacatg agactcctga ttgcactggc cttaccgtgc ctgttttcct tagcagaagc
      301 caattcaaaa gccattacca cctctctcac cacaaagtgg ttttctgccc cactgctgct
      361 ggaagccagt gagttcttag cagaagacag tcaagagaaa ttttggagtt ttgtagaagc
      421 cactcaaaac attggatcat cagatcatca cgatactgat cactcctatt acgatgccgt
      481 attggaagct gcgtttcgct tcctgtcccc tctgcagcag aatttgttga agttttgtct
      541 ctctctccgt tcctactcag cctcaattca agccttccag cagatagcag ttgacgagcc
      601 tccaccagaa gggtgcaagt cgtttctctc agtgcatgga aagcagactt gtgatctaga
      661 cactctggag agccttctgc tgactgccgc tgacagaccg aaaccattat tgttcaaagg
      721 agatcacaga tatccctcat caaatcctga gagtccagtg gtcatccttt attctgagat
      781 tggccatgaa gaattttcta atattcacca ccaacttata tcaaaaagca acgaaggcaa
      841 aattaattat gtattccgac attatatatc taatcccagc aaggagccgg tttacctttc
      901 tggctatgga gtggaactgg cgatcaagag cacggagtac aaggccaagg atgatactca
      961 ggtgaaagga actgaggtaa atgccacggt catcggggag agcgacccta ttgatgaagt
     1021 gcagggattc ctctttggaa aattaagaga actgtacccc gccttggaag gacagctgaa
     1081 agagttccgg aagcaccttg tggagagcac caacgagatg gcccccctga aagtctggca
     1141 gctgcaagat ctcagcttcc agactgctgc ccgaatcttg gctgcttctg gggcattatc
     1201 tctggtggtg atgaaggaca ttagtcagaa ctttcctacc aaggccagag caataacgaa
     1261 aacggctgtg agcgcgcagc ttagagcgga agtggaagag aaccagaagt atttcaaggg
     1321 aactatagga ttacagcctg gagactcagc gctcttcatc aatggacttc atatcgattt
     1381 agacacccag gatatattca gtctatttga tacattgagg aatgaagccc gtgtaatgga
     1441 gggtctgcac aggctgggaa tagaaggcct ttctctacat aatattttga agctgaacat
     1501 ccagccctct gagactgact acgcagtaga catcaggagt cctgctattt cctgggtcaa
     1561 caacctagag gtcgatagcc gatataactc atggccttca agcttacagg agttactccg
     1621 ccccacgttt cctggtgtca tacggcagat cagaaagaac ctgcataaca tggttttcat
     1681 tatcgatcct gtacacgaga ccacagccga gttgattagc atcgccgaga tgttcctcag
     1741 caatcacata ccgctaagga ttggttttat ctttgtggtc aatgactctg aagatgttga
     1801 tgggatgcaa gatgctggag tcgctgttct gagagcgtat aattatgtgg ctcaggaagt
     1861 ggatggctat cacgccttcc agactctcac acagatctat aacaaggtga ggactggaga
     1921 gacagtgaaa gtggagcacg tggtcagtgt cttggagaag aagtacccgt acgtggaagt
     1981 gaatagcatt ctgggaattg attctgctta cgatcagaat cggaaggaag caagaggcta
     2041 ctatgagcag actggagtag gccccctgcc tgttgtcctg ttcaatggaa tgccctttga
     2101 aaaggagcag ttagacccgg atgagctgga aaccatcaca atgcacaaga tcttggagac
     2161 aaccaccttc ttccaaagag ctgtgtactt gggtgagctg tcccatgatc aagatgtggt
     2221 agagtacatc atgaatcagc caaatgttgt tccaagaatc aactctagga ttctgacagc
     2281 taagcgagag tatctggacc taacagcaag caataatttt tatgtggatg actttgccag
     2341 attttctgcc ttggactctc ggggcaagac ggctgctatt gccaacagta tgaactatct
     2401 gacgaaaaaa ggaatgtcct ccaaggaaat ctatgatgat tcttttatta gaccagtgac
     2461 tttttggatt gttggagatt ttgatagccc ttctgggcgg cagctactat atgatgccat
     2521 taaacatcag aaaaccagta acaatgttag gataagtatg atcaacaatc ccagccaaga
     2581 gatcagtgac tcaagcaccc ccatcttcag agccatctgg gcagctctgc aaacacaggc
     2641 ctccagctct gctaagaact tcatcaccaa gatggccaaa gaggagacgg cagaggccct
     2701 ggccgcagga gtggacattg cggaattctc tgtcgggggc atggatgtca gtctttttaa
     2761 agaggtcttt gagtcttcca gaatggattt cattttgtct catgccctgt actgcaggga
     2821 tgttctgaag ctgaagaagg gacagcgagt ggtgatcagc aacggaagga tcattgggcc
     2881 tctggaggac aatgagctct tcaaccaaga tgatttccac ctcctggaaa atatcatcct
     2941 gaaaacatcg ggacagaaaa taaagtctca tatccaacag cttcgagtag aagaagacgt
     3001 ggccagtgat ttggtaatga aggtggatgc tctcctgtca gcacaaccca aaggagaggc
     3061 gaggatcgag taccagttct ttgaggataa acacagtgca attaagctga agcccaaaga
     3121 aggagagaca tactatgatg tggtagccgt tgttgaccct gtcacacgag aagcacagag
     3181 gctcgccccc ttgctcttgg ttttgactca gctgataaac atgaatctaa gagtatttat
     3241 gaattgccaa tccaagcttt ccgacatgcc tttaaaaagc ttttaccgtt acgtcttaga
     3301 gccggagatt tctttcactg cagacagcag ctttgctaag ggaccgatag caaagtttct
     3361 ggatatgcca cagtctccgc tgtttacttt gaatctgaac acacctgaga gttggatggt
     3421 agaatctgtc agaacaccat atgatctgga taatatttat ctagaagagg tggacagtat
     3481 agtggctgct gagtatgagc tggaatatct gttactagaa ggtcattgtt acgacatcac
     3541 cacaggccag ccccctcgag gactacagtt cactttagga acttcagcca acccaacaat
     3601 tgtggacaca attgtgatgg ccaatctggg atattttcag ctcaaagcca atccgggagc
     3661 ctggattctg agactgagga aggggcgctc agatgacatt tataggatct acagccatga
     3721 tggtacagat tcccctcctg atgcaaacga cgttgttgtc atcctcaata acttcaagag
     3781 caagatcatc aaagtgaagg ttcagaagaa ggcagacatg gctaatgaag acttgctgag
     3841 tgatgggaca aatgagaacg agtctggatt ctgggactca ttcaagtggg gcttctcagg
     3901 acagaaggct gaagaagtga agcaagataa agatgacata atcaatattt tctctgttgc
     3961 atctggtcat ctctacgaaa gatttcttcg catcatgatg ctctcagtcc tgaagaatac
     4021 caagactcct gtgaagttct ggttcttgaa gaactacttg tcccccacat ttaaggagtt
     4081 tataccttac atggccaaaa aatacaattt ccagtatgag cttgttcagt acaaatggcc
     4141 aaggtggctt caccagcaga cggagaagca gcgaatcatc tggggctaca agatcctctt
     4201 cctggacgtg cttttcccgc tggttgttga caagttcctc tttgtggatg ctgatcagat
     4261 tgtacggaca gatctgaagg agttaagaga tttcaatttg gatggtgcgc cttacggtta
     4321 cactcccttc tgcgacagca ggagagagat ggatggctac cgcttctgga agtcagggta
     4381 ctgggccagt catttggctg gacgaaagta tcacatcagt gcgctgtatg tcgtggatct
     4441 gaagaagttt aggaaaatag ctgctggaga cagactcagg ggacagtacc aaggtctgag
     4501 ccaggatccc aacagtcttt caaatcttga tcaagatttg cccaataaca tgatccatca
     4561 ggtgccaatc aaatcgctcc ctcaggaatg gctttggtgt gaaacgtggt gtgatgacgc
     4621 ctctaagaag cgggcaaaga ccatcgacct gtgtaataat cccatgacta aggagcccaa
     4681 actggaggct gccgtgcgga tcgtccctga gtggcaagac tacgaccagg agatcaagca
     4741 gctgcagacc ctcttccaag aggagaagga gctggggacc ctgcatacag aggagacgca
     4801 ggaaggctct cagaagcatg aggaattatg atctctggag gaagatggga aacccacctt
     4861 gacagtttgg actaactgct gttttctctg atctttcgat acgactgctg atgaacggat
     4921 tgggcaggtg taccacacct attgatctga gcattgattt agactactgc accctagtgg
     4981 gtgctagatc cttggggcta aggctctgtt ggatttgtac ctcagaggaa gacaagtggc
     5041 tggtcttctg ggactcttct tctcaccaga gggagaaatg ccggcagcaa ctgcaagaag
     5101 cccagtcctt cggtgcccac agcccagagc acacactgct gtgctggccc agaagctggg
     5161 cagaaaggtc accatgttct tccttacctc agtttacctg cagcccttgc tgcagtgcag
     5221 atgcccaccc tgtaccaggt caggccggca gatgcttcat ccatgcctca aggtctacgc
     5281 caacatgctt ctcacgtctc ttcccctccc cacccccctt cccaagcact aggcttgttg
     5341 tttaatggag cccaaccaat aatcatgtgt cttcagggtt ggctcagtgc agttgctaag
     5401 caaatcagtc ttcaggagaa acggggtggt gtggataagg ctggaagaaa tggcaggtag
     5461 tggagagtgt tggggtgttc gatggaagac aaaaacatgg gccgttctct tcagtctagt
     5521 acccagtgaa ctgtccaggt aattgttttg taaacaattt ttctatttat gaaaatgtgt
     5581 gctttttctt cttactttct aaaaagctgt tggttatcag tttcctggct gggcacaggc
     5641 gtcctgagtc cctcagtgac cgctctcagc gtgctcagcc tccgtctgga tgcaccatac
     5701 tgtctgccct ttcccttgta gagttttctc tcagacccag gggataactt tgggtgtttc
     5761 ttcccccaaa tgctctcaga cctgtgacca ggaatgactc tgtctctgga actcggtttc
     5821 ctacactctg tctttccctt gtgctttggc tctgagggtc ccctttggct ttcgagactt
     5881 gccgaggtct ggtccagttc taaggtactg ctgctgtctg aagcagcacc cttcactgct
     5941 ttgtgttcac agccacagcc cagcatcacc tcgggagcag cctgggctga ggagccttcc
     6001 acgtgttgtt aacctggctg gacaggtgtg ggtgtgtggt gtcatctctg cccaggactc
     6061 agggatctac agcagagagt tagtgttgct gggcacaggg tgtggctcag tggcagacag
     6121 agtgcttgtc tagcaagccc aaggccttct gtctggtact gtatctcccc agcccccccc
     6181 ccccaaaaaa aaagactgaa tatgaggaat gagtactgtg ggtaactaag ttcttgcctg
     6241 tccaagctag gtaatatgtg tgttaccatg gaagaatggc ctacaggagc cgtggttagg
     6301 gatttgagtg ggcaattgtt aagtaataag tagagacaga aaactggatt gggaattcag
     6361 agaaccagca ttaaccccct tacctcgtca gctggagctc ccactgagag tcctgggcag
     6421 agcacaagtg tcccctcagg tcaggaatcc acataagaga acaaagagca gcactaaaaa
     6481 caacatcatt tagttcggtg ctcacgacac cccagaaacg agctgggggg ctgctaccat
     6541 cggtcggtca gcagggtttt ctccctctcc ctctgcaggc gcttgggtag caaggacagg
     6601 ctgtagcgag ccctctgacc ttggaaaggt gtctgggaat aaattacttc ccagctgttt
     6661 caagcgatgt attttgactc ttggattatc aaagtgtttt gtcatttgtc ataaagtcag
     6721 ggaaggggca cacatcccca gacaaagggc catggaggat acgtttgaga caaacatgtt
     6781 ccatagcttc ttagcttaac tagcccttga catttattga tacagtgtat attacaacat
     6841 gaatttcaaa aaataaaaaa attaccacac atatatcaag taatatctcc ccccccccca
     6901 ttttcaaatc taaaagttag cttaagagcc agcctttgtt caggcttcat gtccaccctg
     6961 gattaagctc tcagggctgc tgcgcccgac tgtgagcgga agctgtcttc ccagtgccct
     7021 gggagcctgg agtgttgagc aggaatagtc agtgctctga gatgctggcc cggtggccag
     7081 ggtccttctc ttaccaaatt atgtgtgcct cctctgagga agaggaaggc atgggtctcc
     7141 tatggccctt tagtccctcg tgggtcacta cactgacata agtcatattc agagctgatg
     7201 ctggctaggc cagaccctaa actaaaccct tctaaagctg tccaggcccc ccctttcctg
     7261 gtccttcctt gcatcctgtg gattaaatca tctctacaaa ctaagccact gccacaaatg
     7321 ggctgctgcc ggcaagtggc cctggaaggg tgtccctgtc agatttcacc tgacattctc
     7381 actacgaaaa agcatgttgt gactgaaaag agagatgagc tattctccaa gaagcaggaa
     7441 gtgactgagc agacaggtta ttgaggctcc tggagagctc accgccattc ttggcctgcg
     7501 aataaatggt tctttgacct cctgtcatat agcagtagag tgtttccttt ctgaatcact
     7561 agggtagtgt gacctgtgac aagtcagact gtgccgatgt gaatccatga aaagcggccc
     7621 ttgactggac ctggggctgt ggggcacagc tctccagagt cctgggttag aagtatcctg
     7681 gatgcaccca tgtcgagagt ggtaatgtgc tggtttcata agatagttgg cgttgttacc
     7741 cgggcagagg ctacatttct ggttgagcat ggtcgtctcg gggcgtgcat gtgtgcaccg
     7801 tgcagggcct gtctggtcag gagcagactt catggcaggt atgttacctg gctctcgtct
     7861 gagttgctga aagatgagct gagagcccag tgctaaagaa ggaagaaaag aacaagcaaa
     7921 caaacaaaca aaaaacagga aacaaacttg actggcatag tttaggactg gtcagatttg
     7981 gtcaccagta tgaagtcaac tcctcttgtc cgcgtgtcct ccattaaatt acccttctaa
     8041 aattaccctt cctagttaga cccgcatgct tcaaggaaat gatgcacctg aggcgttggg
     8101 aaggcgctca ctcccatgca cttttctggg gagagttcat ggaaggctgc ctagagggac
     8161 acgtgctggc agtacggagc acgacttctt aagagagttg ttgagtccgt ggctttatgg
     8221 gatattgtat gatgatcaga gtcaatcaaa cggctcctca cgttcttgtt tactaagtag
     8281 gggagcagtt ttctgttgaa atttcatgaa ctcccatttt ctctgcctta aggtaatgag
     8341 gacttctcaa atgctggatc aagctcaagc acattaaaca ttgtcactca ggaagtcact
     8401 aaaatttcca agtgtctgga agggtctcac ccctccctca ttgctggtgt tttgtgtctc
     8461 cgtgtaataa cagaaagctc ttctgtgtta catagccatg gtgggttggc ggatccttct
     8521 cgtggagtca ttgcatgctg actgccaaga gcagctgagc gtcggtgcca ggcatcagcg
     8581 tggcacaggg aagtccatca ggtcggggac agaaagcggg aggcctcttc ctagtctccc
     8641 gggtccttag cagtgtggag ggtccgtgac cgaccgtatg agcagggcgt ggagccgtgg
     8701 actttcccag cctgtgcttt ctgcttgcct tacttgaccc cggtgggctc aacaaagaag
     8761 tgggcaccat tcccttagcc agatgcaaac tctactcacc caaggtcggc agtgcaacag
     8821 agactaccaa gcactctgtt ttcctaccca aaaaaagggg aaatggagag agagcttagg
     8881 ggttttaaag aaactgtgtc ctactctgtc cattcaaacc aacacctcac ttggcgatga
     8941 ggttaaactc tgtggatgtc ttagtccacg cgggtttcac cgtgagagta agatctgtcc
     9001 aacacaataa aattcctcct ctcttcttaa aaaaaaaaaa aaaaa
//
