LOCUS       NM_009466               2461 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Mus musculus UDP-glucose dehydrogenase (Ugdh), mRNA.
ACCESSION   NM_009466
VERSION     NM_009466.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2461)
  AUTHORS   Fan,M., Huo,S., Guo,Y., Wang,R., Hao,W., Zhang,Z., Wang,L. and
            Zhao,Y.
  TITLE     UDP-glucose dehydrogenase supports autophagy-deficient PDAC growth
            via increasing hyaluronic acid biosynthesis
  JOURNAL   Cell Rep 43 (2), 113808 (2024)
   PUBMED   38367236
  REMARK    GeneRIF: UDP-glucose dehydrogenase supports autophagy-deficient
            PDAC growth via increasing hyaluronic acid biosynthesis.
REFERENCE   2  (bases 1 to 2461)
  AUTHORS   Lee,J.G., Yon,J.M., Kim,G., Lee,S.G., Kim,C.Y., Cheong,S.A.,
            Kim,H.Y., Yu,J., Kim,K., Sung,Y.H., Yoo,H.J., Woo,D.C., Rho,J.K.,
            Ha,C.H., Pack,C.G., Oh,S.H., Lim,J.S., Han,Y.M., Hong,E.J.,
            Seong,J.K., Lee,H.W., Lee,S.W., Lee,K.U., Kim,C.J., Nam,S.Y.,
            Cho,Y.S. and Baek,I.J.
  TITLE     PIBF1 regulates trophoblast syncytialization and promotes
            cardiovascular development
  JOURNAL   Nat Commun 15 (1), 1487 (2024)
   PUBMED   38374152
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2461)
  AUTHORS   Harrington,B.S., Kamdar,R., Ning,F., Korrapati,S., Caminear,M.W.,
            Hernandez,L.F., Butcher,D., Edmondson,E.F., Traficante,N.,
            Hendley,J., Gough,M., Rogers,R., Lourie,R., Shetty,J., Tran,B.,
            Elloumi,F., Abdelmaksoud,A., Nag,M.L., Mazan-Mamczarz,K.,
            House,C.D., Hooper,J.D. and Annunziata,C.M.
  CONSRTM   Australian Ovarian Cancer Study
  TITLE     UGDH promotes tumor-initiating cells and a fibroinflammatory tumor
            microenvironment in ovarian cancer
  JOURNAL   J Exp Clin Cancer Res 42 (1), 270 (2023)
   PUBMED   37858159
  REMARK    GeneRIF: UGDH promotes tumor-initiating cells and a
            fibroinflammatory tumor microenvironment in ovarian cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2461)
  AUTHORS   Zhang,T., Zhang,N., Xing,J., Zhang,S., Chen,Y., Xu,D. and Gu,J.
  TITLE     UDP-glucuronate metabolism controls RIPK1-driven liver damage in
            nonalcoholic steatohepatitis
  JOURNAL   Nat Commun 14 (1), 2715 (2023)
   PUBMED   37169760
  REMARK    GeneRIF: UDP-glucuronate metabolism controls RIPK1-driven liver
            damage in nonalcoholic steatohepatitis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2461)
  AUTHORS   Chandrasekaran,R., Mathieu,C., Sheth,R., Cheng,A.P., Fong,D.,
            McCormack,R., El-Gabalawy,H., Alishetty,S., Paige,M. and
            Hoemann,C.D.
  TITLE     UDP-glucose dehydrogenase (UGDH) activity is suppressed by peroxide
            and promoted by PDGF in fibroblast-like synoviocytes: Evidence of a
            redox control mechanism
  JOURNAL   PLoS One 17 (9), e0274420 (2022)
   PUBMED   36107941
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2461)
  AUTHORS   Stankunas,K., Hang,C.T., Tsun,Z.Y., Chen,H., Lee,N.V., Wu,J.I.,
            Shang,C., Bayle,J.H., Shou,W., Iruela-Arispe,M.L. and Chang,C.P.
  TITLE     Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment
            for myocardial morphogenesis
  JOURNAL   Dev Cell 14 (2), 298-311 (2008)
   PUBMED   18267097
REFERENCE   7  (bases 1 to 2461)
  AUTHORS   Garcia-Garcia,M.J., Eggenschwiler,J.T., Caspary,T., Alcorn,H.L.,
            Wyler,M.R., Huangfu,D., Rakeman,A.S., Lee,J.D., Feinberg,E.H.,
            Timmer,J.R. and Anderson,K.V.
  TITLE     Analysis of mouse embryonic patterning and morphogenesis by forward
            genetics
  JOURNAL   Proc Natl Acad Sci U S A 102 (17), 5913-5919 (2005)
   PUBMED   15755804
REFERENCE   8  (bases 1 to 2461)
  AUTHORS   Garcia-Garcia,M.J. and Anderson,K.V.
  TITLE     Essential role of glycosaminoglycans in Fgf signaling during mouse
            gastrulation
  JOURNAL   Cell 114 (6), 727-737 (2003)
   PUBMED   14505572
REFERENCE   9  (bases 1 to 2461)
  AUTHORS   Spicer,A.P., Kaback,L.A., Smith,T.J. and Seldin,M.F.
  TITLE     Molecular cloning and characterization of the human and mouse
            UDP-glucose dehydrogenase genes
  JOURNAL   J Biol Chem 273 (39), 25117-25124 (1998)
   PUBMED   9737970
REFERENCE   10 (bases 1 to 2461)
  AUTHORS   Wegrowski,Y., Perreau,C., Bontemps,Y. and Maquart,F.X.
  TITLE     Uridine diphosphoglucose dehydrogenase regulates proteoglycan
            expression: cDNA cloning and antisense study
  JOURNAL   Biochem Biophys Res Commun 250 (2), 206-211 (1998)
   PUBMED   9753608
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC006749.1.
            
            On Jun 19, 2003 this sequence version replaced NM_009466.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006749.1, AK144673.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2461
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 33.67 cM"
     gene            1..2461
                     /gene="Ugdh"
                     /gene_synonym="Udpgdh"
                     /note="UDP-glucose dehydrogenase"
                     /db_xref="GeneID:22235"
                     /db_xref="MGI:MGI:1306785"
     exon            1..219
                     /gene="Ugdh"
                     /gene_synonym="Udpgdh"
                     /inference="alignment:Splign:2.1.0"
     exon            220..388
                     /gene="Ugdh"
                     /gene_synonym="Udpgdh"
                     /inference="alignment:Splign:2.1.0"
     exon            389..490
                     /gene="Ugdh"
                     /gene_synonym="Udpgdh"
                     /inference="alignment:Splign:2.1.0"
     exon            491..691
                     /gene="Ugdh"
                     /gene_synonym="Udpgdh"
                     /inference="alignment:Splign:2.1.0"
     exon            692..889
                     /gene="Ugdh"
                     /gene_synonym="Udpgdh"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1037
                     /gene="Ugdh"
                     /gene_synonym="Udpgdh"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1132
                     /gene="Ugdh"
                     /gene_synonym="Udpgdh"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1263
                     /gene="Ugdh"
                     /gene_synonym="Udpgdh"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1397
                     /gene="Ugdh"
                     /gene_synonym="Udpgdh"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1489
                     /gene="Ugdh"
                     /gene_synonym="Udpgdh"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1600
                     /gene="Ugdh"
                     /gene_synonym="Udpgdh"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..2443
                     /gene="Ugdh"
                     /gene_synonym="Udpgdh"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2417..2422
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ugdh"
                     /gene_synonym="Udpgdh"
                     /note="hexamer: AATAAA"
     polyA_site      2443
                     /gene="Ugdh"
                     /gene_synonym="Udpgdh"
                     /note="major polyA site"
ORIGIN      
        1 gggcagcgcg gggcggtggc cgggtccaga gtcccgggag gcttggctgc aggggaatga
       61 agcctccgcc ttccccggca gaagtattta aatacggccg cgggccgggg actcggggag
      121 cggcgggcgg agcggtgggt agagcctgcg gcttgggagg aaggcgctgt ccgagagaac
      181 gggatctgca cggccgctgt gtccctgctt tggaagtggt tcagtcatgg ttgagattaa
      241 gaagatctgt tgcattggtg cgggctatgt cggcggaccc acgtgcagtg tcattgctca
      301 catgtgccct gaaatcaggg ttacggttgt ggatgtcaac gaggcaagga tcaatgcatg
      361 gaattctcca acccttccta tttatgagcc tggattaaaa gaagtagtcg aatcctgtcg
      421 aggaaaaaac ctattttttt ctaccaatat tgatgatgcc atcagagaag ccgatctagt
      481 atttatttct gtgaacacac caacaaaaac atatgggatg ggaaaaggcc gggcagcaga
      541 cctgaagtat atcgaagctt gtgctcgccg cattgtgcag aactcaaatg ggtacaaaat
      601 tgtcacggag aaaagcacag tccctgtgcg ggcagcagaa agcatccgcc gcatatttga
      661 tgccaacaca aagcccaact tgaatttaca ggtgctgtcc aatcctgagt tcttggcaga
      721 gggaacagcc atcaaggacc taaagaaccc ggacagagtc ctgattggag gggatgaaac
      781 tccagagggc cagaaagccg ttcgggctct gtgtgctgtg tatgagcact gggttcctaa
      841 ggaaaagatc ctcaccacca acacctggtc ctcggagctt tccaagctgg cagccaatgc
      901 atttcttgcg cagaggatca gcagcatcaa ctccatcagc gctctgtgtg aagcaacagg
      961 cgccgatgtg gaagaggtgg caacggccat cgggatggac caaagaattg ggaataagtt
     1021 tctaaaggcc agcgttggtt ttggtggaag ctgcttccaa aaagatgttc tgaatttggt
     1081 ttatctctgt gaggctctga atctgcccga agtagctcgt tactggcagc aggtcataga
     1141 catgaatgac taccagagga ggaggtttgc atcacggatc atagatagcc tgtttaatac
     1201 agtgaccgat aagaagatag ctatcttggg gtttgcattc aaaaaggata ctggtgatac
     1261 cagagaatcc tccagtatct acattagcaa gtacctgatg gacgagggtg cacacctcca
     1321 catatatgat ccaaaagtac ccagggaaca aatagtggtg gacctttctc atccgggtgt
     1381 ctcagcggat gaccaagtgt ccagactggt gaccatttcc aaggacccat acgaagcgtg
     1441 tgatggcgcc catgccctcg ttatctgcac tgagtgggac atgtttaagg aactggatta
     1501 cgaacggatt cataaaaaaa tgctgaagcc agcctttatc tttgatggtc ggcgtgtcct
     1561 ggatgggctc cacagtgagc tacagaccat tggcttccag attgaaacaa ttggcaaaaa
     1621 ggtgtcttcc aagagaattc cgtacactcc tggtgagatt ccgaagttta gtcttcagga
     1681 cccacctaac aagaaaccca aagtctagac attgccctct tacctgggat aacgtggtac
     1741 ttcagggtag ccagtgtctg tctgatacta aatggtaaat gaactacatg tttttaagga
     1801 aacaaaaata tttttgtaat catcaaattt atactagcta tatgggtatt agcatatcca
     1861 gtaattatga gtctagagta atttttacat atttttatat tattgtcctc tcagttactg
     1921 aatgaatgga aaacaatcat gttgttttaa atgtcagttt ttgtaaaata aaaatgaaac
     1981 ctagacattt tcagcattac aaattgtcta cagactgcac tttaataata caagggaaag
     2041 gcagtctcgt tctcatatgt gttgtctgct tatcattcaa tgggactttg aagccatgaa
     2101 atcactgtgc tagtatgggc tggttaaagt tcgctggcct tttgttttaa tgggattatg
     2161 tcattagagg ttttaattgt ttttttgttt ttcccaagag ctcactctgc atttccttcc
     2221 ctgcctaact tgaacagtgc tctctttttt taaaaaaata taacctgaga agaaaaatca
     2281 acagtatggt ctatttcatt ttgtttctta gcttctgtag ctgcttgtta catttgcatc
     2341 tgtgagtcaa gaaatgtttg ttatctttga ttttttattt ctattacaat taaattgttt
     2401 ttcctttaag caaacaaata aaatcccatg tgtagactgg aaaaaaaaaa aaaaaaaaaa
     2461 a
//
