LOCUS       NM_011673               3719 bp    mRNA    linear   ROD 08-OCT-2024
DEFINITION  Mus musculus UDP-glucose ceramide glucosyltransferase (Ugcg), mRNA.
ACCESSION   NM_011673
VERSION     NM_011673.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3719)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3719)
  AUTHORS   Sutter,C.H., Azim,S., Wang,A., Bhuju,J., Simpson,A.S., Uberoi,A.,
            Grice,E.A. and Sutter,T.R.
  TITLE     Ligand Activation of the Aryl Hydrocarbon Receptor Upregulates
            Epidermal Uridine Diphosphate Glucose Ceramide Glucosyltransferase
            and Glucosylceramides
  JOURNAL   J Invest Dermatol 143 (10), 1964-1972 (2023)
   PUBMED   37004877
  REMARK    GeneRIF: Ligand Activation of the Aryl Hydrocarbon Receptor
            Upregulates Epidermal Uridine Diphosphate Glucose Ceramide
            Glucosyltransferase and Glucosylceramides.
REFERENCE   3  (bases 1 to 3719)
  AUTHORS   Komuro,M., Nagane,M., Endo,R., Nakamura,T., Miyamoto,T., Niwa,C.,
            Fukuyama,T., Harashima,H., Aihara,N., Kamiie,J., Suzuki,R. and
            Yamashita,T.
  TITLE     Glucosylceramide in T cells regulates the pathology of inflammatory
            bowel disease
  JOURNAL   Biochem Biophys Res Commun 599, 24-30 (2022)
   PUBMED   35168060
  REMARK    GeneRIF: Glucosylceramide in T cells regulates the pathology of
            inflammatory bowel disease.
REFERENCE   4  (bases 1 to 3719)
  AUTHORS   Ghosh,S., Juin,S.K., Bhattacharyya Majumdar,S. and Majumdar,S.
  TITLE     Crucial role of glucosylceramide synthase in the regulation of stem
            cell-like cancer cells in B16F10 murine melanoma
  JOURNAL   Mol Carcinog 60 (12), 840-858 (2021)
   PUBMED   34516706
  REMARK    GeneRIF: Crucial role of glucosylceramide synthase in the
            regulation of stem cell-like cancer cells in B16F10 murine
            melanoma.
REFERENCE   5  (bases 1 to 3719)
  AUTHORS   Herzer,S., Hagan,C., von Gerichten,J., Dieterle,V., Munteanu,B.,
            Sandhoff,R., Hopf,C. and Nordstrom,V.
  TITLE     Deletion of Specific Sphingolipids in Distinct Neurons Improves
            Spatial Memory in a Mouse Model of Alzheimer's Disease
  JOURNAL   Front Mol Neurosci 11, 206 (2018)
   PUBMED   29973867
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3719)
  AUTHORS   Yamashita,T., Wada,R., Sasaki,T., Deng,C., Bierfreund,U.,
            Sandhoff,K. and Proia,R.L.
  TITLE     A vital role for glycosphingolipid synthesis during development and
            differentiation
  JOURNAL   Proc Natl Acad Sci U S A 96 (16), 9142-9147 (1999)
   PUBMED   10430909
REFERENCE   7  (bases 1 to 3719)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   8  (bases 1 to 3719)
  AUTHORS   Ichikawa,S., Ozawa,K. and Hirabayashi,Y.
  TITLE     Molecular cloning and characterization of the mouse ceramide
            glucosyltransferase gene
  JOURNAL   Biochem Biophys Res Commun 253 (3), 707-711 (1998)
   PUBMED   9918791
REFERENCE   9  (bases 1 to 3719)
  AUTHORS   Ichikawa,S., Ozawa,K. and Hirabayashi,Y.
  TITLE     Molecular cloning and expression of mouse ceramide
            glucosyltransferase
  JOURNAL   Biochem Mol Biol Int 44 (6), 1193-1202 (1998)
   PUBMED   9623774
REFERENCE   10 (bases 1 to 3719)
  AUTHORS   Ichikawa,S., Ozawa,K. and Hirabayashi,Y.
  TITLE     Assignment1 of a UDP-glucose:ceramide glucosyltransferase gene
            (Ugcg) to mouse chromosome band 4B3 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 83 (1-2), 14-15 (1998)
   PUBMED   9925912
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL808112.34.
            
            On Mar 21, 2007 this sequence version replaced NM_011673.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050828.1, D89866.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-192               AL808112.34        73860-74051
            193-334             AL808112.34        92071-92212
            335-437             AL808112.34        96186-96288
            438-539             AL808112.34        97469-97570
            540-652             AL808112.34        98175-98287
            653-831             AL808112.34        101346-101524
            832-918             AL808112.34        102805-102891
            919-1108            AL808112.34        103799-103988
            1109-3719           AL808112.34        104533-107143
FEATURES             Location/Qualifiers
     source          1..3719
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 32.44 cM"
     gene            1..3719
                     /gene="Ugcg"
                     /gene_synonym="Epcs21; GlcT-1; Ugcgl"
                     /note="UDP-glucose ceramide glucosyltransferase"
                     /db_xref="GeneID:22234"
                     /db_xref="MGI:MGI:1332243"
     exon            1..192
                     /gene="Ugcg"
                     /gene_synonym="Epcs21; GlcT-1; Ugcgl"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..1279
                     /gene="Ugcg"
                     /gene_synonym="Epcs21; GlcT-1; Ugcgl"
                     /EC_number="2.4.1.80"
                     /note="ectoplacental cone, invasive trophoblast giant
                     cells, extraembryonic ectoderm and chorion sequence 21;
                     GCS; glucosylceramide synthase;
                     UDP-glucose:N-acylsphingosine D-glucosyltransferase;
                     glycosylceramide synthase"
                     /codon_start=1
                     /product="ceramide glucosyltransferase"
                     /protein_id="NP_035803.1"
                     /db_xref="CCDS:CCDS18219.1"
                     /db_xref="GeneID:22234"
                     /db_xref="MGI:MGI:1332243"
                     /translation="MALLDLAQEGMALFGFVLFVVLWLMHFMSIIYTRLHLNKKATDK
                     QPYSKLPGVSLLKPLKGVDPNLINNLETFFELDYPKYEVLLCVQDHDDPAIDVCKKLL
                     GKYPNVDARLFIGGKKVGINPKINNLMPAYEVAKYDLIWICDSGIRVIPDTLTDMVNQ
                     MTEKVGLVHGLPYVADRQGFAATLEQVYFGTSHPRSYISANVTGFKCVTGMSCLMRKD
                     VLDQAGGLIAFAQYIAEDYFMAKAIADRGWRFSMSTQVAMQNSGSYSISQFQSRMIRW
                     TKLRINMLPATIICEPISECFVASLIIGWAAHHVFRWDIMVFFMCHCLAWFIFDYIQL
                     RGVQGGTLCFSKLDYAVAWFIRESMTIYIFLSALWDPTISWRTGRYRLRCGGTAEEIL
                     DV"
     exon            193..334
                     /gene="Ugcg"
                     /gene_synonym="Epcs21; GlcT-1; Ugcgl"
                     /inference="alignment:Splign:2.1.0"
     exon            335..437
                     /gene="Ugcg"
                     /gene_synonym="Epcs21; GlcT-1; Ugcgl"
                     /inference="alignment:Splign:2.1.0"
     exon            438..539
                     /gene="Ugcg"
                     /gene_synonym="Epcs21; GlcT-1; Ugcgl"
                     /inference="alignment:Splign:2.1.0"
     exon            540..652
                     /gene="Ugcg"
                     /gene_synonym="Epcs21; GlcT-1; Ugcgl"
                     /inference="alignment:Splign:2.1.0"
     exon            653..831
                     /gene="Ugcg"
                     /gene_synonym="Epcs21; GlcT-1; Ugcgl"
                     /inference="alignment:Splign:2.1.0"
     exon            832..918
                     /gene="Ugcg"
                     /gene_synonym="Epcs21; GlcT-1; Ugcgl"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1108
                     /gene="Ugcg"
                     /gene_synonym="Epcs21; GlcT-1; Ugcgl"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..3719
                     /gene="Ugcg"
                     /gene_synonym="Epcs21; GlcT-1; Ugcgl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3602..3607
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ugcg"
                     /gene_synonym="Epcs21; GlcT-1; Ugcgl"
                     /note="hexamer: AATAAA"
     polyA_site      3627
                     /gene="Ugcg"
                     /gene_synonym="Epcs21; GlcT-1; Ugcgl"
                     /note="major polyA site"
     regulatory      3696..3701
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ugcg"
                     /gene_synonym="Epcs21; GlcT-1; Ugcgl"
                     /note="hexamer: AATAAA"
     polyA_site      3715
                     /gene="Ugcg"
                     /gene_synonym="Epcs21; GlcT-1; Ugcgl"
                     /note="major polyA site"
ORIGIN      
        1 cgcgccccgc acccggcggc ccccgcgtcc tcctcccgcg gcagcgctgt ccgcggcggc
       61 cggagcgggc cgggccgggc cagcgggccg ggggatggcg ctgctggacc tggcccagga
      121 gggaatggcc ttgttcggct tcgtgctctt cgtggtgctg tggctgatgc atttcatgtc
      181 catcatctac acccggttac acctcaacaa gaaggcaaca gacaaacagc cgtatagcaa
      241 gctccctggt gtctctcttc tgaagccact gaagggggtg gatcctaacc taatcaacaa
      301 cttggagaca ttctttgaac tggattatcc caaatatgaa gtactccttt gtgtacaaga
      361 tcatgatgat ccagccattg atgtatgtaa gaaattgctt ggaaaatacc caaatgtcga
      421 tgctagatta tttataggtg gcaaaaaggt tggcattaac cctaaaatta ataatttgat
      481 gccagcatat gaagttgcaa aatatgatct catatggatt tgtgatagtg gaataagagt
      541 catcccagac acattaactg acatggtgaa tcagatgaca gagaaagtgg ggttggtcca
      601 cgggctgccg tatgtagccg acagacaagg ctttgctgcc accttagagc aggtatattt
      661 tggaacttca cacccaagat cctatatctc tgccaatgta actggcttca aatgtgtgac
      721 ggggatgtct tgtttgatga ggaaggatgt gctagatcag gcaggagggc tcatagcctt
      781 tgctcagtac attgctgaag attactttat ggccaaagca atagccgacc gaggttggag
      841 gttttcaatg tctactcaag ttgccatgca aaactctggt tcgtactcaa tttctcagtt
      901 tcaatccaga atgatcaggt ggaccaaatt gagaattaac atgcttcctg ctacaataat
      961 ttgtgagcca atttcagaat gctttgttgc cagtttaatt attgggtggg cagcccacca
     1021 tgtattcaga tgggatatca tggtcttctt catgtgccac tgcctggcat ggtttatatt
     1081 tgactacatt caactcaggg gtgtccaggg tggcacactg tgtttttcaa aacttgatta
     1141 tgctgtggcc tggttcatcc gtgaatccat gacaatctac attttcctgt cggcattatg
     1201 ggacccgact ataagctgga gaactggtcg ctacaggtta cgctgtgggg ggacagcaga
     1261 ggagatcctg gatgtgtaag aagacctctg tgactgatgg cgcacagtgt ggaatggaag
     1321 tgttataaat tatgtttata gagacacttt ccagggtctc ccttcagtag tttatcacat
     1381 gtatgttttg gtatctgctc tttaatttat ttgcatggca cttgcatctg tgaaaagcaa
     1441 aaaaacaaaa acaaaacatg tctgtagtct tggccaaata gtatatcttg tggaagtaga
     1501 gaatcaaggc aattggttct aggaagtggg atttgttttt ttttgttgtt gtttattttt
     1561 ttaaacaaat aaatatatat atatatatat atatatacac acacacacac atatacagga
     1621 ctgctctgca gcagacacta tgacagtatc cttcagtagg gaaagtttct tacctgagtt
     1681 cctctgaatc tgtacgggca gaacagcagc tccatgagag aagtcatggc ctctcccctg
     1741 tgtgaagtaa atgctataca gagagacgcc cgctggctga gaaacttttt catgctttat
     1801 gcctacctct tgtagttgtt gcagagcaaa tagaagttag aagttgtaat acggtagcta
     1861 ggccttgcaa aaacaaatgg aaaacttttt aaaataataa taataaaaga gctggagtct
     1921 agtatttata taaatctgtg aggttttttg ttttgttttg ggtttttttt tttgttttgt
     1981 ttttttgttt gtttgggttt ttttgttttg ttttttgttt ttggtctcat tacaattgaa
     2041 ccaaaagtgg ttgagattgg tttttaatgg taaccatgaa ttgaaggcat cttttggacc
     2101 aactgtcgtt ggttctgtct tgaaccatat taatcactgt gctgtaatta ggagagctga
     2161 atctttccct ccctgctccc ggctcacccg gcctgcccca tctttccttc gctttttcca
     2221 gggggtgatg ttgtacaagt ggatgttttg tagtgtaagg aaaatgcatt tcagacagtc
     2281 acacaggagc tattttctta cccgggatgt ctgtattgtt aataagaatg taatttcatg
     2341 atacaagtat ttaatatctt ttttaagtga gtaaaaatat tctagctatt ggcaaataga
     2401 ttacagtaga caattagagg atatgatgag gttgactctt ccaatcaatc agtatcaagc
     2461 taagtcgact gtgtgcgtgt tggtttgttt tccttttttt tctttttttt tactataaca
     2521 gtcttattta aattggattt ttgtattcag tttgtatgac agtagactag gccagcctag
     2581 ctgtaaatgc atgctacact ttcctctccg tcatgcagct aagcttgctt gtcagcccgt
     2641 gcttaacttg tggtgaactg gacttttgtt taaaataagc aaaactgtaa gggacagtgc
     2701 atcggccttt ccccgtcttc ttaagtagaa gtttgctcat ccttccgaat tcgagggcgt
     2761 gttatccatc tgatgcttgc tgttaacccc agcacttggc agcttcccat ccatcctgtg
     2821 ttactatggc ttccatctca gcacacagtg tatagcctat tagcaataac ttcctatgta
     2881 tagagaacat tttcatctta ctgagccagc ccatttgcct aatgactata cagacagtct
     2941 aaattgcaat atatctgtaa atgtgtatat actataaata cacaatatac ttacattttt
     3001 ctgggccaaa cagcatttcc tttcccctcc ttttcctctc ccctctcttg ccttatgatg
     3061 aatttgtttg agggcatttt cttcatgagc aaaggcttgg atgcatattc ctaggtttga
     3121 ttttgttttt gttttttttc tttctgtgaa atgggtatta ttatccccaa ggagagctgc
     3181 gcagtgagag ccagtctagt tatgacccac tacgtgttgt tttttacatt actctttgat
     3241 gagtcgcgtt ttgctgagca cgtttgttgt ccgtcggttt gtttagtgga gtttggtgga
     3301 tgccctttgc actgctgaag tgaaatcttg ctgactactt agcttttttg ttgatctcag
     3361 tatgggcaaa gaaacaaaat ccaaatggct ggacagactt ctgtaaatat ttttttaaaa
     3421 aaacaaaaca aatgttctgt atgtgtgtgt tttacgtggt catgaagtat ttccttaaag
     3481 cgaagctttg agtacacaga gagtaactct ttgtttagca agtttggagt gaagataaaa
     3541 tagcaagaaa tactgtaaaa tgtcaaagca ccacaccaga actgtaggag tccagattta
     3601 taataaactg tctttttaaa aagaaaacaa ttaagtgtct agaatatatc atgttttatt
     3661 atttaaaatc attgtcttaa gttttttgtt gagagaataa aaaatttgaa tacaatcaa
//
