LOCUS       NM_138668               1640 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus UFM1-specific peptidase 2 (Ufsp2), mRNA.
ACCESSION   NM_138668
VERSION     NM_138668.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1640)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1640)
  AUTHORS   Balce,D.R., Wang,Y.T., McAllaster,M.R., Dunlap,B.F., Orvedahl,A.,
            Hykes,B.L. Jr., Droit,L., Handley,S.A., Wilen,C.B., Doench,J.G.,
            Orchard,R.C., Stallings,C.L. and Virgin,H.W.
  TITLE     UFMylation inhibits the proinflammatory capacity of
            interferon-gamma-activated macrophages
  JOURNAL   Proc Natl Acad Sci U S A 118 (1) (2021)
   PUBMED   33372156
REFERENCE   3  (bases 1 to 1640)
  AUTHORS   Yang,R., Wang,H., Kang,B., Chen,B., Shi,Y., Yang,S., Sun,L.,
            Liu,Y., Xiao,W., Zhang,T., Yang,J., Zhang,Y., Zhu,M., Xu,P.,
            Chang,Y., Jia,Y. and Huang,Y.
  TITLE     CDK5RAP3, a UFL1 substrate adaptor, is crucial for liver
            development
  JOURNAL   Development 146 (2) (2019)
   PUBMED   30635284
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1640)
  AUTHORS   Ha,B.H., Jeon,Y.J., Shin,S.C., Tatsumi,K., Komatsu,M., Tanaka,K.,
            Watson,C.M., Wallis,G., Chung,C.H. and Kim,E.E.
  TITLE     Structure of ubiquitin-fold modifier 1-specific protease UfSP2
  JOURNAL   J Biol Chem 286 (12), 10248-10257 (2011)
   PUBMED   21228277
  REMARK    GeneRIF: Structure of ubiquitin-fold modifier 1-specific protease
            UfSP2.
REFERENCE   5  (bases 1 to 1640)
  AUTHORS   Ha,B.H., Ahn,H.C., Kang,S.H., Tanaka,K., Chung,C.H. and Kim,E.E.
  TITLE     Structural basis for Ufm1 processing by UfSP1
  JOURNAL   J Biol Chem 283 (21), 14893-14900 (2008)
   PUBMED   18321862
REFERENCE   6  (bases 1 to 1640)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   7  (bases 1 to 1640)
  AUTHORS   Kang,S.H., Kim,G.R., Seong,M., Baek,S.H., Seol,J.H., Bang,O.S.,
            Ovaa,H., Tatsumi,K., Komatsu,M., Tanaka,K. and Chung,C.H.
  TITLE     Two novel ubiquitin-fold modifier 1 (Ufm1)-specific proteases,
            UfSP1 and UfSP2
  JOURNAL   J Biol Chem 282 (8), 5256-5262 (2007)
   PUBMED   17182609
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK078309.1, AK075795.1 and AC114558.18.
            
            On Mar 13, 2013 this sequence version replaced NM_138668.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK078309.1, AK075795.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AK078309.1         2-7
            7-1587              AK075795.1         2-1582
            1588-1640           AC114558.18        173047-173099       c
FEATURES             Location/Qualifiers
     source          1..1640
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 25.96 cM"
     gene            1..1640
                     /gene="Ufsp2"
                     /gene_synonym="1810047C23Rik"
                     /note="UFM1-specific peptidase 2"
                     /db_xref="GeneID:192169"
                     /db_xref="MGI:MGI:1913679"
     exon            1..61
                     /gene="Ufsp2"
                     /gene_synonym="1810047C23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            62..148
                     /gene="Ufsp2"
                     /gene_synonym="1810047C23Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1470
                     /gene="Ufsp2"
                     /gene_synonym="1810047C23Rik"
                     /EC_number="3.4.22.-"
                     /codon_start=1
                     /product="ufm1-specific protease 2"
                     /protein_id="NP_619609.1"
                     /db_xref="CCDS:CCDS22284.1"
                     /db_xref="GeneID:192169"
                     /db_xref="MGI:MGI:1913679"
                     /translation="MDILFRIRGGFDLAFQLAPPKEMFIKNALRQVLSDLTTKLSSDA
                     LVLRVCNSSVYLWPNSDANTGELTDSSACKNVVRFIQFDQEEDTKRKFIKKKDKKLTD
                     TQQIVNIDLMLEISTPLGAVTPILERENEEHHYINMSLPIDAVVSVAPEESWGKVRKL
                     LVDAILRQLVDVEKCILRYMKGTSIVVPEPLHFQLPGKKNLVTVLYPSGIPDDQLQAY
                     RKELHDLFNLPHDRPYFKRINAYHFPDELYKDGYIRNPHTYLSPPNIEGSMICVVQGT
                     YAYHHYMQDRIDDNGWGCAYRSLQTICSWFRHQGYTERSIPTHREIQQALVDAGDKPA
                     TFVGSRQWIGSIEVQMVLNQLIGVTSKILFVNQGSEMASQGRELANHFQNVGTPVMVG
                     GGVLAHTILGVAWNETTGQIKFLILDPHYTGAEDLQVMLEKGWCGWKSPDFWNKDAYY
                     NLCLPQRPNAL"
     exon            149..326
                     /gene="Ufsp2"
                     /gene_synonym="1810047C23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            327..393
                     /gene="Ufsp2"
                     /gene_synonym="1810047C23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            394..551
                     /gene="Ufsp2"
                     /gene_synonym="1810047C23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            552..744
                     /gene="Ufsp2"
                     /gene_synonym="1810047C23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            745..891
                     /gene="Ufsp2"
                     /gene_synonym="1810047C23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1056
                     /gene="Ufsp2"
                     /gene_synonym="1810047C23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1181
                     /gene="Ufsp2"
                     /gene_synonym="1810047C23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1258
                     /gene="Ufsp2"
                     /gene_synonym="1810047C23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1383
                     /gene="Ufsp2"
                     /gene_synonym="1810047C23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1640
                     /gene="Ufsp2"
                     /gene_synonym="1810047C23Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1519..1524
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ufsp2"
                     /gene_synonym="1810047C23Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1542
                     /gene="Ufsp2"
                     /gene_synonym="1810047C23Rik"
                     /note="major polyA site"
     regulatory      1565..1570
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ufsp2"
                     /gene_synonym="1810047C23Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      1589
                     /gene="Ufsp2"
                     /gene_synonym="1810047C23Rik"
     regulatory      1617..1622
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ufsp2"
                     /gene_synonym="1810047C23Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      1640
                     /gene="Ufsp2"
                     /gene_synonym="1810047C23Rik"
ORIGIN      
        1 acttccggga cgacccttgc ttgcacgaag taggtgttct tgccatcgcc agtggtgctt
       61 ggtggtttcc caaaactatg ctctatggat atactcttca gaataagagg cggcttcgat
      121 ctggcttttc agctagcacc acctaaagaa atgtttatca agaacgcact gagacaggtg
      181 ttgagcgacc tgactaccaa gctctcctca gatgctcttg tgctcagagt ttgcaacagc
      241 tccgtgtacc tgtggccgaa cagcgacgca aacacggggg agctgactga cagctctgcc
      301 tgtaagaacg tagtgcgctt cattcaattt gatcaagagg aggatacaaa gcgaaaattc
      361 attaaaaaga aagacaaaaa gttaactgac acgcaacaga tagtaaatat agacctcatg
      421 ctggagatat cgacccctct gggagccgta acccccatcc tggagaggga aaatgaagag
      481 caccactaca ttaacatgag cttgccaatt gacgccgttg tgtctgttgc tccagaggaa
      541 tcatggggaa aagtgcgcaa acttctagtg gatgcaattc tcaggcagct agttgatgtg
      601 gaaaaatgca tcctgagata tatgaaagga acgtctattg tggtccccga gccactgcac
      661 tttcaattgc cagggaaaaa gaatcttgta acggttttat atccatcagg aatcccagat
      721 gatcagctcc aagcctatcg aaaggagtta catgatctct tcaatctgcc tcatgacaga
      781 ccttatttca aaaggatcaa tgcttatcac tttccagatg aactatataa agatggctat
      841 atcagaaacc cacatactta tctgagtcca cctaacatag agggtagtat gatttgtgtg
      901 gtccagggca cctatgctta tcatcattat atgcaagatc ggattgatga caatggttgg
      961 ggctgtgctt ataggtccct acagactatc tgctcatggt tcagacatca gggttacaca
     1021 gagaggtcca ttcccacaca cagggaaatt cagcaggctc tagttgatgc cggcgacaag
     1081 ccagcaacat ttgttggatc acggcagtgg attgggtcta ttgaagtaca gatggtacta
     1141 aaccaactga ttggtgtgac ttcgaaaata ctgtttgtca accaaggttc agaaatggct
     1201 tctcaaggac gggaactagc caaccatttc cagaatgtgg gcaccccagt gatggtcggg
     1261 ggaggggtat tggctcacac aatactagga gtcgcatgga atgaaaccac ggggcagata
     1321 aaattcctga ttctagaccc acactataca ggtgctgaag acctgcaggt tatgttggaa
     1381 aagggctggt gtggatggaa gagtccagac ttttggaaca aggatgcata ctataactta
     1441 tgccttcctc aacgacctaa tgctctttaa attatcttgg aggcaagact atgaatataa
     1501 aagagctgtt ctaatgttaa taaaagcata cataatttta aatcttagct gtgatttaaa
     1561 aagtagtaaa gaatgcacag aaattttaat tccttgaata ttcttttaat aagttaagta
     1621 aaaaacatgc acatccaaaa
//
