LOCUS       NM_026435               4887 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus ubiquitin-fold modifier 1 (Ufm1), mRNA.
ACCESSION   NM_026435 XM_003084556 XM_003086295
VERSION     NM_026435.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4887)
  AUTHORS   Jiajia,H., Ziyao,Y., Jiaqi,Z., Yanli,C., Xiaotao,Z. and Ming,S.
  TITLE     Screening UFMylation-associated genes in heart tissues of
            Ufm1-transgenic mice
  JOURNAL   BMC Cardiovasc Disord 23 (1), 567 (2023)
   PUBMED   37980507
  REMARK    GeneRIF: Screening UFMylation-associated genes in heart tissues of
            Ufm1-transgenic mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4887)
  AUTHORS   Ishimura,R., El-Gowily,A.H., Noshiro,D., Komatsu-Hirota,S., Ono,Y.,
            Shindo,M., Hatta,T., Abe,M., Uemura,T., Lee-Okada,H.C.,
            Mohamed,T.M., Yokomizo,T., Ueno,T., Sakimura,K., Natsume,T.,
            Sorimachi,H., Inada,T., Waguri,S., Noda,N.N. and Komatsu,M.
  TITLE     The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3
  JOURNAL   Nat Commun 13 (1), 7857 (2022)
   PUBMED   36543799
  REMARK    GeneRIF: The UFM1 system regulates ER-phagy through the ufmylation
            of CYB5R3.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4887)
  AUTHORS   Zhang,J., Zhu,H., Liu,S., Quintero,M., Zhu,T., Xu,R., Cai,Y.,
            Han,Y. and Li,H.
  TITLE     Deficiency of Murine UFM1-Specific E3 Ligase Causes Microcephaly
            and Inflammation
  JOURNAL   Mol Neurobiol 59 (10), 6363-6372 (2022)
   PUBMED   35931931
  REMARK    GeneRIF: Deficiency of Murine UFM1-Specific E3 Ligase Causes
            Microcephaly and Inflammation.
REFERENCE   4  (bases 1 to 4887)
  AUTHORS   Balce,D.R., Wang,Y.T., McAllaster,M.R., Dunlap,B.F., Orvedahl,A.,
            Hykes,B.L. Jr., Droit,L., Handley,S.A., Wilen,C.B., Doench,J.G.,
            Orchard,R.C., Stallings,C.L. and Virgin,H.W.
  TITLE     UFMylation inhibits the proinflammatory capacity of
            interferon-gamma-activated macrophages
  JOURNAL   Proc Natl Acad Sci U S A 118 (1) (2021)
   PUBMED   33372156
  REMARK    GeneRIF: UFMylation inhibits the proinflammatory capacity of
            interferon-gamma-activated macrophages.
REFERENCE   5  (bases 1 to 4887)
  AUTHORS   Hu,X., Zhang,H., Song,Y., Zhuang,L., Yang,Q., Pan,M. and Chen,F.
  TITLE     Ubiquitin fold modifier 1 activates NF-kappaB pathway by
            down-regulating LZAP expression in the macrophage of diabetic mouse
            model
  JOURNAL   Biosci Rep 40 (1) (2020)
   PUBMED   31829413
  REMARK    GeneRIF: Ubiquitin fold modifier 1 activates NF-kappaB pathway by
            down-regulating LZAP expression in the macrophage of diabetic mouse
            model.
REFERENCE   6  (bases 1 to 4887)
  AUTHORS   Ha,B.H., Ahn,H.C., Kang,S.H., Tanaka,K., Chung,C.H. and Kim,E.E.
  TITLE     Structural basis for Ufm1 processing by UfSP1
  JOURNAL   J Biol Chem 283 (21), 14893-14900 (2008)
   PUBMED   18321862
  REMARK    GeneRIF: loop between beta3 and alpha2 in addition to the
            C-terminal region of Ufm1 plays a role in binding to UfSP1
REFERENCE   7  (bases 1 to 4887)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   8  (bases 1 to 4887)
  AUTHORS   Azfer,A., Niu,J., Rogers,L.M., Adamski,F.M. and Kolattukudy,P.E.
  TITLE     Activation of endoplasmic reticulum stress response during the
            development of ischemic heart disease
  JOURNAL   Am J Physiol Heart Circ Physiol 291 (3), H1411-H1420 (2006)
   PUBMED   16617122
  REMARK    GeneRIF: A novel ubiquitin fold modifier (Ufm1) not been previously
            associated with ER stress and not found to be induced under any
            condition was found to be upregulated in the hearts of MCP mice
            (transgenic mice that express MCP-1 specifically in the heart).
REFERENCE   9  (bases 1 to 4887)
  AUTHORS   Kiyozumi,D., Sugimoto,N. and Sekiguchi,K.
  TITLE     Breakdown of the reciprocal stabilization of QBRICK/Frem1, Fras1,
            and Frem2 at the basement membrane provokes Fraser syndrome-like
            defects
  JOURNAL   Proc Natl Acad Sci U S A 103 (32), 11981-11986 (2006)
   PUBMED   16880404
REFERENCE   10 (bases 1 to 4887)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ075089.1, AK167301.1, AC147262.4 and BP754244.1.
            
            On or before Dec 2, 2010 this sequence version replaced
            XM_003084556.1, XM_003086295.1, NM_026435.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148146.1, AK167301.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                CJ075089.1         27-58
            33-3029             AK167301.1         2-2998
            3030-4855           AC147262.4         122912-124737       c
            4856-4887           BP754244.1         1-32                c
FEATURES             Location/Qualifiers
     source          1..4887
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 25.43 cM"
     gene            1..4887
                     /gene="Ufm1"
                     /gene_synonym="1810045K17Rik; Gm10726"
                     /note="ubiquitin-fold modifier 1"
                     /db_xref="GeneID:67890"
                     /db_xref="MGI:MGI:1915140"
     exon            1..59
                     /gene="Ufm1"
                     /gene_synonym="1810045K17Rik; Gm10726"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..315
                     /gene="Ufm1"
                     /gene_synonym="1810045K17Rik; Gm10726"
                     /codon_start=1
                     /product="ubiquitin-fold modifier 1"
                     /protein_id="NP_080711.1"
                     /db_xref="CCDS:CCDS38430.1"
                     /db_xref="GeneID:67890"
                     /db_xref="MGI:MGI:1915140"
                     /translation="MSKVSFKITLTSDPRLPYKVLSVPESTPFTAVLKFAAEEFKVPA
                     ATSAIITNDGIGINPAQTAGNVFLKHGSELRIIPRDRVGSC"
     exon            60..116
                     /gene="Ufm1"
                     /gene_synonym="1810045K17Rik; Gm10726"
                     /inference="alignment:Splign:2.1.0"
     exon            117..174
                     /gene="Ufm1"
                     /gene_synonym="1810045K17Rik; Gm10726"
                     /inference="alignment:Splign:2.1.0"
     exon            175..214
                     /gene="Ufm1"
                     /gene_synonym="1810045K17Rik; Gm10726"
                     /inference="alignment:Splign:2.1.0"
     exon            215..247
                     /gene="Ufm1"
                     /gene_synonym="1810045K17Rik; Gm10726"
                     /inference="alignment:Splign:2.1.0"
     exon            248..4867
                     /gene="Ufm1"
                     /gene_synonym="1810045K17Rik; Gm10726"
                     /inference="alignment:Splign:2.1.0"
     regulatory      962..967
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ufm1"
                     /gene_synonym="1810045K17Rik; Gm10726"
                     /note="hexamer: AATAAA"
     polyA_site      990
                     /gene="Ufm1"
                     /gene_synonym="1810045K17Rik; Gm10726"
                     /note="major polyA site"
     regulatory      1628..1633
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ufm1"
                     /gene_synonym="1810045K17Rik; Gm10726"
                     /note="hexamer: AATAAA"
     polyA_site      1652
                     /gene="Ufm1"
                     /gene_synonym="1810045K17Rik; Gm10726"
                     /note="major polyA site"
     regulatory      1965..1970
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ufm1"
                     /gene_synonym="1810045K17Rik; Gm10726"
                     /note="hexamer: ATTAAA"
     polyA_site      1997
                     /gene="Ufm1"
                     /gene_synonym="1810045K17Rik; Gm10726"
     regulatory      2195..2200
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ufm1"
                     /gene_synonym="1810045K17Rik; Gm10726"
                     /note="hexamer: AATACA"
     polyA_site      2217
                     /gene="Ufm1"
                     /gene_synonym="1810045K17Rik; Gm10726"
     regulatory      2772..2777
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ufm1"
                     /gene_synonym="1810045K17Rik; Gm10726"
                     /note="hexamer: AATAAA"
     polyA_site      2795
                     /gene="Ufm1"
                     /gene_synonym="1810045K17Rik; Gm10726"
     regulatory      3012..3017
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ufm1"
                     /gene_synonym="1810045K17Rik; Gm10726"
                     /note="hexamer: TATAAA"
     polyA_site      3031
                     /gene="Ufm1"
                     /gene_synonym="1810045K17Rik; Gm10726"
     regulatory      4846..4851
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ufm1"
                     /gene_synonym="1810045K17Rik; Gm10726"
                     /note="hexamer: AATAAA"
     polyA_site      4867
                     /gene="Ufm1"
                     /gene_synonym="1810045K17Rik; Gm10726"
ORIGIN      
        1 ggccatcaag gaagcgcggc gggcggctgg gcgcggtgtg tgtcaggcgg ttccaccatg
       61 tcgaaggtgt cctttaaaat cacgttgacg tcggacccgc ggctgccgta caaagttctc
      121 agtgttcctg aaagtacgcc gttcacagca gtgctaaagt ttgcagcaga agaatttaaa
      181 gttcctgcag ctacaagtgc gattattact aatgatggaa taggaataaa tcctgcacag
      241 actgctggga atgttttcct gaagcacggc tcagaactga gaatcattcc tagagaccga
      301 gttggaagct gctaatatat gcttgttgga acacacagcc tttcagaata aatactggta
      361 tttgttgttg ctgtacaatt gaaatcaggc attcaccata caatgaaagc accaagaatc
      421 aacagaacag ggaaagcggc cgcttgtccc ttcctgttca tttttttcat ggaaagagag
      481 aatgcctttg agtggagggt acgacaccac aggtcacact gtggtgactg ctgcctcacc
      541 gggagaagag agtacctctg agacaaatgg actgtgcttt aaaacaaaaa cagcaaaatg
      601 ggaggatgag tgctaactct tttcaggagc atttggaaat tcaaattcac agaattggat
      661 gtagttttta attttgaaat ttaaaaggat aattgatcat agaggtattt gacttgacag
      721 catctcctag ttagattttt aaattatata atttgtgatg aacttaatag gtatttgaat
      781 gaacagttaa atttatacaa agccaaacat taaattatag gatctaacca ttatgagtat
      841 aagttgctat tgtacgtcaa atagtttcga tagtagagat cttgtgaatc cagtatgtca
      901 tggtgggaac tgacagtacc acagaagcac ccttaggtat attatgaatt ccttgataaa
      961 taataaagca ttaggacaga aatccttaaa ccagtctttt tgaggattct atttttgagc
     1021 agcatccaaa attattgttg cagagatgat ctgaagcatt ggtgggtgtc cttaatgaag
     1081 agggaacttt aaagaagctg ttaatatagt cacagtggat aaggaaccag ggatgcaaag
     1141 atagccaggc ccttcccaga agagcagagg aagtgaggag gaacaggagg ctggcagtgt
     1201 ccaaaggcag aggtcagaga acgaagccgc agcaggggtg ggaaagtgtg aaagggagga
     1261 gagtactggg cacagggtca gaaagcaatg cacaggcatc aaaactcacc gtagcaatct
     1321 acaaggattt acataagatt tcagggctgg caccctgtgc ccggtactct tcttcttcag
     1381 aatgaaggag attaccaact ccccagagtc atcctctaac cttactcaga cacccagatg
     1441 tgagccagtc ccctcccacc atgactattt gcctttacac agaaagtcca tgtctggcac
     1501 atgtttcagg atgaattaaa tgctgacagt gactgagtga gagccaggca gctctgcttt
     1561 agtgggttag ctctttggag gtaaggggtc tgtcacatgc tccttagagt tagagatacg
     1621 agttctcaat aaatatttac tgaattcata aataatgtct tcaggaacag tttttatctt
     1681 gtgtctcata gtccctatta cagggcctta cttgatttgg agatggggca cttgtaagag
     1741 aattagggat tggcatctga agggctgtct taatagatga aggaattgtc attgtccaca
     1801 ggtttgtgga gcacattctg gggttcagaa ttatgtagca atacacacct catgtttgct
     1861 gggtttttat gtttctgtct agtgcccaga gaccttattc catatactat taggcttctg
     1921 ttagccagac atttgaaaat atttgctacc taattttgct tactattaaa tttcttccat
     1981 tctgcctttg cacaaaattc tcttgtcagt aatgtttata cagttctaca atatgaaatg
     2041 atttacctaa tcatttgaaa atacatagtc ttcaaaatac tttactcaaa aactagataa
     2101 cttgttagta aataaatatg atctataagt tctttgtgga gaacgtttta ggcatggtat
     2161 ttaatttaaa tgtctataat taatacctta ggaaaataca ttttgttaca ctgtaaatca
     2221 tggctacctt tattttacaa taagacatac tagccagcat acctattgag ccagattatt
     2281 aatactattt ttgtaaatgc agagataaaa ggtaagtcat gaaaaataaa tgtatatttc
     2341 taaatgtcaa tcctttatac agaagaggag aacctttggt ggtctcagcc ctgggtggtg
     2401 tccagaatga agttgggaaa ttagaactac tgacttccga agtcattcct cgggttctcg
     2461 ctcctgcatg aggacctctg taagcaggtc tgggggctgc atgtgctgct tgggtgttag
     2521 caccatgaca acctttccac ccttgagagc aggattacag gtgaaggtca aagtaccctg
     2581 gaatcttggg cgttccttta tgctgcttga ttctggagtc atctgatgga gcacagagat
     2641 aaaagatact gacatttggt cacttctatc tttacaaccc aagtcagtgg gttttggatg
     2701 ctttaattct taggtttgga tgctatttga agaagatgta tataaataag tccaaagcgg
     2761 ttggtgcagc caataaaggt gttcccttac aaaaacctga gttccgtccc tgggacctgc
     2821 atggtggaag gagagaagtg acctccacat tcacactgtg acatacacat ttatacacac
     2881 acacaaatgt aagaacattt gagctactat atgtcttagc cctggagaca tttgggcaaa
     2941 catttgtaga ttggaagcat caatatactg taaaggagca atcctaggtc cttactgtac
     3001 ccaaggctat ttataaagct cggtaaaatt ctgtgtgtag ttgtcattac aatctgttga
     3061 acgagggctg tgcagatggc tcagtggtta agagtgcctc ctgatcttgc agaagaccaa
     3121 ggttttgtcc ccaaaaccca catagtggct cacaaccatc tgtaactgca gttccatggg
     3181 acccattacc cttctggcct ctgtaaatgc tgcactcatg ttcacacact tgcagacaac
     3241 atgtacacac atgtaaattt tggaaaaaaa aaaggtaaat gtctgctgaa cttcaagtgt
     3301 gaagaatagt ataacttggt gaatgggtgc taagtggttt tcactcactg gaaggattag
     3361 taagaatgtg ccttggcttt tgagccaggc tttgccttcg aggctccata taatctggag
     3421 aaatctttgt gtccactttc tgcaaagtac taatttgtat tgaattatac atttaaaagg
     3481 tgaaacaagt tcctcagcat gctggaaatg tatagtaata aatgacaccc ctttgaatac
     3541 atcgtgtagt acggatggaa ggtatagagt ccagaggctt agggcacaca tatataatcc
     3601 cggcagtagg gctgcaagat caaggggagc ctgggctgtg cagcaagact gcctctaaac
     3661 acaaagtaca agaacagtga cagtacctgt ctggagtttt actacacagg ctccgctcac
     3721 tcagaatcta ccatgtgtac aagaggcctt cctggactgg tgtttgtgca tgggcagcca
     3781 tgactgctat ggtcatggtt taattctgca gctgtaccta gcatcagagg ccatttagcc
     3841 ctctggtgtg gcatacttag tcttacacgt tcctaccttc acttccccat ctgtgagtcc
     3901 gggaacccca tgtcctgaga atgggaaacc tctgcttcca agccaaatta ggacttctta
     3961 gtcacctctc tttttgcaga gcagttatta aacacaggat tatttgtctc aaactatgag
     4021 ttttataagt ccaatattat ggtttgataa agaatggccc ccataggctc agagagtcaa
     4081 atgcttagtc accaggtact gtttaaggac aaggaggtgt gaccctgtgg tcattagggt
     4141 tgtgctgtgc ggtcaggcct agtctctctc atctctctct ccactttctc atgctctcac
     4201 cctttcactc tcctgcctgt ggatcaggat gtagctctca gctactcaac agtaccatgc
     4261 ctgcctgctt accaccatgt ttcccaccat gatgatggat caaaccttta aaactgtaag
     4321 caacccctaa ttaaatgctt tctcctttaa gagttggttt agtcatggtg tcagttcaca
     4381 gcaatagaac agtgactgag ataaatatgg ccaaaacttg gtttcaaaat ttaactgctg
     4441 ataacaacta ctttgtaaag caaagaaaca gatgaaaact ttgaaaattg caactatttg
     4501 tgcttcatca tcagtatttg atttgggtat ccatagttcc cacacttacc agctacttgc
     4561 cttgaaaatg ttattgtctg cattctccat ttcagtgaca atattcattt atgtaacagt
     4621 catttgaaaa ggtttgtggc cccgttgtct gatttttttg cagagagtta cgattttgtt
     4681 gttgaataca aaataacaga caaggttgac agacaaatgg agagccagtt tggggcataa
     4741 atctctggtt ctctggcaaa actcatttga aatgtaaaag ctgttactga gagcatatcg
     4801 tgatgataca tcatgtcaat atttgtttgg ctgcctagca ggtttaataa atcaattctt
     4861 aaacataaaa aaaaaaaaaa aaaaaaa
//
