LOCUS       NP_080711                 85 aa            linear   ROD 04-JUN-2024
DEFINITION  ubiquitin-fold modifier 1 [Mus musculus].
ACCESSION   NP_080711 XP_003084604 XP_003086343
VERSION     NP_080711.1
DBSOURCE    REFSEQ: accession NM_026435.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 85)
  AUTHORS   Jiajia,H., Ziyao,Y., Jiaqi,Z., Yanli,C., Xiaotao,Z. and Ming,S.
  TITLE     Screening UFMylation-associated genes in heart tissues of
            Ufm1-transgenic mice
  JOURNAL   BMC Cardiovasc Disord 23 (1), 567 (2023)
   PUBMED   37980507
  REMARK    GeneRIF: Screening UFMylation-associated genes in heart tissues of
            Ufm1-transgenic mice.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 85)
  AUTHORS   Ishimura,R., El-Gowily,A.H., Noshiro,D., Komatsu-Hirota,S., Ono,Y.,
            Shindo,M., Hatta,T., Abe,M., Uemura,T., Lee-Okada,H.C.,
            Mohamed,T.M., Yokomizo,T., Ueno,T., Sakimura,K., Natsume,T.,
            Sorimachi,H., Inada,T., Waguri,S., Noda,N.N. and Komatsu,M.
  TITLE     The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3
  JOURNAL   Nat Commun 13 (1), 7857 (2022)
   PUBMED   36543799
  REMARK    GeneRIF: The UFM1 system regulates ER-phagy through the ufmylation
            of CYB5R3.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 85)
  AUTHORS   Zhang,J., Zhu,H., Liu,S., Quintero,M., Zhu,T., Xu,R., Cai,Y.,
            Han,Y. and Li,H.
  TITLE     Deficiency of Murine UFM1-Specific E3 Ligase Causes Microcephaly
            and Inflammation
  JOURNAL   Mol Neurobiol 59 (10), 6363-6372 (2022)
   PUBMED   35931931
  REMARK    GeneRIF: Deficiency of Murine UFM1-Specific E3 Ligase Causes
            Microcephaly and Inflammation.
REFERENCE   4  (residues 1 to 85)
  AUTHORS   Balce,D.R., Wang,Y.T., McAllaster,M.R., Dunlap,B.F., Orvedahl,A.,
            Hykes,B.L. Jr., Droit,L., Handley,S.A., Wilen,C.B., Doench,J.G.,
            Orchard,R.C., Stallings,C.L. and Virgin,H.W.
  TITLE     UFMylation inhibits the proinflammatory capacity of
            interferon-gamma-activated macrophages
  JOURNAL   Proc Natl Acad Sci U S A 118 (1) (2021)
   PUBMED   33372156
  REMARK    GeneRIF: UFMylation inhibits the proinflammatory capacity of
            interferon-gamma-activated macrophages.
REFERENCE   5  (residues 1 to 85)
  AUTHORS   Hu,X., Zhang,H., Song,Y., Zhuang,L., Yang,Q., Pan,M. and Chen,F.
  TITLE     Ubiquitin fold modifier 1 activates NF-kappaB pathway by
            down-regulating LZAP expression in the macrophage of diabetic mouse
            model
  JOURNAL   Biosci Rep 40 (1) (2020)
   PUBMED   31829413
  REMARK    GeneRIF: Ubiquitin fold modifier 1 activates NF-kappaB pathway by
            down-regulating LZAP expression in the macrophage of diabetic mouse
            model.
REFERENCE   6  (residues 1 to 85)
  AUTHORS   Ha,B.H., Ahn,H.C., Kang,S.H., Tanaka,K., Chung,C.H. and Kim,E.E.
  TITLE     Structural basis for Ufm1 processing by UfSP1
  JOURNAL   J Biol Chem 283 (21), 14893-14900 (2008)
   PUBMED   18321862
  REMARK    GeneRIF: loop between beta3 and alpha2 in addition to the
            C-terminal region of Ufm1 plays a role in binding to UfSP1
REFERENCE   7  (residues 1 to 85)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   8  (residues 1 to 85)
  AUTHORS   Azfer,A., Niu,J., Rogers,L.M., Adamski,F.M. and Kolattukudy,P.E.
  TITLE     Activation of endoplasmic reticulum stress response during the
            development of ischemic heart disease
  JOURNAL   Am J Physiol Heart Circ Physiol 291 (3), H1411-H1420 (2006)
   PUBMED   16617122
  REMARK    GeneRIF: A novel ubiquitin fold modifier (Ufm1) not been previously
            associated with ER stress and not found to be induced under any
            condition was found to be upregulated in the hearts of MCP mice
            (transgenic mice that express MCP-1 specifically in the heart).
REFERENCE   9  (residues 1 to 85)
  AUTHORS   Kiyozumi,D., Sugimoto,N. and Sekiguchi,K.
  TITLE     Breakdown of the reciprocal stabilization of QBRICK/Frem1, Fras1,
            and Frem2 at the basement membrane provokes Fraser syndrome-like
            defects
  JOURNAL   Proc Natl Acad Sci U S A 103 (32), 11981-11986 (2006)
   PUBMED   16880404
REFERENCE   10 (residues 1 to 85)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ075089.1, AK167301.1, AC147262.4 and BP754244.1.
            
            On or before Dec 2, 2010 this sequence version replaced
            XP_003084604.1, XP_003086343.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148146.1, AK167301.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..85
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 25.43 cM"
     Protein         1..85
                     /product="ubiquitin-fold modifier 1"
                     /calculated_mol_wt=8986
     mat_peptide     1..83
                     /product="Ubiquitin-fold modifier 1. /id=PRO_0000042126"
                     /note="propagated from UniProtKB/Swiss-Prot (P61961.1)"
                     /calculated_mol_wt=8927
     Region          4..78
                     /region_name="Ubl_UFM1"
                     /note="ubiquitin-like (Ubl) domain found in ubiquitin fold
                     modifier 1 (UFM1); cd01766"
                     /db_xref="CDD:340465"
     Site            order(19..24,28,31..32,35)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:340465"
     CDS             1..85
                     /gene="Ufm1"
                     /gene_synonym="1810045K17Rik; Gm10726"
                     /coded_by="NM_026435.5:58..315"
                     /db_xref="CCDS:CCDS38430.1"
                     /db_xref="GeneID:67890"
                     /db_xref="MGI:MGI:1915140"
ORIGIN      
        1 mskvsfkitl tsdprlpykv lsvpestpft avlkfaaeef kvpaatsaii tndgiginpa
       61 qtagnvflkh gselriiprd rvgsc
//
