LOCUS       NM_025388                984 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Mus musculus ubiquitin-fold modifier conjugating enzyme 1 (Ufc1),
            transcript variant 1, mRNA.
ACCESSION   NM_025388
VERSION     NM_025388.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 984)
  AUTHORS   Balce,D.R., Wang,Y.T., McAllaster,M.R., Dunlap,B.F., Orvedahl,A.,
            Hykes,B.L. Jr., Droit,L., Handley,S.A., Wilen,C.B., Doench,J.G.,
            Orchard,R.C., Stallings,C.L. and Virgin,H.W.
  TITLE     UFMylation inhibits the proinflammatory capacity of
            interferon-gamma-activated macrophages
  JOURNAL   Proc Natl Acad Sci U S A 118 (1) (2021)
   PUBMED   33372156
REFERENCE   2  (bases 1 to 984)
  AUTHORS   Yang,R., Wang,H., Kang,B., Chen,B., Shi,Y., Yang,S., Sun,L.,
            Liu,Y., Xiao,W., Zhang,T., Yang,J., Zhang,Y., Zhu,M., Xu,P.,
            Chang,Y., Jia,Y. and Huang,Y.
  TITLE     CDK5RAP3, a UFL1 substrate adaptor, is crucial for liver
            development
  JOURNAL   Development 146 (2) (2019)
   PUBMED   30635284
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 984)
  AUTHORS   Hu,X., Pang,Q., Shen,Q., Liu,H., He,J., Wang,J., Xiong,J., Zhang,H.
            and Chen,F.
  TITLE     Ubiquitin-fold modifier 1 inhibits apoptosis by suppressing the
            endoplasmic reticulum stress response in Raw264.7 cells
  JOURNAL   Int J Mol Med 33 (6), 1539-1546 (2014)
   PUBMED   24714921
  REMARK    GeneRIF: results suggest that Ufm1 is upregulated in diabetic mouse
            RPMs and in Raw264.7 cells in response to ER stress and that Ufm1
            protects macrophages against apoptosis.
REFERENCE   4  (bases 1 to 984)
  AUTHORS   Zhang,Y., Zhang,M., Wu,J., Lei,G. and Li,H.
  TITLE     Transcriptional regulation of the Ufm1 conjugation system in
            response to disturbance of the endoplasmic reticulum homeostasis
            and inhibition of vesicle trafficking
  JOURNAL   PLoS One 7 (11), e48587 (2012)
   PUBMED   23152784
REFERENCE   5  (bases 1 to 984)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
REFERENCE   6  (bases 1 to 984)
  AUTHORS   Eddleston,J., Murdoch,J.N., Copp,A.J. and Stanier,P.
  TITLE     Physical and transcriptional map of a 3-Mb region of mouse
            chromosome 1 containing the gene for the neural tube defect mutant
            loop-tail (Lp)
  JOURNAL   Genomics 56 (2), 149-159 (1999)
   PUBMED   10051400
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087229.27 and AK003897.1.
            
            On Feb 17, 2018 this sequence version replaced NM_025388.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a). Variants 1, 2, and 3 all encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK003897.1, BC021936.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AC087229.27        40360-40379         c
            21-984              AK003897.1         2-965
FEATURES             Location/Qualifiers
     source          1..984
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 79.31 cM"
     gene            1..984
                     /gene="Ufc1"
                     /gene_synonym="1110021H02Rik; ESTM29"
                     /note="ubiquitin-fold modifier conjugating enzyme 1"
                     /db_xref="GeneID:66155"
                     /db_xref="MGI:MGI:1913405"
     exon            1..82
                     /gene="Ufc1"
                     /gene_synonym="1110021H02Rik; ESTM29"
                     /inference="alignment:Splign:2.1.0"
     exon            83..276
                     /gene="Ufc1"
                     /gene_synonym="1110021H02Rik; ESTM29"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..657
                     /gene="Ufc1"
                     /gene_synonym="1110021H02Rik; ESTM29"
                     /note="isoform a is encoded by transcript variant 1;
                     Ufm1-conjugating enzyme 1"
                     /codon_start=1
                     /product="ubiquitin-fold modifier-conjugating enzyme 1
                     isoform a"
                     /protein_id="NP_079664.1"
                     /db_xref="CCDS:CCDS15488.1"
                     /db_xref="GeneID:66155"
                     /db_xref="MGI:MGI:1913405"
                     /translation="MADEATRRVVSEIPVLKTNAGPRDRELWVQRLKEEYQSLIRYVE
                     NNKNSDNDWFRLESNKEGTRWFGKCWYIHDFLKYEFDIEFEIPITYPTTAPEIAVPEL
                     DGKTAKMYRGGKICLTDHFKPLWARNVPKFGLAHLMALGLGPWLAVEVPDLIQKGVIQ
                     HKEKCSQ"
     exon            277..344
                     /gene="Ufc1"
                     /gene_synonym="1110021H02Rik; ESTM29"
                     /inference="alignment:Splign:2.1.0"
     exon            345..408
                     /gene="Ufc1"
                     /gene_synonym="1110021H02Rik; ESTM29"
                     /inference="alignment:Splign:2.1.0"
     exon            409..485
                     /gene="Ufc1"
                     /gene_synonym="1110021H02Rik; ESTM29"
                     /inference="alignment:Splign:2.1.0"
     exon            486..576
                     /gene="Ufc1"
                     /gene_synonym="1110021H02Rik; ESTM29"
                     /inference="alignment:Splign:2.1.0"
     exon            577..984
                     /gene="Ufc1"
                     /gene_synonym="1110021H02Rik; ESTM29"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttctctgagc aggctccggt gatttaatga taggtggaca gagtagcccg cctccattct
       61 gttcttccgg acgctcacac cctaaagatg gcgacgccgt gagtaagtga caagcaactg
      121 cacttccgca gttttcctgc tccctggtcc aagatggcgg acgaggccac tcggcgggtc
      181 gtgtctgaga tcccggtgct gaagaccaac gccggacccc gagatcggga attgtgggtg
      241 cagcgactaa aggaggaata tcagtccctg atccggtatg tggagaacaa caagaattcg
      301 gacaatgatt ggttccgact ggagtccaac aaggaaggga cccggtggtt tggaaaatgc
      361 tggtacatcc acgatttcct caaatatgag ttcgacatcg agtttgaaat tcctatcaca
      421 tatcccacta ctgctccgga aattgcagtc cctgagctgg acgggaagac agcaaagatg
      481 tacaggggtg gcaaaatatg tctgactgat catttcaaac ctttgtgggc caggaatgtg
      541 cctaagtttg gactagctca tctcatggcc ctggggctgg gtccttggct ggcagtggaa
      601 gtccccgatc tgatccagaa gggtgtgatc cagcacaaag aaaaatgcag ccaatgaagg
      661 actacgcccc tgaggccgga ctgagggacc gtggctaggc tccattcctg tttgctcctt
      721 tttcaggatt ccttcaaggg tcacctctgg ctgttacaaa gtagctggag ggacaaataa
      781 gaaaacccaa caatagggca aggtcacaaa gtttctaaat gaaactgtac agagagatga
      841 aagatttggg ccttgaaata ggcggtttgt atcccttctc caagtagagc cctggaggca
      901 ttttggaggc ctggggtgta acttacagca catagctttt tggtttctgg agacaacctg
      961 tcaataaaag ctgcttcccc tggt
//
