LOCUS       NM_001360931             988 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Mus musculus ubiquitin-fold modifier conjugating enzyme 1 (Ufc1),
            transcript variant 2, mRNA.
ACCESSION   NM_001360931
VERSION     NM_001360931.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 988)
  AUTHORS   Balce,D.R., Wang,Y.T., McAllaster,M.R., Dunlap,B.F., Orvedahl,A.,
            Hykes,B.L. Jr., Droit,L., Handley,S.A., Wilen,C.B., Doench,J.G.,
            Orchard,R.C., Stallings,C.L. and Virgin,H.W.
  TITLE     UFMylation inhibits the proinflammatory capacity of
            interferon-gamma-activated macrophages
  JOURNAL   Proc Natl Acad Sci U S A 118 (1) (2021)
   PUBMED   33372156
REFERENCE   2  (bases 1 to 988)
  AUTHORS   Yang,R., Wang,H., Kang,B., Chen,B., Shi,Y., Yang,S., Sun,L.,
            Liu,Y., Xiao,W., Zhang,T., Yang,J., Zhang,Y., Zhu,M., Xu,P.,
            Chang,Y., Jia,Y. and Huang,Y.
  TITLE     CDK5RAP3, a UFL1 substrate adaptor, is crucial for liver
            development
  JOURNAL   Development 146 (2) (2019)
   PUBMED   30635284
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 988)
  AUTHORS   Hu,X., Pang,Q., Shen,Q., Liu,H., He,J., Wang,J., Xiong,J., Zhang,H.
            and Chen,F.
  TITLE     Ubiquitin-fold modifier 1 inhibits apoptosis by suppressing the
            endoplasmic reticulum stress response in Raw264.7 cells
  JOURNAL   Int J Mol Med 33 (6), 1539-1546 (2014)
   PUBMED   24714921
  REMARK    GeneRIF: results suggest that Ufm1 is upregulated in diabetic mouse
            RPMs and in Raw264.7 cells in response to ER stress and that Ufm1
            protects macrophages against apoptosis.
REFERENCE   4  (bases 1 to 988)
  AUTHORS   Zhang,Y., Zhang,M., Wu,J., Lei,G. and Li,H.
  TITLE     Transcriptional regulation of the Ufm1 conjugation system in
            response to disturbance of the endoplasmic reticulum homeostasis
            and inhibition of vesicle trafficking
  JOURNAL   PLoS One 7 (11), e48587 (2012)
   PUBMED   23152784
REFERENCE   5  (bases 1 to 988)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
REFERENCE   6  (bases 1 to 988)
  AUTHORS   Eddleston,J., Murdoch,J.N., Copp,A.J. and Stanier,P.
  TITLE     Physical and transcriptional map of a 3-Mb region of mouse
            chromosome 1 containing the gene for the neural tube defect mutant
            loop-tail (Lp)
  JOURNAL   Genomics 56 (2), 149-159 (1999)
   PUBMED   10051400
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087229.27.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BE532194.1, SRR5189679.134510.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                AC087229.27        40294-40379         c
            87-280              AC087229.27        40011-40204         c
            281-348             AC087229.27        35526-35593         c
            349-412             AC087229.27        35261-35324         c
            413-489             AC087229.27        34895-34971         c
            490-580             AC087229.27        34548-34638         c
            581-988             AC087229.27        33941-34348         c
FEATURES             Location/Qualifiers
     source          1..988
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 79.31 cM"
     gene            1..988
                     /gene="Ufc1"
                     /gene_synonym="1110021H02Rik; ESTM29"
                     /note="ubiquitin-fold modifier conjugating enzyme 1"
                     /db_xref="GeneID:66155"
                     /db_xref="MGI:MGI:1913405"
     exon            1..86
                     /gene="Ufc1"
                     /gene_synonym="1110021H02Rik; ESTM29"
                     /inference="alignment:Splign:2.1.0"
     exon            87..280
                     /gene="Ufc1"
                     /gene_synonym="1110021H02Rik; ESTM29"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..661
                     /gene="Ufc1"
                     /gene_synonym="1110021H02Rik; ESTM29"
                     /note="isoform a is encoded by transcript variant 2;
                     Ufm1-conjugating enzyme 1"
                     /codon_start=1
                     /product="ubiquitin-fold modifier-conjugating enzyme 1
                     isoform a"
                     /protein_id="NP_001347860.1"
                     /db_xref="CCDS:CCDS15488.1"
                     /db_xref="GeneID:66155"
                     /db_xref="MGI:MGI:1913405"
                     /translation="MADEATRRVVSEIPVLKTNAGPRDRELWVQRLKEEYQSLIRYVE
                     NNKNSDNDWFRLESNKEGTRWFGKCWYIHDFLKYEFDIEFEIPITYPTTAPEIAVPEL
                     DGKTAKMYRGGKICLTDHFKPLWARNVPKFGLAHLMALGLGPWLAVEVPDLIQKGVIQ
                     HKEKCSQ"
     exon            281..348
                     /gene="Ufc1"
                     /gene_synonym="1110021H02Rik; ESTM29"
                     /inference="alignment:Splign:2.1.0"
     exon            349..412
                     /gene="Ufc1"
                     /gene_synonym="1110021H02Rik; ESTM29"
                     /inference="alignment:Splign:2.1.0"
     exon            413..489
                     /gene="Ufc1"
                     /gene_synonym="1110021H02Rik; ESTM29"
                     /inference="alignment:Splign:2.1.0"
     exon            490..580
                     /gene="Ufc1"
                     /gene_synonym="1110021H02Rik; ESTM29"
                     /inference="alignment:Splign:2.1.0"
     exon            581..988
                     /gene="Ufc1"
                     /gene_synonym="1110021H02Rik; ESTM29"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttctctgagc aggctccggt gatttaatga taggtggaca gagtagcccg cctccattct
       61 gttcttccgg acgctcacac ccgtagtaaa gatggcgacg ccgtgagtaa gtgacaagca
      121 actgcacttc cgcagttttc ctgctccctg gtccaagatg gcggacgagg ccactcggcg
      181 ggtcgtgtct gagatcccgg tgctgaagac caacgccgga ccccgagatc gggaattgtg
      241 ggtgcagcga ctaaaggagg aatatcagtc cctgatccgg tatgtggaga acaacaagaa
      301 ttcggacaat gattggttcc gactggagtc caacaaggaa gggacccggt ggtttggaaa
      361 atgctggtac atccacgatt tcctcaaata tgagttcgac atcgagtttg aaattcctat
      421 cacatatccc actactgctc cggaaattgc agtccctgag ctggacggga agacagcaaa
      481 gatgtacagg ggtggcaaaa tatgtctgac tgatcatttc aaacctttgt gggccaggaa
      541 tgtgcctaag tttggactag ctcatctcat ggccctgggg ctgggtcctt ggctggcagt
      601 ggaagtcccc gatctgatcc agaagggtgt gatccagcac aaagaaaaat gcagccaatg
      661 aaggactacg cccctgaggc cggactgagg gaccgtggct aggctccatt cctgtttgct
      721 cctttttcag gattccttca agggtcacct ctggctgtta caaagtagct ggagggacaa
      781 ataagaaaac ccaacaatag ggcaaggtca caaagtttct aaatgaaact gtacagagag
      841 atgaaagatt tgggccttga aataggcggt ttgtatccct tctccaagta gagccctgga
      901 ggcattttgg aggcctgggg tgtaacttac agcacatagc tttttggttt ctggagacaa
      961 cctgtcaata aaagctgctt cccctggt
//
