LOCUS       NM_009464               2448 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus uncoupling protein 3 (mitochondrial, proton carrier)
            (Ucp3), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_009464
VERSION     NM_009464.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2448)
  AUTHORS   Kreiter,J., Tyschuk,T. and Pohl,E.E.
  TITLE     Uncoupling Protein 3 Catalyzes the Exchange of C4 Metabolites
            Similar to UCP2
  JOURNAL   Biomolecules 14 (1), 21 (2023)
   PUBMED   38254621
  REMARK    GeneRIF: Uncoupling Protein 3 Catalyzes the Exchange of C4
            Metabolites Similar to UCP2.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2448)
  AUTHORS   Sanchez-Perez,P., Mata,A., Torp,M.K., Lopez-Bernardo,E.,
            Heiestad,C.M., Aronsen,J.M., Molina-Iracheta,A.,
            Jimenez-Borreguero,L.J., Garcia-Roves,P., Costa,A.S.H., Frezza,C.,
            Murphy,M.P., Stenslokken,K.O. and Cadenas,S.
  TITLE     Energy substrate metabolism, mitochondrial structure and oxidative
            stress after cardiac ischemia-reperfusion in mice lacking UCP3
  JOURNAL   Free Radic Biol Med 205, 244-261 (2023)
   PUBMED   37295539
REFERENCE   3  (bases 1 to 2448)
  AUTHORS   Paredes,A., Justo-Mendez,R., Jimenez-Blasco,D., Nunez,V.,
            Calero,I., Villalba-Orero,M., Alegre-Marti,A., Fischer,T.,
            Gradillas,A., Sant'Anna,V.A.R., Were,F., Huang,Z.,
            Hernansanz-Agustin,P., Contreras,C., Martinez,F., Camafeita,E.,
            Vazquez,J., Ruiz-Cabello,J., Area-Gomez,E., Sanchez-Cabo,F.,
            Treuter,E., Bolanos,J.P., Estebanez-Perpina,E., Ruperez,F.J.,
            Barbas,C., Enriquez,J.A. and Ricote,M.
  TITLE     gamma-Linolenic acid in maternal milk drives cardiac metabolic
            maturation
  JOURNAL   Nature 618 (7964), 365-373 (2023)
   PUBMED   37225978
  REMARK    Erratum:[Nature. 2023 Jul;619(7968):E24. doi:
            10.1038/s41586-023-06316-w.. PMID: 37322272]
REFERENCE   4  (bases 1 to 2448)
  AUTHORS   Codella,R., Alves,T.C., Befroy,D.E., Choi,C.S., Luzi,L.,
            Rothman,D.L., Kibbey,R.G. and Shulman,G.I.
  TITLE     Overexpression of UCP3 decreases mitochondrial efficiency in mouse
            skeletal muscle in vivo
  JOURNAL   FEBS Lett 597 (2), 309-319 (2023)
   PUBMED   36114012
  REMARK    GeneRIF: Overexpression of UCP3 decreases mitochondrial efficiency
            in mouse skeletal muscle in vivo.
REFERENCE   5  (bases 1 to 2448)
  AUTHORS   Gentile,A., Magnacca,N., de Matteis,R., Moreno,M., Cioffi,F.,
            Giacco,A., Lanni,A., de Lange,P., Senese,R., Goglia,F.,
            Silvestri,E. and Lombardi,A.
  TITLE     Ablation of uncoupling protein 3 affects interrelated factors
            leading to lipolysis and insulin resistance in visceral white
            adipose tissue
  JOURNAL   FASEB J 36 (5), e22325 (2022)
   PUBMED   35452152
  REMARK    GeneRIF: Ablation of uncoupling protein 3 affects interrelated
            factors leading to lipolysis and insulin resistance in visceral
            white adipose tissue.
REFERENCE   6  (bases 1 to 2448)
  AUTHORS   Tsuboyama-Kasaoka,N., Tsunoda,N., Maruyama,K., Takahashi,M.,
            Kim,H., Ikemoto,S. and Ezaki,O.
  TITLE     Up-regulation of uncoupling protein 3 (UCP3) mRNA by exercise
            training and down-regulation of UCP3 by denervation in skeletal
            muscles
  JOURNAL   Biochem Biophys Res Commun 247 (2), 498-503 (1998)
   PUBMED   9642158
REFERENCE   7  (bases 1 to 2448)
  AUTHORS   Shimokawa,T., Kato,M., Ezaki,O. and Hashimoto,S.
  TITLE     Transcriptional regulation of muscle-specific genes during myoblast
            differentiation
  JOURNAL   Biochem Biophys Res Commun 246 (1), 287-292 (1998)
   PUBMED   9600108
REFERENCE   8  (bases 1 to 2448)
  AUTHORS   Hodny,Z., Kolarova,P., Rossmeisl,M., Horakova,M., Nibbelink,M.,
            Penicaud,L., Casteilla,L. and Kopecky,J.
  TITLE     High expression of uncoupling protein 2 in foetal liver
  JOURNAL   FEBS Lett 425 (2), 185-190 (1998)
   PUBMED   9559644
REFERENCE   9  (bases 1 to 2448)
  AUTHORS   Liu,Q., Bai,C., Chen,F., Wang,R., MacDonald,T., Gu,M., Zhang,Q.,
            Morsy,M.A. and Caskey,C.T.
  TITLE     Uncoupling protein-3: a muscle-specific gene upregulated by leptin
            in ob/ob mice
  JOURNAL   Gene 207 (1), 1-7 (1998)
   PUBMED   9511737
REFERENCE   10 (bases 1 to 2448)
  AUTHORS   Gong,D.W., He,Y., Karas,M. and Reitman,M.
  TITLE     Uncoupling protein-3 is a mediator of thermogenesis regulated by
            thyroid hormone, beta3-adrenergic agonists, and leptin
  JOURNAL   J Biol Chem 272 (39), 24129-24132 (1997)
   PUBMED   9305858
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117215.3.
            
            On Mar 21, 2007 this sequence version replaced NM_009464.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB010742.1, AF032902.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               AC117215.3         116410-116513       c
            105-323             AC117215.3         109912-110130       c
            324-525             AC117215.3         109217-109418       c
            526-726             AC117215.3         108823-109023       c
            727-828             AC117215.3         107532-107633       c
            829-1009            AC117215.3         106749-106929       c
            1010-2448           AC117215.3         103072-104510       c
FEATURES             Location/Qualifiers
     source          1..2448
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.36 cM"
     gene            1..2448
                     /gene="Ucp3"
                     /gene_synonym="Slc25a9; UCP-3"
                     /note="uncoupling protein 3 (mitochondrial, proton
                     carrier)"
                     /db_xref="GeneID:22229"
                     /db_xref="MGI:MGI:1099787"
     exon            1..104
                     /gene="Ucp3"
                     /gene_synonym="Slc25a9; UCP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            105..323
                     /gene="Ucp3"
                     /gene_synonym="Slc25a9; UCP-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..1124
                     /gene="Ucp3"
                     /gene_synonym="Slc25a9; UCP-3"
                     /note="mitochondrial uncoupling protein 3; solute carrier
                     family 25 member 9"
                     /codon_start=1
                     /product="putative mitochondrial transporter UCP3"
                     /protein_id="NP_033490.1"
                     /db_xref="CCDS:CCDS21497.1"
                     /db_xref="GeneID:22229"
                     /db_xref="MGI:MGI:1099787"
                     /translation="MVGLQPSEVPPTTVVKFLGAGTAACFADLLTFPLDTAKVRLQIQ
                     GENPGAQSVQYRGVLGTILTMVRTEGPRSPYSGLVAGLHRQMSFASIRIGLYDSVKQF
                     YTPKGADHSSVAIRILAGCTTGAMAVTCAQPTDVVKVRFQAMIRLGTGGERKYRGTMD
                     AYRTIAREEGVRGLWKGTWPNITRNAIVNCAEMVTYDIIKEKLLESHLFTDNFPCHFV
                     SAFGAGFCATVVASPVDVVKTRYMNAPLGRYRSPLHCMLKMVAQEGPTAFYKGFVPSF
                     LRLGAWNVMMFVTYEQLKRALMKVQVLRESPF"
     exon            324..525
                     /gene="Ucp3"
                     /gene_synonym="Slc25a9; UCP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            526..726
                     /gene="Ucp3"
                     /gene_synonym="Slc25a9; UCP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            727..828
                     /gene="Ucp3"
                     /gene_synonym="Slc25a9; UCP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            829..1009
                     /gene="Ucp3"
                     /gene_synonym="Slc25a9; UCP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..2448
                     /gene="Ucp3"
                     /gene_synonym="Slc25a9; UCP-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2430..2435
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ucp3"
                     /gene_synonym="Slc25a9; UCP-3"
                     /note="hexamer: AATAAA"
     polyA_site      2448
                     /gene="Ucp3"
                     /gene_synonym="Slc25a9; UCP-3"
                     /note="major polyA site"
ORIGIN      
        1 agacaacagt gaatggtgag gcccggccgt cagatcctgc tgctacctaa tggagtggag
       61 ccttagggtg gccctgcact acccaacctt ggctagacgc acagcttcct ccctgaactg
      121 aagcaaaaga ttgccaggca agctctctcc tcggacctcc ataggcagca aaggaaccag
      181 gcccattccc cgggaccatg gttggacttc agccctccga agtgcctccc acaacggttg
      241 tgaagttcct gggggccggc actgcggcct gttttgcgga cctcctcact tttcccctgg
      301 acaccgccaa ggtccgtctg cagatccaag gggagaaccc aggggctcag agcgtgcagt
      361 accgcggtgt gctgggtacc atcctgacta tggtgcgcac agagggtccc cgcagcccct
      421 acagcggact ggtcgctggc ctgcaccgcc agatgagttt tgcctccatt cgaattggcc
      481 tctacgactc tgtcaagcag ttctacaccc ccaagggagc ggaccactcc agcgtcgcca
      541 tcaggattct ggcaggctgc acgacaggag ccatggcagt gacctgcgcc cagcccacgg
      601 atgtggtgaa ggtccgattt caagccatga tacgcctggg aactggagga gagaggaaat
      661 acagagggac tatggatgcc tacagaacca tcgccaggga ggaaggagtc aggggcctgt
      721 ggaaagggac ttggcccaac atcacaagaa atgccattgt caactgtgct gagatggtga
      781 cctacgacat catcaaggag aagttgctgg agtctcacct gtttactgac aacttcccct
      841 gtcactttgt ctctgccttt ggagctggct tctgtgccac agtggtggcc tccccggtgg
      901 atgtggtaaa gacccgatac atgaacgctc ccctaggcag gtaccgcagc cctctgcact
      961 gtatgctgaa gatggtggct caggagggac ccacggcctt ctacaaagga tttgtgccct
     1021 cctttctgcg tctgggagct tggaacgtga tgatgtttgt aacatatgag caactgaaga
     1081 gggccttaat gaaagtccag gtactgcggg aatctccgtt ttgaacaagg caagcaggct
     1141 gcctggaaca gaacaaagcg tctctgccct ggggacacag gcccacacgg tccagaaccc
     1201 tgcactgctg ctgacacgag aaactgaact aaaagaggag agttttagtc ctccgtgttt
     1261 cgtcctaaaa cacctctgtt ttgcactgac ctgatgggaa ataaattata ttaattttta
     1321 aaccccttcc ggttggatgc ctaacattta ggcaagagac aacaaagaaa accagagtca
     1381 actcccttga aatgtaggaa taaaggatgc ataataaaca ggaaaggcac aggttttgag
     1441 aagatcagcc cacagtgttg tccttgaatc aaacaaaatg gtcggaggaa cccttcggct
     1501 tcagcacaaa gaggtgacta cagccttctg gtcaccagat gactccgccc ctctgtaatg
     1561 agtctgccaa gtagactcta tcaagattct ggggaaagga gaaagaacac attgatactg
     1621 cacaaatgag tggtgctggg cccaccgagg acactggagg atggagcgtg atctgggata
     1681 acagtccttc tctgtctgcc tcatcagggt gttgggaaga tagaaagcga agcagacatg
     1741 gaagcacttc ctaacaaggc ctgtcatcgt catcatctac aaatgtaagc ctgaggacaa
     1801 tgttttagga gagattctgt ccagagaagt agtttgagga aaatgcagtt tgtagtggta
     1861 aagccatgca cacctggact gcatggtaag gaccaggggt gacggaagcc atggggatcc
     1921 ggtgcctggt aacatcaaag ggctgtgggg ggggggggca ctgcctgtcc atcagttcaa
     1981 agcagcagga ctcagaatct ttagggaatt gttaggactg gtaaaagaat ttccacctta
     2041 gggcaagaac gagaacagct gctcttctgc cttctctctc ggaggttttc tcatctcagg
     2101 gtcctacctg ccaggctcct gaccagctcc acctgcccac acttcctcct gctctcgctg
     2161 cctttggctg cagagccttt gctcctcctg ttaagccttc agtcttccat ctgcaaaagg
     2221 gagggcaaag cacaggacca acttccaagc ttaaaaatgc acatctgaca acaaaatggc
     2281 tcagtggggt ccattcatgg gacccacatg gtggaaggac agaatggact cttgcaaatt
     2341 gtcctctgac ctccatttga gcgccctata catgtgactg tacatatgta caaacacgat
     2401 aaagatggaa acacatgtaa aaacataaaa ataaaaagtt gtactgga
//
