LOCUS       NM_001417454            1696 bp    mRNA    linear   ROD 13-NOV-2024
DEFINITION  Mus musculus uncoupling protein 2 (mitochondrial, proton carrier)
            (Ucp2), transcript variant 4, mRNA.
ACCESSION   NM_001417454
VERSION     NM_001417454.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1696)
  AUTHORS   Huang,B., Lin,G., Chen,F., Yang,W., Zhang,C., Yao,Y., Zeng,Q.,
            Yang,Y. and Huang,J.
  TITLE     UCP2 knockout exacerbates sepsis-induced intestinal injury by
            promoting NLRP3-mediated pyroptosis
  JOURNAL   Int Immunopharmacol 141, 112935 (2024)
   PUBMED   39159561
  REMARK    GeneRIF: UCP2 knockout exacerbates sepsis-induced intestinal injury
            by promoting NLRP3-mediated pyroptosis.
REFERENCE   2  (bases 1 to 1696)
  AUTHORS   Cardarelli,S., Biglietto,M., Orsini,T., Fustaino,V., Monaco,L., de
            Oliveira do Rego,A.G., Liccardo,F., Masciarelli,S., Fazi,F.,
            Naro,F., De Angelis,L. and Pellegrini,M.
  TITLE     Modulation of cAMP/cGMP signaling as prevention of congenital heart
            defects in Pde2A deficient embryos: a matter of oxidative stress
  JOURNAL   Cell Death Dis 15 (2), 169 (2024)
   PUBMED   38395995
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1696)
  AUTHORS   Zhou,P., Zhang,Y., Xu,K., Liu,Y., Huang,J., Yao,Q., Chen,X. and
            Zhou,L.
  TITLE     Uncoupling Protein 2 Alleviates Myocardial Ischemia/Reperfusion
            Injury by Inhibiting Cardiomyocyte Ferroptosis
  JOURNAL   J Vasc Res 61 (3), 109-121 (2024)
   PUBMED   38615660
  REMARK    GeneRIF: Uncoupling Protein 2 Alleviates Myocardial
            Ischemia/Reperfusion Injury by Inhibiting Cardiomyocyte
            Ferroptosis.
REFERENCE   4  (bases 1 to 1696)
  AUTHORS   Kreiter,J., Tyschuk,T. and Pohl,E.E.
  TITLE     Uncoupling Protein 3 Catalyzes the Exchange of C4 Metabolites
            Similar to UCP2
  JOURNAL   Biomolecules 14 (1), 21 (2023)
   PUBMED   38254621
  REMARK    GeneRIF: Uncoupling Protein 3 Catalyzes the Exchange of C4
            Metabolites Similar to UCP2.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1696)
  AUTHORS   Yang,Q., Wang,L., Liang,Y., He,Q., Sun,Q., Luo,J., Cao,H., Fang,Y.,
            Zhou,Y., Yang,J., Wen,P. and Jiang,L.
  TITLE     Loss of UCP2 causes mitochondrial fragmentation by OMA1-dependent
            proteolytic processing of OPA1 in podocytes
  JOURNAL   FASEB J 37 (11), e23265 (2023)
   PUBMED   37874273
  REMARK    GeneRIF: Loss of UCP2 causes mitochondrial fragmentation by
            OMA1-dependent proteolytic processing of OPA1 in podocytes.
REFERENCE   6  (bases 1 to 1696)
  AUTHORS   Hurtaud,C., Gelly,C., Bouillaud,F. and Levi-Meyrueis,C.
  TITLE     Translation control of UCP2 synthesis by the upstream open reading
            frame
  JOURNAL   Cell Mol Life Sci 63 (15), 1780-1789 (2006)
   PUBMED   16845607
REFERENCE   7  (bases 1 to 1696)
  AUTHORS   Hodny,Z., Kolarova,P., Rossmeisl,M., Horakova,M., Nibbelink,M.,
            Penicaud,L., Casteilla,L. and Kopecky,J.
  TITLE     High expression of uncoupling protein 2 in foetal liver
  JOURNAL   FEBS Lett 425 (2), 185-190 (1998)
   PUBMED   9559644
REFERENCE   8  (bases 1 to 1696)
  AUTHORS   Liu,Q., Bai,C., Chen,F., Wang,R., MacDonald,T., Gu,M., Zhang,Q.,
            Morsy,M.A. and Caskey,C.T.
  TITLE     Uncoupling protein-3: a muscle-specific gene upregulated by leptin
            in ob/ob mice
  JOURNAL   Gene 207 (1), 1-7 (1998)
   PUBMED   9511737
REFERENCE   9  (bases 1 to 1696)
  AUTHORS   Gimeno,R.E., Dembski,M., Weng,X., Deng,N., Shyjan,A.W.,
            Gimeno,C.J., Iris,F., Ellis,S.J., Woolf,E.A. and Tartaglia,L.A.
  TITLE     Cloning and characterization of an uncoupling protein homolog: a
            potential molecular mediator of human thermogenesis
  JOURNAL   Diabetes 46 (5), 900-906 (1997)
   PUBMED   9133562
REFERENCE   10 (bases 1 to 1696)
  AUTHORS   Fleury,C., Neverova,M., Collins,S., Raimbault,S., Champigny,O.,
            Levi-Meyrueis,C., Bouillaud,F., Seldin,M.F., Surwit,R.S.,
            Ricquier,D. and Warden,C.H.
  TITLE     Uncoupling protein-2: a novel gene linked to obesity and
            hyperinsulinemia
  JOURNAL   Nat Genet 15 (3), 269-272 (1997)
   PUBMED   9054939
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117215.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2569987.1,
                                           SRR14995047.600636.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            regulatory uORF                    :: PMID: 16845607
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-232               AC117215.3         95494-95725         c
            233-394             AC117215.3         95129-95290         c
            395-617             AC117215.3         92556-92778         c
            618-828             AC117215.3         92199-92409         c
            829-1023            AC117215.3         91232-91426         c
            1024-1125           AC117215.3         91055-91156         c
            1126-1306           AC117215.3         90588-90768         c
            1307-1696           AC117215.3         89879-90268         c
FEATURES             Location/Qualifiers
     source          1..1696
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.36 cM"
     gene            1..1696
                     /gene="Ucp2"
                     /gene_synonym="Slc25a8; UCP 2; UCPH"
                     /note="uncoupling protein 2 (mitochondrial, proton
                     carrier)"
                     /db_xref="GeneID:22228"
                     /db_xref="MGI:MGI:109354"
     exon            1..232
                     /gene="Ucp2"
                     /gene_synonym="Slc25a8; UCP 2; UCPH"
                     /inference="alignment:Splign:2.1.0"
     exon            233..394
                     /gene="Ucp2"
                     /gene_synonym="Slc25a8; UCP 2; UCPH"
                     /inference="alignment:Splign:2.1.0"
     exon            395..617
                     /gene="Ucp2"
                     /gene_synonym="Slc25a8; UCP 2; UCPH"
                     /inference="alignment:Splign:2.1.0"
     CDS             492..1421
                     /gene="Ucp2"
                     /gene_synonym="Slc25a8; UCP 2; UCPH"
                     /note="uncoupling protein 2, mitochondrial; mitochondrial
                     uncoupling protein 2; solute carrier family 25 member 8;
                     dicarboxylate carrier SLC25A8"
                     /codon_start=1
                     /product="dicarboxylate carrier UCP2"
                     /protein_id="NP_001404383.1"
                     /db_xref="GeneID:22228"
                     /db_xref="MGI:MGI:109354"
                     /translation="MVGFKATDVPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQ
                     GESQGLVRTAASAQYRGVLGTILTMVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDS
                     VKQFYTKGSEHAGIGSRLLAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTV
                     EAYKTIAREEGIRGLWKGTSPNVARNAIVNCAELVTYDLIKDTLLKANLMTDDLPCHF
                     TSAFGAGFCTTVIASPVDVVKTRYMNSALGQYHSAGHCALTMLRKEGPRAFYKGFMPS
                     FLRLGSWNVVMFVTYEQLKRALMAAYQSREAPF"
     exon            618..828
                     /gene="Ucp2"
                     /gene_synonym="Slc25a8; UCP 2; UCPH"
                     /inference="alignment:Splign:2.1.0"
     exon            829..1023
                     /gene="Ucp2"
                     /gene_synonym="Slc25a8; UCP 2; UCPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1125
                     /gene="Ucp2"
                     /gene_synonym="Slc25a8; UCP 2; UCPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1306
                     /gene="Ucp2"
                     /gene_synonym="Slc25a8; UCP 2; UCPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1696
                     /gene="Ucp2"
                     /gene_synonym="Slc25a8; UCP 2; UCPH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1677..1682
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ucp2"
                     /gene_synonym="Slc25a8; UCP 2; UCPH"
                     /note="hexamer: CATAAA"
     polyA_site      1696
                     /gene="Ucp2"
                     /gene_synonym="Slc25a8; UCP 2; UCPH"
                     /note="major polyA site"
ORIGIN      
        1 gtatcaaggg ttgtttgtgc ctggaggagc cttggagttt gtttggcctt tgttacacta
       61 tcttatgtgg ctgcctgccg gaggtggaag tagggacaca gggagactgg acctgcctta
      121 tcctgattca acacaaatag atataatgct ccactcaaca gttttgtgac tgtatccccc
      181 aggcacagca cagctgcctg tctacataac tgtctgagaa acaaatttgg aagacacaat
      241 agtatgaact ttaagtgttt cgtctcccag ccattttcta tggaaaatcg aggggatcgg
      301 gccatggtag ccaccggcag ctttgaagaa cgagacacct ttagagaagc ttgaccttgg
      361 aggcctcagc ctgagacctc aaagcagcct ccagaactcc ggcagagttc ctctgtctcg
      421 tcttgccgat tgaaggtccc cgtttctcca atttctctcc atcttctggg aggtagcagg
      481 aaatcagaat catggttggt ttcaaggcca cagatgtgcc cccaacagcc actgtgaagt
      541 tcctgggggc tgggacagct gcctgcattg cagatctcat cactttccct ctggataccg
      601 ccaaggtccg gctgcagatc caaggggaga gtcaagggct agtgcgcacc gcagccagcg
      661 cccagtaccg tggcgttctg ggtaccatcc taaccatggt gcgcactgag ggtccacgca
      721 gcctctacaa tgggctggtc gccggcctgc agcgccagat gagctttgcc tccgtccgca
      781 ttggcctcta cgactctgtc aaacagttct acaccaaggg ctcagagcat gcaggcatcg
      841 ggagccgcct cctggcaggt agcaccacag gtgccctggc cgtggctgta gcccagccta
      901 cagatgtggt aaaggtccgc ttccaggctc aggcccgggc tggtggtggt cggagatacc
      961 agagcactgt cgaagcctac aagaccattg cacgagagga agggatccgg ggcctctgga
     1021 aagggacttc tcccaatgtt gcccgtaatg ccattgtcaa ctgtgctgag ctggtgacct
     1081 atgacctcat caaagatact ctcctgaaag ccaacctcat gacagatgac ctcccttgcc
     1141 acttcacttc tgccttcggg gccggcttct gcaccaccgt catcgcctcc cctgttgatg
     1201 tggtcaagac gagatacatg aactctgcct tgggccagta ccacagcgca ggtcactgtg
     1261 cccttaccat gctccggaag gagggacccc gcgccttcta caaggggttc atgccttcct
     1321 ttctccgctt gggatcctgg aacgtagtga tgtttgtcac ctatgagcag ctcaaaagag
     1381 ccctaatggc tgcctaccaa tctcgggagg cacctttctg agcctctcca tgctgacctg
     1441 gaccctgctt cccagccctg ccctgtcttt ttcttcatcc tctgcccagt cccattctct
     1501 tcccatttcc tgcaccccga tttacttccc acctcacctc cctgtgcctc tgtactgatg
     1561 actcacagtg aggaggcctg acaccagacc ctgagccctc agccctttct acagctaagc
     1621 ccacatcttc atcttcatcc ccagcccagc ccagcccagc tcagccagcc ttcacccata
     1681 aagcaagctc aatgtt
//
