LOCUS       NM_009463               1644 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus uncoupling protein 1 (mitochondrial, proton carrier)
            (Ucp1), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_009463
VERSION     NM_009463.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1644)
  AUTHORS   Zhao,J., Gu,M., Zhang,Y., Jia,X., Xiao,W., Lu,G., Chen,W. and
            Gong,W.
  TITLE     Myeloid-derived suppressor cells in the tumor microenvironment
            reduce uncoupling protein 1 expression to boost immunosuppressive
            activity
  JOURNAL   Biochem Biophys Res Commun 732, 150408 (2024)
   PUBMED   39032414
REFERENCE   2  (bases 1 to 1644)
  AUTHORS   Musiol,E., Fromme,T., Hau,J., Di Pizio,A. and Klingenspor,M.
  TITLE     Comparative functional analysis reveals differential nucleotide
            sensitivity between human and mouse UCP1
  JOURNAL   Acta Physiol (Oxf) 240 (9), e14209 (2024)
   PUBMED   39072954
  REMARK    GeneRIF: Comparative functional analysis reveals differential
            nucleotide sensitivity between human and mouse UCP1.
REFERENCE   3  (bases 1 to 1644)
  AUTHORS   Velez-delValle,C., Hernandez-Mosqueira,C.P., Castro-Rodriguez,L.I.,
            Vazquez-Sandoval,A., Marsch-Moreno,M. and Kuri-Harcuch,W.
  TITLE     Gene expression and characterization of clonally derived murine
            embryonic brown and brite adipocytes
  JOURNAL   FEBS Open Bio 14 (9), 1503-1525 (2024)
   PUBMED   38972757
REFERENCE   4  (bases 1 to 1644)
  AUTHORS   Gu,M., Zhang,Y., Lin,Z., Hu,X., Zhu,Y., Xiao,W., Jia,X., Chen,W.,
            Lu,G. and Gong,W.
  TITLE     Decrease in UCP1 by sustained high lipid promotes NK cell
            necroptosis to exacerbate nonalcoholic liver fibrosis
  JOURNAL   Cell Death Dis 15 (7), 518 (2024)
   PUBMED   39033153
  REMARK    GeneRIF: Decrease in UCP1 by sustained high lipid promotes NK cell
            necroptosis to exacerbate nonalcoholic liver fibrosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1644)
  AUTHORS   Brunner,S., Horing,M., Liebisch,G., Schweizer,S., Scheiber,J.,
            Giansanti,P., Hidrobo,M., Hermeling,S., Oeckl,J., Prudente de
            Mello,N., Perocchi,F., Seeliger,C., Strohmeyer,A., Klingenspor,M.,
            Plagge,J., Kuster,B., Burkhardt,R., Janssen,K.P. and Ecker,J.
  TITLE     Mitochondrial lipidomes are tissue specific - low cholesterol
            contents relate to UCP1 activity
  JOURNAL   Life Sci Alliance 7 (8), e202402828 (2024)
   PUBMED   38843936
  REMARK    GeneRIF: Mitochondrial lipidomes are tissue specific - low
            cholesterol contents relate to UCP1 activity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1644)
  AUTHORS   Lock,L.F., Pines,J., Hunter,T., Gilbert,D.J., Gopalan,G.,
            Jenkins,N.A., Copeland,N.G. and Donovan,P.J.
  TITLE     A single cyclin A gene and multiple cyclin B1-related sequences are
            dispersed in the mouse genome
  JOURNAL   Genomics 13 (2), 415-424 (1992)
   PUBMED   1535334
REFERENCE   7  (bases 1 to 1644)
  AUTHORS   Ovnic,M., Swank,R.T., Fletcher,C., Zhen,L., Novak,E.K., Baumann,H.,
            Heintz,N. and Ganschow,R.E.
  TITLE     Characterization and functional expression of a cDNA encoding
            egasyn (esterase-22): the endoplasmic reticulum-targeting protein
            of beta-glucuronidase
  JOURNAL   Genomics 11 (4), 956-967 (1991)
   PUBMED   1783403
REFERENCE   8  (bases 1 to 1644)
  AUTHORS   Howard,T.A., Rochelle,J.M., Saunders,A.M. and Seldin,M.F.
  TITLE     A linkage map of mouse chromosome 8: further definition of
            homologous linkage relationships between mouse chromosome 8 and
            human chromosomes 8, 16, and 19
  JOURNAL   Genomics 10 (1), 207-213 (1991)
   PUBMED   1675193
REFERENCE   9  (bases 1 to 1644)
  AUTHORS   Ovnic,M., Tepperman,K., Medda,S., Elliott,R.W., Stephenson,D.A.,
            Grant,S.G. and Ganschow,R.E.
  TITLE     Characterization of a murine cDNA encoding a member of the
            carboxylesterase multigene family
  JOURNAL   Genomics 9 (2), 344-354 (1991)
   PUBMED   1840565
REFERENCE   10 (bases 1 to 1644)
  AUTHORS   Ceci,J.D., Justice,M.J., Lock,L.F., Jenkins,N.A. and Copeland,N.G.
  TITLE     An interspecific backcross linkage map of mouse chromosome 8
  JOURNAL   Genomics 6 (1), 72-79 (1990)
   PUBMED   1968046
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB571086.1, BY115039.1, AK002759.1, AV248262.2 and AV006962.1.
            
            On Aug 12, 2009 this sequence version replaced NM_009463.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK076454.1, AK002759.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 BB571086.1         4-4
            2-304               BY115039.1         2-304
            305-1237            AK002759.1         303-1235
            1238-1640           AV248262.2         593-995
            1641-1644           AV006962.1         189-192
FEATURES             Location/Qualifiers
     source          1..1644
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 39.65 cM"
     gene            1..1644
                     /gene="Ucp1"
                     /gene_synonym="Slc25a7; Ucp"
                     /note="uncoupling protein 1 (mitochondrial, proton
                     carrier)"
                     /db_xref="GeneID:22227"
                     /db_xref="MGI:MGI:98894"
     exon            1..361
                     /gene="Ucp1"
                     /gene_synonym="Slc25a7; Ucp"
                     /inference="alignment:Splign:2.1.0"
     exon            362..560
                     /gene="Ucp1"
                     /gene_synonym="Slc25a7; Ucp"
                     /inference="alignment:Splign:2.1.0"
     exon            561..761
                     /gene="Ucp1"
                     /gene_synonym="Slc25a7; Ucp"
                     /inference="alignment:Splign:2.1.0"
     exon            762..863
                     /gene="Ucp1"
                     /gene_synonym="Slc25a7; Ucp"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1044
                     /gene="Ucp1"
                     /gene_synonym="Slc25a7; Ucp"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1644
                     /gene="Ucp1"
                     /gene_synonym="Slc25a7; Ucp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1216..1221
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ucp1"
                     /gene_synonym="Slc25a7; Ucp"
                     /note="hexamer: AATAAA"
     regulatory      1239..1244
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ucp1"
                     /gene_synonym="Slc25a7; Ucp"
                     /note="hexamer: AATGAA"
     polyA_site      1240
                     /gene="Ucp1"
                     /gene_synonym="Slc25a7; Ucp"
                     /note="major polyA site"
     polyA_site      1261
                     /gene="Ucp1"
                     /gene_synonym="Slc25a7; Ucp"
ORIGIN      
        1 aagtgccggg caatctgggc ttaacgggtc ctccctgccc gagcaagagg aagggacgct
       61 cacctttgag ctgctccaca gcgccgcctc tgcactggca ctacctagcc caggtggctc
      121 tgcaggagtc cgaagtcgcg ggtttcgtgc ccgcatcagg caacagtgcc actgttgtct
      181 tcagggctga gtccttttgt tcttgcactc acgcctctct gccctccaag ccaggatggt
      241 gaacccgaca acttccgaag tgcaacccac catgggggtc aagatcttct cagccggagt
      301 ttcagcttgc ctggcagata tcatcacctt cccgctggac actgccaaag tccgccttca
      361 gatccaaggt gaaggccagg cttccagtac cattaggtat aaaggtgtcc tagggaccat
      421 caccaccctg gcaaaaacag aaggattgcc gaaactgtac agcggtctgc ctgcgggcat
      481 tcagaggcaa atcagctttg cctcactcag gattggcctc tacgactcag tccaagagta
      541 cttctcttca gggagagaaa cacctgcctc tctcggaaac aagatctcag ccggcttaat
      601 gactggaggt gtggcagtgt tcattgggca gcctacagag gtcgtgaagg tcagaatgca
      661 agcccagagc catctgcatg ggatcaaacc ccgctacacg gggacctaca atgcttacag
      721 agttatagcc accacagaaa gcttgtcaac actttggaaa gggacgaccc ctaatctaat
      781 gagaaatgtc atcatcaatt gtacagagct ggtaacatat gacctcatga agggggccct
      841 tgtaaacaac aaaatactgg cagatgacgt cccctgccat ttactgtcag ctcttgttgc
      901 cgggttttgc accacactcc tggcctctcc agtggatgtg gtaaaaacaa gattcatcaa
      961 ctctctgcca ggacagtacc caagcgtacc aagctgtgcg atgtccatgt acaccaagga
     1021 aggaccgacg gcctttttca aagggtttgt ggcttctttt ctgcgactcg ggtcctggaa
     1081 cgtcatcatg tttgtgtgct ttgaacagct gaaaaaagag ctgatgaagt ccagacagac
     1141 agtggattgt accacataag caacttggag gaagagatac tgaacatcat tgggcttcta
     1201 tgctgggaga ccacgaataa aaccaaccaa agaaatcaaa tgaacagctc cgttgacttt
     1261 atttacatta caagatcatt tccagtagag agttttgaaa cctcttttaa ttttttttaa
     1321 agggaaaact aacacataca catagttttt attcttactg tcttaaagac agaagagcat
     1381 agcattcact aatattttga gaaaataata cctatataaa gtcctgtatt taactggtct
     1441 ttggggagag gtgggagtgt atgactgggt ataaagaatt ctgattacag ctcaaactag
     1501 tgggaaggaa aaattagtcc aaaacccttt acatcgataa acactttaaa aaagaaagct
     1561 atcaaaaaaa tattgccatt tcatcttatt tattgaccac agttcacagc taatatactc
     1621 aataaagtat tgctaattcc atct
//
