LOCUS       NM_031250               1478 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus urocortin 3 (Ucn3), mRNA.
ACCESSION   NM_031250
VERSION     NM_031250.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1478)
  AUTHORS   Kadhim,A.Z., Vanderkruk,B., Mar,S., Dan,M., Zosel,K., Xu,E.E.,
            Spencer,R.J., Sasaki,S., Cheng,X., Sproul,S.L.J., Speckmann,T.,
            Nian,C., Cullen,R., Shi,R., Luciani,D.S., Hoffman,B.G., Taubert,S.
            and Lynn,F.C.
  TITLE     Transcriptional coactivator MED15 is required for beta cell
            maturation
  JOURNAL   Nat Commun 15 (1), 8711 (2024)
   PUBMED   39379383
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1478)
  AUTHORS   Davidson,R.K., Wu,W., Kanojia,S., George,R.M., Huter,K.,
            Sandoval,K., Osmulski,M., Casey,N. and Spaeth,J.M.
  TITLE     The SWI/SNF chromatin remodelling complex regulates pancreatic
            endocrine cell expansion and differentiation in mice in vivo
  JOURNAL   Diabetologia 67 (10), 2275-2288 (2024)
   PUBMED   38958700
REFERENCE   3  (bases 1 to 1478)
  AUTHORS   Wang,K.Y., Gao,M.X., Qi,H.B., An,W.T., Lin,J.Y., Ning,S.L.,
            Yang,F., Xiao,P., Cheng,J., Pan,W., Cheng,Q.X., Wang,J., Fang,L.,
            Sun,J.P. and Yu,X.
  TITLE     Differential contributions of G protein- or arrestin
            subtype-mediated signalling underlie urocortin 3-induced
            somatostatin secretion in pancreatic delta cells
  JOURNAL   Br J Pharmacol 181 (15), 2600-2621 (2024)
   PUBMED   38613153
REFERENCE   4  (bases 1 to 1478)
  AUTHORS   Yu,V., Yong,F., Marta,A., Khadayate,S., Osakwe,A., Bhattacharya,S.,
            Varghese,S.S., Chabosseau,P., Tabibi,S.M., Chen,K., Georgiadou,E.,
            Parveen,N., Suleiman,M., Stamoulis,Z., Marselli,L., De Luca,C.,
            Tesi,M., Ostinelli,G., Delgadillo-Silva,L., Wu,X., Hatanaka,Y.,
            Montoya,A., Elliott,J., Patel,B., Demchenko,N., Whilding,C.,
            Hajkova,P., Shliaha,P., Kramer,H., Ali,Y., Marchetti,P., Sladek,R.,
            Dhawan,S., Withers,D.J., Rutter,G.A. and Millership,S.J.
  TITLE     Differential CpG methylation at Nnat in the early establishment of
            beta cell heterogeneity
  JOURNAL   Diabetologia 67 (6), 1079-1094 (2024)
   PUBMED   38512414
REFERENCE   5  (bases 1 to 1478)
  AUTHORS   Noguchi,G.M., Castillo,V.C., Donaldson,C.J., Flisher,M.R.,
            Momen,A.T., Saghatelian,A. and Huising,M.O.
  TITLE     Urocortin 3 contributes to paracrine inhibition of islet alpha
            cells in mice
  JOURNAL   J Endocrinol 261 (3), e240018 (2024)
   PUBMED   38593829
  REMARK    GeneRIF: Urocortin 3 contributes to paracrine inhibition of islet
            alpha cells in mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1478)
  AUTHORS   Venihaki,M., Sakihara,S., Subramanian,S., Dikkes,P., Weninger,S.C.,
            Liapakis,G., Graf,T. and Majzoub,J.A.
  TITLE     Urocortin III, a brain neuropeptide of the corticotropin-releasing
            hormone family: modulation by stress and attenuation of some
            anxiety-like behaviours
  JOURNAL   J Neuroendocrinol 16 (5), 411-422 (2004)
   PUBMED   15117334
  REMARK    GeneRIF: Mouse Urocortin III is expressed in brain regions involved
            in stress-related behaviours, and its expression in the
            hypothalamus increases following restraint. Administration of
            mUcnIII stimulates reduced anxiety.
REFERENCE   7  (bases 1 to 1478)
  AUTHORS   Brar,B.K., Jonassen,A.K., Egorina,E.M., Chen,A., Negro,A.,
            Perrin,M.H., Mjos,O.D., Latchman,D.S., Lee,K.F. and Vale,W.
  TITLE     Urocortin-II and urocortin-III are cardioprotective against
            ischemia reperfusion injury: an essential endogenous
            cardioprotective role for corticotropin releasing factor receptor
            type 2 in the murine heart
  JOURNAL   Endocrinology 145 (1), 24-35 (2004)
   PUBMED   12970163
  REMARK    GeneRIF: CRFR2beta selective Ucn-II or Ucn-III will protect
            cardiomyocytes and the ex vivo Langendorff perfused rat heart from
            ischemia reperfusion injury by activation of ERK1/2-p42, 44.
REFERENCE   8  (bases 1 to 1478)
  AUTHORS   Li,C., Chen,P., Vaughan,J., Blount,A., Chen,A., Jamieson,P.M.,
            Rivier,J., Smith,M.S. and Vale,W.
  TITLE     Urocortin III is expressed in pancreatic beta-cells and stimulates
            insulin and glucagon secretion
  JOURNAL   Endocrinology 144 (7), 3216-3224 (2003)
   PUBMED   12810578
  REMARK    GeneRIF: pancreatic Ucn III acting through CRFR2 is involved in the
            local regulation of glucagon and insulin secretion.
REFERENCE   9  (bases 1 to 1478)
  AUTHORS   Lewis,K., Li,C., Perrin,M.H., Blount,A., Kunitake,K., Donaldson,C.,
            Vaughan,J., Reyes,T.M., Gulyas,J., Fischer,W., Bilezikjian,L.,
            Rivier,J., Sawchenko,P.E. and Vale,W.W.
  TITLE     Identification of urocortin III, an additional member of the
            corticotropin-releasing factor (CRF) family with high affinity for
            the CRF2 receptor
  JOURNAL   Proc Natl Acad Sci U S A 98 (13), 7570-7575 (2001)
   PUBMED   11416224
REFERENCE   10 (bases 1 to 1478)
  AUTHORS   Reyes,T.M., Lewis,K., Perrin,M.H., Kunitake,K.S., Vaughan,J.,
            Arias,C.A., Hogenesch,J.B., Gulyas,J., Rivier,J., Vale,W.W. and
            Sawchenko,P.E.
  TITLE     Urocortin II: a member of the corticotropin-releasing factor (CRF)
            neuropeptide family that is selectively bound by type 2 CRF
            receptors
  JOURNAL   Proc Natl Acad Sci U S A 98 (5), 2843-2848 (2001)
   PUBMED   11226328
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK148451.1 and AC139323.4.
            
            On Mar 11, 2009 this sequence version replaced NM_031250.4.
            
            Summary: This gene encodes a member of the corticotropin-releasing
            hormone peptide family that participates in coordinating autonomic,
            endocrine, and behavioral responses to stress. The encoded
            preproprotein undergoes proteolytic processing to generate a
            mature, functional hormone. The pancreatic islets isolated from
            mice lacking the encoded protein secrete less insulin in response
            to high glucose concentrations. Transgenic mice overexpressing the
            encoded protein exhibit a metabolically favorable phenotype
            resisting obesity and hyperglycemia on a high-fat diet. [provided
            by RefSeq, Sep 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148451.1, BY741576.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1475              AK148451.1         2-1476
            1476-1478           AC139323.4         151143-151145       c
FEATURES             Location/Qualifiers
     source          1..1478
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 2.2 cM"
     gene            1..1478
                     /gene="Ucn3"
                     /gene_synonym="ucn III"
                     /note="urocortin 3"
                     /db_xref="GeneID:83428"
                     /db_xref="MGI:MGI:1932970"
     exon            1..509
                     /gene="Ucn3"
                     /gene_synonym="ucn III"
                     /inference="alignment:Splign:2.1.0"
     exon            510..1478
                     /gene="Ucn3"
                     /gene_synonym="ucn III"
                     /inference="alignment:Splign:2.1.0"
     CDS             516..1010
                     /gene="Ucn3"
                     /gene_synonym="ucn III"
                     /note="Urocortin III"
                     /codon_start=1
                     /product="urocortin-3 preproprotein"
                     /protein_id="NP_112540.2"
                     /db_xref="CCDS:CCDS26217.1"
                     /db_xref="GeneID:83428"
                     /db_xref="MGI:MGI:1932970"
                     /translation="MLMPTYFLLPLLLLLGGPRTSLSHKFYNTGPVFSCLNTALSEVK
                     KNKLEDVPLLSKKSFGHLPTQDPSGEEDDNQTHLQIKRTFSGAAGGNGAGSTRYRYQS
                     QAQHKGKLYPDKPKSDRGTKFTLSLDVPTNIMNILFNIDKAKNLRAKAAANAQLMAQI
                     GKKK"
     regulatory      1456..1461
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ucn3"
                     /gene_synonym="ucn III"
                     /note="hexamer: ATTAAA"
     polyA_site      1478
                     /gene="Ucn3"
                     /gene_synonym="ucn III"
                     /note="major polyA site"
ORIGIN      
        1 agaagaggct agaattagct ggaattaaaa tcagtaatga aactctgtcc aaagacattg
       61 cttctcggct tacctgtgtt ttgggttctg ttgttatttg ttttcttttg tctttaatta
      121 atgaagcaag ttgcaagggc aggaggggaa gaaggaggtg actagaggag gggaaggcag
      181 gaggggttac agtctcctga gtacctgtca tctctgtgac gtgcacagcc ggctcttgta
      241 ttttaaatga aatctcatcc taatgtagac actacatctg gaattacgat ccaccctgtg
      301 atctgccact tttacatata tgcacagggg agtggagcgg tttccataga gaggaacgat
      361 cacagcccac tacaatcagt accagagaag acaaagctgc aaccctgaac agtcagaagt
      421 tcagaggacc tgcagggagt agcctcctgg cccggaagct gtgcccctcg acctgagcat
      481 ttccactcca gagcaaagtc cacttacagg gagcgatgct gatgcccacc tacttcctgc
      541 tgccacttct gctgctccta ggaggtccaa ggacaagcct ctcccacaag ttctacaaca
      601 ctggaccagt cttcagctgc ctcaacacag ccctatctga ggtcaagaag aacaagctgg
      661 aagatgtgcc cttgctgagc aagaagagct ttggccacct gcccacacaa gacccctcag
      721 gggaagaaga tgacaaccaa acgcacctcc agatcaaaag aactttctca ggtgccgcgg
      781 gtgggaatgg agctgggagc acccggtaca gataccaatc ccaggcacag cacaagggga
      841 agctgtaccc agacaagccc aaaagcgacc ggggcaccaa gttcaccctt tcccttgatg
      901 ttcccactaa catcatgaac atcctcttca acatcgacaa ggccaagaat ttgcgagcca
      961 aggcagctgc caatgctcag ctcatggcac agattgggaa gaagaagtaa agcaaagccc
     1021 aggcatgagg gtggcacatc aagacaaggg ccccggagta aagggtaaag gaaactgagg
     1081 acgtgccctc gaatttcaaa ggacagtctg ttttcccagg ctgctccact actgtgcccc
     1141 tctgatcctc tcttgcttcc agtccggttt cccttctcag tacatacaca ctcaagcgca
     1201 gtattgctca gcccatatcc acaatggagg ttaacgtctc tccccgaatc ctgtgtctgc
     1261 tttctggttc cctgtaacaa cagacaagtt catgtggtgc ccctccttcc caagctcctc
     1321 cctggtgtca ccatgtctgc agagagagct ttcaggctcc ctccttgtcc cacattggtc
     1381 tgagcctcgg cagagacaca gagatgcaca gctccccctc ttgataccaa atacctcccc
     1441 tacttcctca tctggattaa agtcagtggc ttcttgaa
//
