LOCUS       NM_145077               1002 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus urocortin 2 (Ucn2), mRNA.
ACCESSION   NM_145077 XM_910603
VERSION     NM_145077.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1002)
  AUTHORS   Zhu,C., Pan,L., Zhou,F., Mao,R., Hong,Y., Wan,R., Li,X., Jin,L.,
            Zou,H., Zhang,H., Chen,Q.M. and Li,S.
  TITLE     Urocortin2 attenuates diabetic coronary microvascular dysfunction
            by regulating macrophage extracellular vesicles
  JOURNAL   Biochem Pharmacol 219, 115976 (2024)
   PUBMED   38081372
  REMARK    GeneRIF: Urocortin2 attenuates diabetic coronary microvascular
            dysfunction by regulating macrophage extracellular vesicles.
REFERENCE   2  (bases 1 to 1002)
  AUTHORS   Flaherty,S.E. 3rd, Bezy,O., Zheng,W., Yan,D., Li,X.,
            Jagarlapudi,S., Albuquerque,B., Esquejo,R.M., Peloquin,M.,
            Semache,M., Mancini,A., Kang,L., Drujan,D., Breitkopf,S.B.,
            Griffin,J.D., Jean Beltran,P.M., Xue,L., Stansfield,J., Pashos,E.,
            Shakey,Q., Pehmoller,C., Monetti,M., Birnbaum,M.J., Fortin,J.P. and
            Wu,Z.
  TITLE     Chronic UCN2 treatment desensitizes CRHR2 and improves insulin
            sensitivity
  JOURNAL   Nat Commun 14 (1), 3953 (2023)
   PUBMED   37402735
  REMARK    GeneRIF: Chronic UCN2 treatment desensitizes CRHR2 and improves
            insulin sensitivity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1002)
  AUTHORS   Lautherbach,N., Goncalves,D.A.P., Silveira,W.A., Paula-Gomes,S.,
            Valentim,R.R., Zanon,N.M., Pereira,M.G., Miyabara,E.H.,
            Navegantes,L.C.C. and Kettelhut,I.C.
  TITLE     Urocortin 2 promotes hypertrophy and enhances skeletal muscle
            function through cAMP and insulin/IGF-1 signaling pathways
  JOURNAL   Mol Metab 60, 101492 (2022)
   PUBMED   35390501
  REMARK    GeneRIF: Urocortin 2 promotes hypertrophy and enhances skeletal
            muscle function through cAMP and insulin/IGF-1 signaling pathways.
REFERENCE   4  (bases 1 to 1002)
  AUTHORS   Kageyama,K., Murasawa,S., Niioka,K., Otsuka,F., Yagi,H. and
            Daimon,M.
  TITLE     Regulation of gonadotropins by urocortin 2 in gonadotropic tumor
            LbetaT2 cells
  JOURNAL   Neurosci Lett 660, 63-67 (2017)
   PUBMED   28851616
  REMARK    GeneRIF: Urocortin 2 acts on gonadotrophs expressing the
            corticotropin-releasing factor type 2 receptor, and inhibits the
            production of gonadotropins in the pituitary gonadotropic tumor
            cells.
REFERENCE   5  (bases 1 to 1002)
  AUTHORS   Vaughan,J.M., Donaldson,C.J., Fischer,W.H., Perrin,M.H.,
            Rivier,J.E., Sawchenko,P.E. and Vale,W.W.
  TITLE     Posttranslational processing of human and mouse urocortin 2:
            characterization and bioactivity of gene products
  JOURNAL   Endocrinology 154 (4), 1553-1564 (2013)
   PUBMED   23493376
  REMARK    GeneRIF: Description of ucn2 posttranslational processing and
            peptide sequence. Hypoxia and glycosylation, paradigms that might
            influence secretion or processing of gene products, did not
            significantly impact hUcn 2 prohormone cleavage.
REFERENCE   6  (bases 1 to 1002)
  AUTHORS   Brar,B.K., Jonassen,A.K., Egorina,E.M., Chen,A., Negro,A.,
            Perrin,M.H., Mjos,O.D., Latchman,D.S., Lee,K.F. and Vale,W.
  TITLE     Urocortin-II and urocortin-III are cardioprotective against
            ischemia reperfusion injury: an essential endogenous
            cardioprotective role for corticotropin releasing factor receptor
            type 2 in the murine heart
  JOURNAL   Endocrinology 145 (1), 24-35 (2004)
   PUBMED   12970163
  REMARK    GeneRIF: CRFR2beta selective Ucn-II or Ucn-III will protect
            cardiomyocytes and the ex vivo Langendorff perfused rat heart from
            ischemia reperfusion injury by activation of ERK1/2-p42, 44.
REFERENCE   7  (bases 1 to 1002)
  AUTHORS   Chen,A., Vaughan,J. and Vale,W.W.
  TITLE     Glucocorticoids regulate the expression of the mouse urocortin II
            gene: a putative connection between the corticotropin-releasing
            factor receptor pathways
  JOURNAL   Mol Endocrinol 17 (8), 1622-1639 (2003)
   PUBMED   12764078
  REMARK    GeneRIF: Ucn II is expressed in the hypothalamus, brainstem,
            olfactory bulb, and pituitary. Low levels were also detected in the
            mouse cortex, hippocampus, and spinal cord, Ucn II gene
            transcription was stimulated by glucocorticoids
REFERENCE   8  (bases 1 to 1002)
  AUTHORS   Lewis,K., Li,C., Perrin,M.H., Blount,A., Kunitake,K., Donaldson,C.,
            Vaughan,J., Reyes,T.M., Gulyas,J., Fischer,W., Bilezikjian,L.,
            Rivier,J., Sawchenko,P.E. and Vale,W.W.
  TITLE     Identification of urocortin III, an additional member of the
            corticotropin-releasing factor (CRF) family with high affinity for
            the CRF2 receptor
  JOURNAL   Proc Natl Acad Sci U S A 98 (13), 7570-7575 (2001)
   PUBMED   11416224
REFERENCE   9  (bases 1 to 1002)
  AUTHORS   Hsu,S.Y. and Hsueh,A.J.
  TITLE     Human stresscopin and stresscopin-related peptide are selective
            ligands for the type 2 corticotropin-releasing hormone receptor
  JOURNAL   Nat Med 7 (5), 605-611 (2001)
   PUBMED   11329063
REFERENCE   10 (bases 1 to 1002)
  AUTHORS   Reyes,T.M., Lewis,K., Perrin,M.H., Kunitake,K.S., Vaughan,J.,
            Arias,C.A., Hogenesch,J.B., Gulyas,J., Rivier,J., Vale,W.W. and
            Sawchenko,P.E.
  TITLE     Urocortin II: a member of the corticotropin-releasing factor (CRF)
            neuropeptide family that is selectively bound by type 2 CRF
            receptors
  JOURNAL   Proc Natl Acad Sci U S A 98 (5), 2843-2848 (2001)
   PUBMED   11226328
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC140383.2.
            
            On Jul 25, 2009 this sequence version replaced XM_910603.2.
            
            Summary: This gene encodes a member of the corticotropin-releasing
            hormone peptide family that participates in coordinating autonomic,
            endocrine, and behavioral responses to stress. The encoded
            preproprotein undergoes proteolytic processing to generate a
            mature, functional hormone. Mice lacking the encoded protein
            exhibit increased insulin sensitivity and were protected against
            fat-induced insulin resistance. In addition, female mice lacking
            the encoded protein exhibit a significant increase in the basal
            daily rhythms of adrenocorticotropic hormone and corticosterone,
            and a significant decrease in fluid intake and depressive-like
            behavior. [provided by RefSeq, Sep 2016].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AF331517.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1002              AC140383.2         142986-143987       c
FEATURES             Location/Qualifiers
     source          1..1002
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 59.63 cM"
     gene            1..1002
                     /gene="Ucn2"
                     /gene_synonym="Ucn II; Ucn-2; ucn-II"
                     /note="urocortin 2"
                     /db_xref="GeneID:171530"
                     /db_xref="MGI:MGI:2176375"
     exon            1..1002
                     /gene="Ucn2"
                     /gene_synonym="Ucn II; Ucn-2; ucn-II"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..351
                     /gene="Ucn2"
                     /gene_synonym="Ucn II; Ucn-2; ucn-II"
                     /note="Urocortin II"
                     /codon_start=1
                     /product="urocortin-2 preproprotein"
                     /protein_id="NP_659543.1"
                     /db_xref="CCDS:CCDS52929.1"
                     /db_xref="GeneID:171530"
                     /db_xref="MGI:MGI:2176375"
                     /translation="MMTRWALVVFVVLMLDRILFVPGTPIPTFQLLPQNSLETTPSSV
                     TSESSSGTTTGPSASWSNSKASPYLDTRVILSLDVPIGLLRILLEQARYKAARNQAAT
                     NAQILAHVGRR"
     regulatory      596..601
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ucn2"
                     /gene_synonym="Ucn II; Ucn-2; ucn-II"
                     /note="hexamer: AATATA"
     polyA_site      620
                     /gene="Ucn2"
                     /gene_synonym="Ucn II; Ucn-2; ucn-II"
                     /note="major polyA site"
ORIGIN      
        1 ccttcccaca tgatgaccag gtgggcactg gtggtgttcg tggtcctgat gttggatagg
       61 atcctatttg tcccaggaac tcctatcccc accttccagc tcctccctca gaactctctg
      121 gagacaactc ctagctctgt gacctcagag agctcctcag gtaccaccac aggaccctca
      181 gcttcctgga gcaactctaa agccagccct tacctagaca cccgtgtcat actctccctg
      241 gatgttccca ttggcctcct acggatctta ctggaacagg ctcgttacaa ggctgccagg
      301 aatcaggctg ccactaatgc tcaaatacta gcccatgttg gccgccgctg agactgaaga
      361 aggggttcct aaagatgggg tgaccctgga tgagaagttc tggaggacag ccacaaagct
      421 ggacagtact acatttggcc aaacacatac ccagagatca ccgagatgga ccactgccat
      481 agcttccaag tatctacagt gtgtttctac agcttggcca tatagtgtct tgccatgctt
      541 ctgagcccct aacacttaat atgtttgggc atcttggact ctagcatgta tgttcaatat
      601 atgtaatctt gtcatgtcta gctgagtctg gcagtcacag agcatctaga taccaccatg
      661 tgagctccat ccttaaatgt aaaggagagt caacatagaa ccccagtgct gcacctgaag
      721 tccatctaag gtccacaggc ctgcccccct ccccaggctg ctacaccaga gagtgctgga
      781 gggggtcaca tgcttgtttt gtggtcttgt ttttgttttt aaagacagtc ttgggctggt
      841 gagatggctc agaggttatg agccctagtt gctcttccag aggtcctgag ttcagttccc
      901 agcaaccacc tggtggctca caactatcta taaggggatc tgatgccttc ttctggccta
      961 tggaagtata tgcagcagag cattcacaca ataaataaat tt
//
