LOCUS       NM_021290                644 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus urocortin (Ucn), transcript variant 1, mRNA.
ACCESSION   NM_021290
VERSION     NM_021290.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 644)
  AUTHORS   Sitko,A.A., Frank,M.M., Romero,G.E., Hunt,M. and Goodrich,L.V.
  TITLE     Lateral olivocochlear neurons modulate cochlear responses to noise
            exposure
  JOURNAL   Proc Natl Acad Sci U S A 122 (4), e2404558122 (2025)
   PUBMED   39854232
REFERENCE   2  (bases 1 to 644)
  AUTHORS   Giardino,W.J., Rodriguez,E.D., Smith,M.L., Ford,M.M., Galili,D.,
            Mitchell,S.H., Chen,A. and Ryabinin,A.E.
  TITLE     Control of chronic excessive alcohol drinking by genetic
            manipulation of the Edinger-Westphal nucleus urocortin-1
            neuropeptide system
  JOURNAL   Transl Psychiatry 7 (1), e1021 (2017)
   PUBMED   28140406
  REMARK    GeneRIF: Genetic deletion of Ucn1 reduced high levels of intake and
            preference across 2 weeks of continuous access drinking when
            alcohol concentrations were increased from 10 to 20 to 40%. Ucn1
            deletion did not alter low-level drinking when the alcohol
            concentration remained at 10%.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 644)
  AUTHORS   Hasdemir,B., Mhaske,P., Paruthiyil,S., Garnett,E.A., Heyman,M.B.,
            Matloubian,M. and Bhargava,A.
  TITLE     Sex- and corticotropin-releasing factor receptor 2- dependent
            actions of urocortin 1 during inflammation
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 310 (11), R1244-R1257 (2016)
   PUBMED   27053649
  REMARK    GeneRIF: Taken together, our data indicate that sex shows
            significant interaction with genotype and Ucn1 during colitis.
            Human duodenal and colonic biopsies revealed that sex-specific
            differences exist in levels of CRF receptors and Ucn1 expression in
            patients with CD compared with the matched non-IBD subjects. To
            conclude, Ucn1 mediates sex-specific immune and cellular signaling
            responses via CRF2, emphasizing the need for inclus
REFERENCE   4  (bases 1 to 644)
  AUTHORS   Buckinx,R., Bagyanszki,M., Avula,L.R., Adriaensen,D., Van
            Nassauw,L. and Timmermans,J.P.
  TITLE     Expression of corticotropin-releasing factor and urocortins in the
            normal and Schistosoma mansoni-infected mouse ileum
  JOURNAL   Cell Tissue Res 359 (2), 453-463 (2015)
   PUBMED   25358399
  REMARK    GeneRIF: This study aims to investigate the cellular localization
            of CRF and UCNs in the ileum and to explore whether and how this
            cellular expression is altered in conditions of intestinal
            Schistosoma mansoni-induced inflammation.
REFERENCE   5  (bases 1 to 644)
  AUTHORS   Vergetaki,A., Jeschke,U., Vrekoussis,T., Taliouri,E., Sabatini,L.,
            Papakonstanti,E.A. and Makrigiannakis,A.
  TITLE     Galectin-1 overexpression in endometriosis and its regulation by
            neuropeptides (CRH, UCN) indicating its important role in
            reproduction and inflammation
  JOURNAL   PLoS One 9 (12), e114229 (2014)
   PUBMED   25473847
  REMARK    GeneRIF: it is shown that CRH and UCN upregulate galectin-1
            expression in Ishikawa cell line and macrophages and this effect is
            mediated through CRHR1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 644)
  AUTHORS   Wang,X., Su,H., Copenhagen,L.D., Vaishnav,S., Pieri,F., Shope,C.D.,
            Brownell,W.E., De Biasi,M., Paylor,R. and Bradley,A.
  TITLE     Urocortin-deficient mice display normal stress-induced anxiety
            behavior and autonomic control but an impaired acoustic startle
            response
  JOURNAL   Mol Cell Biol 22 (18), 6605-6610 (2002)
   PUBMED   12192058
REFERENCE   7  (bases 1 to 644)
  AUTHORS   Vetter,D.E., Li,C., Zhao,L., Contarino,A., Liberman,M.C.,
            Smith,G.W., Marchuk,Y., Koob,G.F., Heinemann,S.F., Vale,W. and
            Lee,K.F.
  TITLE     Urocortin-deficient mice show hearing impairment and increased
            anxiety-like behavior
  JOURNAL   Nat Genet 31 (4), 363-369 (2002)
   PUBMED   12091910
  REMARK    GeneRIF: Urocortin-deficient mice show hearing impairment and
            increased anxiety-like behavior.
REFERENCE   8  (bases 1 to 644)
  AUTHORS   Weninger,S.C., Peters,L.L. and Majzoub,J.A.
  TITLE     Urocortin expression in the Edinger-Westphal nucleus is
            up-regulated by stress and corticotropin-releasing hormone
            deficiency
  JOURNAL   Endocrinology 141 (1), 256-263 (2000)
   PUBMED   10614646
REFERENCE   9  (bases 1 to 644)
  AUTHORS   Asakawa,A., Inui,A., Ueno,N., Makino,S., Fujino,M.A. and Kasuga,M.
  TITLE     Urocortin reduces food intake and gastric emptying in lean and
            ob/ob obese mice
  JOURNAL   Gastroenterology 116 (6), 1287-1292 (1999)
   PUBMED   10348810
REFERENCE   10 (bases 1 to 644)
  AUTHORS   Zhao,L., Donaldson,C.J., Smith,G.W. and Vale,W.W.
  TITLE     The structures of the mouse and human urocortin genes (Ucn and UCN)
  JOURNAL   Genomics 50 (1), 23-33 (1998)
   PUBMED   9628819
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC109608.14.
            
            On Dec 1, 2007 this sequence version replaced NM_021290.1.
            
            Summary: This gene encodes a member of the corticotropin-releasing
            hormone peptide family that participates in coordinating autonomic,
            endocrine, and behavioral responses to stress. The encoded
            preproprotein undergoes proteolytic processing to generate a
            mature, functional hormone. Mice lacking the encoded protein
            exhibit a heightened anxiety-like behaviors and a significantly
            reduced acoustic startle response. [provided by RefSeq, Sep 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC116950.1, ERR3363658.3308840.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                AC109608.14        20607-20705
            100-644             AC109608.14        20969-21513
FEATURES             Location/Qualifiers
     source          1..644
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 17.11 cM"
     gene            1..644
                     /gene="Ucn"
                     /gene_synonym="Mpv17; Ucn1"
                     /note="urocortin"
                     /db_xref="GeneID:22226"
                     /db_xref="MGI:MGI:1276123"
     exon            1..99
                     /gene="Ucn"
                     /gene_synonym="Mpv17; Ucn1"
                     /inference="alignment:Splign:2.1.0"
     exon            100..644
                     /gene="Ucn"
                     /gene_synonym="Mpv17; Ucn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..481
                     /gene="Ucn"
                     /gene_synonym="Mpv17; Ucn1"
                     /codon_start=1
                     /product="urocortin preproprotein"
                     /protein_id="NP_067265.1"
                     /db_xref="CCDS:CCDS19174.1"
                     /db_xref="GeneID:22226"
                     /db_xref="MGI:MGI:1276123"
                     /translation="MIQRGRATLLVALLLLAQLRPESSQWSPAAAAATGVQDPNLRWS
                     PGVRNQGGGVRALLLLLAERFPRRAGSEPAGERQRRDDPPLSIDLTFHLLRTLLELAR
                     TQSQRERAEQNRIIFDSVGK"
     regulatory      623..628
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ucn"
                     /gene_synonym="Mpv17; Ucn1"
                     /note="hexamer: AATAAA"
     polyA_site      644
                     /gene="Ucn"
                     /gene_synonym="Mpv17; Ucn1"
                     /note="major polyA site"
ORIGIN      
        1 ggtcccggga cagaccccgt gctccccaag gcgtcttcag cccgtccccg gggacagagt
       61 ggagctccat cttgcactgg gcagacactc cgataacctg gcaggcggca ccatgataca
      121 gaggggacgc gctacgctcc tggtggcgtt gctgctcttg gcacagcttc gcccggagag
      181 cagccagtgg agcccagcgg ctgcggcggc aactggggtc caggatccga atctgcgatg
      241 gagccctgga gtgcggaatc agggcggcgg cgtccgcgcg ctcctcttgc tgttagcgga
      301 gcgcttcccg cgccgcgcag gatctgagcc tgcgggcgag cggcagcgac gggacgaccc
      361 tccactgtcc atcgacctca ccttccacct gctgcggacc ctgctggagc tagctcggac
      421 acagagccag cgcgagcgcg cagagcagaa ccgcatcata ttcgattcgg tgggcaagtg
      481 atcggccccg tatggggtca cgaaagcctt gaccctttcc cttacctacc ccggggctgg
      541 aacgcgcaca accggagctg tctcagtccc gcggtgcagc gccgcccaga gtcaccctga
      601 atactctgag tggttatttt ttaataaaac tgcccaagag ctta
//
