LOCUS       NM_026765               1811 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus uridine-cytidine kinase 1-like 1 (Uckl1), transcript
            variant 2, mRNA.
ACCESSION   NM_026765
VERSION     NM_026765.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1811)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1811)
  AUTHORS   Wu,W., Zhao,Y., Qin,B., Jiang,X., Wang,C., Hu,R., Ma,R., Lee,M.H.,
            Liu,H., Li,K. and Yuan,P.
  TITLE     Non-canonical role of UCKL1 on ferroptosis defence in colorectal
            cancer
  JOURNAL   EBioMedicine 93, 104650 (2023)
   PUBMED   37343364
  REMARK    GeneRIF: Non-canonical role of UCKL1 on ferroptosis defence in
            colorectal cancer.
REFERENCE   3  (bases 1 to 1811)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL844529.10.
            
            On Nov 17, 2006 this sequence version replaced NM_026765.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016535.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               AL844529.10        21230-21347         c
            119-309             AL844529.10        14221-14411         c
            310-416             AL844529.10        14025-14131         c
            417-587             AL844529.10        13743-13913         c
            588-659             AL844529.10        13586-13657         c
            660-849             AL844529.10        12589-12778         c
            850-911             AL844529.10        12448-12509         c
            912-928             AL844529.10        11844-11860         c
            929-1027            AL844529.10        9874-9972           c
            1028-1121           AL844529.10        9683-9776           c
            1122-1184           AL844529.10        9507-9569           c
            1185-1307           AL844529.10        9283-9405           c
            1308-1415           AL844529.10        9070-9177           c
            1416-1572           AL844529.10        8842-8998           c
            1573-1811           AL844529.10        8526-8764           c
FEATURES             Location/Qualifiers
     source          1..1811
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 103.66 cM"
     gene            1..1811
                     /gene="Uckl1"
                     /gene_synonym="1110007H10Rik; Urkl1"
                     /note="uridine-cytidine kinase 1-like 1"
                     /db_xref="GeneID:68556"
                     /db_xref="MGI:MGI:1915806"
     exon            1..118
                     /gene="Uckl1"
                     /gene_synonym="1110007H10Rik; Urkl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..1652
                     /gene="Uckl1"
                     /gene_synonym="1110007H10Rik; Urkl1"
                     /EC_number="2.7.1.48"
                     /note="isoform 2 is encoded by transcript variant 2;
                     uridine kinase-like 1; uridine-cytidine kinase-like 1"
                     /codon_start=1
                     /product="uridine-cytidine kinase-like 1 isoform 2"
                     /protein_id="NP_081041.2"
                     /db_xref="CCDS:CCDS17216.1"
                     /db_xref="GeneID:68556"
                     /db_xref="MGI:MGI:1915806"
                     /translation="MAAPPASMSAAPSPLQSAVAPDVPGRQAEQNETACEDRSNAGTL
                     DRLLPPVGTGRSPRKRTTSQCKSEPPLLRTSKRTIYTAGRPPWYNEHGTQSKEAFAIG
                     LGGGSASGKTTVARMIIEALDVPWVVLLSMDSFYKVLTQQQQEQAACNNFNFDHPDAF
                     DFDLIISTLKKLKQGRSVQVPIYDFTTHSRKKDWKTLYGANVIIFEGIMAFADKTLLE
                     LLDMKIFVDTDSDIRLVRRLRRDISERGRDIEGVIKQYNKFVKPAFDQYIQPTMRLAD
                     IVVPRGSGNTVAIDLIVQHVHSQLEERELSVRAALASAHQCHPLPQTLSVLKSTPQVR
                     GMHTIIRDKETSRDEFIFYSKRLMRLLIEHALSFLPFQDCTVQTPQGQDYVGKCYAGK
                     QITGVSILRAGETMEPALRAVCKDVRIGTILIQTNQLTGEPELHYLRLPKDISDDHVI
                     LMDCTVSTGAAAMMAVRVLLDHDVPEDKIFLLSLLMAEMGVHSVAYAFPRVRIITTAV
                     DKRVNDLFRIIPGIGNFGDRYFGTDAVPDGSDDDEAATVG"
     exon            119..309
                     /gene="Uckl1"
                     /gene_synonym="1110007H10Rik; Urkl1"
                     /inference="alignment:Splign:2.1.0"
     exon            310..416
                     /gene="Uckl1"
                     /gene_synonym="1110007H10Rik; Urkl1"
                     /inference="alignment:Splign:2.1.0"
     exon            417..587
                     /gene="Uckl1"
                     /gene_synonym="1110007H10Rik; Urkl1"
                     /inference="alignment:Splign:2.1.0"
     exon            588..659
                     /gene="Uckl1"
                     /gene_synonym="1110007H10Rik; Urkl1"
                     /inference="alignment:Splign:2.1.0"
     exon            660..849
                     /gene="Uckl1"
                     /gene_synonym="1110007H10Rik; Urkl1"
                     /inference="alignment:Splign:2.1.0"
     exon            850..911
                     /gene="Uckl1"
                     /gene_synonym="1110007H10Rik; Urkl1"
                     /inference="alignment:Splign:2.1.0"
     exon            912..928
                     /gene="Uckl1"
                     /gene_synonym="1110007H10Rik; Urkl1"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1027
                     /gene="Uckl1"
                     /gene_synonym="1110007H10Rik; Urkl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1121
                     /gene="Uckl1"
                     /gene_synonym="1110007H10Rik; Urkl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1184
                     /gene="Uckl1"
                     /gene_synonym="1110007H10Rik; Urkl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1307
                     /gene="Uckl1"
                     /gene_synonym="1110007H10Rik; Urkl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1415
                     /gene="Uckl1"
                     /gene_synonym="1110007H10Rik; Urkl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1572
                     /gene="Uckl1"
                     /gene_synonym="1110007H10Rik; Urkl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1811
                     /gene="Uckl1"
                     /gene_synonym="1110007H10Rik; Urkl1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1787..1792
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Uckl1"
                     /gene_synonym="1110007H10Rik; Urkl1"
                     /note="hexamer: AATAAA"
     regulatory      1791..1796
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Uckl1"
                     /gene_synonym="1110007H10Rik; Urkl1"
                     /note="hexamer: AATAAA"
     polyA_site      1806
                     /gene="Uckl1"
                     /gene_synonym="1110007H10Rik; Urkl1"
     polyA_site      1811
                     /gene="Uckl1"
                     /gene_synonym="1110007H10Rik; Urkl1"
                     /note="major polyA site"
ORIGIN      
        1 acgccatggc tgcgccgccg gcctcaatga gcgccgcccc ttcgcccctg cagtctgctg
       61 tggccccaga cgtgcctggc cgccaggccg agcagaatga aacggcgtgc gaggaccgca
      121 gcaatgcagg gaccttggac agacttctcc caccagtggg tactgggcgc tcaccccgga
      181 agcgcaccac cagccagtgc aagtcagaac cacccctgct tcgcacaagc aaacgtacca
      241 tctacacagc tgggcggcca ccatggtaca atgaacatgg tacacagtcc aaggaggcct
      301 ttgctattgg cttaggaggt ggcagtgcat ctgggaagac cactgtggcc agaatgatca
      361 ttgaggcact agatgtgccc tgggtggtcc tgttgtccat ggactccttc tataaggttc
      421 tgacgcagca gcagcaggaa caggctgcct gtaacaattt caactttgac caccctgatg
      481 cctttgactt cgatctcatc atttccaccc ttaagaagct aaaacagggc aggagtgtcc
      541 aagtgcccat ctatgatttc actacccata gccggaaaaa ggactggaaa accctgtatg
      601 gtgcgaatgt catcatcttt gagggtatca tggcctttgc tgataagaca ctgctggagc
      661 tcctggacat gaagatcttt gtggacacgg actctgatat ccgactggtt cggcgtctgc
      721 gcagggacat cagcgaacga ggccgggaca ttgagggtgt cattaagcag tacaacaagt
      781 ttgtcaaacc tgcatttgat cagtatatcc agcctaccat gcggctggca gatattgtgg
      841 tgcccagagg gagcgggaac acagtagcca ttgacctgat tgtgcagcat gttcacagcc
      901 agctggaaga gcgcgaactc agcgtcaggg ccgcgttggc ctccgctcac cagtgccatc
      961 ccctccccca gacactgagt gtcctcaaga gtacaccgca ggtccgaggc atgcacacca
     1021 tcatcaggga caaggagact agccgggatg aattcatctt ctactccaaa agactgatgc
     1081 ggctgcttat tgaacatgca ctgtccttcc taccctttca ggactgcact gtacagactc
     1141 cacaggggca ggactacgtg ggaaagtgct acgctggaaa acagatcacc ggcgtgtcaa
     1201 ttctgcgtgc aggagaaacc atggagcctg cactgcgtgc cgtgtgcaag gatgtgcgca
     1261 tcggcactat cctcatccag accaaccagc tcacagggga gcctgagctc cattacctga
     1321 ggcttcccaa ggatatcagt gatgaccatg tgatcctgat ggactgcaca gtatccacag
     1381 gtgctgcggc catgatggct gtacgtgtac tcctggacca tgatgtgcct gaggacaaga
     1441 tctttttgct gtccctgctc atggcagaga tgggtgtgca ttctgtggcc tacgctttcc
     1501 cacgcgtgag aatcatcacc acagctgtgg acaagcgtgt caatgacctt ttccgtatca
     1561 tcccaggcat tgggaacttt ggtgatcgct actttgggac agatgcagtc cctgatggca
     1621 gtgatgatga tgaggcagcc actgtgggtt agttccctgt ccgagctact cttatttcta
     1681 cccagccttc tgtcttctgg tctggaattg cagggacaac acattaactt attttgagtt
     1741 taaaaatgtt accgaaataa aaataatcag tttacacatt ttataaaata aataaagctt
     1801 tatttagaaa a
//
