LOCUS       NP_081041                548 aa            linear   ROD 30-APR-2024
DEFINITION  uridine-cytidine kinase-like 1 isoform 2 [Mus musculus].
ACCESSION   NP_081041
VERSION     NP_081041.2
DBSOURCE    REFSEQ: accession NM_026765.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 548)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 548)
  AUTHORS   Wu,W., Zhao,Y., Qin,B., Jiang,X., Wang,C., Hu,R., Ma,R., Lee,M.H.,
            Liu,H., Li,K. and Yuan,P.
  TITLE     Non-canonical role of UCKL1 on ferroptosis defence in colorectal
            cancer
  JOURNAL   EBioMedicine 93, 104650 (2023)
   PUBMED   37343364
  REMARK    GeneRIF: Non-canonical role of UCKL1 on ferroptosis defence in
            colorectal cancer.
REFERENCE   3  (residues 1 to 548)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL844529.10.
            
            On Jun 9, 2003 this sequence version replaced NP_081041.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016535.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..548
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 103.66 cM"
     Protein         1..548
                     /product="uridine-cytidine kinase-like 1 isoform 2"
                     /EC_number="2.7.1.48"
                     /note="uridine kinase-like 1; uridine-cytidine kinase-like
                     1"
                     /calculated_mol_wt=60711
     Region          1..74
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91YL3.1)"
     Site            56
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9NWZ5; propagated from
                     UniProtKB/Swiss-Prot (Q91YL3.1)"
     Site            63
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q91YL3.1)"
     Region          101..299
                     /region_name="UMPK"
                     /note="Uridine monophosphate kinase (UMPK, EC 2.7.1.48),
                     also known as uridine kinase or uridine-cytidine kinase
                     (UCK), catalyzes the reversible phosphoryl transfer from
                     ATP to uridine or cytidine to yield UMP or CMP. In the
                     primidine nucleotide-salvage pathway; cd02023"
                     /db_xref="CDD:238981"
     Site            order(112,236,284)
                     /site_type="other"
                     /note="ATP-binding site [chemical binding]"
                     /db_xref="CDD:238981"
     Site            order(133,157,237)
                     /site_type="active"
                     /note="Sugar specificity [active]"
                     /db_xref="CDD:238981"
     Site            order(136,154,183,185,188,245)
                     /site_type="active"
                     /note="Pyrimidine base specificity [active]"
                     /db_xref="CDD:238981"
     Region          329..532
                     /region_name="UPRTase"
                     /note="Uracil phosphoribosyltransferase; pfam14681"
                     /db_xref="CDD:434124"
     Site            order(400,402,453..455,457..461,487)
                     /site_type="active"
                     /db_xref="CDD:206754"
     Site            539
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9NWZ5; propagated from
                     UniProtKB/Swiss-Prot (Q91YL3.1)"
     CDS             1..548
                     /gene="Uckl1"
                     /gene_synonym="1110007H10Rik; Urkl1"
                     /coded_by="NM_026765.3:6..1652"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS17216.1"
                     /db_xref="GeneID:68556"
                     /db_xref="MGI:MGI:1915806"
ORIGIN      
        1 maappasmsa apsplqsava pdvpgrqaeq netacedrsn agtldrllpp vgtgrsprkr
       61 ttsqcksepp llrtskrtiy tagrppwyne hgtqskeafa iglgggsasg kttvarmiie
      121 aldvpwvvll smdsfykvlt qqqqeqaacn nfnfdhpdaf dfdliistlk klkqgrsvqv
      181 piydftthsr kkdwktlyga nviifegima fadktllell dmkifvdtds dirlvrrlrr
      241 disergrdie gvikqynkfv kpafdqyiqp tmrladivvp rgsgntvaid livqhvhsql
      301 eerelsvraa lasahqchpl pqtlsvlkst pqvrgmhtii rdketsrdef ifyskrlmrl
      361 liehalsflp fqdctvqtpq gqdyvgkcya gkqitgvsil ragetmepal ravckdvrig
      421 tiliqtnqlt gepelhylrl pkdisddhvi lmdctvstga aammavrvll dhdvpedkif
      481 llsllmaemg vhsvayafpr vriittavdk rvndlfriip gignfgdryf gtdavpdgsd
      541 ddeaatvg
//
