LOCUS       NM_030724               4483 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Mus musculus uridine-cytidine kinase 2 (Uck2), transcript variant
            1, mRNA.
ACCESSION   NM_030724 XM_991804
VERSION     NM_030724.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4483)
  AUTHORS   Zocher,S., McCloskey,A., Karasinsky,A., Schulte,R., Friedrich,U.,
            Lesche,M., Rund,N., Gage,F.H., Hetzer,M.W. and Toda,T.
  TITLE     Lifelong persistence of nuclear RNAs in the mouse brain
  JOURNAL   Science 384 (6691), 53-59 (2024)
   PUBMED   38574132
REFERENCE   2  (bases 1 to 4483)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4483)
  AUTHORS   Xu,Z., Flensburg,C., Bilardi,R.A. and Majewski,I.J.
  TITLE     Uridine-cytidine kinase 2 potentiates the mutagenic influence of
            the antiviral beta-d-N4-hydroxycytidine
  JOURNAL   Nucleic Acids Res 51 (22), 12031-12042 (2023)
   PUBMED   37953355
  REMARK    GeneRIF: Uridine-cytidine kinase 2 potentiates the mutagenic
            influence of the antiviral beta-d-N4-hydroxycytidine.
REFERENCE   4  (bases 1 to 4483)
  AUTHORS   van Kuilenburg,A.B. and Meinsma,R.
  TITLE     The pivotal role of uridine-cytidine kinases in pyrimidine
            metabolism and activation of cytotoxic nucleoside analogues in
            neuroblastoma
  JOURNAL   Biochim Biophys Acta 1862 (9), 1504-1512 (2016)
   PUBMED   27239701
REFERENCE   5  (bases 1 to 4483)
  AUTHORS   Papin,J. and Subramaniam,S.
  TITLE     Bioinformatics and cellular signaling
  JOURNAL   Curr Opin Biotechnol 15 (1), 78-81 (2004)
   PUBMED   15102471
  REMARK    Review article
REFERENCE   6  (bases 1 to 4483)
  AUTHORS   Van Rompay,A.R., Norda,A., Linden,K., Johansson,M. and Karlsson,A.
  TITLE     Phosphorylation of uridine and cytidine nucleoside analogs by two
            human uridine-cytidine kinases
  JOURNAL   Mol Pharmacol 59 (5), 1181-1186 (2001)
   PUBMED   11306702
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC142244.11.
            
            On Mar 13, 2023 this sequence version replaced NM_030724.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK082837.1, SRR17784650.1313581.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164141 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-313               AC142244.11        7536-7848
            314-473             AC142244.11        54976-55135
            474-570             AC142244.11        55925-56021
            571-713             AC142244.11        57790-57932
            714-811             AC142244.11        62634-62731
            812-860             AC142244.11        64844-64892
            861-4483            AC142244.11        66103-69725
FEATURES             Location/Qualifiers
     source          1..4483
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 74.61 cM"
     gene            1..4483
                     /gene="Uck2"
                     /gene_synonym="TSA903; UK; UMK; Umpk"
                     /note="uridine-cytidine kinase 2"
                     /db_xref="GeneID:80914"
                     /db_xref="MGI:MGI:1931744"
     exon            1..313
                     /gene="Uck2"
                     /gene_synonym="TSA903; UK; UMK; Umpk"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..1000
                     /gene="Uck2"
                     /gene_synonym="TSA903; UK; UMK; Umpk"
                     /EC_number="2.7.1.48"
                     /note="isoform a is encoded by transcript variant 1;
                     uridine monophosphate kinase 2; cytidine monophosphokinase
                     2; UCK 2; uridine monophosphokinase 2"
                     /codon_start=1
                     /product="uridine-cytidine kinase 2 isoform a"
                     /protein_id="NP_109649.1"
                     /db_xref="CCDS:CCDS15455.1"
                     /db_xref="GeneID:80914"
                     /db_xref="MGI:MGI:1931744"
                     /translation="MAGDSEQTLQNHQQPNGGEPFLIGVSGGTASGKSSVCAKIVQLL
                     GQNEVDYHQKQVVILSQDSFYRVLTSEQKAKALKGQFNFDHPDAFDNELIFKTLKEIT
                     EGKTVQIPVYDFVSHSRKEETVTIYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDAD
                     TRLSRRVLRDISERGRDLEQILSQYITFVKPAFEEFCLPTKKYADVIIPRGADNLVAI
                     NLIVQHIQDILNGGLSKRQTNGYLNGYTPSRKRQASESSSRPH"
     exon            314..473
                     /gene="Uck2"
                     /gene_synonym="TSA903; UK; UMK; Umpk"
                     /inference="alignment:Splign:2.1.0"
     exon            474..570
                     /gene="Uck2"
                     /gene_synonym="TSA903; UK; UMK; Umpk"
                     /inference="alignment:Splign:2.1.0"
     exon            571..713
                     /gene="Uck2"
                     /gene_synonym="TSA903; UK; UMK; Umpk"
                     /inference="alignment:Splign:2.1.0"
     exon            714..811
                     /gene="Uck2"
                     /gene_synonym="TSA903; UK; UMK; Umpk"
                     /inference="alignment:Splign:2.1.0"
     exon            812..860
                     /gene="Uck2"
                     /gene_synonym="TSA903; UK; UMK; Umpk"
                     /inference="alignment:Splign:2.1.0"
     exon            861..4483
                     /gene="Uck2"
                     /gene_synonym="TSA903; UK; UMK; Umpk"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1292..1297
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Uck2"
                     /gene_synonym="TSA903; UK; UMK; Umpk"
                     /note="hexamer: TATAAA"
     polyA_site      1299
                     /gene="Uck2"
                     /gene_synonym="TSA903; UK; UMK; Umpk"
                     /note="major polyA site"
     regulatory      4463..4468
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Uck2"
                     /gene_synonym="TSA903; UK; UMK; Umpk"
                     /note="hexamer: AATAAA"
     polyA_site      4483
                     /gene="Uck2"
                     /gene_synonym="TSA903; UK; UMK; Umpk"
                     /note="major polyA site"
ORIGIN      
        1 gtaaacccca cgggccgcca cgggcacagg agagctctcg gcacctccgg gaaagccacc
       61 tcggcctccc ccgcgcccgg gctccagccg cggccggccc agcctcgacc tcagcagcga
      121 ccagctgctc ctgcgaggag ccgagcgagc ccggtcgcgg gcggggagcg tgcgtcggtt
      181 cgcacaggct gcgagaggag gggcggcgcg agtcatggcc ggggacagcg agcagaccct
      241 gcagaaccac cagcagccca acggcggcga gcccttcctg atcggcgtga gcgggggcac
      301 ggccagcggg aagtcttccg tttgtgctaa gatcgtccag cttttggggc agaatgaggt
      361 ggattaccac cagaagcagg tggtgatcct gagccaggat agcttctacc gagtcctcac
      421 ctcagagcag aaggccaaag ccctcaaggg ccaattcaac tttgatcacc cggatgcctt
      481 tgacaacgaa ctcatcttca aaacactcaa agaaatcacc gaaggaaaaa ccgtccagat
      541 ccccgtgtac gactttgtct cccactcacg gaaagaggag acggtcacca tctaccccgc
      601 cgacgtggtg ctcttcgaag ggatcctagc cttctattcc caggaggtcc gagacctgtt
      661 ccagatgaag ctttttgtgg acacagatgc ggatacccgt ctgtctcgcc gagtattgag
      721 ggacatcagc gaaagaggga gggaccttga gcagatttta tcacagtaca ttacgtttgt
      781 gaagcctgcc tttgaggaat tctgcttgcc aacaaagaaa tacgccgatg tgatcattcc
      841 tagaggtgcc gacaatctcg tggccatcaa cctcatcgtg caacacatcc aggacatcct
      901 caacgggggg ctctccaagc ggcagacgaa cggctatctc aacggctaca ccccttcccg
      961 caagaggcag gcgtcagagt ccagcagccg accacattga ctcccgtgcc cctgactcca
     1021 aaccccagcc ccccagctcc aagacacagg aggggtcgag aggctctggt cacctgtaca
     1081 tacgcctcct cagaaaatta ctgtatttaa gaaaacacca cggagatgaa atgccttgat
     1141 ttccctttct gcctttttgt actttggaac agcaaatctt gatggaactt gaccctgagc
     1201 ttaagtgaca aactgtgcca actagtactg gtgatgccta attatgaacc caacgtgtaa
     1261 ccagttataa atacacacat acatacgtct atataaaaag aaaggatcta tttttgtgta
     1321 actgtacaga tactgtaaag ctgtttgcca taagtatcct gtaggaacct gtgcgtgggt
     1381 gtcgggcctg gagccccgct cagcagtcag tgttctgtgc tctggccacc ggggagccac
     1441 gggagtcggg tggttgattg gttgatgtcc cttgttctca gcaccctggg cctcagtggg
     1501 gatgggactc aaccctcaag ggctcccctg tcagatgcca cctccttgaa actggagctg
     1561 agggagatac ttctattttt ttttttttcc tgttttgttt tggagttgaa attaagtgtg
     1621 atctcaactc acctcaatct cagggaagag gcccactgag gaagatcagt ctgtctgcgt
     1681 tgtctgccgt tccttcttgc ctcgctctgg ttgcctgggc acctccatga ctcctttctt
     1741 cctgtgctat ctttgttccc caggaagcca gagctgtctc caatttccag gtggggattt
     1801 tttagggtct catcctgtgc gaaaagagag aagggggtgg gaggggactc tgtctcctgg
     1861 agagtgtaag gaactagctg gccaattgcc tgacaaatta ttggataaga atatttatct
     1921 taatgagctt tggttaacga catctggtat ggaccactga catttatttg aggttgcccc
     1981 aggagttcta cccatggagc tggcaatagt tttttgtctc gtctgagctg gggctgtatt
     2041 gggaggtgac agccaatgcc tcacccccag agattctctt gaagcagcag catcaggatg
     2101 atttcctgaa ccacactgtc actgtgttaa taaggtggct gcctagcagg aaggggccgg
     2161 gagaagagaa gttatttctt agaagatgtt aagggagggt agttaaatca tgggtaccta
     2221 agctggggtt ttagattgaa gatgcccaag gtagagatct tcagctcctc tgagcacttc
     2281 ctcttggtgc tgactcctgc ctagaggagg ttgatggatg gcttgctgag aagacagctg
     2341 gagggaatgg gaccaagcaa gaagggacag gtgtgaggta gaggcctcag tctgtgctgg
     2401 ctgcagaaga gccgtggatt gtcacgttgg tggtcaccat cctgcgcttt gtgggtcaca
     2461 tgcttagtcc ctcaacccat gggagagcct catgtctgag tagcacttgg agcccactga
     2521 ggctcttact ctgatactcc acaaaccgca ccgaggttcc ctcgagctgt cccgtctgat
     2581 tccccaatca ggattcaaat ttgccttcaa ttccgttttt ctatttaggt gtcattaacc
     2641 cagtcctcag cagagctttg tcacttttct gaggcagtag ggggccgagg tgcaggctct
     2701 gtagcaagtt catatgctgg tagctgcctt tggagcaggg agctctcagc tcaggagcct
     2761 gtggggaagg cgcactcacc aaggcagatc catctagagt atttggggaa gcagtcttta
     2821 tcacatcaac ttcgtgaaat cctgagatta gaaaacggta ggttaggacc tggcctcaga
     2881 tcccaagaac aaggacctcg gtgttgcatg ttgcatgtgc tcatgggaaa aacttattcc
     2941 tgtgtacaag agccttggca gctcagtggg tagcacgctc aactttactt gaagcttcca
     3001 ggtgccaaac cacttcgtgc cttggctgtc tatcccactg ccgtggaaaa gggattcttc
     3061 ccatctctga gcctttatta gctgctccct catctaccca tggtgttggg accaagcctc
     3121 cgaaacctct gagcagccca cttgttgcag cttggacacc gctgtaggac caccttaccc
     3181 ctatctccgt gggaagttct ggattggcta gaagcagtat ttgctgggta tagggaaggg
     3241 ctggacgctg tactgtttcc agaccgccgc ccagcttttt ggccaattgt gcatttgaac
     3301 cttctctacg ggaaacattg tggtctgagc cttgaggttt tggttttgcc attccattgt
     3361 cgagtaggga ggtaaaggga tcttgaagcc atggcatttg tcatctgggg actcagagct
     3421 gttctagaga ggaagccgag ctgggcagag ctgcacaacc ttgaacacag gtgcatagat
     3481 ccttccactt cagagccacc caatggtgct tgcttccccc acccgttcac agacgtcttt
     3541 ggcctgagtg tttaggaaac gaaaattctg agtcttgtgt cacaggaagg tccagcctta
     3601 cacctcatca tggtaataca accccccccc cccccgcccc cctgacttct ctttggataa
     3661 cccgaggctg aaaaagatag gcatctgatc tagcttgggt agagtaggcc tggggaaggg
     3721 agtgaagcag gttcatgcct tggggctagg gcagtggcca agtcacctgt ctccgaacga
     3781 acacttagcg gtgactactc agaccgtggg ggaagttggc tccagctcgc tctctccagg
     3841 gtgagtctct tgggaggccg ctgggtcagt gcccctgagt agtcaaaagt ggagaccgga
     3901 tcaaccttgg cctcaaagcc cccactgctg cagaggaatg cagtctctgg cagggaaatg
     3961 tttttcactg cccttggaac ctgtgttgtt catgtccaag agtccaaaga aagggctgat
     4021 ttcctgaggc tggggtcagc ccctggtaca tgcaggccct tgctttcttc gaaggaccag
     4081 ctggccttct ctgtctcctt tgccgttcat attttcctct gggccattgc tgtatgctct
     4141 ttgtgtcagg acaaggaaga gggcaggttg gaaaggcaca attggatgca tctagtagtg
     4201 tatacaagtc ccttttaaga ttctggctct ggtcctgctg tgttctcacg gtgccagcca
     4261 caggtgaccg agtttcagca gcggagtcct gtttctctcg ggcagtgagt tcctacccag
     4321 ccctgcctcc agagcaaggt tgggtggcta gagacctagg ctgttctttc cctggaagat
     4381 gctgcctctt cccgtctttg ctttttactg ccctgccttt gttcgtgcta tgaaatgacc
     4441 acaccctatg tacttggctg taaataaaga caaataaaaa caa
//
