LOCUS       NM_011675               1966 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Mus musculus uridine-cytidine kinase 1 (Uck1), transcript variant
            3, mRNA.
ACCESSION   NM_011675
VERSION     NM_011675.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1966)
  AUTHORS   Zocher,S., McCloskey,A., Karasinsky,A., Schulte,R., Friedrich,U.,
            Lesche,M., Rund,N., Gage,F.H., Hetzer,M.W. and Toda,T.
  TITLE     Lifelong persistence of nuclear RNAs in the mouse brain
  JOURNAL   Science 384 (6691), 53-59 (2024)
   PUBMED   38574132
REFERENCE   2  (bases 1 to 1966)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1966)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1966)
  AUTHORS   Eddleston,J., Murdoch,J.N., Copp,A.J. and Stanier,P.
  TITLE     Physical and transcriptional map of a 3-Mb region of mouse
            chromosome 1 containing the gene for the neural tube defect mutant
            loop-tail (Lp)
  JOURNAL   Genomics 56 (2), 149-159 (1999)
   PUBMED   10051400
REFERENCE   5  (bases 1 to 1966)
  AUTHORS   Ropp,P.A. and Traut,T.W.
  TITLE     Cloning and expression of a cDNA encoding uridine kinase from mouse
            brain
  JOURNAL   Arch Biochem Biophys 336 (1), 105-112 (1996)
   PUBMED   8951040
REFERENCE   6  (bases 1 to 1966)
  AUTHORS   Traut,T.W.
  TITLE     The functions and consensus motifs of nine types of peptide
            segments that form different types of nucleotide-binding sites
  JOURNAL   Eur J Biochem 222 (1), 9-19 (1994)
   PUBMED   8200357
  REMARK    Review article
REFERENCE   7  (bases 1 to 1966)
  AUTHORS   Satlin,A., Kucherlapati,R. and Ruddle,F.H.
  TITLE     Assignment of the gene for human uridine monophosphate kinase to
            chromosome 1 using somatic cell hybrid clone panels
  JOURNAL   Cytogenet Cell Genet 15 (3), 146-152 (1975)
   PUBMED   172293
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY338721.1, L31783.1, AK132100.1 and CJ194826.1.
            
            On Apr 25, 2009 this sequence version replaced NM_011675.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025146.1, L31783.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               BY338721.1         2-141
            141-728             L31783.1           1-588
            729-1950            AK132100.1         1-1222
            1951-1966           CJ194826.1         464-479
FEATURES             Location/Qualifiers
     source          1..1966
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 22.09 cM"
     gene            1..1966
                     /gene="Uck1"
                     /gene_synonym="Umpk; URK1"
                     /note="uridine-cytidine kinase 1"
                     /db_xref="GeneID:22245"
                     /db_xref="MGI:MGI:98904"
     exon            1..197
                     /gene="Uck1"
                     /gene_synonym="Umpk; URK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..923
                     /gene="Uck1"
                     /gene_synonym="Umpk; URK1"
                     /EC_number="2.7.1.48"
                     /note="isoform 3 is encoded by transcript variant 3;
                     uridine monophosphate kinase; uridine monophosphokinase 1;
                     cytidine monophosphokinase 1"
                     /codon_start=1
                     /product="uridine-cytidine kinase 1 isoform 3"
                     /protein_id="NP_035805.2"
                     /db_xref="CCDS:CCDS15909.2"
                     /db_xref="GeneID:22245"
                     /db_xref="MGI:MGI:98904"
                     /translation="MSVAPDMASAGGGGSESAAPEADRPQPRPFLIGVSGGTASGKST
                     VCEKIMELLGQNEVDRRQRKLVILSQDCFYKVLTAEQKAKALKGQYNFDHPDAFDNDL
                     MHKTLKNIVEGKTVEVPTYDFVTHSRLPETTVVYPADVVLFEGILVFYTQEIRDMFHL
                     RLFVDTDSDVRLSRRVLRDVQRGRDLEQILTQYTAFVKPAFEEFCLPTKKYADVIIPR
                     GVDNMVAINLIVQHIQDILNGDLCKRHRGGPNGRNHKRTFPEPGDHPGVLATGKRSHL
                     ESSSRPH"
     exon            198..357
                     /gene="Uck1"
                     /gene_synonym="Umpk; URK1"
                     /inference="alignment:Splign:2.1.0"
     exon            358..454
                     /gene="Uck1"
                     /gene_synonym="Umpk; URK1"
                     /inference="alignment:Splign:2.1.0"
     exon            455..597
                     /gene="Uck1"
                     /gene_synonym="Umpk; URK1"
                     /inference="alignment:Splign:2.1.0"
     exon            598..692
                     /gene="Uck1"
                     /gene_synonym="Umpk; URK1"
                     /inference="alignment:Splign:2.1.0"
     exon            693..741
                     /gene="Uck1"
                     /gene_synonym="Umpk; URK1"
                     /inference="alignment:Splign:2.1.0"
     exon            742..1951
                     /gene="Uck1"
                     /gene_synonym="Umpk; URK1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1930..1935
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Uck1"
                     /gene_synonym="Umpk; URK1"
                     /note="hexamer: AATAAA"
     polyA_site      1951
                     /gene="Uck1"
                     /gene_synonym="Umpk; URK1"
                     /note="major polyA site"
ORIGIN      
        1 atgtccccgg aagcgatgcg cacagcatcc gtcactacgt ccaggcggga gcgggcagag
       61 tcggtgaatg tatgtccgtc gctccggata tggcttcggc gggaggcggc ggctcggaga
      121 gcgccgcgcc cgaggccgat cgtccccagc cgcggccgtt cctcatcggc gtgagcggcg
      181 gcaccgctag tggcaagtca acagtgtgtg agaagatcat ggagctgctg ggacagaacg
      241 aagtggaccg ccggcagcgc aagttggtca tcctgagcca ggactgcttc tacaaggttc
      301 tgacggccga gcagaaggcc aaggctttga agggacagta caattttgac cacccagatg
      361 cttttgataa tgatctgatg cacaagaccc tgaaaaacat tgttgaaggc aaaactgtcg
      421 aggtccctac ctatgatttt gtgacccact caaggttacc agagaccact gtggtctacc
      481 cagctgatgt ggttctgttc gagggcatct tggtattcta cacccaggag atccgggaca
      541 tgttccacct gcgcctcttt gtggacacag actctgatgt taggctgtct cgaagagttc
      601 tccgggatgt gcaacgagga agggacctgg agcagatcct gactcagtac accgcctttg
      661 tgaaaccagc ctttgaggag ttctgcctgc cgactaagaa gtacgctgac gtgatcatcc
      721 ctcgaggagt tgataatatg gtggccatca acctgatcgt gcaacacatc caggacatcc
      781 tcaacgggga cctgtgcaag cggcaccgag gcgggcccaa cgggcgcaac cacaagagga
      841 ccttccccga gccaggagat caccctgggg tgttggccac tggcaagcgc tcacacctgg
      901 agtctagcag cagaccccat tgaggaccag catatgtagg ttccccacag acccaggatt
      961 aagggcctgg ggacgaccac tggctcctaa aagcacagtc agggatccct ctcaatgagt
     1021 gggacctagg gtggcatcag gaccaaagcc ttccttgcac ggagggcaga ctcatgctga
     1081 cagagcattc tggggtcctc ccattcctct cattggagga ggccacaggt ctctgggtca
     1141 ctgtcccaaa cagcatagta agcccatggt accagcttcc ccaggggatg cgggacacaa
     1201 atcatggtgc aacaggaaac agcccgggca ctggctggtc tggtgttgac agtgagccca
     1261 agggaagtgc ttccccgtat ggtgtggctt gtgtccatgt tgcagaagta aagcttgcag
     1321 agatgttaga tcccttgttt gttttgtggc aggctgtttg tgagctctga acctagtttt
     1381 acaaccgacc actgggctat ggtccagttt aaggagcctg aggcagggac cctaaggact
     1441 acccacatga ctctatctgg gggcctggat cttgggtaga tgggagtggg ccatcaggtc
     1501 tcttgtggct gaaacattgt ctcccaattc tgcaggcagc cttgaaccag ggggctgcct
     1561 gtgtacaagt cacttgggta cagttcatgg ctagcatgcc aggcaggctc tctccagcca
     1621 gggagcactt cagtgcagag gcaggtgacc gtggctgcct aaagccagct agtctcctgc
     1681 acacccagct caagctcctg gcttcacaaa cgctcccttc tgtgttgtca agtttgtcgt
     1741 ccctccccat gggacggctg tttttggaag tgccctttgc tgtcgccaca agccatggca
     1801 cgggacgtct cgttttatgt tcaatacaac tgtggatcac agcagctgag ctgtgatgag
     1861 ctcggggctg ccttctgcta gtgctgggct ggttttgttg aactgaaacc cctctttgga
     1921 gggagaatca ataaataaca taaaacatta aaaaaaaaaa aaaaaa
//
