LOCUS       NM_019562               1851 bp    mRNA    linear   ROD 12-DEC-2024
DEFINITION  Mus musculus ubiquitin carboxyl-terminal esterase L5 (Uchl5),
            transcript variant 1, mRNA.
ACCESSION   NM_019562
VERSION     NM_019562.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1851)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1851)
  AUTHORS   Yang,X., Wang,C., Zhu,G., Guo,Z. and Fan,L.
  TITLE     METTL14/YTHDF1 axis-modified UCHL5 aggravates atherosclerosis by
            activating the NLRP3 inflammasome
  JOURNAL   Exp Cell Res 427 (2), 113587 (2023)
   PUBMED   37044315
  REMARK    GeneRIF: METTL14/YTHDF1 axis-modified UCHL5 aggravates
            atherosclerosis by activating the NLRP3 inflammasome.
REFERENCE   3  (bases 1 to 1851)
  AUTHORS   Zhao,W., Cao,Y., Chen,Y., Chen,Y., Wang,T., Li,L., Xu,Y., Yuan,H.,
            Wang,H., Wang,R. and Sun,W.
  TITLE     NLRP3 Regulates Mandibular Healing through Interaction with UCHL5
            in MSCs
  JOURNAL   Int J Biol Sci 19 (3), 936-949 (2023)
   PUBMED   36778113
  REMARK    GeneRIF: NLRP3 Regulates Mandibular Healing through Interaction
            with UCHL5 in MSCs.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1851)
  AUTHORS   Ma,Y.S., Wang,X.F., Yu,F., Wu,T.M., Liu,J.B., Zhang,Y.J., Xia,Q.,
            Jiang,Z.Y., Lin,Q.L. and Fu,D.
  TITLE     Inhibition of USP14 and UCH37 deubiquitinating activity by b-AP15
            as a potential therapy for tumors with p53 deficiency
  JOURNAL   Signal Transduct Target Ther 5 (1), 30 (2020)
   PUBMED   32296042
  REMARK    GeneRIF: Inhibition of USP14 and UCH37 deubiquitinating activity by
            b-AP15 as a potential therapy for tumors with p53 deficiency.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1851)
  AUTHORS   Kim,S.K., Avila,J.J. and Massett,M.P.
  TITLE     Strain survey and genetic analysis of vasoreactivity in mouse aorta
  JOURNAL   Physiol Genomics 48 (11), 861-873 (2016)
   PUBMED   27764765
REFERENCE   6  (bases 1 to 1851)
  AUTHORS   Peth,A., Kukushkin,N., Bosse,M. and Goldberg,A.L.
  TITLE     Ubiquitinated proteins activate the proteasomal ATPases by binding
            to Usp14 or Uch37 homologs
  JOURNAL   J Biol Chem 288 (11), 7781-7790 (2013)
   PUBMED   23341450
  REMARK    GeneRIF: ubiquitinated loosely folded proteins, after becoming
            bound to the 26 S, interact with Ubp6/Usp14 or Uch37 to activate
            ATP hydrolysis and enhance their own destruction
REFERENCE   7  (bases 1 to 1851)
  AUTHORS   Al-Shami,A., Jhaver,K.G., Vogel,P., Wilkins,C., Humphries,J.,
            Davis,J.J., Xu,N., Potter,D.G., Gerhardt,B., Mullinax,R.,
            Shirley,C.R., Anderson,S.J. and Oravecz,T.
  TITLE     Regulators of the proteasome pathway, Uch37 and Rpn13, play
            distinct roles in mouse development
  JOURNAL   PLoS One 5 (10), e13654 (2010)
   PUBMED   21048919
  REMARK    GeneRIF: this is the first report characterizing the physiological
            roles of Uch37 and Rpn13 in murine development and implicating a
            non-ATPase proteasomal protein, Rpn13, in the process of
            gametogenesis
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1851)
  AUTHORS   Wicks,S.J., Haros,K., Maillard,M., Song,L., Cohen,R.E., Dijke,P.T.
            and Chantry,A.
  TITLE     The deubiquitinating enzyme UCH37 interacts with Smads and
            regulates TGF-beta signalling
  JOURNAL   Oncogene 24 (54), 8080-8084 (2005)
   PUBMED   16027725
REFERENCE   9  (bases 1 to 1851)
  AUTHORS   Yalcin,B., Willis-Owen,S.A., Fullerton,J., Meesaq,A., Deacon,R.M.,
            Rawlins,J.N., Copley,R.R., Morris,A.P., Flint,J. and Mott,R.
  TITLE     Genetic dissection of a behavioral quantitative trait locus shows
            that Rgs2 modulates anxiety in mice
  JOURNAL   Nat Genet 36 (11), 1197-1202 (2004)
   PUBMED   15489855
REFERENCE   10 (bases 1 to 1851)
  AUTHORS   Hwang,S.Y., Oh,B., Knowles,B.B., Solter,D. and Lee,J.S.
  TITLE     Expression of genes involved in mammalian meiosis during the
            transition from egg to embryo
  JOURNAL   Mol Reprod Dev 59 (2), 144-158 (2001)
   PUBMED   11389549
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY279731.1, AF148447.1 and AL592403.6.
            
            On May 7, 2009 this sequence version replaced NM_019562.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK011117.1, AF148447.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-403               BY279731.1         1-403
            404-1200            AF148447.1         347-1143
            1201-1851           AL592403.6         115612-116262
FEATURES             Location/Qualifiers
     source          1..1851
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 62.54 cM"
     gene            1..1851
                     /gene="Uchl5"
                     /gene_synonym="5830413B11Rik; Uch37"
                     /note="ubiquitin carboxyl-terminal esterase L5"
                     /db_xref="GeneID:56207"
                     /db_xref="MGI:MGI:1914848"
     exon            1..199
                     /gene="Uchl5"
                     /gene_synonym="5830413B11Rik; Uch37"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..1113
                     /gene="Uchl5"
                     /gene_synonym="5830413B11Rik; Uch37"
                     /EC_number="3.4.19.12"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ubiquitin C-terminal hydrolase 37; ubiquitin
                     carboxyl-terminal hydrolase isozyme L5; UCH-L5; ubiquitin
                     thioesterase L5; ubiquitin C-terminal hydrolase UCH37"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase isozyme L5
                     isoform 1"
                     /protein_id="NP_062508.2"
                     /db_xref="CCDS:CCDS15346.1"
                     /db_xref="GeneID:56207"
                     /db_xref="MGI:MGI:1914848"
                     /translation="MSSNAGEWCLMESDPGVFTELIKGFGCRGAQVEEIWSLEPESFE
                     KLKPVHGLIFLFKWQPGEEPAGSVVQDSRLETIFFAKQVINNACATQAIVSVLLNCTH
                     QDVHLGETLSEFKEFSQSFDAAMKGLALSNSDVIRQVHNSFARQQMFEFDTKTPAKEE
                     DAFHFVSYVPVNGRLYELDGLREGPIDLGACNQDDWITAVRPVIEKRIQKYSEGEIRF
                     NLMAIVSDRKMIYEQKIAELQRQLAEEEPMDTDQGSTVLSAIQSEVARNQMLIEEEVQ
                     KLKRYKIENIRRKHNYLPFIMELLKTLAEHQQLIPLVEKAKEKQNAKKAQETK"
     exon            200..263
                     /gene="Uchl5"
                     /gene_synonym="5830413B11Rik; Uch37"
                     /inference="alignment:Splign:2.1.0"
     exon            264..369
                     /gene="Uchl5"
                     /gene_synonym="5830413B11Rik; Uch37"
                     /inference="alignment:Splign:2.1.0"
     exon            370..495
                     /gene="Uchl5"
                     /gene_synonym="5830413B11Rik; Uch37"
                     /inference="alignment:Splign:2.1.0"
     exon            496..557
                     /gene="Uchl5"
                     /gene_synonym="5830413B11Rik; Uch37"
                     /inference="alignment:Splign:2.1.0"
     exon            558..688
                     /gene="Uchl5"
                     /gene_synonym="5830413B11Rik; Uch37"
                     /inference="alignment:Splign:2.1.0"
     exon            689..752
                     /gene="Uchl5"
                     /gene_synonym="5830413B11Rik; Uch37"
                     /inference="alignment:Splign:2.1.0"
     exon            753..855
                     /gene="Uchl5"
                     /gene_synonym="5830413B11Rik; Uch37"
                     /inference="alignment:Splign:2.1.0"
     exon            856..969
                     /gene="Uchl5"
                     /gene_synonym="5830413B11Rik; Uch37"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1068
                     /gene="Uchl5"
                     /gene_synonym="5830413B11Rik; Uch37"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1851
                     /gene="Uchl5"
                     /gene_synonym="5830413B11Rik; Uch37"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1170..1175
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Uchl5"
                     /gene_synonym="5830413B11Rik; Uch37"
                     /note="hexamer: AATAAA"
     polyA_site      1192
                     /gene="Uchl5"
                     /gene_synonym="5830413B11Rik; Uch37"
     regulatory      1301..1306
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Uchl5"
                     /gene_synonym="5830413B11Rik; Uch37"
                     /note="hexamer: AATAAA"
     polyA_site      1318
                     /gene="Uchl5"
                     /gene_synonym="5830413B11Rik; Uch37"
                     /note="major polyA site"
     regulatory      1662..1667
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Uchl5"
                     /gene_synonym="5830413B11Rik; Uch37"
                     /note="hexamer: AATAAA"
     polyA_site      1685
                     /gene="Uchl5"
                     /gene_synonym="5830413B11Rik; Uch37"
ORIGIN      
        1 ggtgacgtgg ggttgacgct cggcggcggg ttttgctgag gtctgcggcc ggtggcagct
       61 tgtgctgcgg ggctccggag agcgcgaggt ggaagcgggg cggtgtgtgt gtggtcgggg
      121 accatgtcga gcaatgccgg ggagtggtgt ctcatggaaa gcgaccccgg ggtcttcacc
      181 gagctcatta aaggattcgg ttgccgaggg gcccaagtag aagaaatatg gagcttagaa
      241 cctgagagtt ttgaaaagct aaagccagtt catgggttaa tttttctttt caagtggcag
      301 ccaggagaag aacctgctgg ctctgtggtc caggactcca gacttgaaac aatatttttt
      361 gccaagcagg taattaataa tgcttgtgcc actcaggcta tcgtaagtgt actactgaac
      421 tgtacgcatc aagatgtgca tttaggagag acattatcag aatttaaaga attttctcaa
      481 agttttgatg cagctatgaa ggggctggca ttgagtaact cagatgtgat tcgacaagtg
      541 cacaacagtt ttgccaggca gcagatgttt gaatttgata caaagacacc agccaaagag
      601 gaggatgctt ttcactttgt cagttacgtt ccagtcaatg ggaggctgta tgaactagac
      661 gggttaagag agggcccaat tgatttaggt gcatgcaatc aagatgactg gattactgca
      721 gtgaggccag taatagagaa aaggattcaa aagtatagtg aaggagaaat tcgatttaat
      781 ttaatggcca ttgtatctga cagaaaaatg atatatgaac agaagatagc agagttacaa
      841 agacaacttg cagaggagga acccatggat acagatcaag gtagtaccgt gttaagtgct
      901 attcagtcag aagttgccag aaaccagatg cttattgaag aagaggtaca aaagttaaag
      961 agatataaga ttgaaaatat cagaaggaag cataattact tgcctttcat tatggaattg
     1021 ttaaagacct tagctgagca ccagcagtta attccacttg tggaaaaggc aaaagaaaaa
     1081 cagaatgcaa agaaagctca ggaaactaag tgaagaggat atttggacgt gtgtacagtg
     1141 tgctgcactt aatttcatgg acaccattaa ataaaaggaa ctttggacaa catcttaatt
     1201 gactcagtgc acgtttggca tagtaccagt ctgtcttgtc ctttatgcat ggagttaaaa
     1261 ttctttccct acctgcatca tgggcatgta gtgcatatta aataaaagtg acgaaaaagt
     1321 gctggctaaa ctccattctt caattctgga tctgggagtt cttggtactc tagaaataca
     1381 actatagtaa tgaacataga aaatacacat ataatatact ttatctgtag ttgctctgat
     1441 taatattttt atttattagc ttagtctatt caatttataa atgtcagatc ttacttaaac
     1501 tgggtcatct gtttctaatt gtggcaaaaa taattagtgt ttttgtcttt ggggtgtgtt
     1561 gtgcagatct taaaactgaa ttttatctta cacctatttg atttttaagg ccagccattt
     1621 ggaaagactg atacgatttt tgatgaatat gtaaagaaga caataaatat cccaattata
     1681 ttttagcaaa gtttcttgga ttatttgttt atatattgta gaattattct agaaagccct
     1741 ggatattttt ttgctttgaa acgaaactgt agaaaacata aatattgaga gttttttgac
     1801 aacctgtttt tcaagataac gttatgtgca ttcattaaaa attaagggtt t
//
