LOCUS       NM_016723                947 bp    mRNA    linear   ROD 02-FEB-2024
DEFINITION  Mus musculus ubiquitin carboxyl-terminal esterase L3 (ubiquitin
            thiolesterase) (Uchl3), mRNA.
ACCESSION   NM_016723
VERSION     NM_016723.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 947)
  AUTHORS   Liu,T., Fan,M.Q., Xie,X.X., Shu,Q.P., Du,X.H., Qi,L.Z., Zhang,X.D.,
            Zhang,M.H., Shan,G., Du,R.L. and Li,S.Z.
  TITLE     Activation of CTNNB1 by deubiquitinase UCHL3-mediated stabilization
            facilitates bladder cancer progression
  JOURNAL   J Transl Med 21 (1), 656 (2023)
   PUBMED   37740194
  REMARK    GeneRIF: Activation of CTNNB1 by deubiquitinase UCHL3-mediated
            stabilization facilitates bladder cancer progression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 947)
  AUTHORS   Lee,S.Y., Park,S.Y., Lee,S.H., Kim,H., Kwon,J.H., Yoo,J.Y., Kim,K.,
            Park,M.S., Lee,C.G., Elias,J.A., Sohn,M.H., Shim,H.S. and Yoon,H.G.
  TITLE     The deubiquitinase UCHL3 mediates p300-dependent chemokine
            signaling in alveolar type II cells to promote pulmonary fibrosis
  JOURNAL   Exp Mol Med 55 (8), 1795-1805 (2023)
   PUBMED   37524875
  REMARK    GeneRIF: The deubiquitinase UCHL3 mediates p300-dependent chemokine
            signaling in alveolar type II cells to promote pulmonary fibrosis.
REFERENCE   3  (bases 1 to 947)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 947)
  AUTHORS   Jahan,A.S., Lestra,M., Swee,L.K., Fan,Y., Lamers,M.M.,
            Tafesse,F.G., Theile,C.S., Spooner,E., Bruzzone,R., Ploegh,H.L. and
            Sanyal,S.
  TITLE     Usp12 stabilizes the T-cell receptor complex at the cell surface
            during signaling
  JOURNAL   Proc Natl Acad Sci U S A 113 (6), E705-E714 (2016)
   PUBMED   26811477
REFERENCE   5  (bases 1 to 947)
  AUTHORS   Kazmierczak,M., Harris,S.L., Kazmierczak,P., Shah,P.,
            Starovoytov,V., Ohlemiller,K.K. and Schwander,M.
  TITLE     Progressive Hearing Loss in Mice Carrying a Mutation in Usp53
  JOURNAL   J Neurosci 35 (47), 15582-15598 (2015)
   PUBMED   26609154
REFERENCE   6  (bases 1 to 947)
  AUTHORS   Kurihara,L.J., Semenova,E., Miller,W., Ingram,R.S., Guan,X.J. and
            Tilghman,S.M.
  TITLE     Candidate genes required for embryonic development: a comparative
            analysis of distal mouse chromosome 14 and human chromosome 13q22
  JOURNAL   Genomics 79 (2), 154-161 (2002)
   PUBMED   11829485
REFERENCE   7  (bases 1 to 947)
  AUTHORS   Kurihara,L.J., Kikuchi,T., Wada,K. and Tilghman,S.M.
  TITLE     Loss of Uch-L1 and Uch-L3 leads to neurodegeneration, posterior
            paralysis and dysphagia
  JOURNAL   Hum Mol Genet 10 (18), 1963-1970 (2001)
   PUBMED   11555633
REFERENCE   8  (bases 1 to 947)
  AUTHORS   Osawa,Y., Wang,Y.L., Osaka,H., Aoki,S. and Wada,K.
  TITLE     Cloning, expression, and mapping of a mouse gene, Uchl4, highly
            homologous to human and mouse Uchl3
  JOURNAL   Biochem Biophys Res Commun 283 (3), 627-633 (2001)
   PUBMED   11341770
REFERENCE   9  (bases 1 to 947)
  AUTHORS   Kurihara,L.J., Semenova,E., Levorse,J.M. and Tilghman,S.M.
  TITLE     Expression and functional analysis of Uch-L3 during mouse
            development
  JOURNAL   Mol Cell Biol 20 (7), 2498-2504 (2000)
   PUBMED   10713173
REFERENCE   10 (bases 1 to 947)
  AUTHORS   Wada,H., Kito,K., Caskey,L.S., Yeh,E.T. and Kamitani,T.
  TITLE     Cleavage of the C-terminus of NEDD8 by UCH-L3
  JOURNAL   Biochem Biophys Res Commun 251 (3), 688-692 (1998)
   PUBMED   9790970
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK050278.1 and AB033370.1.
            
            [WARNING] On Apr 1, 2024 this sequence was replaced by NM_016723.3.
            
            On Apr 4, 2007 this sequence version replaced NM_016723.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB033370.1, BC048481.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AK050278.1         1-27
            28-947              AB033370.1         1-920
FEATURES             Location/Qualifiers
     source          1..947
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 50.9 cM"
     gene            1..947
                     /gene="Uchl3"
                     /note="ubiquitin carboxyl-terminal esterase L3 (ubiquitin
                     thiolesterase)"
                     /db_xref="GeneID:50933"
                     /db_xref="MGI:MGI:1355274"
     exon            1..139
                     /gene="Uchl3"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..790
                     /gene="Uchl3"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin thiolesterase; UCH-L3; ubiquitin
                     thioesterase L3"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase isozyme
                     L3"
                     /protein_id="NP_057932.2"
                     /db_xref="CCDS:CCDS27313.1"
                     /db_xref="GeneID:50933"
                     /db_xref="MGI:MGI:1355274"
                     /translation="MEGQRWLPLEANPEVTNQFLKQLGLHPNWQFVDVYGMEPELLSM
                     VPRPVCAVLLLFPITEKYEVFRTEEEEKIKSQGQDVTSSVYFMKQTISNACGTIGLIH
                     AIANNKDKMHFESGSTLKKFLEESVSMSPEERAKFLENYDAIRVTHETSAHEGQTEAP
                     SIDEKVDLHFIALVHVDGHLYELDGRKPFPINHGKTSDETLLEDAIEVCKKFMERDPD
                     ELRFNAIALSAA"
     exon            140..151
                     /gene="Uchl3"
                     /inference="alignment:Splign:2.1.0"
     exon            152..280
                     /gene="Uchl3"
                     /inference="alignment:Splign:2.1.0"
     exon            281..437
                     /gene="Uchl3"
                     /inference="alignment:Splign:2.1.0"
     exon            438..523
                     /gene="Uchl3"
                     /inference="alignment:Splign:2.1.0"
     exon            524..571
                     /gene="Uchl3"
                     /inference="alignment:Splign:2.1.0"
     exon            572..647
                     /gene="Uchl3"
                     /inference="alignment:Splign:2.1.0"
     exon            648..706
                     /gene="Uchl3"
                     /inference="alignment:Splign:2.1.0"
     exon            707..930
                     /gene="Uchl3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtgccggcc ggagcgcgcg ggggcggaag cggcggcggc ggcggctgcg gcggtggtgg
       61 cggctgtcag agctggagag cggccggcgg agcagtcatg gagggtcaac gctggctgcc
      121 gctggaggcc aaccctgagg tcaccaacca gtttctcaag cagttaggcc tgcatcctaa
      181 ctggcagttt gttgatgtgt acggaatgga gcctgaactt cttagcatgg taccaagacc
      241 agtatgcgca gtgttactcc tcttccctat cacagaaaag tatgaagtct tcagaacaga
      301 agaggaagaa aagataaaat ctcaaggaca agatgtgaca tcatcagtat attttatgaa
      361 acaaaccatc agcaatgcct gtggaacgat tggactaatc catgccattg cgaacaacaa
      421 agacaagatg cacttcgaat cagggtcaac attgaaaaag ttcctggagg agtctgtatc
      481 aatgagccct gaagagagag ccaaattcct ggagaactat gacgctattc gagttactca
      541 tgaaaccagt gcacatgaag gtcagactga ggcaccaagt atagatgaaa aagtagatct
      601 tcattttatt gcgttagtac atgtagatgg gcatctctat gaattagatg gacggaaacc
      661 atttccaatt aaccatggga aaactagtga tgagacgttg ttagaggatg ccatagaagt
      721 ttgcaagaag ttcatggaac gcgaccctga tgagttaaga tttaatgcaa ttgctctctc
      781 agcggcatag catcttgaca gaaacaccaa atactgtatt atttgcaaca aaagttaaat
      841 ttctgatgcc ataactaact caaaattttt aatattttca ttaacttgac taattaaact
      901 ttatgtgaat aaactttgac tctacctgta aaaaaaaaaa aaaaaaa
//
