LOCUS       NM_011670               1156 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus ubiquitin carboxy-terminal hydrolase L1 (Uchl1), mRNA.
ACCESSION   NM_011670
VERSION     NM_011670.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1156)
  AUTHORS   Luo,J., Zhang,J., Zhang,Y., Li,M., Yu,L., Song,D. and Sun,Z.
  TITLE     Genetic loss of Uchl1 leads to female infertility by affecting
            oocyte quality and follicular development
  JOURNAL   Mol Cell Endocrinol 597, 112440 (2025)
   PUBMED   39667488
REFERENCE   2  (bases 1 to 1156)
  AUTHORS   Pan,H., Song,J., An,Q., Chen,J., Zheng,W., Zhang,L., Gu,J., Deng,C.
            and Yang,B.
  TITLE     Inhibition of Ubiquitin C-Terminal Hydrolase L1 Facilitates
            Cutaneous Wound Healing via Activating TGF-beta/Smad Signalling
            Pathway in Fibroblasts
  JOURNAL   Exp Dermatol 33 (10), e15186 (2024)
   PUBMED   39367569
  REMARK    GeneRIF: Inhibition of Ubiquitin C-Terminal Hydrolase L1
            Facilitates Cutaneous Wound Healing via Activating TGF-beta/Smad
            Signalling Pathway in Fibroblasts.
REFERENCE   3  (bases 1 to 1156)
  AUTHORS   Antony,R., Aby,K., Montgomery,M. and Li,Y.
  TITLE     Skeletal Muscle UCHL1 Negatively Regulates Muscle Development and
            Recovery after Muscle Injury
  JOURNAL   Int J Mol Sci 25 (13), 7330 (2024)
   PUBMED   39000437
  REMARK    GeneRIF: Skeletal Muscle UCHL1 Negatively Regulates Muscle
            Development and Recovery after Muscle Injury.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1156)
  AUTHORS   Morikawa,M., Yoshizaki,H., Yasui,Y., Nishida,S., Saikawa,Y.,
            Kohno,M. and Okajima,H.
  TITLE     Mesenchymal cells regulate enteric neural crest cell migration via
            RET-GFRA1b trans-signaling
  JOURNAL   Biochem Biophys Res Commun 710, 149861 (2024)
   PUBMED   38581949
REFERENCE   5  (bases 1 to 1156)
  AUTHORS   Virtanen,H.T., Choopanian,P., Porokuokka,L.L., Forsgard,R.,
            Garton,D.R., Olfat,S., Korpela,R., Mirzaie,M. and Andressoo,J.O.
  TITLE     Interindividual Variation in Gut Nitrergic Neuron Density Is
            Regulated By GDNF Levels and ETV1
  JOURNAL   Cell Mol Gastroenterol Hepatol 18 (6), 101405 (2024)
   PUBMED   39299667
REFERENCE   6  (bases 1 to 1156)
  AUTHORS   Yamazaki,K., Moriya,H., Ichihara,N., Mitsushio,H., Inagaki,S. and
            Kikuchi,T.
  TITLE     Substance P-immunoreactive astrocytes in gracile sensory nervous
            tract of spinal cord in gracile axonal dystrophy mutant mouse
  JOURNAL   Mol Chem Neuropathol 20 (1), 1-20 (1993)
   PUBMED   7504492
REFERENCE   7  (bases 1 to 1156)
  AUTHORS   Yamazaki,K., Nakazawa,T., Matsunaga,M., Kumazawa,A., Kaneko,T. and
            Wakabayashi,T.
  TITLE     Behavioral study on the gracile axonal dystrophy (GAD) mutant mouse
  JOURNAL   Jikken Dobutsu 41 (4), 523-527 (1992)
   PUBMED   1451762
REFERENCE   8  (bases 1 to 1156)
  AUTHORS   Oda,K., Yamazaki,K., Miura,H., Shibasaki,H. and Kikuchi,T.
  TITLE     Dying back type axonal degeneration of sensory nerve terminals in
            muscle spindles of the gracile axonal dystrophy (GAD) mutant mouse
  JOURNAL   Neuropathol Appl Neurobiol 18 (3), 265-281 (1992)
   PUBMED   1630580
REFERENCE   9  (bases 1 to 1156)
  AUTHORS   Mukoyama,M., Yamazaki,K., Kikuchi,T. and Tomita,T.
  TITLE     Neuropathology of gracile axonal dystrophy (GAD) mouse. An animal
            model of central distal axonopathy in primary sensory neurons
  JOURNAL   Acta Neuropathol 79 (3), 294-299 (1989)
   PUBMED   2558488
REFERENCE   10 (bases 1 to 1156)
  AUTHORS   Yamazaki,K., Wakasugi,N., Tomita,T., Kikuchi,T., Mukoyama,M. and
            Ando,K.
  TITLE     Gracile axonal dystrophy (GAD), a new neurological mutant in the
            mouse
  JOURNAL   Proc Soc Exp Biol Med 187 (2), 209-215 (1988)
   PUBMED   3340629
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX241178.1, AK013729.1 and AF172334.1.
            
            On May 15, 2008 this sequence version replaced NM_011670.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF172334.1, SRR1660813.352497.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-602               CX241178.1         1-602
            603-1142            AK013729.1         483-1022
            1143-1156           AF172334.1         982-995
FEATURES             Location/Qualifiers
     source          1..1156
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 35.95 cM"
     gene            1..1156
                     /gene="Uchl1"
                     /gene_synonym="gad; PGP 9.5; PGP9.5; UCH-L1; UCHL-1"
                     /note="ubiquitin carboxy-terminal hydrolase L1"
                     /db_xref="GeneID:22223"
                     /db_xref="MGI:MGI:103149"
     exon            1..202
                     /gene="Uchl1"
                     /gene_synonym="gad; PGP 9.5; PGP9.5; UCH-L1; UCHL-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..841
                     /gene="Uchl1"
                     /gene_synonym="gad; PGP 9.5; PGP9.5; UCH-L1; UCHL-1"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin thioesterase L1; neuron cytoplasmic
                     protein 9.5; gracile axonal dystrophy; protein gene
                     product 9.5"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase isozyme
                     L1"
                     /protein_id="NP_035800.2"
                     /db_xref="CCDS:CCDS19315.1"
                     /db_xref="GeneID:22223"
                     /db_xref="MGI:MGI:103149"
                     /translation="MQLKPMEINPEMLNKVLAKLGVAGQWRFADVLGLEEETLGSVPS
                     PACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANN
                     QDKLEFEDGSVLKQFLSETEKLSPEDRAKCFEKNEAIQAAHDSVAQEGQCRVDDKVNF
                     HFILFNNVDGHLYELDGRMPFPVNHGASSEDSLLQDAAKVCREFTEREQGEVRFSAVA
                     LCKAA"
     exon            203..214
                     /gene="Uchl1"
                     /gene_synonym="gad; PGP 9.5; PGP9.5; UCH-L1; UCHL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            215..343
                     /gene="Uchl1"
                     /gene_synonym="gad; PGP 9.5; PGP9.5; UCH-L1; UCHL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            344..494
                     /gene="Uchl1"
                     /gene_synonym="gad; PGP 9.5; PGP9.5; UCH-L1; UCHL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            495..580
                     /gene="Uchl1"
                     /gene_synonym="gad; PGP 9.5; PGP9.5; UCH-L1; UCHL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            581..628
                     /gene="Uchl1"
                     /gene_synonym="gad; PGP 9.5; PGP9.5; UCH-L1; UCHL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            629..695
                     /gene="Uchl1"
                     /gene_synonym="gad; PGP 9.5; PGP9.5; UCH-L1; UCHL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            696..754
                     /gene="Uchl1"
                     /gene_synonym="gad; PGP 9.5; PGP9.5; UCH-L1; UCHL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            755..1147
                     /gene="Uchl1"
                     /gene_synonym="gad; PGP 9.5; PGP9.5; UCH-L1; UCHL-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1121..1126
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Uchl1"
                     /gene_synonym="gad; PGP 9.5; PGP9.5; UCH-L1; UCHL-1"
                     /note="hexamer: AATAAA"
     polyA_site      1144
                     /gene="Uchl1"
                     /gene_synonym="gad; PGP 9.5; PGP9.5; UCH-L1; UCHL-1"
                     /note="major polyA site"
ORIGIN      
        1 gggagttcga gccctcttgg ccttcctcct ctgcttgttt ctgctcccgt ctcccctgct
       61 caggctttcc cagtgagcga ggccggcgct ttataacagc agcctgggcg gctccaccgg
      121 ctgttttttc ggctcctcgg gtttgtgtct gcaggtgcca tccgcgaaga tgcagctgaa
      181 gccgatggag attaaccccg agatgctgaa caaagtgttg gccaagctgg gggtcgccgg
      241 ccagtggcgc ttcgccgacg tgctagggct ggaggaggag actctgggct cagtgccatc
      301 ccctgcctgc gccctgctgc tcctgtttcc cctcacggcc cagcatgaaa acttcaggaa
      361 aaagcaaatt gaggaactga agggacagga agttagccct aaagtttact tcatgaagca
      421 gaccatcgga aactcctgtg gtaccatcgg gttgatccac gcagtggcca acaaccaaga
      481 caagctggaa tttgaggatg gatccgtcct gaaacagttt ctgtctgaaa cggagaagct
      541 gtcccccgaa gatagagcca agtgtttcga gaagaacgag gccatccagg cggcccatga
      601 ctccgtggcc caggagggcc agtgtcgggt agatgacaaa gtgaatttcc attttattct
      661 gttcaacaac gtggacggcc atctgtacga gctcgatggg cgaatgccct ttccagtgaa
      721 ccatggcgcc agctcagagg actctctgct gcaggatgct gccaaggtct gcagagaatt
      781 cactgagcgc gagcaggggg aggtccgctt ctctgccgtg gctctctgca aagcagctta
      841 agtctgggga gagagaacca gccgatcccc ccttccctgg gcaggtgcgc gcggcccgcc
      901 cttggtttgc agctttagca cttagaacca cagctgtctt cttgcgttct acagccccat
      961 cccctccacc ccacccaggc caccaggggg ctctgtcaca gccacaccag gctgagcact
     1021 ttccctcctg tgtgtctcgt accttgctct ctacggtctc tttggtttct gtctgtaagt
     1081 tacggccctg gatgtggttt gtctagtcct taagaggaag aataaaactt tgctggtgag
     1141 agtatcaaaa aaaaaa
//
