LOCUS       NM_001379361            2947 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus UBX domain protein 6 (Ubxn6), transcript variant 2,
            mRNA.
ACCESSION   NM_001379361
VERSION     NM_001379361.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2947)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2947)
  AUTHORS   Bai,Y., Yu,G., Zhou,H.M., Amarasinghe,O., Zhou,Y., Zhu,P., Li,Q.,
            Zhang,L., Nguele Meke,F., Miao,Y., Chapman,E., Tao,W.A. and
            Zhang,Z.Y.
  TITLE     PTP4A2 promotes lysophagy by dephosphorylation of VCP/p97 at Tyr805
  JOURNAL   Autophagy 19 (5), 1562-1581 (2023)
   PUBMED   36300783
REFERENCE   3  (bases 1 to 2947)
  AUTHORS   Guo,X. and Qi,X.
  TITLE     VCP cooperates with UBXD1 to degrade mitochondrial outer membrane
            protein MCL1 in model of Huntington's disease
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1863 (2), 552-559 (2017)
   PUBMED   27913212
  REMARK    GeneRIF: These results indicate that the outer membrane protein
            MCL1 is degraded by the VCP-UBXD1 complex and that the process is
            promoted by the presence of mutant Huntingtin.
REFERENCE   4  (bases 1 to 2947)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Kitamura,H., Nakagawa,T., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of FLJ
            genes: the complete nucleotide sequences of 110 mouse
            FLJ-homologous cDnas identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (2), 127-135 (2004)
   PUBMED   15449545
REFERENCE   5  (bases 1 to 2947)
  AUTHORS   Carim-Todd,L., Escarceller,M., Estivill,X. and Sumoy,L.
  TITLE     Identification and characterization of UBXD1, a novel UBX
            domain-containing gene on human chromosome 19p13, and its mouse
            ortholog
  JOURNAL   Biochim Biophys Acta 1517 (2), 298-301 (2001)
   PUBMED   11342112
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT009719.10.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148170.1, BC049963.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-191               CT009719.10        119024-119214       c
            192-355             CT009719.10        117261-117424       c
            356-420             CT009719.10        116908-116972       c
            421-549             CT009719.10        116589-116717       c
            550-647             CT009719.10        115076-115173       c
            648-723             CT009719.10        114840-114915       c
            724-808             CT009719.10        113879-113963       c
            809-1028            CT009719.10        113582-113801       c
            1029-1159           CT009719.10        113372-113502       c
            1160-1308           CT009719.10        113148-113296       c
            1309-2947           CT009719.10        111233-112871       c
FEATURES             Location/Qualifiers
     source          1..2947
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.14 cM"
     gene            1..2947
                     /gene="Ubxn6"
                     /gene_synonym="1200008L11Rik; 2210415J11Rik; Ubxd1;
                     Ubxdc2"
                     /note="UBX domain protein 6"
                     /db_xref="GeneID:66530"
                     /db_xref="MGI:MGI:1913780"
     exon            1..191
                     /gene="Ubxn6"
                     /gene_synonym="1200008L11Rik; 2210415J11Rik; Ubxd1;
                     Ubxdc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1437
                     /gene="Ubxn6"
                     /gene_synonym="1200008L11Rik; 2210415J11Rik; Ubxd1;
                     Ubxdc2"
                     /note="isoform 1 is encoded by transcript variant 2; UBX
                     domain-containing protein 6; UBX domain-containing protein
                     1"
                     /codon_start=1
                     /product="UBX domain-containing protein 6 isoform 1"
                     /protein_id="NP_001366290.1"
                     /db_xref="GeneID:66530"
                     /db_xref="MGI:MGI:1913780"
                     /translation="MKKFFQEIKADIKFKSAGPGQKLTDSAGEKTTKGKSPQLALRQP
                     RQGPTDEAQMAAAAALARLEQKQPRARGPTSQDSIRNQVRKELQAEATSSNNPGAPGT
                     NSVPEPKEEISPHLAVPGVFFICPLTGVTLRRDQRDAHIKQAILSHFSTDPVAASIMK
                     IHTFNRDRDRVKLGVDTIAKYLDNIHLHPEEEKYQKIKLQNKVFQERINCLEGSHEFF
                     EAIGFKKVTLPVPDQEGQEEFYVLGEDARAQPQNLARHKQQLLDAEPVRATLDRQLRV
                     FRPSALASHFELPSDFFSLTAEEVKREQRLRTEAVERLSSLRTKAMREKEEQRELRKY
                     TYALVRVRLPDGCLLQGTFYAREKLSALFRFVREALQNDWLPFELRASGGQKLEENEA
                     LALNECGLVPSALLTFSWDASVLEDIRAAGAEPAKSVLRPELLAAIEQLS"
     exon            192..355
                     /gene="Ubxn6"
                     /gene_synonym="1200008L11Rik; 2210415J11Rik; Ubxd1;
                     Ubxdc2"
                     /inference="alignment:Splign:2.1.0"
     exon            356..420
                     /gene="Ubxn6"
                     /gene_synonym="1200008L11Rik; 2210415J11Rik; Ubxd1;
                     Ubxdc2"
                     /inference="alignment:Splign:2.1.0"
     exon            421..549
                     /gene="Ubxn6"
                     /gene_synonym="1200008L11Rik; 2210415J11Rik; Ubxd1;
                     Ubxdc2"
                     /inference="alignment:Splign:2.1.0"
     exon            550..647
                     /gene="Ubxn6"
                     /gene_synonym="1200008L11Rik; 2210415J11Rik; Ubxd1;
                     Ubxdc2"
                     /inference="alignment:Splign:2.1.0"
     exon            648..723
                     /gene="Ubxn6"
                     /gene_synonym="1200008L11Rik; 2210415J11Rik; Ubxd1;
                     Ubxdc2"
                     /inference="alignment:Splign:2.1.0"
     exon            724..808
                     /gene="Ubxn6"
                     /gene_synonym="1200008L11Rik; 2210415J11Rik; Ubxd1;
                     Ubxdc2"
                     /inference="alignment:Splign:2.1.0"
     exon            809..1028
                     /gene="Ubxn6"
                     /gene_synonym="1200008L11Rik; 2210415J11Rik; Ubxd1;
                     Ubxdc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1159
                     /gene="Ubxn6"
                     /gene_synonym="1200008L11Rik; 2210415J11Rik; Ubxd1;
                     Ubxdc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1308
                     /gene="Ubxn6"
                     /gene_synonym="1200008L11Rik; 2210415J11Rik; Ubxd1;
                     Ubxdc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..2947
                     /gene="Ubxn6"
                     /gene_synonym="1200008L11Rik; 2210415J11Rik; Ubxd1;
                     Ubxdc2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1437..1442
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ubxn6"
                     /gene_synonym="1200008L11Rik; 2210415J11Rik; Ubxd1;
                     Ubxdc2"
                     /note="hexamer: AATAAA"
     polyA_site      1462
                     /gene="Ubxn6"
                     /gene_synonym="1200008L11Rik; 2210415J11Rik; Ubxd1;
                     Ubxdc2"
                     /note="major polyA site"
     regulatory      1721..1726
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ubxn6"
                     /gene_synonym="1200008L11Rik; 2210415J11Rik; Ubxd1;
                     Ubxdc2"
                     /note="hexamer: AATAAA"
     polyA_site      1743
                     /gene="Ubxn6"
                     /gene_synonym="1200008L11Rik; 2210415J11Rik; Ubxd1;
                     Ubxdc2"
                     /note="major polyA site"
     polyA_site      2807
                     /gene="Ubxn6"
                     /gene_synonym="1200008L11Rik; 2210415J11Rik; Ubxd1;
                     Ubxdc2"
     regulatory      2928..2933
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ubxn6"
                     /gene_synonym="1200008L11Rik; 2210415J11Rik; Ubxd1;
                     Ubxdc2"
                     /note="hexamer: ATTAAA"
     polyA_site      2947
                     /gene="Ubxn6"
                     /gene_synonym="1200008L11Rik; 2210415J11Rik; Ubxd1;
                     Ubxdc2"
ORIGIN      
        1 acttccgtcg ccgcgatatt ttctttccgg tggttggccg cctgctcctc atccacccgg
       61 gccctgcgcc ctccgccctg cggcccaagc cgccgggccg ctgccgccat gaagaagttc
      121 ttccaggaaa tcaaggctga catcaagttc aagagcgcgg ggcccggcca gaagcttacg
      181 gattccgcag gggagaagac caccaaagga aagtcaccac agctggccct ccggcagccc
      241 cgtcagggcc ccactgatga ggcacagatg gctgccgctg ctgccctggc ccggctggaa
      301 cagaaacagc cccgagcccg gggccctaca tctcaggact ccatccggaa ccaggtgagg
      361 aaggaacttc aggccgaagc cacctccagc aacaatccag gagctcctgg gaccaactcg
      421 gtacctgagc ccaaggagga aatctctccc catttggcag tgcctggtgt gttcttcatc
      481 tgtccgctca caggtgtcac cctgaggagg gaccagcggg atgcccacat caagcaggcc
      541 atcctgtcgc acttttccac agaccccgtg gctgcctcca tcatgaagat acatacattc
      601 aatagagacc gggaccgagt gaagctgggt gtggatacta tcgccaaata cctggacaac
      661 atccatttac acccagagga agaaaaatac cagaaaatca aactgcagaa caaggtgttc
      721 caggagcgca tcaactgtct cgagggaagc cacgagttct ttgaagccat tggcttcaag
      781 aaggtcaccc tacctgtgcc ggatcaggag ggccaggagg agttctacgt tctgggtgag
      841 gatgcacggg cgcagccgca gaacctggcg cggcacaagc agcagctgtt ggatgccgag
      901 cctgtgcggg ccactctgga tcggcagctc cgagtcttcc gcccctcggc tctggcctca
      961 cattttgaac tcccctcaga tttcttcagc cttacagctg aggaggtgaa gcgggagcaa
     1021 aggctcagga cagaggcggt ggagcgactg agctcactca ggaccaaagc catgcgggag
     1081 aaagaggagc agcgggagct tcgcaagtat acctatgccc ttgtgcgcgt gcgcctgcca
     1141 gatggctgtc tactgcaagg gaccttctat gcccgggaga agctatccgc gctcttccga
     1201 tttgtgcgcg aggcgctaca gaacgactgg ctgccctttg agctgagggc ctccggtgga
     1261 cagaagctgg aggagaacga ggccctggcc ttgaatgagt gtgggctggt accctctgcc
     1321 ctgttgacct tctcctggga tgcttcagtg ttggaagata taagggcagc aggagctgag
     1381 ccagcaaaat ctgtcttgag gcctgagctg cttgcagcca tcgagcaact ctcctgaata
     1441 aatgcaggct tggcccactg tggctccagt ctcatgctgt tcccaaaccc attcctttcc
     1501 ctgagtcccc agcaatagga aggacagtag tagcagtaga gttggagaca aggtcctacc
     1561 tcctctgtgg gctgcaaggg acaggcttgt cctggcttgc ggtgtgtgga gccttagccc
     1621 tctggtgcca tcttggagtg cagcacaggt ggaatgcaca caggctgtgg atggagacag
     1681 ctggcagcat ggagctgtaa ttcctaagtt ataaacccca aataaacagg ctatttaaac
     1741 tcagcctccc agtgtttcat cagagccata gcaccatggc cgttgaaggg ctggcagtat
     1801 gaatctgtcc tataagtcaa ccaaccaact gtagctttag tatcattctg aggtccctgg
     1861 gtgtttcttt tctaccagca ccctagcagg cttggactgt gcccaggaca agtggaagga
     1921 catgcaccag tgtaatatga tagttgagac agaagacaga gggctcaagt agagtatgtt
     1981 tatacatgtc cacatttgcc cagggcctgc acagcagcca catcatccct agcacaattc
     2041 atagcagatg tttgcccaca gcaagtgctg tgattaaggc ccaagcaggc atctgtcaat
     2101 taagaagggc agattagcac acggacccag agtctttaca atttggaagt agctgtccag
     2161 gcctccccca gactccagac ctaggaatgt aggacaaagt gctctttatc atgagagtca
     2221 gcaggaggct cactctggtg gttgctagtc agatgctgca gggagcaggc tgttgctggt
     2281 ctccattccc atctccctca gcagctctac aaggctgagg ggaagcacag cctccactgc
     2341 ccagaacatg cctactacca accttgcact tcaggtgcct acactccact actccctgtc
     2401 acctaggtca atttccccca ggtctttcaa cttgacacct gtcacttgca aagtgtggga
     2461 gcaggtatgg gagcttctga cacgtcactc ccaacatctg gcacatctat gatcatacag
     2521 tctgtgtcat cctcttcatc ctcttctgtg tctgcctgga agccatccat gtccccagac
     2581 ccaacctgtg caaaatacag cctgtcagca tgttgaccat gtaccaccac ccccaacata
     2641 ctgtactgga cagtaattcc tggtgaaact gtctacactg ggacctattg ctgcaaaccc
     2701 agtgctaaga tgagctatgt tccaatctca aaattgccag cggcagtacc ccacagcaac
     2761 ctgaatggct tctggacttt agattcagat aaccaactga acatgcactt tcttggtctg
     2821 tctttctttt tttgtttgtt tattttttca agacagggtt tctctggcat agtcctggct
     2881 gtcctggaac tcagaagtct gcctgcctct gcctcccaag tgctgggatt aaaggtgtgt
     2941 gccacca
//
