LOCUS       NM_026534               4735 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus UBX domain protein 2B (Ubxn2b), mRNA.
ACCESSION   NM_026534
VERSION     NM_026534.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4735)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4735)
  AUTHORS   Kress,E., Schwager,F., Holtackers,R., Seiler,J., Prodon,F.,
            Zanin,E., Eiteneuer,A., Toya,M., Sugimoto,A., Meyer,H., Meraldi,P.
            and Gotta,M.
  TITLE     The UBXN-2/p37/p47 adaptors of CDC-48/p97 regulate mitosis by
            limiting the centrosomal recruitment of Aurora A
  JOURNAL   J Cell Biol 201 (4), 559-575 (2013)
   PUBMED   23649807
REFERENCE   3  (bases 1 to 4735)
  AUTHORS   Uchiyama,K., Totsukawa,G., Puhka,M., Kaneko,Y., Jokitalo,E.,
            Dreveny,I., Beuron,F., Zhang,X., Freemont,P. and Kondo,H.
  TITLE     p37 is a p97 adaptor required for Golgi and ER biogenesis in
            interphase and at the end of mitosis
  JOURNAL   Dev Cell 11 (6), 803-816 (2006)
   PUBMED   17141156
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC076632.1 and BY745604.1.
            
            On Jun 30, 2005 this sequence version replaced NM_026534.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC076632.1, SRR1660817.46493.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1575              BC076632.1         1-1575
            1576-4425           BC076632.1         1577-4426
            4426-4735           BY745604.1         281-590
FEATURES             Location/Qualifiers
     source          1..4735
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 2.91 cM"
     gene            1..4735
                     /gene="Ubxn2b"
                     /gene_synonym="3110003A22Rik; 6430407D20Rik; p37"
                     /note="UBX domain protein 2B"
                     /db_xref="GeneID:68053"
                     /db_xref="MGI:MGI:1915303"
     exon            1..109
                     /gene="Ubxn2b"
                     /gene_synonym="3110003A22Rik; 6430407D20Rik; p37"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..1021
                     /gene="Ubxn2b"
                     /gene_synonym="3110003A22Rik; 6430407D20Rik; p37"
                     /note="p97 cofactor p37; NSFL1 cofactor p37"
                     /codon_start=1
                     /product="UBX domain-containing protein 2B"
                     /protein_id="NP_080810.2"
                     /db_xref="CCDS:CCDS17949.1"
                     /db_xref="GeneID:68053"
                     /db_xref="MGI:MGI:1915303"
                     /translation="MAEGGRAEPEEQERGSSRPRPPSARDLQLALAELYEDEMKCKSS
                     KPDRSTPATCRSPRTPPHRLYSGDHKYDGLHIVQPPTGKIVNELFKEAREHGAVPLNE
                     ATRSSREDKTKSFTGGGYRLGNSFYKRSEYIYGENQLQDVQVLLKLWRNGFSLDDGEL
                     RPYSDPTNAQFLESVKRGETPLELQRLVHGAQVNLDMEDHQDQEYIKPRLRFKAFSGE
                     GQKLGSLTPEIVSTPSSPEEEDKSILNAAVLIDDSMPTTKIQIRLADGSRLVQRFNST
                     HRILDVRDFIVRSRPEFATTDFILVTSFPSKELTDETVTLQEADILNTVILQQLK"
     exon            110..213
                     /gene="Ubxn2b"
                     /gene_synonym="3110003A22Rik; 6430407D20Rik; p37"
                     /inference="alignment:Splign:2.1.0"
     exon            214..364
                     /gene="Ubxn2b"
                     /gene_synonym="3110003A22Rik; 6430407D20Rik; p37"
                     /inference="alignment:Splign:2.1.0"
     exon            365..448
                     /gene="Ubxn2b"
                     /gene_synonym="3110003A22Rik; 6430407D20Rik; p37"
                     /inference="alignment:Splign:2.1.0"
     exon            449..558
                     /gene="Ubxn2b"
                     /gene_synonym="3110003A22Rik; 6430407D20Rik; p37"
                     /inference="alignment:Splign:2.1.0"
     exon            559..696
                     /gene="Ubxn2b"
                     /gene_synonym="3110003A22Rik; 6430407D20Rik; p37"
                     /inference="alignment:Splign:2.1.0"
     exon            697..858
                     /gene="Ubxn2b"
                     /gene_synonym="3110003A22Rik; 6430407D20Rik; p37"
                     /inference="alignment:Splign:2.1.0"
     exon            859..4735
                     /gene="Ubxn2b"
                     /gene_synonym="3110003A22Rik; 6430407D20Rik; p37"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1509..1514
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ubxn2b"
                     /gene_synonym="3110003A22Rik; 6430407D20Rik; p37"
                     /note="hexamer: AATATA"
     polyA_site      1510
                     /gene="Ubxn2b"
                     /gene_synonym="3110003A22Rik; 6430407D20Rik; p37"
                     /note="major polyA site"
     polyA_site      1540
                     /gene="Ubxn2b"
                     /gene_synonym="3110003A22Rik; 6430407D20Rik; p37"
     regulatory      1548..1553
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ubxn2b"
                     /gene_synonym="3110003A22Rik; 6430407D20Rik; p37"
                     /note="hexamer: CATAAA"
     regulatory      1567..1572
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ubxn2b"
                     /gene_synonym="3110003A22Rik; 6430407D20Rik; p37"
                     /note="hexamer: GATAAA"
     polyA_site      1575
                     /gene="Ubxn2b"
                     /gene_synonym="3110003A22Rik; 6430407D20Rik; p37"
     polyA_site      1593
                     /gene="Ubxn2b"
                     /gene_synonym="3110003A22Rik; 6430407D20Rik; p37"
     regulatory      1599..1604
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ubxn2b"
                     /gene_synonym="3110003A22Rik; 6430407D20Rik; p37"
                     /note="hexamer: GATAAA"
     polyA_site      1621
                     /gene="Ubxn2b"
                     /gene_synonym="3110003A22Rik; 6430407D20Rik; p37"
     regulatory      2291..2296
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ubxn2b"
                     /gene_synonym="3110003A22Rik; 6430407D20Rik; p37"
                     /note="hexamer: AATAAA"
     polyA_site      2315
                     /gene="Ubxn2b"
                     /gene_synonym="3110003A22Rik; 6430407D20Rik; p37"
ORIGIN      
        1 ggcaggcgcc gcaagcgggt gaaagatggc ggagggtggc cgtgcggagc cggaggagca
       61 ggagcgtggg tcctccaggc cacggccccc aagtgcgcgg gacttacagt tggccttggc
      121 agaattatat gaagatgaaa tgaaatgcaa gtcttccaag cctgacagat ccacacctgc
      181 aacctgtagg agcccacgaa caccgccaca tcggctttat tcaggtgatc acaaatatga
      241 tggattacat atagttcaac ctccaactgg gaaaattgtg aatgaacttt tcaaagaggc
      301 aagggaacat ggagctgtcc ctctaaacga agccacaaga tcttcaaggg aagacaaaac
      361 taagtcattt acaggtggag gatacagatt ggggaattcc ttctacaagc gatcagagta
      421 tatctatggg gaaaatcagc tccaagatgt tcaggtttta ctgaagctgt ggcgcaatgg
      481 tttcagttta gacgatggag aattgaggcc ttacagtgac ccaacaaatg ctcagttttt
      541 ggaatctgtt aagagaggag agactcccct ggagcttcag cgactggtcc atggcgccca
      601 agtgaacctg gatatggagg atcatcaaga ccaagagtac ataaaaccca ggttgcgatt
      661 caaggctttt agtggagaag ggcaaaaact tggaagcctt acacctgaaa tcgtcagtac
      721 tccttcctcc ccagaagaag aggataaatc aatactgaat gcagctgttc ttattgatga
      781 ttcaatgccc accacaaaaa ttcagatcag gttggcagat ggaagtcgtc tcgtacagag
      841 attcaatagc acacaccgga ttctggatgt acgagacttt atagtacggt cacgtcctga
      901 atttgcgact actgacttta ttcttgtgac ttcatttcca agtaaagaac taacagatga
      961 aaccgtgaca ctacaagaag cggacattct taacactgtg atactccaac agctaaaata
     1021 gtattgctcc aacccgtgta gtggcatata ggaataggta atgttgtgtg tattagtaaa
     1081 gtacttccag cataaaacaa ccagattatt tttattattc agaaattctg gttttcctgt
     1141 tattctgtct ttcagtcttt gtctagataa atttagacta aggatagatc ttgatgtttg
     1201 aattcttagt tgtagggctg gcttgtattg atagcttata aatgtttaga tcagtcaact
     1261 tattacatgc tcagtgctaa atgtaataac attttcagat gaaatgaaca gaaccccttt
     1321 ttggtaagtg tatttgataa aatttgcact caagtttctt aatgtagcag tgaccagtag
     1381 ccagaaagga tccttctctg taatatatgc catagtgtct cccctgattt tgaaattgtt
     1441 tgttcataca acaattaaga ttttgcatat tctttttgca tattgtttaa accatgctag
     1501 taccacaaaa tatattttgt ccttgtgttt tataaaatta caactgtcat aaactgaatt
     1561 ttaatagata aaaaagtcat cagctcttgg taagatgtga taaacagcac tttagcatca
     1621 agaaattatc gtcctttcca gagcctgtct ggatcacagt tgttcactca ttcagcattt
     1681 ttatagggac tctgttacac acacaaacac cgttggaggt gtccaacaca tagtctgttc
     1741 ctcagtgtag gaactcagtc tgagagactg aagtgaaaat taccagcaag atgtttgtgt
     1801 ttccctagtc caggcacttc ttggatagct tgggaaatat caaaactgac agaaacactt
     1861 gtttgccccc tgagctcctc ctatccgtgg tcaccatttc tctgtcattt cctgttgttg
     1921 atataagaaa gtacagaatt tgtgactgaa gtagcaccgg tttagaacta tgtaagtgga
     1981 aagtgaacac gtttctctgc tagcatctag gtgttggtgg gattgcatgg tggctccaga
     2041 gaattccgcc ctggctgctc agcctccaga gaccactgtg ccccttcccc gtggtgctct
     2101 ccatcatcaa cagccagcat tgcggctctg tgacaatgat aggataggaa ggagcacagg
     2161 gcaagtcgtt ggcactgccg agtgtgaact ttatagtaac cttggtcatt cttcagagtt
     2221 gctcttctct ttggagggac tgacatgcat ttttacccga gtccacaccg tctccaagat
     2281 tcacttgcca aataaactca ccccactcac aggtgctcag gtatcccagc ctggtacatt
     2341 gattccagct ccaaaacctt acctggattt tattgactca gaagtcccaa atctcattaa
     2401 gattatctac attaagtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     2461 tgtgttgggg ggggggcggc tttgacagta caattgtctg ctcacaagtt aatggcagga
     2521 caattataaa ctatgctata aacattgacc tgtaaagggg caggaggcag tggaagcgga
     2581 gtcactggtg tcaagaacac agaatcagcc agacacacca ttcaccatct aaggccccag
     2641 gctgatgtgc agctgcacag ctcaggcctc tgagttttgg ctgtccctgt caccttcctt
     2701 tcacagaagc cactcagctc gcttcttcct tcttctatgg tactgtgtac tcttcatgct
     2761 aagatagcaa aggtctgtca agaaaccgca ggatctcctg tgagccttgg agactaggcc
     2821 cactaagtag gacacacttc caagcatctt tctgtgtaac agaaataatc ccgtctctaa
     2881 tttttacttt ttcagagaaa aaggaactgt gtcatatgca taatctcctc agagagaact
     2941 ttgactgaat atgcatacct ttttgttaga tgtgcgttgg ggtgggcaag cctgaatgtg
     3001 atggtggcca tcttcctcag tttctttcca ccttattcag gcagggtttc ccagttacaa
     3061 ccagagttca ccattgcacc tagtttggct agcctgccct agggatttcc tgtctctgtc
     3121 ttctgagtgc tggaattgta ggcaaccatc ctacccaccc cacaagacaa gcactttagc
     3181 tactgagcca tctcctctgc ccttcccctg ctctcacatt ctctaaagat ttacagtcac
     3241 ctcctcattt ctttctatac atcaggttgt cctgacagtg ctgtcatttt ttaagtgtta
     3301 gtagttgttt acatacacaa agtattctac caagccctgc tttctcttta taaatcacct
     3361 ctccacacac tgtttctgtt tactatcaaa ctctattaca actagcaaag agaacacagg
     3421 ttaacgttta cttgaaaaat tcagcttagt cttaaactca tcatacaaat tctgtttgtc
     3481 acatacctgc ccagctgcac actgtggctg tatggaatgt ctgagtctgt agccacatct
     3541 accttctggg attgtcccag cagcaggctc cacttcttcc tggttagctg gaatgtgctg
     3601 tagggaccca gggttctctg gttattgcaa ggaaatgagc tgggattttt gctttgtagt
     3661 ctttgaaaca gggtcttgct atatagtccc tggctggtct gggattcatt aggtagacca
     3721 tgctgacctc aaactcagat ctgcctgcct ctacctcctg agtgctagga ttaaagtcct
     3781 gtgtcatctg agagctaaga ttttaaatac ttgagtctgt tgcaacaaga tctctggaga
     3841 atttttctca gtcatataga aaacaaacac ttcagaatct ttcctctcac tatacagact
     3901 ctgccctgcc ccttttcctg tgttaagtac aatgtgggta acagttgtag ctcaaaagat
     3961 tactaaagcc agctgtgggc acacacgcct gatcctacca ctaaggaaag accactggag
     4021 accagcctag gctacagtat aaaactgcct tcaaaacaaa acaaaacagg aaaacacata
     4081 atttcagatg gaggaaaagt agtgccagag agatggaatc agtaggtaga gcagggatga
     4141 ggagcagaac ctgcaggccc agaatccatg tcagtcccag cagctatgtg gccacctgta
     4201 gtctcaggac ggggcaggca gaagtggtgc tgtctggaac agggggctaa ctagactggc
     4261 tggattgggt acttccagac tccgcaagag gtccttcttc aataactaga gaacaatcag
     4321 gaagtcgtgg tcagcttcag ccctctaggc acacacacac gtatgggcat acataatcct
     4381 ggggttgcct cctccccaac atacatgtgc aaaaaaaaaa aaaaagcaaa aatggagaaa
     4441 taccttaatc attggaaaca aatgggcatt acctgttttt aaaatgggaa aaaaaaatct
     4501 ctaaaccttt aaaataattt gaatttttct tgtagtgttt ttatccatta tatggaatgc
     4561 ctacaggtgc atatacaaaa aggatggctg ctgtttttgt gcacaattgt tttccaaaag
     4621 acagaggtgt gcattaggac aaagaatcga atgcctgcat ggatgacggg gactttgaca
     4681 gcgactccag tgtatgcttt attgagaatc cacatatact ctaggcacca taact
//
