LOCUS       NM_145441               4762 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus UBX domain protein 2A (Ubxn2a), mRNA.
ACCESSION   NM_145441
VERSION     NM_145441.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4762)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4762)
  AUTHORS   Sane,S., Srinivasan,R., Potts,R.A., Eikanger,M., Zagirova,D.,
            Freeling,J., Reihe,C.A., Antony,R.M., Gupta,B.K., Lynch,D.,
            Bleeker,J., Turaihi,H., Pillatzki,A., Zhou,W., Luo,X.,
            Linnebacher,M., Agany,D., Zohim,E.G., Humphrey,L.E., Black,A.R. and
            Rezvani,K.
  TITLE     UBXN2A suppresses the Rictor-mTORC2 signaling pathway, an
            established tumorigenic pathway in human colorectal cancer
  JOURNAL   Oncogene 42 (21), 1763-1776 (2023)
   PUBMED   37037900
  REMARK    GeneRIF: UBXN2A suppresses the Rictor-mTORC2 signaling pathway, an
            established tumorigenic pathway in human colorectal cancer.
REFERENCE   3  (bases 1 to 4762)
  AUTHORS   Sane,S., Hafner,A., Srinivasan,R., Masood,D., Slunecka,J.L.,
            Noldner,C.J., Hanson,A.D., Kruisselbrink,T., Wang,X., Wang,Y.,
            Yin,J. and Rezvani,K.
  TITLE     UBXN2A enhances CHIP-mediated proteasomal degradation of
            oncoprotein mortalin-2 in cancer cells
  JOURNAL   Mol Oncol 12 (10), 1753-1777 (2018)
   PUBMED   30107089
  REMARK    GeneRIF: The existence of a multiprotein complex containing UBXN2A,
            CHIP, and mot-2 suggests a synergistic tumor suppressor activity of
            UBXN2A and CHIP in mot-2-enriched tumors.
REFERENCE   4  (bases 1 to 4762)
  AUTHORS   Teng,Y., Rezvani,K. and De Biasi,M.
  TITLE     UBXN2A regulates nicotinic receptor degradation by modulating the
            E3 ligase activity of CHIP
  JOURNAL   Biochem Pharmacol 97 (4), 518-530 (2015)
   PUBMED   26265139
REFERENCE   5  (bases 1 to 4762)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 4762)
  AUTHORS   Tang,F., Barbacioru,C., Nordman,E., Bao,S., Lee,C., Wang,X.,
            Tuch,B.B., Heard,E., Lao,K. and Surani,M.A.
  TITLE     Deterministic and stochastic allele specific gene expression in
            single mouse blastomeres
  JOURNAL   PLoS One 6 (6), e21208 (2011)
   PUBMED   21731673
REFERENCE   7  (bases 1 to 4762)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   8  (bases 1 to 4762)
  AUTHORS   Rezvani,K., Teng,Y., Pan,Y., Dani,J.A., Lindstrom,J., Garcia
            Gras,E.A., McIntosh,J.M. and De Biasi,M.
  TITLE     UBXD4, a UBX-containing protein, regulates the cell surface number
            and stability of alpha3-containing nicotinic acetylcholine
            receptors
  JOURNAL   J Neurosci 29 (21), 6883-6896 (2009)
   PUBMED   19474315
REFERENCE   9  (bases 1 to 4762)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT571254.7.
            
            On Dec 6, 2019 this sequence version replaced NM_145441.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031821.1, SRR17784646.1376382.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               CT571254.7         67142-67346         c
            206-258             CT571254.7         62013-62065         c
            259-400             CT571254.7         54331-54472         c
            401-507             CT571254.7         51108-51214         c
            508-645             CT571254.7         45514-45651         c
            646-804             CT571254.7         43616-43774         c
            805-4762            CT571254.7         36607-40564         c
FEATURES             Location/Qualifiers
     source          1..4762
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 2.13 cM"
     gene            1..4762
                     /gene="Ubxn2a"
                     /gene_synonym="6330407P03Rik; Ubxd4"
                     /note="UBX domain protein 2A"
                     /db_xref="GeneID:217379"
                     /db_xref="MGI:MGI:2442310"
     exon            1..205
                     /gene="Ubxn2a"
                     /gene_synonym="6330407P03Rik; Ubxd4"
                     /inference="alignment:Splign:2.1.0"
     exon            206..258
                     /gene="Ubxn2a"
                     /gene_synonym="6330407P03Rik; Ubxd4"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..994
                     /gene="Ubxn2a"
                     /gene_synonym="6330407P03Rik; Ubxd4"
                     /note="UBX domain containing 4; UBX domain-containing
                     protein 4"
                     /codon_start=1
                     /product="UBX domain-containing protein 2A"
                     /protein_id="NP_663416.1"
                     /db_xref="CCDS:CCDS25795.1"
                     /db_xref="GeneID:217379"
                     /db_xref="MGI:MGI:2442310"
                     /translation="MKEVDNLDSIKEEWACETGPPDSQPLNDNQQKDCEYFVDSLFEE
                     AGKAGAKCLSPTEQKKQVDVNIKLWKNGFTVNDDFRSYSDGASQQFLNSIKKGELPSE
                     LWGIFDKEEVDVKVEDKKNEVCMSTKPVFQPFSGQGHRLGSATPRIVSKAKSVEVDNK
                     STLSAVSLNNLEPITRIQIWLANGERTVQRFNVSHRVSHIKDFIEKYQGSQRSPPFAL
                     ATALPFLRFLDETLTLEEADLKNAVIIQRLQKTAEPFRKL"
     exon            259..400
                     /gene="Ubxn2a"
                     /gene_synonym="6330407P03Rik; Ubxd4"
                     /inference="alignment:Splign:2.1.0"
     exon            401..507
                     /gene="Ubxn2a"
                     /gene_synonym="6330407P03Rik; Ubxd4"
                     /inference="alignment:Splign:2.1.0"
     exon            508..645
                     /gene="Ubxn2a"
                     /gene_synonym="6330407P03Rik; Ubxd4"
                     /inference="alignment:Splign:2.1.0"
     exon            646..804
                     /gene="Ubxn2a"
                     /gene_synonym="6330407P03Rik; Ubxd4"
                     /inference="alignment:Splign:2.1.0"
     exon            805..4762
                     /gene="Ubxn2a"
                     /gene_synonym="6330407P03Rik; Ubxd4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4442..4447
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ubxn2a"
                     /gene_synonym="6330407P03Rik; Ubxd4"
                     /note="hexamer: GATAAA"
     polyA_site      4463
                     /gene="Ubxn2a"
                     /gene_synonym="6330407P03Rik; Ubxd4"
                     /note="major polyA site"
     polyA_site      4597
                     /gene="Ubxn2a"
                     /gene_synonym="6330407P03Rik; Ubxd4"
     polyA_site      4648
                     /gene="Ubxn2a"
                     /gene_synonym="6330407P03Rik; Ubxd4"
     regulatory      4737..4742
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ubxn2a"
                     /gene_synonym="6330407P03Rik; Ubxd4"
                     /note="hexamer: AGTAAA"
     polyA_site      4762
                     /gene="Ubxn2a"
                     /gene_synonym="6330407P03Rik; Ubxd4"
ORIGIN      
        1 agtcaggctc gctcctccga gccgcgcgga gccggcgccg gcgcgcgccg ggcagtctga
       61 gggaggccgg tcagatctgc gcggcgaggc cgctggtcgc gacagggttt cccggcgctc
      121 cggggctgag gggcttcagc ccagcggcgc cggcgcttgc cctagccggg gcaccgagga
      181 ctaggccgtg gggccgcgcc ctgagtgcag aaagagaatg aaagaagtag ataatcttga
      241 cagtataaaa gaagaatggg cttgtgaaac aggacctcct gacagtcaac ccctcaatga
      301 taatcaacaa aaggactgtg aatattttgt tgacagcctt tttgaggaag cagggaaggc
      361 tggtgccaaa tgcttgtccc ccactgaaca gaagaaacag gtagatgtaa atataaaatt
      421 gtggaaaaac ggattcactg tcaatgatga ttttagaagt tactctgatg gtgcaagtca
      481 gcagtttctg aactccatca aaaaggggga attaccttca gaattatggg gaatttttga
      541 taaagaggag gtggatgtta aagttgaaga taagaaaaat gaagtatgta tgtctacaaa
      601 gcctgtgttc cagcccttct caggacaggg ccacagacta ggaagtgcta caccaagaat
      661 cgtttctaaa gcaaagagtg ttgaagttga caataaaagt actttgtctg ctgtttcact
      721 gaacaacttg gagcccatta ccaggatcca gatctggtta gccaatgggg aaagaactgt
      781 ccaaagattt aatgtttctc atagggtgag ccacatcaaa gacttcattg aaaaatacca
      841 aggatctcag agaagccctc cctttgccct ggcaacagct cttcctttcc tcaggtttct
      901 ggatgaaacg ctcacattgg aagaagcaga tttgaagaat gctgtaatca ttcagagact
      961 ccaaaaaact gccgagcctt ttagaaaact ttgatagttt ttatttttga gagactgaga
     1021 aaaatgatgg ttgcaagtag acatgcagag tgggagacag aagtcaatgt gactaaactt
     1081 gcggtttgag ggcttctcaa tcccttatga gggggttcag tcgtcacaag ctaggagagt
     1141 gacatggctc taagccaggg tcagtgcatt tttctcaaca ggctattcag aaaaaaatac
     1201 ctatttttca aatattagtt agccaatatg acattaaata gctgtgtcat taatcttaat
     1261 gtggtctaaa ttagcagagt attcaattag ctaaatcagc atcagcattc aaatattatc
     1321 tccaaacagc agatatttat ataaatgtta gctatctcag tttttaaata gcaatacatc
     1381 aaaatattat ccatgccata ttaaaagcat caatgtagtt attgcccgtg cttcatcctc
     1441 ggagcttttc agtttctact tgtgatggca aaagatactc aaatactcat ttggcaacag
     1501 tatccaagat gtagactctt ctcggaataa aattgtgtag cttagtataa tatcaatact
     1561 aatctatata cacagttttc tataccttct acatgtaatt ttatggactg ggaatgtagt
     1621 tcagtggtag ggattatttg ccatacatac atgagactag tttaaatcca tcccagcact
     1681 acaaaaaaat cctttcaatt tgtaatgtaa aagcacacac aaaaaaaatt cttcaaagct
     1741 gggtggtggt agtggcaaag caggccttta gtttaatcct agcactttgg aggcagaggc
     1801 aggaggatct ctgagttcaa ggacagcctg tcctacagag ctaactaact tccagggtta
     1861 cacagagaaa ccctgtctag aaaaaactat agaaaagttt tcaaatcttt actcatttaa
     1921 aaggaacttt gaaactgccc acaggtgtat gccctagctc tagctcacac caagctgaga
     1981 ggagaggagc ccaggagttt ggtcagcata agagacatag caaaaccctg tctcttgata
     2041 gtaacaacct tcccacccgg agacatagat ggctcagctg ttaagaacac tggctgcgcc
     2101 aggcggtggt ggcgcacgcc tttaatccca gcactcggga ggcagaggca ggtggatttg
     2161 tgaggccagt ctacaaagtg agttccagga cagccagggc tacacagaga aaccctctct
     2221 cgaaaaacaa acaaaaagca aaacaaacaa acaaacaaac aaaaaaacac tggctgccct
     2281 ggctgtagat ccaggttcaa tttccagcat acacatggca gtgcacagcc atatgaaact
     2341 tctgctacaa gatatccaac tccctcttct ggcctctgtg gtcactgcac tcaagttata
     2401 cgtagacata cacgcagaca aaatatcatg catattaaac taataatttt caacgagtgg
     2461 aaagatttat agagaaaggt ggtgttgtat ttccttttct ccaaaaatgt aatgtctaac
     2521 aatgaagata aagattctca cctggctggg tgtggttgta catgccttta atcccagcgc
     2581 tctggaggca gaggcaggcg gatttctgag ttcaaggaca gcctggtcta cagagtgagt
     2641 tccaggacag ccagggctat acagagaaac cctgtctcga aaaaaaaaaa caaaacaaaa
     2701 aacccacaaa agattcttac ctgtttcaca ttcactgtga tgcagtgtca cctagcttat
     2761 agtctctaga agacaacact ccatttgtgg gaatgaaaaa gaaacattta actatatgat
     2821 tagaaaagac agtttgacaa ggggtcattt gggagtcctg gccaaacatg ggaattcaca
     2881 ctgatcacaa gcccttgaga ggctgaggca ggaggattac tgtgaagtca gggccagctt
     2941 gggctacaga atgagagtct gtttcctgcc cctgtcacaa gcattgtgcg tcactgtctg
     3001 agatgggtga cagctgcact tggaaccttg agtgactcgt aggtatttgg tgtaaatgca
     3061 ggaattctac cctcgcccga gtcggcccca tatgcttcac caaggacaga gaatggctcc
     3121 acccaagtgg tttccgcggt tgagctttat ccccttgccc agtttcctca ggctctgcct
     3181 tgcctcccat ccgcccagga ggatggaaag tgtgaatgag gctttaagga agactcagga
     3241 agaacaagag ggagcctgtg tgcgtgtata actagatgtc ctttctttca gcccttcctt
     3301 gtgcaatcct gttttaaaga tgctttcttc ccaggcttcc atgccagact tctgtatttt
     3361 gggtgggctt tgtgtaatag agaatgaaag agagcatttt attttgccct ttacctatga
     3421 aatcagcatg tatataatag aaaaattaaa tatttgtcaa taacatttac acaacactat
     3481 cagagtccct tttagcaata taaacaattc attaacaaga aaggggatag taaaatcaat
     3541 ggttttattt ttcagatata ggcaaaaact tttgattgtt aatatgttca ggaatctcta
     3601 tggaaatgtt tcatataggc ctatcctgaa acctttctat ttacatagtt ataattgaca
     3661 aatggttctc catattttta tgaggaacct ctcacaagaa tgtttcttgt gtatctacaa
     3721 ataaggcctc cagtctctaa ccagaaggta aagtgggggt tcttgtgtgt ccatgtagag
     3781 tacttgccag ggaaatgttc cactaggaag gtaaagtggg ggttcttgtg tgtccgtgta
     3841 gagtacttgc cagggaaatg ttccactagg aaggtaaagt gggggttctt gtgtgtccgt
     3901 gtagagtact tgccagggaa atgttccact aggaagaaca atcatcagca ataagttgca
     3961 ttttttaaaa ctgtgaaaat gttaatgtaa ataatgtttg caaagatttc cttaaagata
     4021 atcacctgat aaatcttttt acttgaaaat tcaaaagtta taaagttgct agcatataga
     4081 ctccttatta caggttgatt ttgaaaggat aaattgccaa gggaagcaaa atttaaagta
     4141 agtgaacatc tcaggagtag aatacaggtt gacccaagtc attgctccag aattgtcata
     4201 gtccgttgtc ttgttttgca gatgagatag acattgaaat acatatctga ttgcacacat
     4261 cataatttac gagttagatt actatcacta tcacagctaa aatagccgta cttcatcacg
     4321 actcattcag caaacctcat gatgtttcca ttcattgaca atgtagtagt atgtatttat
     4381 tttagtgcct taatatattt ttgatgtatt tggctaatgg taaaatgaac tgtctcttga
     4441 agataaaatg ctgctcactg aaaggatctg tttagtgatt cacacttgtt atacgatggc
     4501 tactgggaat gctttcgtcg tgttttattt ggccgagtcc tacagtttga gaatcagtga
     4561 ttgtctggtc tagtgattat tagatgtctt ttcattagcc aatgttgttt tcatttcata
     4621 ctcagaaatg tgaagaagtg atactttagt ggctgtccaa tggttgttat ttattctttg
     4681 ccctagcatg gaggcttgtt tacagtgttc actcccttgt acatttctgc cacttcagta
     4741 aaaagatgct catcacactg ga
//
