LOCUS       NM_001362044            1154 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus UBX domain protein 1 (Ubxn1), transcript variant 2,
            mRNA.
ACCESSION   NM_001362044 XM_006526922
VERSION     NM_001362044.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1154)
  AUTHORS   Jiao,K., Xu,G., Liu,Y., Yang,Z., Xiang,L., Chen,Z., Xu,C., Zuo,Y.,
            Wu,Z., Zheng,N., Xu,W., Zhang,L. and Liu,Y.
  TITLE     UBXN1 promotes liver tumorigenesis by regulating mitochondrial
            homeostasis
  JOURNAL   J Transl Med 22 (1), 485 (2024)
   PUBMED   38773518
  REMARK    GeneRIF: UBXN1 promotes liver tumorigenesis by regulating
            mitochondrial homeostasis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1154)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1154)
  AUTHORS   Li,G., Zhao,G., Zhou,X., Schindelin,H. and Lennarz,W.J.
  TITLE     The AAA ATPase p97 links peptide N-glycanase to the endoplasmic
            reticulum-associated E3 ligase autocrine motility factor receptor
  JOURNAL   Proc Natl Acad Sci U S A 103 (22), 8348-8353 (2006)
   PUBMED   16709668
REFERENCE   4  (bases 1 to 1154)
  AUTHORS   Ishibashi,T., Ogawa,S., Hashiguchi,Y., Inoue,Y., Udo,H., Ohzono,H.,
            Kato,A., Minakami,R. and Sugiyama,H.
  TITLE     A novel protein specifically interacting with Homer2 regulates
            ubiquitin-proteasome systems
  JOURNAL   J Biochem 137 (5), 617-623 (2005)
   PUBMED   15944415
  REMARK    GeneRIF: Specific interaction of rat protein 2B28 with rat Homer2
            may play a role in regulation of protein degradation by
            ubiquitin-proteasome systems and that this function may be specific
            to Homer2 proteins among Homer family proteins.
REFERENCE   5  (bases 1 to 1154)
  AUTHORS   Park,H., Suzuki,T. and Lennarz,W.J.
  TITLE     Identification of proteins that interact with mammalian
            peptide:N-glycanase and implicate this hydrolase in the
            proteasome-dependent pathway for protein degradation
  JOURNAL   Proc Natl Acad Sci U S A 98 (20), 11163-11168 (2001)
   PUBMED   11562482
REFERENCE   6  (bases 1 to 1154)
  AUTHORS   Ko,M.S.
  TITLE     An 'equalized cDNA library' by the reassociation of short
            double-stranded cDNAs
  JOURNAL   Nucleic Acids Res 18 (19), 5705-5711 (1990)
   PUBMED   2216762
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX123666.1, BY238872.1, AK150442.1 and BY606648.1.
            
            On Mar 31, 2018 this sequence version replaced XM_006526922.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150442.1, AK159708.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 CX123666.1         47-48
            3-95                BY238872.1         1-93
            96-1136             AK150442.1         3-1043
            1137-1154           BY606648.1         353-370
FEATURES             Location/Qualifiers
     source          1..1154
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 5.88 cM"
     gene            1..1154
                     /gene="Ubxn1"
                     /gene_synonym="2B28; 4930455J02Rik; D19Ertd721e; mY33K"
                     /note="UBX domain protein 1"
                     /db_xref="GeneID:225896"
                     /db_xref="MGI:MGI:1289301"
     exon            1..209
                     /gene="Ubxn1"
                     /gene_synonym="2B28; 4930455J02Rik; D19Ertd721e; mY33K"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..1044
                     /gene="Ubxn1"
                     /gene_synonym="2B28; 4930455J02Rik; D19Ertd721e; mY33K"
                     /note="protein 2B28; SAPK substrate protein 1; UBA/UBX
                     33.3 kDa protein"
                     /codon_start=1
                     /product="UBX domain-containing protein 1"
                     /protein_id="NP_001348973.1"
                     /db_xref="CCDS:CCDS29553.1"
                     /db_xref="GeneID:225896"
                     /db_xref="MGI:MGI:1289301"
                     /translation="MAELTALESLIEMGFPRGRAEKALALTGNQGIEAAMDWLMEHED
                     DPDVDEPLETPLSHVLGREPTPSEQVGPEGSGSAAGESRPILTEEERQEQTKRMLELV
                     AQKQREREEREEREALEREKQRRRQGQELSVARQKLQEDEMRRAAEERRREKAEELAA
                     RQRVREKIERDKAERAKKYGGSVGSRSSPPATDPGPVPSSPSQEPPTKREYDQCRIQV
                     RLPDGTSLTQTFRAREQLAAVRLYVELHRGEEPGQDQDPVQLLSGFPRRAFSEADMER
                     PLQELGLVPSAVLIVAKKCPS"
     exon            210..263
                     /gene="Ubxn1"
                     /gene_synonym="2B28; 4930455J02Rik; D19Ertd721e; mY33K"
                     /inference="alignment:Splign:2.1.0"
     exon            264..370
                     /gene="Ubxn1"
                     /gene_synonym="2B28; 4930455J02Rik; D19Ertd721e; mY33K"
                     /inference="alignment:Splign:2.1.0"
     exon            371..440
                     /gene="Ubxn1"
                     /gene_synonym="2B28; 4930455J02Rik; D19Ertd721e; mY33K"
                     /inference="alignment:Splign:2.1.0"
     exon            441..632
                     /gene="Ubxn1"
                     /gene_synonym="2B28; 4930455J02Rik; D19Ertd721e; mY33K"
                     /inference="alignment:Splign:2.1.0"
     exon            633..684
                     /gene="Ubxn1"
                     /gene_synonym="2B28; 4930455J02Rik; D19Ertd721e; mY33K"
                     /inference="alignment:Splign:2.1.0"
     exon            685..801
                     /gene="Ubxn1"
                     /gene_synonym="2B28; 4930455J02Rik; D19Ertd721e; mY33K"
                     /inference="alignment:Splign:2.1.0"
     exon            802..994
                     /gene="Ubxn1"
                     /gene_synonym="2B28; 4930455J02Rik; D19Ertd721e; mY33K"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1139
                     /gene="Ubxn1"
                     /gene_synonym="2B28; 4930455J02Rik; D19Ertd721e; mY33K"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1112..1117
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ubxn1"
                     /gene_synonym="2B28; 4930455J02Rik; D19Ertd721e; mY33K"
                     /note="hexamer: AATAAA"
     polyA_site      1137
                     /gene="Ubxn1"
                     /gene_synonym="2B28; 4930455J02Rik; D19Ertd721e; mY33K"
                     /note="major polyA site"
ORIGIN      
        1 actgtctact cccccctcgt ccctgggtct cccgccccgt gagttagcga gcgccgggag
       61 ggcggcgtcg cgggcggagt cgccccgggc tgacccttgc ggtcttcctt ctggtccccg
      121 caggtccccg cggaggcgga ggcgggcgcc atggcggagc tgacggctct ggagagcctc
      181 atcgagatgg gctttcccag gggacgcgcg gagaaggctc tggccctcac agggaaccag
      241 ggcatcgagg ctgcgatgga ttggctgatg gagcatgaag acgaccccga tgtggatgag
      301 cctctggaga ctcccctcag ccatgtcctg ggacgagaac ccacgccctc agagcaagtt
      361 ggccctgaag gctctgggtc tgctgctgga gaaagcagac ccattttgac tgaagaggag
      421 agacaagaac agaccaagag aatgttggaa cttgtggcac aaaagcagcg ggaacgtgaa
      481 gaaagagagg agcgagaagc tttagaacga gaaaagcagc ggaggagaca agggcaagag
      541 ctgtcagttg cacgacagaa actgcaggaa gatgagatgc gccgggctgc ggaggagcgc
      601 aggagggaaa aggctgaaga gttagctgcc agacaaaggg ttcgagaaaa aattgaaagg
      661 gacaaagcag agagagccaa gaagtatggt ggtagtgtgg gttctcggtc atccccacca
      721 gcaacagacc caggtcctgt tccttcttct cccagccagg agccccctac taagcgggag
      781 tatgaccagt gtcgtataca ggttaggctg cctgatggga cttcactgac ccagactttc
      841 cgggcccggg aacagctggc agctgtgagg ctctacgtgg agcttcaccg tggggaggag
      901 cctggacagg accaggaccc tgtgcagttg ctcagtggct tccccagacg ggctttctca
      961 gaggctgata tggaacggcc tctgcaggaa ctgggactcg tgccttctgc tgtcctcatt
     1021 gtggccaaga agtgtcccag ctgagggttc tccatcccac catctctttc taacctcttc
     1081 atctttgata aagcactgac gtttccttcc taataaatag accctttgag ttctgtataa
     1141 aaaaaaaaaa aaaa
//
