LOCUS       NM_001404624            4463 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus upstream binding transcription factor, RNA polymerase
            I (Ubtf), transcript variant 17, mRNA.
ACCESSION   NM_001404624
VERSION     NM_001404624.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4463)
  AUTHORS   Nakagawa,S., Carnevali,D., Tan,X., Alvarez,M.J., Parfitt,D.E., Di
            Vicino,U., Arumugam,K., Shin,W., Aranda,S., Normanno,D.,
            Sebastian-Perez,R., Cannata,C., Cortes,P., Neguembor,M.V.,
            Shen,M.M., Califano,A. and Cosma,M.P.
  TITLE     The Wnt-dependent master regulator NKX1-2 controls mouse
            pre-implantation development
  JOURNAL   Stem Cell Reports 19 (5), 689-709 (2024)
   PUBMED   38701778
REFERENCE   2  (bases 1 to 4463)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4463)
  AUTHORS   Comerford,S.A., Hinnant,E.A., Chen,Y. and Hammer,R.E.
  TITLE     Hepatic ribosomal protein S6 (Rps6) insufficiency results in failed
            bile duct development and loss of hepatocyte viability; a
            ribosomopathy-like phenotype that is partially p53-dependent
  JOURNAL   PLoS Genet 19 (1), e1010595 (2023)
   PUBMED   36656901
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4463)
  AUTHORS   Hori,R.T., Moshahid Khan,M., Xiao,J., Hargrove,P.W., Moss,T. and
            LeDoux,M.S.
  TITLE     Behavioral and molecular effects of Ubtf knockout and knockdown in
            mice
  JOURNAL   Brain Res 1793, 148053 (2022)
   PUBMED   35973608
REFERENCE   5  (bases 1 to 4463)
  AUTHORS   Chomiak,A.A., Guo,Y., Kopsidas,C.A., McDaniel,D.P., Lowe,C.C.,
            Pan,H., Zhou,X., Zhou,Q., Doughty,M.L. and Feng,Y.
  TITLE     Nde1 is required for heterochromatin compaction and stability in
            neocortical neurons
  JOURNAL   iScience 25 (6), 104354 (2022)
   PUBMED   35601919
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4463)
  AUTHORS   Sutherland,H.G., Mumford,G.K., Newton,K., Ford,L.V., Farrall,R.,
            Dellaire,G., Caceres,J.F. and Bickmore,W.A.
  TITLE     Large-scale identification of mammalian proteins localized to
            nuclear sub-compartments
  JOURNAL   Hum Mol Genet 10 (18), 1995-2011 (2001)
   PUBMED   11555636
REFERENCE   7  (bases 1 to 4463)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (bases 1 to 4463)
  AUTHORS   Nagai,K.
  TITLE     Molecular evolution of Sry and Sox gene
  JOURNAL   Gene 270 (1-2), 161-169 (2001)
   PUBMED   11404013
REFERENCE   9  (bases 1 to 4463)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   10 (bases 1 to 4463)
  AUTHORS   Hisatake,K., Nishimura,T., Maeda,Y., Hanada,K., Song,C.Z. and
            Muramatsu,M.
  TITLE     Cloning and structural analysis of cDNA and the gene for mouse
            transcription factor UBF
  JOURNAL   Nucleic Acids Res 19 (17), 4631-4637 (1991)
   PUBMED   1891354
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL954730.15.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422589.454214.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN01164131,
                                           SAMN01164135 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               AL954730.15        152410-152553       c
            145-263             AL954730.15        149915-150033       c
            264-439             AL954730.15        148430-148605       c
            440-523             AL954730.15        147705-147788       c
            524-679             AL954730.15        147464-147619       c
            680-744             AL954730.15        145320-145384       c
            745-865             AL954730.15        144946-145066       c
            866-999             AL954730.15        144009-144142       c
            1000-1141           AL954730.15        143757-143898       c
            1142-1183           AL954730.15        143434-143475       c
            1184-1297           AL954730.15        143220-143333       c
            1298-1453           AL954730.15        142963-143118       c
            1454-1609           AL954730.15        142460-142615       c
            1610-1720           AL954730.15        142265-142375       c
            1721-1809           AL954730.15        141795-141883       c
            1810-1999           AL954730.15        141515-141704       c
            2000-2047           AL954730.15        140810-140857       c
            2048-2119           AL954730.15        140645-140716       c
            2120-2263           AL954730.15        140422-140565       c
            2264-4463           AL954730.15        138133-140332       c
FEATURES             Location/Qualifiers
     source          1..4463
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 66.29 cM"
     gene            1..4463
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /note="upstream binding transcription factor, RNA
                     polymerase I"
                     /db_xref="GeneID:21429"
                     /db_xref="MGI:MGI:98512"
     exon            1..144
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            145..263
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..2389
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /note="isoform 2 is encoded by transcript variant 17;
                     nucleolar transcription factor 1; upstream-binding factor
                     1; transcription factor UBF"
                     /codon_start=1
                     /product="nucleolar transcription factor 1 isoform 2"
                     /protein_id="NP_001391553.1"
                     /db_xref="GeneID:21429"
                     /db_xref="MGI:MGI:98512"
                     /translation="MNGEADCPTDLEMAAPKGQDRWSQEDMLTLLECMKNNLPSNDSS
                     KFKTTESHMDWEKVAFKDFSGDMCKLKWVEISNEVRKFRTLTELILDAQEHVKNPYKG
                     KKLKKHPDFPKKPLTPYFRFFMEKRAKYAKLHPEMSNLDLTKILSKKYKELPEKKKMK
                     YIQDFQREKQEFERNLARFREDHPDLIQNAKKSDIPEKPKTPQQLWYTHEKKVYLKVR
                     PDEIMRDYIQKHPELNISEEGITKSTLTKAERQLKDKFDGRPTKPPPNSYSLYCAELM
                     ANMKDVPSTERMVLCSQQWKLLSQKEKDAYHKKCDQKKKDYEVELLRFLESLPEEEQQ
                     RVLGEEKMLNINKKQTTSPASKKPSQEGGKGGSEKPKRPVSAMFIFSEEKRRQLQEER
                     PELSESELTRLLARMWNDLSEKKKAKYKAREAALKAQSERKPGGEREDRGKLPESPKR
                     AEEIWQQSVIGDYLARFKNDRVKALKAMEMTWNNMEKKEKLMWIKKAAEDQKRYEREL
                     SEMRAPPAATNSSKKMKFQGEPKKPPMNGYQKFSQELLSNGELNHLPLKERMVEIGSR
                     WQRISQSQKEHYKKLAEEQQRQYKVHLDLWVKSLSPQDRAAYKEYISNKRKNMTKLRG
                     PNPKSSRTTLQSKSESEEDDDEEEEDDEEEEEEEDDENGDSSEDGGDSSESSSEDESE
                     DGDENDDDDDDEDDEDDDDEDEDNESEGSSSSSSSSGDSSDSDSN"
     exon            264..439
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            440..523
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            524..679
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            680..744
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            745..865
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            866..999
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1141
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1183
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1297
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1453
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1609
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1720
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1809
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..1999
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2047
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2119
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2120..2263
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2264..4463
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3039
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /note="major polyA site"
     regulatory      4446..4451
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /note="hexamer: AATAAA"
     polyA_site      4463
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
ORIGIN      
        1 agccgtcgct ccgcttcgcc atctcgggct ttgtctggag actcgctgcc cgggcgccgg
       61 cagctgcgga gctgcggctc ggctcttccg cttgccgtgc tgcctggcgc ccccggccct
      121 cactagcacc cacttgctcg gtaagtggct ttgaccccgg gtggcccggc cagcgcgacc
      181 gaggaggtgg ctggacagct ggagaatgaa cggagaagcg gactgtccca cagacctgga
      241 aatggccgcc cccaaaggcc aagaccgctg gtcccaggaa gatatgctga ctctgctgga
      301 atgcatgaag aacaacctcc catccaacga cagctccaag ttcaaaacca cagagtcgca
      361 catggattgg gaaaaagttg cgtttaagga tttttcagga gatatgtgca agctcaaatg
      421 ggtggagatt tctaacgagg taaggaagtt ccgtacattg acagaattga tccttgatgc
      481 tcaggaacat gttaaaaacc cttacaaagg caaaaagctc aagaaacacc cggattttcc
      541 aaagaaacct ctcacccctt acttccgctt cttcatggag aagcgggcca agtacgcgaa
      601 gctccacccg gagatgagca acctggacct gactaagatc ctgtctaaga aatacaagga
      661 acttccagag aagaagaaga tgaaatatat tcaggacttc cagagggaga aacaggagtt
      721 cgagcgaaac ctggcccgat tcagggagga tcaccctgac cttatccaga atgccaagaa
      781 gtcggacatc cccgagaaac ccaaaactcc ccagcaactg tggtacaccc acgagaagaa
      841 ggtgtatctc aaagtgcggc cggatgagat tatgcgggac tatatccaga agcaccctga
      901 gctgaacatc agtgaggaag gcatcaccaa gtccaccctc accaaggccg agcgccagct
      961 caaggacaag ttcgatgggc gacctaccaa gccgcctccg aacagctact ccctgtactg
     1021 tgcggagctc atggccaaca tgaaggatgt gcccagcaca gagcgcatgg tgctatgcag
     1081 ccagcaatgg aagctgctct ctcagaagga gaaggatgcc tatcacaaga aatgtgacca
     1141 gaaaaagaaa gattatgagg tagagctgct gcggttcctt gagagcttgc cggaggaaga
     1201 gcagcagcgg gttctggggg aggagaagat gctgaacatc aataagaagc aaaccaccag
     1261 tccggcctcc aagaagcctt cacaggaagg tggcaagggt ggctccgaga agcccaagcg
     1321 gcctgtgtct gctatgttca tcttctctga ggagaagcga aggcagctac aggaggaacg
     1381 acctgagctc tccgaaagcg aactgacccg ccttctggcc cgcatgtgga acgacttgtc
     1441 cgagaagaag aaggctaaat acaaggcccg ggaggctgcg ctgaaggcgc agtctgagag
     1501 gaagccgggc ggggagcgtg aagatagggg caagctgccg gagtcgccca agagggctga
     1561 ggagatctgg cagcagagtg tcatcggaga ctatctggcc cgcttcaaga atgaccgggt
     1621 gaaagccttg aaagccatgg agatgacttg gaacaacatg gagaagaagg agaagctgat
     1681 gtggattaag aaggcagcag aagaccaaaa acgatatgag agagagttaa gtgagatgcg
     1741 ggcccctcca gctgctacaa actcttccaa gaagatgaag ttccagggag aacccaagaa
     1801 acctcctatg aacggttacc agaagttctc ccaggagctg ctgtccaatg gggagctaaa
     1861 tcacctgccg ctgaaggagc gcatggtgga gattggcagc cgctggcagc gcatctccca
     1921 gagccagaag gagcactata agaagctggc ggaggagcaa cagaggcagt acaaggtgca
     1981 cttggacctc tgggtcaaga gcctgtctcc ccaggaccgc gcagcataca aagaatacat
     2041 ctccaataaa cgtaagaaca tgaccaagct ccgaggccca aaccccaagt ctagccggac
     2101 caccctgcag tccaagtcgg agtccgagga ggatgacgat gaggaggagg aggacgacga
     2161 ggaggaggag gaagaggaag atgatgagaa cggtgactct tctgaggatg gcggggactc
     2221 ttctgagtcc agcagtgaag atgaaagcga ggatggggat gagaatgatg atgacgacga
     2281 cgatgaagat gacgaagatg acgacgatga ggatgaagac aacgagtctg agggcagtag
     2341 ctccagctct tcatcctcag gggactcttc ggattctgac tccaactgag gctcagcctc
     2401 caccccaggc aggcaggcag gcaggcagcc aaggagagag cccctgcaga gctcatctcc
     2461 ccaactgaca acctttgaca acctttgtct ctccctgtgt tctgtcccgt accctccaga
     2521 cttccccact ttctttcttt ctttcttttt tgttttttaa atcagtgggg ggtaggaggc
     2581 tgcatgagcc caagctagga ctctgcagcc ttggagcctc agctccaggg ttctccaggg
     2641 acagcaacca tcagactgag ccagcgctgg acgggcccac cctgcccctc ttctgcattt
     2701 gcagttccgg catggacaat ggactgggga gtttgggggt gggagagagt cttaaagagt
     2761 ttggtgagac ctccacacct gcagcctgca gcaaggtgga tgttcggggg gcctttcctt
     2821 cccagatggg cttgctacct ggacccccca cattgaactg gagggagaca agggtgctgc
     2881 cttcaagaaa gcaggcagtg gccctgtccc tcttccctgc ccctgcagga aggagctgcc
     2941 tggacccgtt cgtgggggag gggcagagtg tttttttata tatgtgtgta tatatttttt
     3001 ttttaagctc tgagctgtca acgagacgtt tcctaccgat ctcggctgcc gtctctgttg
     3061 tcatttctgg gactgggagg gcctgggatg gggtggattg agacttaaaa aaaaaaaaaa
     3121 ggtctaggta tgcatagaat gtgtgtgagg ctgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     3181 gtgtgtgtgt gaggctgtgt gtgtgatgtg cacacacgtg agcgagcgat acagcatgac
     3241 tgcgcctgtg gataggagag agagagaaga gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     3301 gtgtgtgtgt gtgtgtgtct agagcctgtc tctttgaatc tggaaaaagg gtcggtagag
     3361 gcctgggaga tggtgtccct agcaggaaca aaccaaggct gcccctccct gccatcttcc
     3421 attgtggggt tcagggacac cacctgatgc ttcctatact agtttgcccc tgccaaggcc
     3481 atgtccctga gctgctgcag gtctgtgctg tccagcagga aagtgggagg ggcaaaccat
     3541 ggcatgagcc ttaaagcttt tctctggtgc cctgggcttc aggaagttct tcctgccttg
     3601 ccccgtgtcc tctggccatc cccatttcct ttgagttctc aggtctgctc cctctttcct
     3661 gccgccaccc ctgtatgcag aagatgctct ctgcaactgc tcctctaact gcttgccagc
     3721 agtttgggac cttctgaaga gggtcagtcc cttgacggtg aaatcctagt cacctttacc
     3781 tgtggtgatt atcagtttta ctatgttggc cagaattttt gttcgtgcta ttgggttttg
     3841 cttcttaaat gaaagccaga ggtgggaagt aggctctcca cagaaagtag gctgcagccc
     3901 agctgccagt ccctcttgaa agcaaagaca tttgcctgga ctgtgtgatg gagattccta
     3961 aagagaagat tccctcccac cccaccccct gccctcagcg cgcgcgcacg cacacacaca
     4021 cacacacaca cacacacaca ctgtccttat tctaaaattt agtaccaggg ttttaagttc
     4081 ctgagagggc ttgcagagaa ctccatctcc ttgtttgaac accctggact gttacacttg
     4141 agtgaaatgc gttttcactt agaaacaact ttgaacagga catgtgttcc tcccactgca
     4201 agtattggaa aattcttaga ggtagggctg tgggggtggg acatgttggt gctgtcagag
     4261 gttgcccagg atatatttca gcactgggac ccttctcctt ttttctaata tttaaggagt
     4321 cttttgtagg tttcaacaac caccacactt gaatttgtac cacgggagcg gcttagacgt
     4381 gactgtccca gatcaaggcc cactgtggag gttttgtttt cccctttttt tttttttttt
     4441 tgtataataa agtgaaaaac caa
//
