LOCUS       NM_001404622            4469 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus upstream binding transcription factor, RNA polymerase
            I (Ubtf), transcript variant 15, mRNA.
ACCESSION   NM_001404622
VERSION     NM_001404622.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4469)
  AUTHORS   Nakagawa,S., Carnevali,D., Tan,X., Alvarez,M.J., Parfitt,D.E., Di
            Vicino,U., Arumugam,K., Shin,W., Aranda,S., Normanno,D.,
            Sebastian-Perez,R., Cannata,C., Cortes,P., Neguembor,M.V.,
            Shen,M.M., Califano,A. and Cosma,M.P.
  TITLE     The Wnt-dependent master regulator NKX1-2 controls mouse
            pre-implantation development
  JOURNAL   Stem Cell Reports 19 (5), 689-709 (2024)
   PUBMED   38701778
REFERENCE   2  (bases 1 to 4469)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4469)
  AUTHORS   Comerford,S.A., Hinnant,E.A., Chen,Y. and Hammer,R.E.
  TITLE     Hepatic ribosomal protein S6 (Rps6) insufficiency results in failed
            bile duct development and loss of hepatocyte viability; a
            ribosomopathy-like phenotype that is partially p53-dependent
  JOURNAL   PLoS Genet 19 (1), e1010595 (2023)
   PUBMED   36656901
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4469)
  AUTHORS   Hori,R.T., Moshahid Khan,M., Xiao,J., Hargrove,P.W., Moss,T. and
            LeDoux,M.S.
  TITLE     Behavioral and molecular effects of Ubtf knockout and knockdown in
            mice
  JOURNAL   Brain Res 1793, 148053 (2022)
   PUBMED   35973608
REFERENCE   5  (bases 1 to 4469)
  AUTHORS   Chomiak,A.A., Guo,Y., Kopsidas,C.A., McDaniel,D.P., Lowe,C.C.,
            Pan,H., Zhou,X., Zhou,Q., Doughty,M.L. and Feng,Y.
  TITLE     Nde1 is required for heterochromatin compaction and stability in
            neocortical neurons
  JOURNAL   iScience 25 (6), 104354 (2022)
   PUBMED   35601919
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4469)
  AUTHORS   Sutherland,H.G., Mumford,G.K., Newton,K., Ford,L.V., Farrall,R.,
            Dellaire,G., Caceres,J.F. and Bickmore,W.A.
  TITLE     Large-scale identification of mammalian proteins localized to
            nuclear sub-compartments
  JOURNAL   Hum Mol Genet 10 (18), 1995-2011 (2001)
   PUBMED   11555636
REFERENCE   7  (bases 1 to 4469)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (bases 1 to 4469)
  AUTHORS   Nagai,K.
  TITLE     Molecular evolution of Sry and Sox gene
  JOURNAL   Gene 270 (1-2), 161-169 (2001)
   PUBMED   11404013
REFERENCE   9  (bases 1 to 4469)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   10 (bases 1 to 4469)
  AUTHORS   Hisatake,K., Nishimura,T., Maeda,Y., Hanada,K., Song,C.Z. and
            Muramatsu,M.
  TITLE     Cloning and structural analysis of cDNA and the gene for mouse
            transcription factor UBF
  JOURNAL   Nucleic Acids Res 19 (17), 4631-4637 (1991)
   PUBMED   1891354
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL954730.15.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345560.306061.1,
                                           SRR17784645.861377.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN01164131,
                                           SAMN01164135 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               AL954730.15        152410-152553       c
            145-269             AL954730.15        149915-150039       c
            270-445             AL954730.15        148430-148605       c
            446-529             AL954730.15        147705-147788       c
            530-685             AL954730.15        147464-147619       c
            686-750             AL954730.15        145320-145384       c
            751-871             AL954730.15        144946-145066       c
            872-1005            AL954730.15        144009-144142       c
            1006-1147           AL954730.15        143757-143898       c
            1148-1189           AL954730.15        143434-143475       c
            1190-1303           AL954730.15        143220-143333       c
            1304-1459           AL954730.15        142963-143118       c
            1460-1615           AL954730.15        142460-142615       c
            1616-1726           AL954730.15        142265-142375       c
            1727-1815           AL954730.15        141795-141883       c
            1816-2005           AL954730.15        141515-141704       c
            2006-2053           AL954730.15        140810-140857       c
            2054-2125           AL954730.15        140645-140716       c
            2126-2269           AL954730.15        140422-140565       c
            2270-4469           AL954730.15        138133-140332       c
FEATURES             Location/Qualifiers
     source          1..4469
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 66.29 cM"
     gene            1..4469
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /note="upstream binding transcription factor, RNA
                     polymerase I"
                     /db_xref="GeneID:21429"
                     /db_xref="MGI:MGI:98512"
     exon            1..144
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            145..269
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..2395
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /note="isoform 2 is encoded by transcript variant 15;
                     nucleolar transcription factor 1; upstream-binding factor
                     1; transcription factor UBF"
                     /codon_start=1
                     /product="nucleolar transcription factor 1 isoform 2"
                     /protein_id="NP_001391551.1"
                     /db_xref="GeneID:21429"
                     /db_xref="MGI:MGI:98512"
                     /translation="MNGEADCPTDLEMAAPKGQDRWSQEDMLTLLECMKNNLPSNDSS
                     KFKTTESHMDWEKVAFKDFSGDMCKLKWVEISNEVRKFRTLTELILDAQEHVKNPYKG
                     KKLKKHPDFPKKPLTPYFRFFMEKRAKYAKLHPEMSNLDLTKILSKKYKELPEKKKMK
                     YIQDFQREKQEFERNLARFREDHPDLIQNAKKSDIPEKPKTPQQLWYTHEKKVYLKVR
                     PDEIMRDYIQKHPELNISEEGITKSTLTKAERQLKDKFDGRPTKPPPNSYSLYCAELM
                     ANMKDVPSTERMVLCSQQWKLLSQKEKDAYHKKCDQKKKDYEVELLRFLESLPEEEQQ
                     RVLGEEKMLNINKKQTTSPASKKPSQEGGKGGSEKPKRPVSAMFIFSEEKRRQLQEER
                     PELSESELTRLLARMWNDLSEKKKAKYKAREAALKAQSERKPGGEREDRGKLPESPKR
                     AEEIWQQSVIGDYLARFKNDRVKALKAMEMTWNNMEKKEKLMWIKKAAEDQKRYEREL
                     SEMRAPPAATNSSKKMKFQGEPKKPPMNGYQKFSQELLSNGELNHLPLKERMVEIGSR
                     WQRISQSQKEHYKKLAEEQQRQYKVHLDLWVKSLSPQDRAAYKEYISNKRKNMTKLRG
                     PNPKSSRTTLQSKSESEEDDDEEEEDDEEEEEEEDDENGDSSEDGGDSSESSSEDESE
                     DGDENDDDDDDEDDEDDDDEDEDNESEGSSSSSSSSGDSSDSDSN"
     exon            270..445
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            446..529
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            530..685
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            686..750
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            751..871
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1005
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1147
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1189
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1303
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1459
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1615
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1726
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1815
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..2005
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2053
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..2125
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2269
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2270..4469
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3045
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /note="major polyA site"
     regulatory      4452..4457
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /note="hexamer: AATAAA"
     polyA_site      4469
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
ORIGIN      
        1 agccgtcgct ccgcttcgcc atctcgggct ttgtctggag actcgctgcc cgggcgccgg
       61 cagctgcgga gctgcggctc ggctcttccg cttgccgtgc tgcctggcgc ccccggccct
      121 cactagcacc cacttgctcg gtaaggtgag gtggctttga ccccgggtgg cccggccagc
      181 gcgaccgagg aggtggctgg acagctggag aatgaacgga gaagcggact gtcccacaga
      241 cctggaaatg gccgccccca aaggccaaga ccgctggtcc caggaagata tgctgactct
      301 gctggaatgc atgaagaaca acctcccatc caacgacagc tccaagttca aaaccacaga
      361 gtcgcacatg gattgggaaa aagttgcgtt taaggatttt tcaggagata tgtgcaagct
      421 caaatgggtg gagatttcta acgaggtaag gaagttccgt acattgacag aattgatcct
      481 tgatgctcag gaacatgtta aaaaccctta caaaggcaaa aagctcaaga aacacccgga
      541 ttttccaaag aaacctctca ccccttactt ccgcttcttc atggagaagc gggccaagta
      601 cgcgaagctc cacccggaga tgagcaacct ggacctgact aagatcctgt ctaagaaata
      661 caaggaactt ccagagaaga agaagatgaa atatattcag gacttccaga gggagaaaca
      721 ggagttcgag cgaaacctgg cccgattcag ggaggatcac cctgacctta tccagaatgc
      781 caagaagtcg gacatccccg agaaacccaa aactccccag caactgtggt acacccacga
      841 gaagaaggtg tatctcaaag tgcggccgga tgagattatg cgggactata tccagaagca
      901 ccctgagctg aacatcagtg aggaaggcat caccaagtcc accctcacca aggccgagcg
      961 ccagctcaag gacaagttcg atgggcgacc taccaagccg cctccgaaca gctactccct
     1021 gtactgtgcg gagctcatgg ccaacatgaa ggatgtgccc agcacagagc gcatggtgct
     1081 atgcagccag caatggaagc tgctctctca gaaggagaag gatgcctatc acaagaaatg
     1141 tgaccagaaa aagaaagatt atgaggtaga gctgctgcgg ttccttgaga gcttgccgga
     1201 ggaagagcag cagcgggttc tgggggagga gaagatgctg aacatcaata agaagcaaac
     1261 caccagtccg gcctccaaga agccttcaca ggaaggtggc aagggtggct ccgagaagcc
     1321 caagcggcct gtgtctgcta tgttcatctt ctctgaggag aagcgaaggc agctacagga
     1381 ggaacgacct gagctctccg aaagcgaact gacccgcctt ctggcccgca tgtggaacga
     1441 cttgtccgag aagaagaagg ctaaatacaa ggcccgggag gctgcgctga aggcgcagtc
     1501 tgagaggaag ccgggcgggg agcgtgaaga taggggcaag ctgccggagt cgcccaagag
     1561 ggctgaggag atctggcagc agagtgtcat cggagactat ctggcccgct tcaagaatga
     1621 ccgggtgaaa gccttgaaag ccatggagat gacttggaac aacatggaga agaaggagaa
     1681 gctgatgtgg attaagaagg cagcagaaga ccaaaaacga tatgagagag agttaagtga
     1741 gatgcgggcc cctccagctg ctacaaactc ttccaagaag atgaagttcc agggagaacc
     1801 caagaaacct cctatgaacg gttaccagaa gttctcccag gagctgctgt ccaatgggga
     1861 gctaaatcac ctgccgctga aggagcgcat ggtggagatt ggcagccgct ggcagcgcat
     1921 ctcccagagc cagaaggagc actataagaa gctggcggag gagcaacaga ggcagtacaa
     1981 ggtgcacttg gacctctggg tcaagagcct gtctccccag gaccgcgcag catacaaaga
     2041 atacatctcc aataaacgta agaacatgac caagctccga ggcccaaacc ccaagtctag
     2101 ccggaccacc ctgcagtcca agtcggagtc cgaggaggat gacgatgagg aggaggagga
     2161 cgacgaggag gaggaggaag aggaagatga tgagaacggt gactcttctg aggatggcgg
     2221 ggactcttct gagtccagca gtgaagatga aagcgaggat ggggatgaga atgatgatga
     2281 cgacgacgat gaagatgacg aagatgacga cgatgaggat gaagacaacg agtctgaggg
     2341 cagtagctcc agctcttcat cctcagggga ctcttcggat tctgactcca actgaggctc
     2401 agcctccacc ccaggcaggc aggcaggcag gcagccaagg agagagcccc tgcagagctc
     2461 atctccccaa ctgacaacct ttgacaacct ttgtctctcc ctgtgttctg tcccgtaccc
     2521 tccagacttc cccactttct ttctttcttt cttttttgtt ttttaaatca gtggggggta
     2581 ggaggctgca tgagcccaag ctaggactct gcagccttgg agcctcagct ccagggttct
     2641 ccagggacag caaccatcag actgagccag cgctggacgg gcccaccctg cccctcttct
     2701 gcatttgcag ttccggcatg gacaatggac tggggagttt gggggtggga gagagtctta
     2761 aagagtttgg tgagacctcc acacctgcag cctgcagcaa ggtggatgtt cggggggcct
     2821 ttccttccca gatgggcttg ctacctggac cccccacatt gaactggagg gagacaaggg
     2881 tgctgccttc aagaaagcag gcagtggccc tgtccctctt ccctgcccct gcaggaagga
     2941 gctgcctgga cccgttcgtg ggggaggggc agagtgtttt tttatatatg tgtgtatata
     3001 tttttttttt aagctctgag ctgtcaacga gacgtttcct accgatctcg gctgccgtct
     3061 ctgttgtcat ttctgggact gggagggcct gggatggggt ggattgagac ttaaaaaaaa
     3121 aaaaaaggtc taggtatgca tagaatgtgt gtgaggctgt gtgtgtgtgt gtgtgtgtgt
     3181 gtgtgtgtgt gtgtgtgagg ctgtgtgtgt gatgtgcaca cacgtgagcg agcgatacag
     3241 catgactgcg cctgtggata ggagagagag agaagagtgt gtgtgtgtgt gtgtgtgtgt
     3301 gtgtgtgtgt gtgtgtgtgt gtgtctagag cctgtctctt tgaatctgga aaaagggtcg
     3361 gtagaggcct gggagatggt gtccctagca ggaacaaacc aaggctgccc ctccctgcca
     3421 tcttccattg tggggttcag ggacaccacc tgatgcttcc tatactagtt tgcccctgcc
     3481 aaggccatgt ccctgagctg ctgcaggtct gtgctgtcca gcaggaaagt gggaggggca
     3541 aaccatggca tgagccttaa agcttttctc tggtgccctg ggcttcagga agttcttcct
     3601 gccttgcccc gtgtcctctg gccatcccca tttcctttga gttctcaggt ctgctccctc
     3661 tttcctgccg ccacccctgt atgcagaaga tgctctctgc aactgctcct ctaactgctt
     3721 gccagcagtt tgggaccttc tgaagagggt cagtcccttg acggtgaaat cctagtcacc
     3781 tttacctgtg gtgattatca gttttactat gttggccaga atttttgttc gtgctattgg
     3841 gttttgcttc ttaaatgaaa gccagaggtg ggaagtaggc tctccacaga aagtaggctg
     3901 cagcccagct gccagtccct cttgaaagca aagacatttg cctggactgt gtgatggaga
     3961 ttcctaaaga gaagattccc tcccacccca ccccctgccc tcagcgcgcg cgcacgcaca
     4021 cacacacaca cacacacaca cacacactgt ccttattcta aaatttagta ccagggtttt
     4081 aagttcctga gagggcttgc agagaactcc atctccttgt ttgaacaccc tggactgtta
     4141 cacttgagtg aaatgcgttt tcacttagaa acaactttga acaggacatg tgttcctccc
     4201 actgcaagta ttggaaaatt cttagaggta gggctgtggg ggtgggacat gttggtgctg
     4261 tcagaggttg cccaggatat atttcagcac tgggaccctt ctcctttttt ctaatattta
     4321 aggagtcttt tgtaggtttc aacaaccacc acacttgaat ttgtaccacg ggagcggctt
     4381 agacgtgact gtcccagatc aaggcccact gtggaggttt tgttttcccc tttttttttt
     4441 tttttttgta taataaagtg aaaaaccaa
//
