LOCUS       NM_001362549            4365 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus upstream binding transcription factor, RNA polymerase
            I (Ubtf), transcript variant 9, mRNA.
ACCESSION   NM_001362549
VERSION     NM_001362549.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4365)
  AUTHORS   Nakagawa,S., Carnevali,D., Tan,X., Alvarez,M.J., Parfitt,D.E., Di
            Vicino,U., Arumugam,K., Shin,W., Aranda,S., Normanno,D.,
            Sebastian-Perez,R., Cannata,C., Cortes,P., Neguembor,M.V.,
            Shen,M.M., Califano,A. and Cosma,M.P.
  TITLE     The Wnt-dependent master regulator NKX1-2 controls mouse
            pre-implantation development
  JOURNAL   Stem Cell Reports 19 (5), 689-709 (2024)
   PUBMED   38701778
REFERENCE   2  (bases 1 to 4365)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4365)
  AUTHORS   Comerford,S.A., Hinnant,E.A., Chen,Y. and Hammer,R.E.
  TITLE     Hepatic ribosomal protein S6 (Rps6) insufficiency results in failed
            bile duct development and loss of hepatocyte viability; a
            ribosomopathy-like phenotype that is partially p53-dependent
  JOURNAL   PLoS Genet 19 (1), e1010595 (2023)
   PUBMED   36656901
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4365)
  AUTHORS   Hori,R.T., Moshahid Khan,M., Xiao,J., Hargrove,P.W., Moss,T. and
            LeDoux,M.S.
  TITLE     Behavioral and molecular effects of Ubtf knockout and knockdown in
            mice
  JOURNAL   Brain Res 1793, 148053 (2022)
   PUBMED   35973608
REFERENCE   5  (bases 1 to 4365)
  AUTHORS   Chomiak,A.A., Guo,Y., Kopsidas,C.A., McDaniel,D.P., Lowe,C.C.,
            Pan,H., Zhou,X., Zhou,Q., Doughty,M.L. and Feng,Y.
  TITLE     Nde1 is required for heterochromatin compaction and stability in
            neocortical neurons
  JOURNAL   iScience 25 (6), 104354 (2022)
   PUBMED   35601919
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4365)
  AUTHORS   Sutherland,H.G., Mumford,G.K., Newton,K., Ford,L.V., Farrall,R.,
            Dellaire,G., Caceres,J.F. and Bickmore,W.A.
  TITLE     Large-scale identification of mammalian proteins localized to
            nuclear sub-compartments
  JOURNAL   Hum Mol Genet 10 (18), 1995-2011 (2001)
   PUBMED   11555636
REFERENCE   7  (bases 1 to 4365)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (bases 1 to 4365)
  AUTHORS   Nagai,K.
  TITLE     Molecular evolution of Sry and Sox gene
  JOURNAL   Gene 270 (1-2), 161-169 (2001)
   PUBMED   11404013
REFERENCE   9  (bases 1 to 4365)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   10 (bases 1 to 4365)
  AUTHORS   Hisatake,K., Nishimura,T., Maeda,Y., Hanada,K., Song,C.Z. and
            Muramatsu,M.
  TITLE     Cloning and structural analysis of cDNA and the gene for mouse
            transcription factor UBF
  JOURNAL   Nucleic Acids Res 19 (17), 4631-4637 (1991)
   PUBMED   1891354
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL954730.15.
            
            On Apr 12, 2022 this sequence version replaced NM_001362549.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.70841.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-351               AL954730.15        149915-150265       c
            352-527             AL954730.15        148430-148605       c
            528-611             AL954730.15        147705-147788       c
            612-767             AL954730.15        147464-147619       c
            768-901             AL954730.15        144009-144142       c
            902-1043            AL954730.15        143757-143898       c
            1044-1085           AL954730.15        143434-143475       c
            1086-1199           AL954730.15        143220-143333       c
            1200-1355           AL954730.15        142963-143118       c
            1356-1511           AL954730.15        142460-142615       c
            1512-1622           AL954730.15        142265-142375       c
            1623-1711           AL954730.15        141795-141883       c
            1712-1901           AL954730.15        141515-141704       c
            1902-1949           AL954730.15        140810-140857       c
            1950-2021           AL954730.15        140645-140716       c
            2022-2165           AL954730.15        140422-140565       c
            2166-4365           AL954730.15        138133-140332       c
FEATURES             Location/Qualifiers
     source          1..4365
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 66.29 cM"
     gene            1..4365
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /note="upstream binding transcription factor, RNA
                     polymerase I"
                     /db_xref="GeneID:21429"
                     /db_xref="MGI:MGI:98512"
     exon            1..351
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             294..2291
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /note="isoform 4 is encoded by transcript variant 9;
                     nucleolar transcription factor 1; upstream-binding factor
                     1; transcription factor UBF"
                     /codon_start=1
                     /product="nucleolar transcription factor 1 isoform 4"
                     /protein_id="NP_001349478.1"
                     /db_xref="GeneID:21429"
                     /db_xref="MGI:MGI:98512"
                     /translation="MNGEADCPTDLEMAAPKGQDRWSQEDMLTLLECMKNNLPSNDSS
                     KFKTTESHMDWEKVAFKDFSGDMCKLKWVEISNEVRKFRTLTELILDAQEHVKNPYKG
                     KKLKKHPDFPKKPLTPYFRFFMEKRAKYAKLHPEMSNLDLTKILSKKYKELPEKKKEI
                     MRDYIQKHPELNISEEGITKSTLTKAERQLKDKFDGRPTKPPPNSYSLYCAELMANMK
                     DVPSTERMVLCSQQWKLLSQKEKDAYHKKCDQKKKDYEVELLRFLESLPEEEQQRVLG
                     EEKMLNINKKQTTSPASKKPSQEGGKGGSEKPKRPVSAMFIFSEEKRRQLQEERPELS
                     ESELTRLLARMWNDLSEKKKAKYKAREAALKAQSERKPGGEREDRGKLPESPKRAEEI
                     WQQSVIGDYLARFKNDRVKALKAMEMTWNNMEKKEKLMWIKKAAEDQKRYERELSEMR
                     APPAATNSSKKMKFQGEPKKPPMNGYQKFSQELLSNGELNHLPLKERMVEIGSRWQRI
                     SQSQKEHYKKLAEEQQRQYKVHLDLWVKSLSPQDRAAYKEYISNKRKNMTKLRGPNPK
                     SSRTTLQSKSESEEDDDEEEEDDEEEEEEEDDENGDSSEDGGDSSESSSEDESEDGDE
                     NDDDDDDEDDEDDDDEDEDNESEGSSSSSSSSGDSSDSDSN"
     exon            352..527
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            528..611
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            612..767
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            768..901
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1043
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1085
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1199
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1355
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1511
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1622
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1711
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1901
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..1949
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2021
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2165
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..4365
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2941
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /note="major polyA site"
     regulatory      4348..4353
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /note="hexamer: AATAAA"
     polyA_site      4365
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
ORIGIN      
        1 agtctctcgc gtgggcaggg gagggcgcat gcggcaccgc ctggctctgg gggctggggt
       61 agagaagagt ggggctcact cctgcaccca ctgatgaagt ctatgagcct cctgttcggg
      121 tctcgctgag agtgtggacc tatgccccct cccatgtgtg agggggtggg atagaaagcc
      181 cccctcctct cagcctcctt aagtgggttt ggtgtctctt caaaagggtg aggtggcttt
      241 gaccccgggt ggcccggcca gcgcgaccga ggaggtggct ggacagctgg agaatgaacg
      301 gagaagcgga ctgtcccaca gacctggaaa tggccgcccc caaaggccaa gaccgctggt
      361 cccaggaaga tatgctgact ctgctggaat gcatgaagaa caacctccca tccaacgaca
      421 gctccaagtt caaaaccaca gagtcgcaca tggattggga aaaagttgcg tttaaggatt
      481 tttcaggaga tatgtgcaag ctcaaatggg tggagatttc taacgaggta aggaagttcc
      541 gtacattgac agaattgatc cttgatgctc aggaacatgt taaaaaccct tacaaaggca
      601 aaaagctcaa gaaacacccg gattttccaa agaaacctct caccccttac ttccgcttct
      661 tcatggagaa gcgggccaag tacgcgaagc tccacccgga gatgagcaac ctggacctga
      721 ctaagatcct gtctaagaaa tacaaggaac ttccagagaa gaagaaggag attatgcggg
      781 actatatcca gaagcaccct gagctgaaca tcagtgagga aggcatcacc aagtccaccc
      841 tcaccaaggc cgagcgccag ctcaaggaca agttcgatgg gcgacctacc aagccgcctc
      901 cgaacagcta ctccctgtac tgtgcggagc tcatggccaa catgaaggat gtgcccagca
      961 cagagcgcat ggtgctatgc agccagcaat ggaagctgct ctctcagaag gagaaggatg
     1021 cctatcacaa gaaatgtgac cagaaaaaga aagattatga ggtagagctg ctgcggttcc
     1081 ttgagagctt gccggaggaa gagcagcagc gggttctggg ggaggagaag atgctgaaca
     1141 tcaataagaa gcaaaccacc agtccggcct ccaagaagcc ttcacaggaa ggtggcaagg
     1201 gtggctccga gaagcccaag cggcctgtgt ctgctatgtt catcttctct gaggagaagc
     1261 gaaggcagct acaggaggaa cgacctgagc tctccgaaag cgaactgacc cgccttctgg
     1321 cccgcatgtg gaacgacttg tccgagaaga agaaggctaa atacaaggcc cgggaggctg
     1381 cgctgaaggc gcagtctgag aggaagccgg gcggggagcg tgaagatagg ggcaagctgc
     1441 cggagtcgcc caagagggct gaggagatct ggcagcagag tgtcatcgga gactatctgg
     1501 cccgcttcaa gaatgaccgg gtgaaagcct tgaaagccat ggagatgact tggaacaaca
     1561 tggagaagaa ggagaagctg atgtggatta agaaggcagc agaagaccaa aaacgatatg
     1621 agagagagtt aagtgagatg cgggcccctc cagctgctac aaactcttcc aagaagatga
     1681 agttccaggg agaacccaag aaacctccta tgaacggtta ccagaagttc tcccaggagc
     1741 tgctgtccaa tggggagcta aatcacctgc cgctgaagga gcgcatggtg gagattggca
     1801 gccgctggca gcgcatctcc cagagccaga aggagcacta taagaagctg gcggaggagc
     1861 aacagaggca gtacaaggtg cacttggacc tctgggtcaa gagcctgtct ccccaggacc
     1921 gcgcagcata caaagaatac atctccaata aacgtaagaa catgaccaag ctccgaggcc
     1981 caaaccccaa gtctagccgg accaccctgc agtccaagtc ggagtccgag gaggatgacg
     2041 atgaggagga ggaggacgac gaggaggagg aggaagagga agatgatgag aacggtgact
     2101 cttctgagga tggcggggac tcttctgagt ccagcagtga agatgaaagc gaggatgggg
     2161 atgagaatga tgatgacgac gacgatgaag atgacgaaga tgacgacgat gaggatgaag
     2221 acaacgagtc tgagggcagt agctccagct cttcatcctc aggggactct tcggattctg
     2281 actccaactg aggctcagcc tccaccccag gcaggcaggc aggcaggcag ccaaggagag
     2341 agcccctgca gagctcatct ccccaactga caacctttga caacctttgt ctctccctgt
     2401 gttctgtccc gtaccctcca gacttcccca ctttctttct ttctttcttt tttgtttttt
     2461 aaatcagtgg ggggtaggag gctgcatgag cccaagctag gactctgcag ccttggagcc
     2521 tcagctccag ggttctccag ggacagcaac catcagactg agccagcgct ggacgggccc
     2581 accctgcccc tcttctgcat ttgcagttcc ggcatggaca atggactggg gagtttgggg
     2641 gtgggagaga gtcttaaaga gtttggtgag acctccacac ctgcagcctg cagcaaggtg
     2701 gatgttcggg gggcctttcc ttcccagatg ggcttgctac ctggaccccc cacattgaac
     2761 tggagggaga caagggtgct gccttcaaga aagcaggcag tggccctgtc cctcttccct
     2821 gcccctgcag gaaggagctg cctggacccg ttcgtggggg aggggcagag tgttttttta
     2881 tatatgtgtg tatatatttt ttttttaagc tctgagctgt caacgagacg tttcctaccg
     2941 atctcggctg ccgtctctgt tgtcatttct gggactggga gggcctggga tggggtggat
     3001 tgagacttaa aaaaaaaaaa aaggtctagg tatgcataga atgtgtgtga ggctgtgtgt
     3061 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgaggctgt gtgtgtgatg tgcacacacg
     3121 tgagcgagcg atacagcatg actgcgcctg tggataggag agagagagaa gagtgtgtgt
     3181 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt ctagagcctg tctctttgaa
     3241 tctggaaaaa gggtcggtag aggcctggga gatggtgtcc ctagcaggaa caaaccaagg
     3301 ctgcccctcc ctgccatctt ccattgtggg gttcagggac accacctgat gcttcctata
     3361 ctagtttgcc cctgccaagg ccatgtccct gagctgctgc aggtctgtgc tgtccagcag
     3421 gaaagtggga ggggcaaacc atggcatgag ccttaaagct tttctctggt gccctgggct
     3481 tcaggaagtt cttcctgcct tgccccgtgt cctctggcca tccccatttc ctttgagttc
     3541 tcaggtctgc tccctctttc ctgccgccac ccctgtatgc agaagatgct ctctgcaact
     3601 gctcctctaa ctgcttgcca gcagtttggg accttctgaa gagggtcagt cccttgacgg
     3661 tgaaatccta gtcaccttta cctgtggtga ttatcagttt tactatgttg gccagaattt
     3721 ttgttcgtgc tattgggttt tgcttcttaa atgaaagcca gaggtgggaa gtaggctctc
     3781 cacagaaagt aggctgcagc ccagctgcca gtccctcttg aaagcaaaga catttgcctg
     3841 gactgtgtga tggagattcc taaagagaag attccctccc accccacccc ctgccctcag
     3901 cgcgcgcgca cgcacacaca cacacacaca cacacacaca cactgtcctt attctaaaat
     3961 ttagtaccag ggttttaagt tcctgagagg gcttgcagag aactccatct ccttgtttga
     4021 acaccctgga ctgttacact tgagtgaaat gcgttttcac ttagaaacaa ctttgaacag
     4081 gacatgtgtt cctcccactg caagtattgg aaaattctta gaggtagggc tgtgggggtg
     4141 ggacatgttg gtgctgtcag aggttgccca ggatatattt cagcactggg acccttctcc
     4201 ttttttctaa tatttaagga gtcttttgta ggtttcaaca accaccacac ttgaatttgt
     4261 accacgggag cggcttagac gtgactgtcc cagatcaagg cccactgtgg aggttttgtt
     4321 ttcccctttt tttttttttt tttgtataat aaagtgaaaa accaa
//
