LOCUS       NM_001362548            4546 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus upstream binding transcription factor, RNA polymerase
            I (Ubtf), transcript variant 8, mRNA.
ACCESSION   NM_001362548 XM_011248891
VERSION     NM_001362548.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4546)
  AUTHORS   Nakagawa,S., Carnevali,D., Tan,X., Alvarez,M.J., Parfitt,D.E., Di
            Vicino,U., Arumugam,K., Shin,W., Aranda,S., Normanno,D.,
            Sebastian-Perez,R., Cannata,C., Cortes,P., Neguembor,M.V.,
            Shen,M.M., Califano,A. and Cosma,M.P.
  TITLE     The Wnt-dependent master regulator NKX1-2 controls mouse
            pre-implantation development
  JOURNAL   Stem Cell Reports 19 (5), 689-709 (2024)
   PUBMED   38701778
REFERENCE   2  (bases 1 to 4546)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4546)
  AUTHORS   Comerford,S.A., Hinnant,E.A., Chen,Y. and Hammer,R.E.
  TITLE     Hepatic ribosomal protein S6 (Rps6) insufficiency results in failed
            bile duct development and loss of hepatocyte viability; a
            ribosomopathy-like phenotype that is partially p53-dependent
  JOURNAL   PLoS Genet 19 (1), e1010595 (2023)
   PUBMED   36656901
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4546)
  AUTHORS   Hori,R.T., Moshahid Khan,M., Xiao,J., Hargrove,P.W., Moss,T. and
            LeDoux,M.S.
  TITLE     Behavioral and molecular effects of Ubtf knockout and knockdown in
            mice
  JOURNAL   Brain Res 1793, 148053 (2022)
   PUBMED   35973608
REFERENCE   5  (bases 1 to 4546)
  AUTHORS   Chomiak,A.A., Guo,Y., Kopsidas,C.A., McDaniel,D.P., Lowe,C.C.,
            Pan,H., Zhou,X., Zhou,Q., Doughty,M.L. and Feng,Y.
  TITLE     Nde1 is required for heterochromatin compaction and stability in
            neocortical neurons
  JOURNAL   iScience 25 (6), 104354 (2022)
   PUBMED   35601919
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4546)
  AUTHORS   Sutherland,H.G., Mumford,G.K., Newton,K., Ford,L.V., Farrall,R.,
            Dellaire,G., Caceres,J.F. and Bickmore,W.A.
  TITLE     Large-scale identification of mammalian proteins localized to
            nuclear sub-compartments
  JOURNAL   Hum Mol Genet 10 (18), 1995-2011 (2001)
   PUBMED   11555636
REFERENCE   7  (bases 1 to 4546)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (bases 1 to 4546)
  AUTHORS   Nagai,K.
  TITLE     Molecular evolution of Sry and Sox gene
  JOURNAL   Gene 270 (1-2), 161-169 (2001)
   PUBMED   11404013
REFERENCE   9  (bases 1 to 4546)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   10 (bases 1 to 4546)
  AUTHORS   Hisatake,K., Nishimura,T., Maeda,Y., Hanada,K., Song,C.Z. and
            Muramatsu,M.
  TITLE     Cloning and structural analysis of cDNA and the gene for mouse
            transcription factor UBF
  JOURNAL   Nucleic Acids Res 19 (17), 4631-4637 (1991)
   PUBMED   1891354
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL954730.15.
            
            On Apr 12, 2022 this sequence version replaced NM_001362548.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3058189.1,
                                           SRR7652917.934237.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-221               AL954730.15        151148-151368       c
            222-346             AL954730.15        149915-150039       c
            347-522             AL954730.15        148430-148605       c
            523-606             AL954730.15        147705-147788       c
            607-762             AL954730.15        147464-147619       c
            763-827             AL954730.15        145320-145384       c
            828-948             AL954730.15        144946-145066       c
            949-1082            AL954730.15        144009-144142       c
            1083-1224           AL954730.15        143757-143898       c
            1225-1266           AL954730.15        143434-143475       c
            1267-1380           AL954730.15        143220-143333       c
            1381-1536           AL954730.15        142963-143118       c
            1537-1692           AL954730.15        142460-142615       c
            1693-1803           AL954730.15        142265-142375       c
            1804-1892           AL954730.15        141795-141883       c
            1893-2082           AL954730.15        141515-141704       c
            2083-2130           AL954730.15        140810-140857       c
            2131-2202           AL954730.15        140645-140716       c
            2203-2346           AL954730.15        140422-140565       c
            2347-4546           AL954730.15        138133-140332       c
FEATURES             Location/Qualifiers
     source          1..4546
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 66.29 cM"
     gene            1..4546
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /note="upstream binding transcription factor, RNA
                     polymerase I"
                     /db_xref="GeneID:21429"
                     /db_xref="MGI:MGI:98512"
     exon            1..221
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            222..346
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             289..2472
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /note="isoform 2 is encoded by transcript variant 8;
                     nucleolar transcription factor 1; upstream-binding factor
                     1; transcription factor UBF"
                     /codon_start=1
                     /product="nucleolar transcription factor 1 isoform 2"
                     /protein_id="NP_001349477.1"
                     /db_xref="CCDS:CCDS36343.1"
                     /db_xref="GeneID:21429"
                     /db_xref="MGI:MGI:98512"
                     /translation="MNGEADCPTDLEMAAPKGQDRWSQEDMLTLLECMKNNLPSNDSS
                     KFKTTESHMDWEKVAFKDFSGDMCKLKWVEISNEVRKFRTLTELILDAQEHVKNPYKG
                     KKLKKHPDFPKKPLTPYFRFFMEKRAKYAKLHPEMSNLDLTKILSKKYKELPEKKKMK
                     YIQDFQREKQEFERNLARFREDHPDLIQNAKKSDIPEKPKTPQQLWYTHEKKVYLKVR
                     PDEIMRDYIQKHPELNISEEGITKSTLTKAERQLKDKFDGRPTKPPPNSYSLYCAELM
                     ANMKDVPSTERMVLCSQQWKLLSQKEKDAYHKKCDQKKKDYEVELLRFLESLPEEEQQ
                     RVLGEEKMLNINKKQTTSPASKKPSQEGGKGGSEKPKRPVSAMFIFSEEKRRQLQEER
                     PELSESELTRLLARMWNDLSEKKKAKYKAREAALKAQSERKPGGEREDRGKLPESPKR
                     AEEIWQQSVIGDYLARFKNDRVKALKAMEMTWNNMEKKEKLMWIKKAAEDQKRYEREL
                     SEMRAPPAATNSSKKMKFQGEPKKPPMNGYQKFSQELLSNGELNHLPLKERMVEIGSR
                     WQRISQSQKEHYKKLAEEQQRQYKVHLDLWVKSLSPQDRAAYKEYISNKRKNMTKLRG
                     PNPKSSRTTLQSKSESEEDDDEEEEDDEEEEEEEDDENGDSSEDGGDSSESSSEDESE
                     DGDENDDDDDDEDDEDDDDEDEDNESEGSSSSSSSSGDSSDSDSN"
     exon            347..522
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            523..606
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            607..762
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            763..827
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            828..948
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1082
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1224
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1266
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1380
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1536
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1692
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1803
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1892
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..2082
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2130
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2202
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2203..2346
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2347..4546
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3122
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /note="major polyA site"
     regulatory      4529..4534
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /note="hexamer: AATAAA"
     polyA_site      4546
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
ORIGIN      
        1 gtgcttttcg ccgcgaggag cagcaggcag cagccacagc cgccgccgcc acagcagcag
       61 cagcagccgc cgccccagcg ccgccgccgc gcccggagga ggagccgctg ccgccgcggg
      121 agggagttgc ggctgtgccc ggccgagcgg gggagggcgc cgcgctcaga gccgagaagg
      181 gagccgccgg agcggggagc tcagaggccg cgctgcgccg gggtgaggtg gctttgaccc
      241 cgggtggccc ggccagcgcg accgaggagg tggctggaca gctggagaat gaacggagaa
      301 gcggactgtc ccacagacct ggaaatggcc gcccccaaag gccaagaccg ctggtcccag
      361 gaagatatgc tgactctgct ggaatgcatg aagaacaacc tcccatccaa cgacagctcc
      421 aagttcaaaa ccacagagtc gcacatggat tgggaaaaag ttgcgtttaa ggatttttca
      481 ggagatatgt gcaagctcaa atgggtggag atttctaacg aggtaaggaa gttccgtaca
      541 ttgacagaat tgatccttga tgctcaggaa catgttaaaa acccttacaa aggcaaaaag
      601 ctcaagaaac acccggattt tccaaagaaa cctctcaccc cttacttccg cttcttcatg
      661 gagaagcggg ccaagtacgc gaagctccac ccggagatga gcaacctgga cctgactaag
      721 atcctgtcta agaaatacaa ggaacttcca gagaagaaga agatgaaata tattcaggac
      781 ttccagaggg agaaacagga gttcgagcga aacctggccc gattcaggga ggatcaccct
      841 gaccttatcc agaatgccaa gaagtcggac atccccgaga aacccaaaac tccccagcaa
      901 ctgtggtaca cccacgagaa gaaggtgtat ctcaaagtgc ggccggatga gattatgcgg
      961 gactatatcc agaagcaccc tgagctgaac atcagtgagg aaggcatcac caagtccacc
     1021 ctcaccaagg ccgagcgcca gctcaaggac aagttcgatg ggcgacctac caagccgcct
     1081 ccgaacagct actccctgta ctgtgcggag ctcatggcca acatgaagga tgtgcccagc
     1141 acagagcgca tggtgctatg cagccagcaa tggaagctgc tctctcagaa ggagaaggat
     1201 gcctatcaca agaaatgtga ccagaaaaag aaagattatg aggtagagct gctgcggttc
     1261 cttgagagct tgccggagga agagcagcag cgggttctgg gggaggagaa gatgctgaac
     1321 atcaataaga agcaaaccac cagtccggcc tccaagaagc cttcacagga aggtggcaag
     1381 ggtggctccg agaagcccaa gcggcctgtg tctgctatgt tcatcttctc tgaggagaag
     1441 cgaaggcagc tacaggagga acgacctgag ctctccgaaa gcgaactgac ccgccttctg
     1501 gcccgcatgt ggaacgactt gtccgagaag aagaaggcta aatacaaggc ccgggaggct
     1561 gcgctgaagg cgcagtctga gaggaagccg ggcggggagc gtgaagatag gggcaagctg
     1621 ccggagtcgc ccaagagggc tgaggagatc tggcagcaga gtgtcatcgg agactatctg
     1681 gcccgcttca agaatgaccg ggtgaaagcc ttgaaagcca tggagatgac ttggaacaac
     1741 atggagaaga aggagaagct gatgtggatt aagaaggcag cagaagacca aaaacgatat
     1801 gagagagagt taagtgagat gcgggcccct ccagctgcta caaactcttc caagaagatg
     1861 aagttccagg gagaacccaa gaaacctcct atgaacggtt accagaagtt ctcccaggag
     1921 ctgctgtcca atggggagct aaatcacctg ccgctgaagg agcgcatggt ggagattggc
     1981 agccgctggc agcgcatctc ccagagccag aaggagcact ataagaagct ggcggaggag
     2041 caacagaggc agtacaaggt gcacttggac ctctgggtca agagcctgtc tccccaggac
     2101 cgcgcagcat acaaagaata catctccaat aaacgtaaga acatgaccaa gctccgaggc
     2161 ccaaacccca agtctagccg gaccaccctg cagtccaagt cggagtccga ggaggatgac
     2221 gatgaggagg aggaggacga cgaggaggag gaggaagagg aagatgatga gaacggtgac
     2281 tcttctgagg atggcgggga ctcttctgag tccagcagtg aagatgaaag cgaggatggg
     2341 gatgagaatg atgatgacga cgacgatgaa gatgacgaag atgacgacga tgaggatgaa
     2401 gacaacgagt ctgagggcag tagctccagc tcttcatcct caggggactc ttcggattct
     2461 gactccaact gaggctcagc ctccacccca ggcaggcagg caggcaggca gccaaggaga
     2521 gagcccctgc agagctcatc tccccaactg acaacctttg acaacctttg tctctccctg
     2581 tgttctgtcc cgtaccctcc agacttcccc actttctttc tttctttctt ttttgttttt
     2641 taaatcagtg gggggtagga ggctgcatga gcccaagcta ggactctgca gccttggagc
     2701 ctcagctcca gggttctcca gggacagcaa ccatcagact gagccagcgc tggacgggcc
     2761 caccctgccc ctcttctgca tttgcagttc cggcatggac aatggactgg ggagtttggg
     2821 ggtgggagag agtcttaaag agtttggtga gacctccaca cctgcagcct gcagcaaggt
     2881 ggatgttcgg ggggcctttc cttcccagat gggcttgcta cctggacccc ccacattgaa
     2941 ctggagggag acaagggtgc tgccttcaag aaagcaggca gtggccctgt ccctcttccc
     3001 tgcccctgca ggaaggagct gcctggaccc gttcgtgggg gaggggcaga gtgttttttt
     3061 atatatgtgt gtatatattt tttttttaag ctctgagctg tcaacgagac gtttcctacc
     3121 gatctcggct gccgtctctg ttgtcatttc tgggactggg agggcctggg atggggtgga
     3181 ttgagactta aaaaaaaaaa aaaggtctag gtatgcatag aatgtgtgtg aggctgtgtg
     3241 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgaggctg tgtgtgtgat gtgcacacac
     3301 gtgagcgagc gatacagcat gactgcgcct gtggatagga gagagagaga agagtgtgtg
     3361 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tctagagcct gtctctttga
     3421 atctggaaaa agggtcggta gaggcctggg agatggtgtc cctagcagga acaaaccaag
     3481 gctgcccctc cctgccatct tccattgtgg ggttcaggga caccacctga tgcttcctat
     3541 actagtttgc ccctgccaag gccatgtccc tgagctgctg caggtctgtg ctgtccagca
     3601 ggaaagtggg aggggcaaac catggcatga gccttaaagc ttttctctgg tgccctgggc
     3661 ttcaggaagt tcttcctgcc ttgccccgtg tcctctggcc atccccattt cctttgagtt
     3721 ctcaggtctg ctccctcttt cctgccgcca cccctgtatg cagaagatgc tctctgcaac
     3781 tgctcctcta actgcttgcc agcagtttgg gaccttctga agagggtcag tcccttgacg
     3841 gtgaaatcct agtcaccttt acctgtggtg attatcagtt ttactatgtt ggccagaatt
     3901 tttgttcgtg ctattgggtt ttgcttctta aatgaaagcc agaggtggga agtaggctct
     3961 ccacagaaag taggctgcag cccagctgcc agtccctctt gaaagcaaag acatttgcct
     4021 ggactgtgtg atggagattc ctaaagagaa gattccctcc caccccaccc cctgccctca
     4081 gcgcgcgcgc acgcacacac acacacacac acacacacac acactgtcct tattctaaaa
     4141 tttagtacca gggttttaag ttcctgagag ggcttgcaga gaactccatc tccttgtttg
     4201 aacaccctgg actgttacac ttgagtgaaa tgcgttttca cttagaaaca actttgaaca
     4261 ggacatgtgt tcctcccact gcaagtattg gaaaattctt agaggtaggg ctgtgggggt
     4321 gggacatgtt ggtgctgtca gaggttgccc aggatatatt tcagcactgg gacccttctc
     4381 cttttttcta atatttaagg agtcttttgt aggtttcaac aaccaccaca cttgaatttg
     4441 taccacggga gcggcttaga cgtgactgtc ccagatcaag gcccactgtg gaggttttgt
     4501 tttccccttt tttttttttt ttttgtataa taaagtgaaa aaccaa
//
