LOCUS       NM_001362545            4662 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus upstream binding transcription factor, RNA polymerase
            I (Ubtf), transcript variant 6, mRNA.
ACCESSION   NM_001362545
VERSION     NM_001362545.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4662)
  AUTHORS   Nakagawa,S., Carnevali,D., Tan,X., Alvarez,M.J., Parfitt,D.E., Di
            Vicino,U., Arumugam,K., Shin,W., Aranda,S., Normanno,D.,
            Sebastian-Perez,R., Cannata,C., Cortes,P., Neguembor,M.V.,
            Shen,M.M., Califano,A. and Cosma,M.P.
  TITLE     The Wnt-dependent master regulator NKX1-2 controls mouse
            pre-implantation development
  JOURNAL   Stem Cell Reports 19 (5), 689-709 (2024)
   PUBMED   38701778
REFERENCE   2  (bases 1 to 4662)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4662)
  AUTHORS   Comerford,S.A., Hinnant,E.A., Chen,Y. and Hammer,R.E.
  TITLE     Hepatic ribosomal protein S6 (Rps6) insufficiency results in failed
            bile duct development and loss of hepatocyte viability; a
            ribosomopathy-like phenotype that is partially p53-dependent
  JOURNAL   PLoS Genet 19 (1), e1010595 (2023)
   PUBMED   36656901
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4662)
  AUTHORS   Hori,R.T., Moshahid Khan,M., Xiao,J., Hargrove,P.W., Moss,T. and
            LeDoux,M.S.
  TITLE     Behavioral and molecular effects of Ubtf knockout and knockdown in
            mice
  JOURNAL   Brain Res 1793, 148053 (2022)
   PUBMED   35973608
REFERENCE   5  (bases 1 to 4662)
  AUTHORS   Chomiak,A.A., Guo,Y., Kopsidas,C.A., McDaniel,D.P., Lowe,C.C.,
            Pan,H., Zhou,X., Zhou,Q., Doughty,M.L. and Feng,Y.
  TITLE     Nde1 is required for heterochromatin compaction and stability in
            neocortical neurons
  JOURNAL   iScience 25 (6), 104354 (2022)
   PUBMED   35601919
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4662)
  AUTHORS   Sutherland,H.G., Mumford,G.K., Newton,K., Ford,L.V., Farrall,R.,
            Dellaire,G., Caceres,J.F. and Bickmore,W.A.
  TITLE     Large-scale identification of mammalian proteins localized to
            nuclear sub-compartments
  JOURNAL   Hum Mol Genet 10 (18), 1995-2011 (2001)
   PUBMED   11555636
REFERENCE   7  (bases 1 to 4662)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (bases 1 to 4662)
  AUTHORS   Nagai,K.
  TITLE     Molecular evolution of Sry and Sox gene
  JOURNAL   Gene 270 (1-2), 161-169 (2001)
   PUBMED   11404013
REFERENCE   9  (bases 1 to 4662)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   10 (bases 1 to 4662)
  AUTHORS   Hisatake,K., Nishimura,T., Maeda,Y., Hanada,K., Song,C.Z. and
            Muramatsu,M.
  TITLE     Cloning and structural analysis of cDNA and the gene for mouse
            transcription factor UBF
  JOURNAL   Nucleic Acids Res 19 (17), 4631-4637 (1991)
   PUBMED   1891354
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL954730.15.
            
            On Apr 12, 2022 this sequence version replaced NM_001362545.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X60831.1, SRR13422600.1088450.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-351               AL954730.15        149915-150265       c
            352-527             AL954730.15        148430-148605       c
            528-611             AL954730.15        147705-147788       c
            612-767             AL954730.15        147464-147619       c
            768-832             AL954730.15        145320-145384       c
            833-953             AL954730.15        144946-145066       c
            954-1064            AL954730.15        144492-144602       c
            1065-1198           AL954730.15        144009-144142       c
            1199-1340           AL954730.15        143757-143898       c
            1341-1382           AL954730.15        143434-143475       c
            1383-1496           AL954730.15        143220-143333       c
            1497-1652           AL954730.15        142963-143118       c
            1653-1808           AL954730.15        142460-142615       c
            1809-1919           AL954730.15        142265-142375       c
            1920-2008           AL954730.15        141795-141883       c
            2009-2198           AL954730.15        141515-141704       c
            2199-2246           AL954730.15        140810-140857       c
            2247-2318           AL954730.15        140645-140716       c
            2319-2462           AL954730.15        140422-140565       c
            2463-4662           AL954730.15        138133-140332       c
FEATURES             Location/Qualifiers
     source          1..4662
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 66.29 cM"
     gene            1..4662
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /note="upstream binding transcription factor, RNA
                     polymerase I"
                     /db_xref="GeneID:21429"
                     /db_xref="MGI:MGI:98512"
     exon            1..351
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             294..2588
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /note="isoform 1 is encoded by transcript variant 6;
                     nucleolar transcription factor 1; upstream-binding factor
                     1; transcription factor UBF"
                     /codon_start=1
                     /product="nucleolar transcription factor 1 isoform 1"
                     /protein_id="NP_001349474.1"
                     /db_xref="CCDS:CCDS25495.1"
                     /db_xref="GeneID:21429"
                     /db_xref="MGI:MGI:98512"
                     /translation="MNGEADCPTDLEMAAPKGQDRWSQEDMLTLLECMKNNLPSNDSS
                     KFKTTESHMDWEKVAFKDFSGDMCKLKWVEISNEVRKFRTLTELILDAQEHVKNPYKG
                     KKLKKHPDFPKKPLTPYFRFFMEKRAKYAKLHPEMSNLDLTKILSKKYKELPEKKKMK
                     YIQDFQREKQEFERNLARFREDHPDLIQNAKKSDIPEKPKTPQQLWYTHEKKVYLKVR
                     PDATTKEVKDSLGKQWSQLSDKKRLKWIHKALEQRKEYEEIMRDYIQKHPELNISEEG
                     ITKSTLTKAERQLKDKFDGRPTKPPPNSYSLYCAELMANMKDVPSTERMVLCSQQWKL
                     LSQKEKDAYHKKCDQKKKDYEVELLRFLESLPEEEQQRVLGEEKMLNINKKQTTSPAS
                     KKPSQEGGKGGSEKPKRPVSAMFIFSEEKRRQLQEERPELSESELTRLLARMWNDLSE
                     KKKAKYKAREAALKAQSERKPGGEREDRGKLPESPKRAEEIWQQSVIGDYLARFKNDR
                     VKALKAMEMTWNNMEKKEKLMWIKKAAEDQKRYERELSEMRAPPAATNSSKKMKFQGE
                     PKKPPMNGYQKFSQELLSNGELNHLPLKERMVEIGSRWQRISQSQKEHYKKLAEEQQR
                     QYKVHLDLWVKSLSPQDRAAYKEYISNKRKNMTKLRGPNPKSSRTTLQSKSESEEDDD
                     EEEEDDEEEEEEEDDENGDSSEDGGDSSESSSEDESEDGDENDDDDDDEDDEDDDDED
                     EDNESEGSSSSSSSSGDSSDSDSN"
     exon            352..527
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            528..611
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            612..767
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            768..832
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            833..953
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1064
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1198
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1340
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1382
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1496
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1652
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1808
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1919
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..2008
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2198
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2246
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2318
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2319..2462
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2463..4662
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3238
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /note="major polyA site"
     regulatory      4645..4650
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /note="hexamer: AATAAA"
     polyA_site      4662
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
ORIGIN      
        1 agtctctcgc gtgggcaggg gagggcgcat gcggcaccgc ctggctctgg gggctggggt
       61 agagaagagt ggggctcact cctgcaccca ctgatgaagt ctatgagcct cctgttcggg
      121 tctcgctgag agtgtggacc tatgccccct cccatgtgtg agggggtggg atagaaagcc
      181 cccctcctct cagcctcctt aagtgggttt ggtgtctctt caaaagggtg aggtggcttt
      241 gaccccgggt ggcccggcca gcgcgaccga ggaggtggct ggacagctgg agaatgaacg
      301 gagaagcgga ctgtcccaca gacctggaaa tggccgcccc caaaggccaa gaccgctggt
      361 cccaggaaga tatgctgact ctgctggaat gcatgaagaa caacctccca tccaacgaca
      421 gctccaagtt caaaaccaca gagtcgcaca tggattggga aaaagttgcg tttaaggatt
      481 tttcaggaga tatgtgcaag ctcaaatggg tggagatttc taacgaggta aggaagttcc
      541 gtacattgac agaattgatc cttgatgctc aggaacatgt taaaaaccct tacaaaggca
      601 aaaagctcaa gaaacacccg gattttccaa agaaacctct caccccttac ttccgcttct
      661 tcatggagaa gcgggccaag tacgcgaagc tccacccgga gatgagcaac ctggacctga
      721 ctaagatcct gtctaagaaa tacaaggaac ttccagagaa gaagaagatg aaatatattc
      781 aggacttcca gagggagaaa caggagttcg agcgaaacct ggcccgattc agggaggatc
      841 accctgacct tatccagaat gccaagaagt cggacatccc cgagaaaccc aaaactcccc
      901 agcaactgtg gtacacccac gagaagaagg tgtatctcaa agtgcggccg gatgccacta
      961 cgaaggaggt gaaggactcc ctggggaagc agtggtctca gctctcggac aaaaagaggc
     1021 tgaaatggat tcataaggcc ctggagcagc ggaaggagta cgaggagatt atgcgggact
     1081 atatccagaa gcaccctgag ctgaacatca gtgaggaagg catcaccaag tccaccctca
     1141 ccaaggccga gcgccagctc aaggacaagt tcgatgggcg acctaccaag ccgcctccga
     1201 acagctactc cctgtactgt gcggagctca tggccaacat gaaggatgtg cccagcacag
     1261 agcgcatggt gctatgcagc cagcaatgga agctgctctc tcagaaggag aaggatgcct
     1321 atcacaagaa atgtgaccag aaaaagaaag attatgaggt agagctgctg cggttccttg
     1381 agagcttgcc ggaggaagag cagcagcggg ttctggggga ggagaagatg ctgaacatca
     1441 ataagaagca aaccaccagt ccggcctcca agaagccttc acaggaaggt ggcaagggtg
     1501 gctccgagaa gcccaagcgg cctgtgtctg ctatgttcat cttctctgag gagaagcgaa
     1561 ggcagctaca ggaggaacga cctgagctct ccgaaagcga actgacccgc cttctggccc
     1621 gcatgtggaa cgacttgtcc gagaagaaga aggctaaata caaggcccgg gaggctgcgc
     1681 tgaaggcgca gtctgagagg aagccgggcg gggagcgtga agataggggc aagctgccgg
     1741 agtcgcccaa gagggctgag gagatctggc agcagagtgt catcggagac tatctggccc
     1801 gcttcaagaa tgaccgggtg aaagccttga aagccatgga gatgacttgg aacaacatgg
     1861 agaagaagga gaagctgatg tggattaaga aggcagcaga agaccaaaaa cgatatgaga
     1921 gagagttaag tgagatgcgg gcccctccag ctgctacaaa ctcttccaag aagatgaagt
     1981 tccagggaga acccaagaaa cctcctatga acggttacca gaagttctcc caggagctgc
     2041 tgtccaatgg ggagctaaat cacctgccgc tgaaggagcg catggtggag attggcagcc
     2101 gctggcagcg catctcccag agccagaagg agcactataa gaagctggcg gaggagcaac
     2161 agaggcagta caaggtgcac ttggacctct gggtcaagag cctgtctccc caggaccgcg
     2221 cagcatacaa agaatacatc tccaataaac gtaagaacat gaccaagctc cgaggcccaa
     2281 accccaagtc tagccggacc accctgcagt ccaagtcgga gtccgaggag gatgacgatg
     2341 aggaggagga ggacgacgag gaggaggagg aagaggaaga tgatgagaac ggtgactctt
     2401 ctgaggatgg cggggactct tctgagtcca gcagtgaaga tgaaagcgag gatggggatg
     2461 agaatgatga tgacgacgac gatgaagatg acgaagatga cgacgatgag gatgaagaca
     2521 acgagtctga gggcagtagc tccagctctt catcctcagg ggactcttcg gattctgact
     2581 ccaactgagg ctcagcctcc accccaggca ggcaggcagg caggcagcca aggagagagc
     2641 ccctgcagag ctcatctccc caactgacaa cctttgacaa cctttgtctc tccctgtgtt
     2701 ctgtcccgta ccctccagac ttccccactt tctttctttc tttctttttt gttttttaaa
     2761 tcagtggggg gtaggaggct gcatgagccc aagctaggac tctgcagcct tggagcctca
     2821 gctccagggt tctccaggga cagcaaccat cagactgagc cagcgctgga cgggcccacc
     2881 ctgcccctct tctgcatttg cagttccggc atggacaatg gactggggag tttgggggtg
     2941 ggagagagtc ttaaagagtt tggtgagacc tccacacctg cagcctgcag caaggtggat
     3001 gttcgggggg cctttccttc ccagatgggc ttgctacctg gaccccccac attgaactgg
     3061 agggagacaa gggtgctgcc ttcaagaaag caggcagtgg ccctgtccct cttccctgcc
     3121 cctgcaggaa ggagctgcct ggacccgttc gtgggggagg ggcagagtgt ttttttatat
     3181 atgtgtgtat atattttttt tttaagctct gagctgtcaa cgagacgttt cctaccgatc
     3241 tcggctgccg tctctgttgt catttctggg actgggaggg cctgggatgg ggtggattga
     3301 gacttaaaaa aaaaaaaaag gtctaggtat gcatagaatg tgtgtgaggc tgtgtgtgtg
     3361 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg aggctgtgtg tgtgatgtgc acacacgtga
     3421 gcgagcgata cagcatgact gcgcctgtgg ataggagaga gagagaagag tgtgtgtgtg
     3481 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtcta gagcctgtct ctttgaatct
     3541 ggaaaaaggg tcggtagagg cctgggagat ggtgtcccta gcaggaacaa accaaggctg
     3601 cccctccctg ccatcttcca ttgtggggtt cagggacacc acctgatgct tcctatacta
     3661 gtttgcccct gccaaggcca tgtccctgag ctgctgcagg tctgtgctgt ccagcaggaa
     3721 agtgggaggg gcaaaccatg gcatgagcct taaagctttt ctctggtgcc ctgggcttca
     3781 ggaagttctt cctgccttgc cccgtgtcct ctggccatcc ccatttcctt tgagttctca
     3841 ggtctgctcc ctctttcctg ccgccacccc tgtatgcaga agatgctctc tgcaactgct
     3901 cctctaactg cttgccagca gtttgggacc ttctgaagag ggtcagtccc ttgacggtga
     3961 aatcctagtc acctttacct gtggtgatta tcagttttac tatgttggcc agaatttttg
     4021 ttcgtgctat tgggttttgc ttcttaaatg aaagccagag gtgggaagta ggctctccac
     4081 agaaagtagg ctgcagccca gctgccagtc cctcttgaaa gcaaagacat ttgcctggac
     4141 tgtgtgatgg agattcctaa agagaagatt ccctcccacc ccaccccctg ccctcagcgc
     4201 gcgcgcacgc acacacacac acacacacac acacacacac tgtccttatt ctaaaattta
     4261 gtaccagggt tttaagttcc tgagagggct tgcagagaac tccatctcct tgtttgaaca
     4321 ccctggactg ttacacttga gtgaaatgcg ttttcactta gaaacaactt tgaacaggac
     4381 atgtgttcct cccactgcaa gtattggaaa attcttagag gtagggctgt gggggtggga
     4441 catgttggtg ctgtcagagg ttgcccagga tatatttcag cactgggacc cttctccttt
     4501 tttctaatat ttaaggagtc ttttgtaggt ttcaacaacc accacacttg aatttgtacc
     4561 acgggagcgg cttagacgtg actgtcccag atcaaggccc actgtggagg ttttgttttc
     4621 cccttttttt tttttttttt gtataataaa gtgaaaaacc aa
//
