LOCUS       NM_001302954            4465 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus upstream binding transcription factor, RNA polymerase
            I (Ubtf), transcript variant 3, mRNA.
ACCESSION   NM_001302954
VERSION     NM_001302954.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4465)
  AUTHORS   Nakagawa,S., Carnevali,D., Tan,X., Alvarez,M.J., Parfitt,D.E., Di
            Vicino,U., Arumugam,K., Shin,W., Aranda,S., Normanno,D.,
            Sebastian-Perez,R., Cannata,C., Cortes,P., Neguembor,M.V.,
            Shen,M.M., Califano,A. and Cosma,M.P.
  TITLE     The Wnt-dependent master regulator NKX1-2 controls mouse
            pre-implantation development
  JOURNAL   Stem Cell Reports 19 (5), 689-709 (2024)
   PUBMED   38701778
REFERENCE   2  (bases 1 to 4465)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4465)
  AUTHORS   Comerford,S.A., Hinnant,E.A., Chen,Y. and Hammer,R.E.
  TITLE     Hepatic ribosomal protein S6 (Rps6) insufficiency results in failed
            bile duct development and loss of hepatocyte viability; a
            ribosomopathy-like phenotype that is partially p53-dependent
  JOURNAL   PLoS Genet 19 (1), e1010595 (2023)
   PUBMED   36656901
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4465)
  AUTHORS   Hori,R.T., Moshahid Khan,M., Xiao,J., Hargrove,P.W., Moss,T. and
            LeDoux,M.S.
  TITLE     Behavioral and molecular effects of Ubtf knockout and knockdown in
            mice
  JOURNAL   Brain Res 1793, 148053 (2022)
   PUBMED   35973608
REFERENCE   5  (bases 1 to 4465)
  AUTHORS   Chomiak,A.A., Guo,Y., Kopsidas,C.A., McDaniel,D.P., Lowe,C.C.,
            Pan,H., Zhou,X., Zhou,Q., Doughty,M.L. and Feng,Y.
  TITLE     Nde1 is required for heterochromatin compaction and stability in
            neocortical neurons
  JOURNAL   iScience 25 (6), 104354 (2022)
   PUBMED   35601919
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4465)
  AUTHORS   Sutherland,H.G., Mumford,G.K., Newton,K., Ford,L.V., Farrall,R.,
            Dellaire,G., Caceres,J.F. and Bickmore,W.A.
  TITLE     Large-scale identification of mammalian proteins localized to
            nuclear sub-compartments
  JOURNAL   Hum Mol Genet 10 (18), 1995-2011 (2001)
   PUBMED   11555636
REFERENCE   7  (bases 1 to 4465)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (bases 1 to 4465)
  AUTHORS   Nagai,K.
  TITLE     Molecular evolution of Sry and Sox gene
  JOURNAL   Gene 270 (1-2), 161-169 (2001)
   PUBMED   11404013
REFERENCE   9  (bases 1 to 4465)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   10 (bases 1 to 4465)
  AUTHORS   Hisatake,K., Nishimura,T., Maeda,Y., Hanada,K., Song,C.Z. and
            Muramatsu,M.
  TITLE     Cloning and structural analysis of cDNA and the gene for mouse
            transcription factor UBF
  JOURNAL   Nucleic Acids Res 19 (17), 4631-4637 (1991)
   PUBMED   1891354
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL954730.15.
            
            On Apr 12, 2022 this sequence version replaced NM_001302954.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK128947.1, SRR13422600.2014070.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               AL954730.15        152414-152553       c
            141-265             AL954730.15        149915-150039       c
            266-441             AL954730.15        148430-148605       c
            442-525             AL954730.15        147705-147788       c
            526-681             AL954730.15        147464-147619       c
            682-746             AL954730.15        145320-145384       c
            747-867             AL954730.15        144946-145066       c
            868-1001            AL954730.15        144009-144142       c
            1002-1143           AL954730.15        143757-143898       c
            1144-1185           AL954730.15        143434-143475       c
            1186-1299           AL954730.15        143220-143333       c
            1300-1455           AL954730.15        142963-143118       c
            1456-1611           AL954730.15        142460-142615       c
            1612-1722           AL954730.15        142265-142375       c
            1723-1811           AL954730.15        141795-141883       c
            1812-2001           AL954730.15        141515-141704       c
            2002-2049           AL954730.15        140810-140857       c
            2050-2121           AL954730.15        140645-140716       c
            2122-2265           AL954730.15        140422-140565       c
            2266-4465           AL954730.15        138133-140332       c
FEATURES             Location/Qualifiers
     source          1..4465
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 66.29 cM"
     gene            1..4465
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /note="upstream binding transcription factor, RNA
                     polymerase I"
                     /db_xref="GeneID:21429"
                     /db_xref="MGI:MGI:98512"
     exon            1..140
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            141..265
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..2391
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /note="isoform 2 is encoded by transcript variant 3;
                     nucleolar transcription factor 1; upstream-binding factor
                     1; transcription factor UBF"
                     /codon_start=1
                     /product="nucleolar transcription factor 1 isoform 2"
                     /protein_id="NP_001289883.1"
                     /db_xref="CCDS:CCDS36343.1"
                     /db_xref="GeneID:21429"
                     /db_xref="MGI:MGI:98512"
                     /translation="MNGEADCPTDLEMAAPKGQDRWSQEDMLTLLECMKNNLPSNDSS
                     KFKTTESHMDWEKVAFKDFSGDMCKLKWVEISNEVRKFRTLTELILDAQEHVKNPYKG
                     KKLKKHPDFPKKPLTPYFRFFMEKRAKYAKLHPEMSNLDLTKILSKKYKELPEKKKMK
                     YIQDFQREKQEFERNLARFREDHPDLIQNAKKSDIPEKPKTPQQLWYTHEKKVYLKVR
                     PDEIMRDYIQKHPELNISEEGITKSTLTKAERQLKDKFDGRPTKPPPNSYSLYCAELM
                     ANMKDVPSTERMVLCSQQWKLLSQKEKDAYHKKCDQKKKDYEVELLRFLESLPEEEQQ
                     RVLGEEKMLNINKKQTTSPASKKPSQEGGKGGSEKPKRPVSAMFIFSEEKRRQLQEER
                     PELSESELTRLLARMWNDLSEKKKAKYKAREAALKAQSERKPGGEREDRGKLPESPKR
                     AEEIWQQSVIGDYLARFKNDRVKALKAMEMTWNNMEKKEKLMWIKKAAEDQKRYEREL
                     SEMRAPPAATNSSKKMKFQGEPKKPPMNGYQKFSQELLSNGELNHLPLKERMVEIGSR
                     WQRISQSQKEHYKKLAEEQQRQYKVHLDLWVKSLSPQDRAAYKEYISNKRKNMTKLRG
                     PNPKSSRTTLQSKSESEEDDDEEEEDDEEEEEEEDDENGDSSEDGGDSSESSSEDESE
                     DGDENDDDDDDEDDEDDDDEDEDNESEGSSSSSSSSGDSSDSDSN"
     exon            266..441
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            442..525
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            526..681
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            682..746
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            747..867
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1001
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1143
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1185
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1299
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1455
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1611
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1722
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1811
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..2001
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2049
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2050..2121
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2265
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2266..4465
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3041
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /note="major polyA site"
     regulatory      4448..4453
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
                     /note="hexamer: AATAAA"
     polyA_site      4465
                     /gene="Ubtf"
                     /gene_synonym="A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1;
                     UBF1"
ORIGIN      
        1 agccgtcgct ccgcttcgcc atctcgggct ttgtctggag actcgctgcc cgggcgccgg
       61 cagctgcgga gctgcggctc ggctcttccg cttgccgtgc tgcctggcgc ccccggccct
      121 cactagcacc cacttgctcg ggtgaggtgg ctttgacccc gggtggcccg gccagcgcga
      181 ccgaggaggt ggctggacag ctggagaatg aacggagaag cggactgtcc cacagacctg
      241 gaaatggccg cccccaaagg ccaagaccgc tggtcccagg aagatatgct gactctgctg
      301 gaatgcatga agaacaacct cccatccaac gacagctcca agttcaaaac cacagagtcg
      361 cacatggatt gggaaaaagt tgcgtttaag gatttttcag gagatatgtg caagctcaaa
      421 tgggtggaga tttctaacga ggtaaggaag ttccgtacat tgacagaatt gatccttgat
      481 gctcaggaac atgttaaaaa cccttacaaa ggcaaaaagc tcaagaaaca cccggatttt
      541 ccaaagaaac ctctcacccc ttacttccgc ttcttcatgg agaagcgggc caagtacgcg
      601 aagctccacc cggagatgag caacctggac ctgactaaga tcctgtctaa gaaatacaag
      661 gaacttccag agaagaagaa gatgaaatat attcaggact tccagaggga gaaacaggag
      721 ttcgagcgaa acctggcccg attcagggag gatcaccctg accttatcca gaatgccaag
      781 aagtcggaca tccccgagaa acccaaaact ccccagcaac tgtggtacac ccacgagaag
      841 aaggtgtatc tcaaagtgcg gccggatgag attatgcggg actatatcca gaagcaccct
      901 gagctgaaca tcagtgagga aggcatcacc aagtccaccc tcaccaaggc cgagcgccag
      961 ctcaaggaca agttcgatgg gcgacctacc aagccgcctc cgaacagcta ctccctgtac
     1021 tgtgcggagc tcatggccaa catgaaggat gtgcccagca cagagcgcat ggtgctatgc
     1081 agccagcaat ggaagctgct ctctcagaag gagaaggatg cctatcacaa gaaatgtgac
     1141 cagaaaaaga aagattatga ggtagagctg ctgcggttcc ttgagagctt gccggaggaa
     1201 gagcagcagc gggttctggg ggaggagaag atgctgaaca tcaataagaa gcaaaccacc
     1261 agtccggcct ccaagaagcc ttcacaggaa ggtggcaagg gtggctccga gaagcccaag
     1321 cggcctgtgt ctgctatgtt catcttctct gaggagaagc gaaggcagct acaggaggaa
     1381 cgacctgagc tctccgaaag cgaactgacc cgccttctgg cccgcatgtg gaacgacttg
     1441 tccgagaaga agaaggctaa atacaaggcc cgggaggctg cgctgaaggc gcagtctgag
     1501 aggaagccgg gcggggagcg tgaagatagg ggcaagctgc cggagtcgcc caagagggct
     1561 gaggagatct ggcagcagag tgtcatcgga gactatctgg cccgcttcaa gaatgaccgg
     1621 gtgaaagcct tgaaagccat ggagatgact tggaacaaca tggagaagaa ggagaagctg
     1681 atgtggatta agaaggcagc agaagaccaa aaacgatatg agagagagtt aagtgagatg
     1741 cgggcccctc cagctgctac aaactcttcc aagaagatga agttccaggg agaacccaag
     1801 aaacctccta tgaacggtta ccagaagttc tcccaggagc tgctgtccaa tggggagcta
     1861 aatcacctgc cgctgaagga gcgcatggtg gagattggca gccgctggca gcgcatctcc
     1921 cagagccaga aggagcacta taagaagctg gcggaggagc aacagaggca gtacaaggtg
     1981 cacttggacc tctgggtcaa gagcctgtct ccccaggacc gcgcagcata caaagaatac
     2041 atctccaata aacgtaagaa catgaccaag ctccgaggcc caaaccccaa gtctagccgg
     2101 accaccctgc agtccaagtc ggagtccgag gaggatgacg atgaggagga ggaggacgac
     2161 gaggaggagg aggaagagga agatgatgag aacggtgact cttctgagga tggcggggac
     2221 tcttctgagt ccagcagtga agatgaaagc gaggatgggg atgagaatga tgatgacgac
     2281 gacgatgaag atgacgaaga tgacgacgat gaggatgaag acaacgagtc tgagggcagt
     2341 agctccagct cttcatcctc aggggactct tcggattctg actccaactg aggctcagcc
     2401 tccaccccag gcaggcaggc aggcaggcag ccaaggagag agcccctgca gagctcatct
     2461 ccccaactga caacctttga caacctttgt ctctccctgt gttctgtccc gtaccctcca
     2521 gacttcccca ctttctttct ttctttcttt tttgtttttt aaatcagtgg ggggtaggag
     2581 gctgcatgag cccaagctag gactctgcag ccttggagcc tcagctccag ggttctccag
     2641 ggacagcaac catcagactg agccagcgct ggacgggccc accctgcccc tcttctgcat
     2701 ttgcagttcc ggcatggaca atggactggg gagtttgggg gtgggagaga gtcttaaaga
     2761 gtttggtgag acctccacac ctgcagcctg cagcaaggtg gatgttcggg gggcctttcc
     2821 ttcccagatg ggcttgctac ctggaccccc cacattgaac tggagggaga caagggtgct
     2881 gccttcaaga aagcaggcag tggccctgtc cctcttccct gcccctgcag gaaggagctg
     2941 cctggacccg ttcgtggggg aggggcagag tgttttttta tatatgtgtg tatatatttt
     3001 ttttttaagc tctgagctgt caacgagacg tttcctaccg atctcggctg ccgtctctgt
     3061 tgtcatttct gggactggga gggcctggga tggggtggat tgagacttaa aaaaaaaaaa
     3121 aaggtctagg tatgcataga atgtgtgtga ggctgtgtgt gtgtgtgtgt gtgtgtgtgt
     3181 gtgtgtgtgt gtgaggctgt gtgtgtgatg tgcacacacg tgagcgagcg atacagcatg
     3241 actgcgcctg tggataggag agagagagaa gagtgtgtgt gtgtgtgtgt gtgtgtgtgt
     3301 gtgtgtgtgt gtgtgtgtgt ctagagcctg tctctttgaa tctggaaaaa gggtcggtag
     3361 aggcctggga gatggtgtcc ctagcaggaa caaaccaagg ctgcccctcc ctgccatctt
     3421 ccattgtggg gttcagggac accacctgat gcttcctata ctagtttgcc cctgccaagg
     3481 ccatgtccct gagctgctgc aggtctgtgc tgtccagcag gaaagtggga ggggcaaacc
     3541 atggcatgag ccttaaagct tttctctggt gccctgggct tcaggaagtt cttcctgcct
     3601 tgccccgtgt cctctggcca tccccatttc ctttgagttc tcaggtctgc tccctctttc
     3661 ctgccgccac ccctgtatgc agaagatgct ctctgcaact gctcctctaa ctgcttgcca
     3721 gcagtttggg accttctgaa gagggtcagt cccttgacgg tgaaatccta gtcaccttta
     3781 cctgtggtga ttatcagttt tactatgttg gccagaattt ttgttcgtgc tattgggttt
     3841 tgcttcttaa atgaaagcca gaggtgggaa gtaggctctc cacagaaagt aggctgcagc
     3901 ccagctgcca gtccctcttg aaagcaaaga catttgcctg gactgtgtga tggagattcc
     3961 taaagagaag attccctccc accccacccc ctgccctcag cgcgcgcgca cgcacacaca
     4021 cacacacaca cacacacaca cactgtcctt attctaaaat ttagtaccag ggttttaagt
     4081 tcctgagagg gcttgcagag aactccatct ccttgtttga acaccctgga ctgttacact
     4141 tgagtgaaat gcgttttcac ttagaaacaa ctttgaacag gacatgtgtt cctcccactg
     4201 caagtattgg aaaattctta gaggtagggc tgtgggggtg ggacatgttg gtgctgtcag
     4261 aggttgccca ggatatattt cagcactggg acccttctcc ttttttctaa tatttaagga
     4321 gtcttttgta ggtttcaaca accaccacac ttgaatttgt accacgggag cggcttagac
     4381 gtgactgtcc cagatcaagg cccactgtgg aggttttgtt ttcccctttt tttttttttt
     4441 tttgtataat aaagtgaaaa accaa
//
