LOCUS       NM_001112721            9773 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus ubiquitin protein ligase E3 component n-recognin 5
            (Ubr5), transcript variant 2, mRNA.
ACCESSION   NM_001112721
VERSION     NM_001112721.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9773)
  AUTHORS   Yang,D., Geng,T., Harrison,A.G., Cahoon,J.G., Xing,J., Jiao,B.,
            Wang,M., Cheng,C., Hill,R.E., Wang,H., Vella,A.T., Cheng,G.,
            Wang,Y. and Wang,P.
  TITLE     UBR5 promotes antiviral immunity by disengaging the transcriptional
            brake on RIG-I like receptors
  JOURNAL   Nat Commun 15 (1), 780 (2024)
   PUBMED   38278841
  REMARK    GeneRIF: UBR5 promotes antiviral immunity by disengaging the
            transcriptional brake on RIG-I like receptors.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9773)
  AUTHORS   Mellis,D., Staines,K.A., Peluso,S., Georgiou,I.C., Dora,N.,
            Kubiak,M., Van't Hof,R., Grillo,M., Farquharson,C., Kinsella,E.,
            Thornburn,A., Ralston,S.H., Salter,D.M., Riobo-Del Galdo,N.A.,
            Hill,R.E. and Ditzel,M.
  TITLE     Ubiquitin-protein ligase Ubr5 cooperates with hedgehog signalling
            to promote skeletal tissue homeostasis
  JOURNAL   PLoS Genet 17 (4), e1009275 (2021)
   PUBMED   33819267
  REMARK    GeneRIF: Ubiquitin-protein ligase Ubr5 cooperates with hedgehog
            signalling to promote skeletal tissue homeostasis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9773)
  AUTHORS   Hughes,D.C., Turner,D.C., Baehr,L.M., Seaborne,R.A., Viggars,M.,
            Jarvis,J.C., Gorski,P.P., Stewart,C.E., Owens,D.J., Bodine,S.C. and
            Sharples,A.P.
  TITLE     Knockdown of the E3 ubiquitin ligase UBR5 and its role in skeletal
            muscle anabolism
  JOURNAL   Am J Physiol Cell Physiol 320 (1), C45-C56 (2021)
   PUBMED   33052072
  REMARK    GeneRIF: Knockdown of the E3 ubiquitin ligase UBR5 and its role in
            skeletal muscle anabolism.
REFERENCE   4  (bases 1 to 9773)
  AUTHORS   Song,M., Yeku,O.O., Rafiq,S., Purdon,T., Dong,X., Zhu,L., Zhang,T.,
            Wang,H., Yu,Z., Mai,J., Shen,H., Nixon,B., Li,M., Brentjens,R.J.
            and Ma,X.
  TITLE     Tumor derived UBR5 promotes ovarian cancer growth and metastasis
            through inducing immunosuppressive macrophages
  JOURNAL   Nat Commun 11 (1), 6298 (2020)
   PUBMED   33293516
  REMARK    GeneRIF: Tumor derived UBR5 promotes ovarian cancer growth and
            metastasis through inducing immunosuppressive macrophages.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9773)
  AUTHORS   Loupe,J.M., Pinto,R.M., Kim,K.H., Gillis,T., Mysore,J.S.,
            Andrew,M.A., Kovalenko,M., Murtha,R., Seong,I., Gusella,J.F.,
            Kwak,S., Howland,D., Lee,R., Lee,J.M., Wheeler,V.C. and
            MacDonald,M.E.
  TITLE     Promotion of somatic CAG repeat expansion by Fan1 knock-out in
            Huntington's disease knock-in mice is blocked by Mlh1 knock-out
  JOURNAL   Hum Mol Genet 29 (18), 3044-3053 (2020)
   PUBMED   32876667
REFERENCE   6  (bases 1 to 9773)
  AUTHORS   Saunders,D.N., Hird,S.L., Withington,S.L., Dunwoodie,S.L.,
            Henderson,M.J., Biben,C., Sutherland,R.L., Ormandy,C.J. and
            Watts,C.K.
  TITLE     Edd, the murine hyperplastic disc gene, is essential for yolk sac
            vascularization and chorioallantoic fusion
  JOURNAL   Mol Cell Biol 24 (16), 7225-7234 (2004)
   PUBMED   15282321
  REMARK    GeneRIF: Results suggest that Edd has an essential role in
            extraembryonic development.
REFERENCE   7  (bases 1 to 9773)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   8  (bases 1 to 9773)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 9773)
  AUTHORS   Henderson,M.J., Russell,A.J., Hird,S., Munoz,M., Clancy,J.L.,
            Lehrbach,G.M., Calanni,S.T., Jans,D.A., Sutherland,R.L. and
            Watts,C.K.
  TITLE     EDD, the human hyperplastic discs protein, has a role in
            progesterone receptor coactivation and potential involvement in DNA
            damage response
  JOURNAL   J Biol Chem 277 (29), 26468-26478 (2002)
   PUBMED   12011095
REFERENCE   10 (bases 1 to 9773)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ063125.1, AY550908.1, AK162029.1, CB527808.1 and AK014485.1.
            
            On Nov 5, 2013 this sequence version replaced NM_001112721.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the central coding region, compared to variant 1.
            The encoded isoform (2) is shorter, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY550908.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-400               CJ063125.1         4-403
            401-3124            AY550908.1         9-2732
            3125-3125           AK162029.1         2089-2089
            3126-4913           AY550908.1         2734-4521
            4914-4914           CB527808.1         115-115
            4915-7892           AY550908.1         4523-7500
            7893-9773           AK014485.1         1073-2953
FEATURES             Location/Qualifiers
     source          1..9773
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 15.1 cM"
     gene            1..9773
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /note="ubiquitin protein ligase E3 component n-recognin 5"
                     /db_xref="GeneID:70790"
                     /db_xref="MGI:MGI:1918040"
     exon            1..491
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            492..536
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            537..618
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            619..695
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            696..815
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            816..1005
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1165
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1315
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1509
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1626
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1737
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1892
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..2010
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2195
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2196..2305
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2418
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..2562
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2563..2674
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2675..2829
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2830..3027
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3028..3238
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3239..3365
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3366..3517
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3518..3613
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3614..3737
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3738..3835
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3836..3984
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3985..4076
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            4077..4223
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            4224..4342
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            4343..4469
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            4470..4599
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            4600..4760
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            4761..5000
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            5001..5124
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            5125..5236
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            5237..5368
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            5369..5626
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            5627..5895
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            5896..6107
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            6108..6338
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            6339..6412
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            6413..6585
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            6586..6699
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            6700..6920
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            6921..7041
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            7042..7140
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            7141..7384
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            7385..7496
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            7497..7641
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            7642..7772
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            7773..7833
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            7834..8009
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            8010..8094
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            8095..8250
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            8251..8364
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            8365..8509
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            8510..8595
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     exon            8596..9773
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9207..9212
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /note="hexamer: AATAAA"
     polyA_site      9224
                     /gene="Ubr5"
                     /gene_synonym="Edd; Edd1"
                     /note="major polyA site"
ORIGIN      
        1 ggctgcgaga cggagaaact ggggcagaag tgaagatggc ggcggcggcg ctggcggcgg
       61 cggttcgtcg ccagtgacgc gcgctgcggg ctgctgtccc tccccgctcc ccgcgtccgc
      121 cgcgtccgcc ccggcacctc tccacccgcc gctcgccgcg ctccgggctg ccctcgtccg
      181 tgcgcgccgt ggccggccga gcgggcggcg cgttgatccg ccctcccgcc cgccgcgccg
      241 ggccgccggg ccgcggacac acgctcggcg gggaggcggc ggtccctgcg cgctcgcggc
      301 cctccgtttg gggaccggga ggaggaggcg gtggcggcgg ccgtgggatc cggggacggg
      361 aaggggatcg gggggccgga cgacagcggg agcggctcgt tcccgggagc ggggcgcgca
      421 ggcggtacca tgacgtccat ccatttcgtg gtccacccgc tgccgggcac cgaggaccag
      481 ctcaatgaca ggttacggga agtttcagag aagctgaaca agtacaattt gaacagccac
      541 ccacctctga atgtactgga gcaggctact attaaacagt gtgtggtggg acccaatcac
      601 gccgcgtttc ttcttgagga tggcagaatt tgtaggattg gtttttcagt acaaccagac
      661 agactggaat tgggtaaacc tgataataat gatgggtcaa aactgaacag cagctcgggg
      721 acagggagga cctctaggcc aggaaggaca agtgactccc cgtggtttct ctcaggttct
      781 gagactctgg gcaggttggc aggcaacact ctgggaagcc gctggagttc tggcgtgggg
      841 ggaagtggag gaggctcctc tggtcggtcg tctgctggag ctcgtgattc ccggcgacag
      901 actcgagtca ttcggactgg ccgggatcgg gggtctggac tcctgggcag tcagccccag
      961 ccagttattc cagcatctgt cattcctgag gagctgatat cacaggcaca agttgttcta
     1021 caaggcaaat cgagaagtgt cattattcga gaacttcaga gaacaaatct tgatgtcaac
     1081 cttgctgtaa ataacttact gagccgggat gatgaggatg gagatgacgg tgatgacaca
     1141 gccagtgaat cttacctgcc gggagaagat cttatgtctc ttcttgacgc tgacattcac
     1201 tctgcccacc caagtgtcat tattgatgct gatgccatgt tttctgagga cattagctat
     1261 tttggttatc cttcttttcg tcgttcatca ctctctaggc taggctcatc acgagagaga
     1321 gactcagagc ttctgcggga acgggagtct gttctacgtt tacgggagcg gcggtggctt
     1381 gatggagcct catttgataa tgaaaggggc tctaccagca aagagggaga gtcaaacccg
     1441 gataagaaga acacgcctgt tcagagtcca gtgtctctgg gagaagactt acagtggtgg
     1501 cctgataagg atggaacaaa atttacctgc attggggctc tgtattctga gcttcttgct
     1561 gtcagcagca aaggagaact ttatcaatgg aaatggagtg aatctgagcc ttacagaaat
     1621 gcccagaatc cttcattgca tcatccacga gcaacatttt tggggttgac caatgaaaag
     1681 atagtcctct tgtctgcaaa tagcataaga gcaactgtag ctactgaaaa taacaaggtt
     1741 gctacatggg tggatgaaac attaagttct gtggcttcta agttagaaca cacagcacag
     1801 acttactctg aacttcaagg agaacggata gtttctttac attgctgtgc cctttatacc
     1861 tgtgcccagc tggagaataa tttgtattgg tggggtgttg ttcctttcag tcaaaggaag
     1921 aaaatgttag agaaagctag agcaaaaaat aaaaagccca aatccagtgc tggtatttct
     1981 tccatgccaa acatcactgt tggaactcag gtgtgcttga gaaataaccc tctctaccat
     2041 gctggagcgg ttgccttttc aattagtgct ggcattccta aagttggtgt cttgatggag
     2101 tcagtatgga atatgaatga tagctgtaga tttcaacttc ggtctccaga gagcctgaag
     2161 agcatggaaa aagccagcaa aactcttgag acaaagcccg agagtaagca ggaaccagta
     2221 aaaacagaaa tgggccctcc accatcacca gcatccacct gcagcgacgc gtcctcaatt
     2281 gccagcagtg catccatgcc atacaaacga cgtcggtcaa ctcctgcccc gagagaagag
     2341 gagaaggtga acgaggagca gtggcccctt cgggaagttg tttttgttga agatgttaag
     2401 aacgttcctg ttggcaaggt gctgaaggta gatggtgcct atgtcgctgt aaagtttcca
     2461 ggaacatcta ctaacaccac ctgtcagaac agctctggtc cagacgccga cccttcctcg
     2521 ctcctgcagg actgcaggct gcttcgaatt gatgagctgc aggttgtcaa aacgggcggc
     2581 accccaaaag ttcccgactg ttttcagagg actcccaaaa agctttgtat acccgagaag
     2641 actgaaatac tagcagtaaa tgtggattcc aaaggtgtcc atgctgttct gaagactgga
     2701 agctgggttc ggtactgtgt ctttgatctt gccacaggga aggctgaaca agagaataat
     2761 ttcccaacaa gcagtgttgc ttttcttggt caggatgaga ggagtgtcgc tatcttcact
     2821 gctgggcagg aatctcctat tgttcttcga gatggaaatg gtactatcta cccaatggcc
     2881 aaggattgca tgggaggaat acgggatcct gactggcttg atctcccacc aatcagtagt
     2941 cttgggatgg gtgtacattc tttaataaat cttcctgcca actcaacaat caaaaagaaa
     3001 gcagctatta tcatcatggc tgtagagaag caaaccttaa tgcagcacat tctcagatgt
     3061 gactacgagg cctgccgaca gtatctcgtg aatctggagc aagccgtggt tttagagcag
     3121 aacctgcaga tgttacagac gttcatcagc cacagatgtg atgggaaccg gaacatttta
     3181 catgcttgtg tatcagtttg ctttccaacc agcaataagg aaactaaaga agaagaggaa
     3241 gctgagcgct cagaaagaaa tacatttgct gaaaggcttt ctgctgtgga ggccattgca
     3301 aatgcaatat cagttgtttc aagtaacggc ccaggtaatc gggctggatc atcaaatagt
     3361 cgaagtttga gattacgaga aatgatgaga cgttcattga gagcagctgg tttgggtaga
     3421 catgaggctg gagcttcatc cagtgaccac caggatccag tttcaccccc catagctccc
     3481 cctagctggg ttcctgaccc tccttcaatg gatcctgatg gtgatattga ttttatcctg
     3541 gcccccgctg tgggatctct taccacagca gcgactggca gtggtcaagg acccagcacc
     3601 tccaccattc caggtccttc cacagagcca tctgtagtag aatccaagga tcgaaaggca
     3661 aacgcacatt tcatattaaa attactatgc gacagtgcgg ttctgcagcc ttatctacga
     3721 gagcttcttt ctgccaagga tgcaagagga atgaccccgt ttatgtcagc tgtaagtggc
     3781 cgggcttatc ctgctgcaat caccatccta gaaacagccc agaagattgc caaagctgaa
     3841 gtatctgcaa gtgaaaagga ggaagatgtg ttcatgggaa tggtttgccc gtcaggtacc
     3901 aaccctgacg actccccttt gtatgtctta tgttgcaacg acacctgcag ctttacctgg
     3961 actggagcag agcacattaa ccaggacatt tttgaatgtc ggacttgtgg tttactggag
     4021 tcgctttgtt gttgtacaga atgtgcaagg gtttgtcata aagggcacga ttgcaaactc
     4081 aagaggactt caccaacagc ttattgtgat tgttgggaga aatgtaaatg taaaacattg
     4141 attgctggac agaagtctgc tcgtcttgat ctactttatc gcctgcttac tgctacaaat
     4201 ctggtcaccc taccaaacag taggggagag caccttttgc tgttcttagt acagaccgtg
     4261 gccaggcaga cagtggagca ctgtcagtat aggcctccac gaatcaggga ggatcgcaac
     4321 aggaaaacag ccagtcctga agattcagat atgcctgacc atgacttaga gcccccaagg
     4381 tttgcccagc ttgccctaga gcgcgtcctt caggactgga atgctttgag atctatgatt
     4441 atgtttgggt cacaagagaa caaagatcct ctgagtgcca gcagcaggat aggccatctt
     4501 ttgccagaag agcaggtcta cctcaaccag cagagcggca cgattcggct cgactgtttc
     4561 actcattgcc ttattgtcaa gtgtacagca gatattttgc ttttagatac tctgctaggc
     4621 accttagtaa aagaactcca aaacaagtac acacccggac gccgggaaga agcaattgcc
     4681 gtgacaatga ggtttctacg atctgtggca agagtgtttg tcattcttag tgtggaaatg
     4741 gcttcgtcca aaaagaaaaa caactttatt ccacagccaa ttggaaaatg caaacgtgtg
     4801 tttcaagcac tgcttcctta tgctgtagaa gaattgtgta atgtggcaga gtctctgatt
     4861 gttcctgtca gaatggggat tgcccggccg acagcaccgt ttactctggc cagtactagc
     4921 atagatgcca tgcagggcag tgaagaatta ttttcagtag aaccattacc accacggccg
     4981 tcatcagatc aggcaagcag ctccagtcag tctcagtcat cttacatcat tcggaaccca
     5041 cagcagaggc gcatcagcca gtcacagccc gtcagaggcc gagacgagga gcaggatgat
     5101 attgtgtcag cagacgtgga agaggttgag gtggtggaag gcgtggctgg agaggaggat
     5161 catcatgatg aacaggaaga gcacggggaa gagaatgctg aggctgaggg acatcacgat
     5221 gagcatgatg aagacggaag tgacatggag ctagatttgt tagcagcagc tgaaacggaa
     5281 agtgacagtg aaagtaacca tagtaaccaa gataatgcta gtgggcgcag aagtgttgtc
     5341 accgcagcca ctgctggctc agaagcagga gcgagcagtg ttcctgcctt tttttctgaa
     5401 gatgactctc agtcaaatga ctcaagtgac tctgacagca gtagcagtca gagtgatgac
     5461 atagagcagg agacctttat gctcgatgag ccactagaaa ggacaacgaa tagctcccat
     5521 gcaaatggtg ctgcccaggc tcctcgctcc atgcagtggg ctgtccgaaa tccgcagcat
     5581 cagcgagcag caagcacagc tccgtccagc acatctacgc cagcagcaag ttctgcaggt
     5641 ttgatttata ttgatccttc aaatttacgc cggagcggca ccatcagtac aagtgctgca
     5701 gcggcagcag ctgctttgga agctagcaat gccagcagct acttaacatc tgcaagcagt
     5761 ttagccaggg cttacagcat tgtcatcaga caaatctcgg acttgatggg ccttatccct
     5821 aagtataatc acctagtata ctctcagatt ccagcagctg tgaaattgac ttaccaagat
     5881 gcagtcaact tacagaacta tgtagaagaa aagcttattc ctacgtggaa ctggatggtc
     5941 agtgttatgg attctactga agctcaatta cgttatggtt ctgcactagc atctgctggt
     6001 gacccaggac acccaaatca tccccttcat gcctctcaga attcagctcg aagagagagg
     6061 atgactgcac gggaagaggc cagtctaaga acgcttgaag gcagacgacg tgctacattg
     6121 ctgagcgccc gccagggaat gatgtctgct cgaggagact ttctcaatta tgctctgtct
     6181 ttaatgagat ctcataatga tgagcattct gatgttcttc cagtattgga tgtgtgctca
     6241 ttgaaacatg tggcatatgt tttccaagcc cttatatact ggattaaagc aatgaatcag
     6301 cagacaacat tagacactcc tcaactggaa cgcaaaagga cacgagaact tctggaactg
     6361 ggtattgata atgaagattc agaacatgaa aatgatgatg acaccagtca aagtgctact
     6421 ttgaatgata aggatgacga ctctcttcct gcagaaactg gccaaaacca tccatttttc
     6481 cgacgttcag actctatgac attccttgga tgtatacctc caaatccatt tgaagtgcct
     6541 ttggctgaag ccataccctt ggctgatcag ccacatttgt tgcagccaaa tgctagaaag
     6601 gaagatcttt ttggtcgccc aagtcagggt ctttattcct catctgccgg aagtgggaaa
     6661 tgcatagtag aggttacaat ggacagaaat tgtctcgagg ttcttccaac taaaatgtct
     6721 tatgctgcca atctaaaaaa tgtaatgaac atgcaaaacc ggcagaagaa agaaggggaa
     6781 gaacagagcc tgctggccga agaagctgac agttcaaagc caggtccatc cgctcctgat
     6841 gttgctgccc agttgaaaag cagtttacta gcagagatag gactcacgga aagtgaaggg
     6901 ccccccctta catctttcag gcctcagtgc agtttcatgg gcatggttat ctcccatgac
     6961 atgctgctgg gacgctggcg cctgtcttta gaactgttcg gcagagtatt catggaagat
     7021 gttggtgcag agcctggatc gattttaact gaattgggtg gttttgaggt aaaagaatca
     7081 aagttccgta gagagatgga aaaactgaga aaccagcaat caagagattt atcactagag
     7141 gtcgatcgcg atcgggatct tctcattcag cagactatga gacagcttaa caaccatttt
     7201 ggccgaagat gtgctaccac gccaatggct gtgcacagag tcaaagtcac ctttaaggat
     7261 gaaccaggag agggcagtgg tgtagcaaga agtttctata cagccattgc acaagcgttt
     7321 ttatcaaatg aaaaattgcc aaatctagat tgtatccaaa atgccaacaa aggtactcat
     7381 acaagtttaa tgcaaagatt gaggaacaga ggtgaaagag accgggagag agagagagaa
     7441 cgggaaatga ggaggagcag tggcttgcgt gcaggatctc gaagagacag ggatagagac
     7501 ttcaggagac agctctccat tgacaccagg cctttcagac ctgcttctga ggggaatcct
     7561 agtgatgacc ctgaccctct tccagctcat cggcaggcac ttggagagag gctttacccc
     7621 cgagtgcaag caatgcagcc cgcatttgca agtaaaatca ctggcatgct gttggagtta
     7681 tccccagctc agctgcttct ccttctagca agtgaagatt ctctgagggc gagagtcgac
     7741 gaggccatgg aactcattat tgctcatgga cgggaaaatg gagctgacag tattttggac
     7801 ctcggattat tagactcttc agaaaaggta caggaaaaca gaaagcgcca tggctctagt
     7861 agaagtgtag tggatatgga tttagaggac acagatgatg gtgatgacaa cgctcccttg
     7921 ttttaccaac ctgggaagag aggattttat actccgagac ctggcaaaaa cacagaagca
     7981 aggctgaatt gtttcagaaa catcggcagg attcttggac tatgtctgtt gcaaaatgaa
     8041 ctatgtccta tcacattgaa taggcatgta attaaagtgt tgcttggtag aaaagtcaac
     8101 tggcatgact ttgctttttt cgaccctgta atgtatgaga gtttacgaca actgatcctt
     8161 gcatctcaga gttcagatgc tgatgctgtt ttctcagcaa tggatttggc atttgcaatt
     8221 gacctgtgta aagaagaggg tggaggacag gttgaactta ttccaaatgg tgtaaatata
     8281 ccagtcactc cgcagaatgt atatgagtat gtaaggaaat atgcagagca tagaatgttg
     8341 gtggttgcag aacagccatt gcacgcaatg agaaagggtc tactagacgt gcttccaaaa
     8401 aattccttag aagacttaac agctgaggac ttccggctct tggtgaacgg ctgtggtgaa
     8461 gtcaatgtgc agatgctgat cagtttcact tctttcaatg atgagtcagg agaaaatgct
     8521 gagaagctcc tccagttcaa acggtggttc tggtcaatag tagagaaaat gagcatgaca
     8581 gaacggcagg acctggttta cttctggaca tctagcccat cattgccagc cagtgaagaa
     8641 ggttttcagc ctatgccctc gatcacaata agaccaccag atgaccaaca tcttcctact
     8701 gcaaatactt gtatttctcg actttatgtc ccactctatt cctctaaaca gattctcaaa
     8761 caaaaattac tactcgccat taagaccaag aattttggtt ttgtgtagag tataaaaagt
     8821 gtgtattgct gtgtaatatt actagctaat tttgtagatt ttttttccca tttgtctata
     8881 aaagtttatg gaagttaatg ctgtcataac ccccacccca ccccaccccc ggtggtacct
     8941 taaagagatt aaatgcaaac attccttgct gagtttgtag cttaaaggcc tgagaagcac
     9001 tggcaccttt tctctatgat ggtttgctag tcgccaactt ctaggtctaa ccccagccaa
     9061 agatgacagc agaacaacat aatttacact gtgatttatc ttttttgctg agggggaaaa
     9121 atgtaaaatg ttctgaaaat tcactgctgc ctttgtggaa agtgtttcag caaaggttct
     9181 tgtatagagg gaatagggaa tttcaaaata aaaaattaag tatgttctgt gttttcattt
     9241 tagctttttt atggtgttat ttgtggttgg ctgcaattgt gtatcatgta tatggaactt
     9301 gtaaaaagtt cttgacattc ggattttaga gacaaaacca cttttaccta taaaaacctc
     9361 acttttagtg tgggttattt cagctacatt gagctctagg atactaaata cactaatagt
     9421 ttgcatgtaa tgtgttcatt tgagagaggc acttttctgt acataaaatg ggccgacgca
     9481 cagtaccttg ccacagtcac cttttttctt tgtacccctc tttcagtgca ggtggatagg
     9541 tcacactgca cttgagtgct aaccagatgt ctgtactaag gttatgtgta ctcagcctgg
     9601 gcactttctg ataactgtaa aatgttttat aagatcatga atactgaaaa ttttaaattt
     9661 tggagaattt taaatgttct tgagcagctt aactactttt gtatctagcc ttttttttta
     9721 agtatcttgt tacattttac ttttttaaat aaattacaga agaaatgtca agt
//
