LOCUS       NM_018798               3343 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus ubiquilin 2 (Ubqln2), mRNA.
ACCESSION   NM_018798
VERSION     NM_018798.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3343)
  AUTHORS   Nedomova,M., Haberecht-Muller,S., Moller,S., Venz,S.,
            Prochazkova,M., Prochazka,J., Sedlak,F., Chawengsaksophak,K.,
            Hammer,E., Kasparek,P., Adamek,M., Sedlacek,R., Konvalinka,J.,
            Kruger,E. and Grantz Saskova,K.
  TITLE     DDI2 protease controls embryonic development and inflammation via
            TCF11/NRF1
  JOURNAL   iScience 27 (10), 110893 (2024)
   PUBMED   39328932
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3343)
  AUTHORS   Sandoval-Pistorius,S.S., Gerson,J.E., Liggans,N., Ryou,J.H.,
            Oak,K., Li,X., Negron-Rios,K.Y., Fischer,S., Barsh,H.,
            Crowley,E.V., Skinner,M.E., Sharkey,L.M., Barmada,S.J. and
            Paulson,H.L.
  TITLE     Ubiquilin-2 regulates pathological alpha-synuclein
  JOURNAL   Sci Rep 13 (1), 293 (2023)
   PUBMED   36609661
  REMARK    GeneRIF: Ubiquilin-2 regulates pathological alpha-synuclein.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3343)
  AUTHORS   Mohan,H.M., Trzeciakiewicz,H., Pithadia,A., Crowley,E.V.,
            Pacitto,R., Safren,N., Trotter,B., Zhang,C., Zhou,X., Zhang,Y.,
            Basrur,V., Paulson,H.L. and Sharkey,L.M.
  TITLE     RTL8 promotes nuclear localization of UBQLN2 to subnuclear
            compartments associated with protein quality control
  JOURNAL   Cell Mol Life Sci 79 (3), 176 (2022)
   PUBMED   35247097
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3343)
  AUTHORS   Gerson,J.E., Sandoval-Pistorius,S., Welday,J.P., Rodriguez,A.,
            Gregory,J.D., Liggans,N., Schache,K., Li,X., Trzeciakiewicz,H.,
            Barmada,S., Sharkey,L.M. and Paulson,H.L.
  TITLE     Disrupting the Balance of Protein Quality Control Protein UBQLN2
            Accelerates Tau Proteinopathy
  JOURNAL   J Neurosci 42 (9), 1845-1863 (2022)
   PUBMED   35082119
  REMARK    GeneRIF: Disrupting the Balance of Protein Quality Control Protein
            UBQLN2 Accelerates Tau Proteinopathy.
REFERENCE   5  (bases 1 to 3343)
  AUTHORS   Zhang,K., Wang,A., Zhong,K., Qi,S., Wei,C., Shu,X., Tu,W.Y., Xu,W.,
            Xia,C., Xiao,Y., Chen,A., Bai,L., Zhang,J., Luo,B., Wang,W. and
            Shen,C.
  TITLE     UBQLN2-HSP70 axis reduces poly-Gly-Ala aggregates and alleviates
            behavioral defects in the C9ORF72 animal model
  JOURNAL   Neuron 109 (12), 1949-1962 (2021)
   PUBMED   33991504
  REMARK    GeneRIF: UBQLN2-HSP70 axis reduces poly-Gly-Ala aggregates and
            alleviates behavioral defects in the C9ORF72 animal model.
REFERENCE   6  (bases 1 to 3343)
  AUTHORS   Bulfone,A., Carotenuto,P., Faedo,A., Aglio,V., Garzia,L.,
            Bello,A.M., Basile,A., Andre,A., Cocchia,M., Guardiola,O.,
            Ballabio,A., Rubenstein,J.L. and Zollo,M.
  TITLE     Telencephalic embryonic subtractive sequences: a unique collection
            of neurodevelopmental genes
  JOURNAL   J Neurosci 25 (33), 7586-7600 (2005)
   PUBMED   16107646
REFERENCE   7  (bases 1 to 3343)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   8  (bases 1 to 3343)
  AUTHORS   Mattar,P., Britz,O., Johannes,C., Nieto,M., Ma,L., Rebeyka,A.,
            Klenin,N., Polleux,F., Guillemot,F. and Schuurmans,C.
  TITLE     A screen for downstream effectors of Neurogenin2 in the embryonic
            neocortex
  JOURNAL   Dev Biol 273 (2), 373-389 (2004)
   PUBMED   15328020
REFERENCE   9  (bases 1 to 3343)
  AUTHORS   Kleijnen,M.F., Shih,A.H., Zhou,P., Kumar,S., Soccio,R.E.,
            Kedersha,N.L., Gill,G. and Howley,P.M.
  TITLE     The hPLIC proteins may provide a link between the ubiquitination
            machinery and the proteasome
  JOURNAL   Mol Cell 6 (2), 409-419 (2000)
   PUBMED   10983987
REFERENCE   10 (bases 1 to 3343)
  AUTHORS   Wu,A.L., Wang,J., Zheleznyak,A. and Brown,E.J.
  TITLE     Ubiquitin-related proteins regulate interaction of vimentin
            intermediate filaments with the plasma membrane
  JOURNAL   Mol Cell 4 (4), 619-625 (1999)
   PUBMED   10549293
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC053022.1.
            
            On Aug 28, 2003 this sequence version replaced NM_018798.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC053022.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..3343
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 68.46 cM"
     gene            1..3343
                     /gene="Ubqln2"
                     /gene_synonym="Chap1; Dsk2; HRIHFB2157; Plic-2; Plic2"
                     /note="ubiquilin 2"
                     /db_xref="GeneID:54609"
                     /db_xref="MGI:MGI:1860283"
     exon            1..3331
                     /gene="Ubqln2"
                     /gene_synonym="Chap1; Dsk2; HRIHFB2157; Plic-2; Plic2"
                     /inference="alignment:Splign:2.1.0"
     CDS             223..2139
                     /gene="Ubqln2"
                     /gene_synonym="Chap1; Dsk2; HRIHFB2157; Plic-2; Plic2"
                     /note="Ubiquitin-related protein; ubiquitin-like product
                     Chap1/Dsk2; protein linking IAP with cytoskeleton 2"
                     /codon_start=1
                     /product="ubiquilin-2"
                     /protein_id="NP_061268.2"
                     /db_xref="CCDS:CCDS30482.1"
                     /db_xref="GeneID:54609"
                     /db_xref="MGI:MGI:1860283"
                     /translation="MAENGESSGPPRPSRGPAAAPGAASPPAEPKIIKVTVKTPKEKE
                     EFAVPENSTVQQFKEAISKRFKSQTDQLVLIFAGKILKDQDTLMQHGIHDGLTVHLVI
                     KSQNRPQGQATTQPSTTAGTSTTTTTTTTAAAPAATTSSAPRSSSTPTTTNSSSFGLG
                     SLSSLSNLGLNSPNFTELQNQMQQQLLASPEMMIQIMENPFVQSMLSNPDLMRQLIMA
                     NPQMQQLIQRNPEISHLLNNPDIMRQTLEIARNPAMMQEMMRNQDLALSNLESIPGGY
                     NALRRMYTDIQEPMLNAAQEQFGGNPFATVGSSSTSGEGTQPSRTENRDPLPNPWAPP
                     PTTQTAATTTTTTTTSSGSGSGSSSSSTTAGNTMAAANYVASIFSTPGMQSLLQQITE
                     NPQLIQNMLSAPYMRSMMQSLSQNPDMAAQMMLSSPLFTSNPQLQEQMRPQLPNFLQQ
                     MQNPETIAAMSNPRAMQALMQIQQGLQTLATEAPGLIPSFAPGVGMGVLGTAITPVGP
                     VTPIGPIGPIVPFTPIGPIGPIGPTGPASSPGSTGTGIPPATTVSSSAPTETISPTSE
                     SGPNQQFIQQMVQALTGGSPPQPPNPEVRFQQQLEQLNAMGFLNREANLQALIATGGD
                     INAAIERLLGSQPS"
ORIGIN      
        1 cggagacggc ctgcaggacc tgctctctca gccctcagcc gaggcctacg ccgagccgag
       61 tgcgcagccg acgaccggga ggagccgcag ccttcaactc tgaggtactg tgatccgcgc
      121 tgcccgccgg gccgccccag tccgctgctg cggcacctcc ttccctcgcg ccctcttcgc
      181 tcgccagcgc cttccctgtg agcctgcgtc accgcggccg ccatggctga gaacggcgag
      241 agcagcggcc ccccgcgccc ctcccgcggc cctgcggcgg ccccaggcgc ggccagcccg
      301 ccggccgagc ccaaaatcat caaagtcact gtgaagaccc ccaaagagaa ggaggagttc
      361 gcggtgcccg agaacagcac cgtgcagcag ttcaaggaag cgatttccaa acgcttcaaa
      421 tcgcagaccg atcagctcgt gctgattttc gccggaaaga tcctgaaaga tcaagatacc
      481 ttgatgcagc atggcatcca tgatggactg actgttcacc tggttatcaa aagccagaac
      541 cgtccgcagg gccaggccac cacgcagccc agcacgactg cgggaacgag cacgacgacc
      601 acgaccacca ccacggcggc ggcgccggcg gcgacgacat catcggctcc caggagtagc
      661 tccacaccta ccaccacgaa tagcagctcc tttgggctgg gaagcctttc cagccttagt
      721 aacctgggct tgaactcgcc caacttcacc gagcttcaga accagatgca gcagcagctc
      781 ctggccagcc ctgagatgat gatccagatc atggaaaatc cctttgttca gagcatgctt
      841 tcgaatcctg atctgatgag gcagctcatc atggccaatc cacagatgca acaattgatc
      901 cagagaaacc cagaaatcag ccacctactg aacaacccag atataatgag gcagacgctg
      961 gaaatcgcca ggaatcctgc catgatgcaa gagatgatgc gaaatcaaga cctggctctc
     1021 agtaatctcg aaagcatccc aggtggctac aatgctctgc ggcgcatgta cactgacatt
     1081 caagaaccta tgctgaatgc cgcacaggag cagtttgggg gcaacccgtt tgccacggtg
     1141 gggagcagtt ccacctcagg ggaaggtact cagccctccc gcacggagaa tcgtgatccg
     1201 ctgcccaatc cttgggcacc accgccaaca acccagacgg ctgcgaccac caccaccacc
     1261 acgaccacaa gcagtggcag tggctctggc agcagctcca gcagcaccac cgccgggaac
     1321 accatggctg cagctaatta cgtggctagc atcttcagca ccccaggaat gcagagcctg
     1381 ctgcagcaga taactgagaa tccccagctg attcagaata tgctgtctgc gccctacatg
     1441 cggagcatga tgcagtcgct gagccagaat ccagatatgg cggcccagat gatgctgagt
     1501 agcccgctgt tcacttcgaa tcctcagctg caggagcaga tgcgtccaca gctcccgaat
     1561 ttcctgcagc agatgcagaa tccagaaacc atcgcggcca tgtcaaaccc gagagcgatg
     1621 caagcgctaa tgcagatcca gcaggggcta cagactctag ccactgaagc acctggcctc
     1681 attcccagct tcgctccagg tgtggggatg ggagtgctgg gaaccgccat aacccctgtg
     1741 ggcccagtca ctcccatagg gcccatcggc cctatagttc ctttcacccc cataggcccc
     1801 atcgggccta taggacccac tggccctgca agctcccccg gctccaccgg cactggcatc
     1861 ccgcctgcaa ccactgtgtc cagctctgca cctactgaaa ccataagtcc aacctcggaa
     1921 tctggaccca accagcagtt cattcaacaa atggtgcagg ctctcactgg aggaagccct
     1981 ccacagccgc cgaatcctga agtgagattt cagcagcaac tggaacagct caacgccatg
     2041 gggttcttaa accgcgaagc aaacttgcag gccctaatag caacaggagg cgacatcaac
     2101 gcggccattg agaggctgct gggctctcag ccatcctaat tacgtttctg taccttgaaa
     2161 aaaaatgtat cttatttttg ataatggctc ttaaatcttt aaacacacaa aattgtgctt
     2221 tacttttatt ttgattcttt taaatctgtc tacctataaa tctaatagga tgcattttaa
     2281 ggtggagtcc ctccctccct ccctccctcc ctccctgctc ctcctccccc caccctctcc
     2341 cttcccttcc agcctgccct ctcccctctt tgtttccttc attcctttct tttcttcttt
     2401 tgatttcctt ccttctctga tttgaatggt gggaatcaat actgtttcac tcaaaggtgt
     2461 tgcatgcaaa cacttctctt tattctgcat ttattgtgat ttttggaaac aggtatcagc
     2521 cttcacagtt gggtgaacaa gttttgtcct acagatgtcc agtttatttg cattttaaac
     2581 attagcctat gatagtaatt taatgtagaa tgaagatatt aaaaaaacag aagcaaatta
     2641 tttgaagctc tctaatttgt ggtaaaatat tgcttattgt gactttggca tgtatttttg
     2701 ctagcaaatg ctgtaagatt tataccattc attgatcgtt tttgctattt gtacacagta
     2761 cagtaagcac aattggaatt gtacatctag aagtattact gtagaatctc tgagcagaat
     2821 atgtgtaacc aaaataagaa agaatataag aaatattcct gaagctaggt atgtctcaca
     2881 attttgtaga atcttacagc atatttgata aatttctcag tgaaaatgtt ggctaggcaa
     2941 gttcagttaa aatatagtag aaatgtttat cctggtttct ctaagtatac attaaattgt
     3001 acagaaacct tacagtgtaa cattgtgtca acagttgcag attgattgta tatgacctta
     3061 atctttgtgc agcctgaagg atcagtgtag tgactccagg aaagtgcttt ttatctaaga
     3121 gttcctcagc ttctcccatg aagagacctt catatgcatt ttgatttgta attggaaatg
     3181 taacttttac tggaagtgtc atgtgatgtt tgcattactt ttaactgcta tgtataaagg
     3241 aaagtgtatc ttttggctct atcagttatt tctcttgtgc acagggaaaa atgcattaaa
     3301 atgactaaaa aaataaaaaa ataataaaaa aaaaaaaaaa aaa
//
