LOCUS       NM_026842               3693 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus ubiquilin 1 (Ubqln1), transcript variant 1, mRNA.
ACCESSION   NM_026842 NM_019509
VERSION     NM_026842.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3693)
  AUTHORS   Wu,D., Zhang,H., Li,F., Liu,S., Wang,Y., Zhang,Z., Wang,J. and
            Wu,Q.
  TITLE     Sec13 promotes glycolysis by inhibiting Ubqln1 mediated Pgm1
            ubiquitination in ALI
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (8), 167475 (2024)
   PUBMED   39159700
  REMARK    GeneRIF: Sec13 promotes glycolysis by inhibiting Ubqln1 mediated
            Pgm1 ubiquitination in ALI.
REFERENCE   2  (bases 1 to 3693)
  AUTHORS   Nedomova,M., Haberecht-Muller,S., Moller,S., Venz,S.,
            Prochazkova,M., Prochazka,J., Sedlak,F., Chawengsaksophak,K.,
            Hammer,E., Kasparek,P., Adamek,M., Sedlacek,R., Konvalinka,J.,
            Kruger,E. and Grantz Saskova,K.
  TITLE     DDI2 protease controls embryonic development and inflammation via
            TCF11/NRF1
  JOURNAL   iScience 27 (10), 110893 (2024)
   PUBMED   39328932
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3693)
  AUTHORS   Li,Y., Xu,J., Chen,W., Wang,X., Zhao,Z., Li,Y., Zhang,L., Jiao,J.,
            Yang,Q., Ding,Q., Yang,P., Wei,L., Chen,Y., Chen,Y., Ruan,X.Z. and
            Zhao,L.
  TITLE     Hepatocyte CD36 modulates UBQLN1-mediated proteasomal degradation
            of autophagic SNARE proteins contributing to septic liver injury
  JOURNAL   Autophagy 19 (9), 2504-2519 (2023)
   PUBMED   37014234
  REMARK    GeneRIF: Hepatocyte CD36 modulates UBQLN1-mediated proteasomal
            degradation of autophagic SNARE proteins contributing to septic
            liver injury.
REFERENCE   4  (bases 1 to 3693)
  AUTHORS   Zhou,H., Xie,C., Xie,Y., He,Y., Chen,Y., Zhang,C., Zhang,Y.,
            Zhao,Y. and Liu,H.
  TITLE     UBQLN1 deficiency mediates telomere shortening and IPF through
            interacting with RPA1
  JOURNAL   PLoS Genet 19 (7), e1010856 (2023)
   PUBMED   37463174
  REMARK    GeneRIF: UBQLN1 deficiency mediates telomere shortening and IPF
            through interacting with RPA1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3693)
  AUTHORS   Kurten,T., Ihbe,N., Ueberbach,T., Distler,U., Sielaff,M., Tenzer,S.
            and Mittmann,T.
  TITLE     GABAA Receptor-Stabilizing Protein Ubqln1 Affects Hyperexcitability
            and Epileptogenesis after Traumatic Brain Injury and in a Model of
            In Vitro Epilepsy in Mice
  JOURNAL   Int J Mol Sci 23 (7), 3902 (2022)
   PUBMED   35409261
  REMARK    GeneRIF: GABAA Receptor-Stabilizing Protein Ubqln1 Affects
            Hyperexcitability and Epileptogenesis after Traumatic Brain Injury
            and in a Model of In Vitro Epilepsy in Mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3693)
  AUTHORS   N'Diaye,E.N., Kajihara,K.K., Hsieh,I., Morisaki,H., Debnath,J. and
            Brown,E.J.
  TITLE     PLIC proteins or ubiquilins regulate autophagy-dependent cell
            survival during nutrient starvation
  JOURNAL   EMBO Rep 10 (2), 173-179 (2009)
   PUBMED   19148225
  REMARK    GeneRIF: UBQLN1-transfected cells did not show increased
            starvation-induced cell death
REFERENCE   7  (bases 1 to 3693)
  AUTHORS   Massey,L.K., Mah,A.L., Ford,D.L., Miller,J., Liang,J., Doong,H. and
            Monteiro,M.J.
  TITLE     Overexpression of ubiquilin decreases ubiquitination and
            degradation of presenilin proteins
  JOURNAL   J Alzheimers Dis 6 (1), 79-92 (2004)
   PUBMED   15004330
  REMARK    GeneRIF: Described results suggest that ubiquilin proteins play an
            important role in regulating presenilin 2 (PS2) protein levels in
            cells.
REFERENCE   8  (bases 1 to 3693)
  AUTHORS   Kleijnen,M.F., Shih,A.H., Zhou,P., Kumar,S., Soccio,R.E.,
            Kedersha,N.L., Gill,G. and Howley,P.M.
  TITLE     The hPLIC proteins may provide a link between the ubiquitination
            machinery and the proteasome
  JOURNAL   Mol Cell 6 (2), 409-419 (2000)
   PUBMED   10983987
REFERENCE   9  (bases 1 to 3693)
  AUTHORS   Hanaoka,E., Ozaki,T., Ohira,M., Nakamura,Y., Suzuki,M.,
            Takahashi,E., Moriya,H., Nakagawara,A. and Sakiyama,S.
  TITLE     Molecular cloning and expression analysis of the human DA41 gene
            and its mapping to chromosome 9q21.2-q21.3
  JOURNAL   J Hum Genet 45 (3), 188-191 (2000)
   PUBMED   10807547
REFERENCE   10 (bases 1 to 3693)
  AUTHORS   Wu,A.L., Wang,J., Zheleznyak,A. and Brown,E.J.
  TITLE     Ubiquitin-related proteins regulate interaction of vimentin
            intermediate filaments with the plasma membrane
  JOURNAL   Mol Cell 4 (4), 619-625 (1999)
   PUBMED   10549293
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163038.5, AK049298.1, AK165456.1 and AI425982.1.
            
            On or before Apr 25, 2010 this sequence version replaced
            NM_019509.1, NM_026842.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC080667.1, AK049298.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-246               AC163038.5         134240-134485       c
            247-2498            AK049298.1         2-2253
            2499-3679           AK165456.1         2380-3560
            3680-3693           AI425982.1         1-14                c
FEATURES             Location/Qualifiers
     source          1..3693
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 30.95 cM"
     gene            1..3693
                     /gene="Ubqln1"
                     /gene_synonym="1110046H03Rik; 1810030E05Rik; D13Ertd372e;
                     Da41; Dsk2; Plic-1; Plic1; Xdrp1"
                     /note="ubiquilin 1"
                     /db_xref="GeneID:56085"
                     /db_xref="MGI:MGI:1860276"
     exon            1..370
                     /gene="Ubqln1"
                     /gene_synonym="1110046H03Rik; 1810030E05Rik; D13Ertd372e;
                     Da41; Dsk2; Plic-1; Plic1; Xdrp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..1966
                     /gene="Ubqln1"
                     /gene_synonym="1110046H03Rik; 1810030E05Rik; D13Ertd372e;
                     Da41; Dsk2; Plic-1; Plic1; Xdrp1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein linking IAP with cytoskeleton 1"
                     /codon_start=1
                     /product="ubiquilin-1 isoform 1"
                     /protein_id="NP_081118.4"
                     /db_xref="CCDS:CCDS49281.1"
                     /db_xref="GeneID:56085"
                     /db_xref="MGI:MGI:1860276"
                     /translation="MAESAESGGPPGAQDSAADGGPAEPKIMKVTVKTPKEKEEFAVP
                     ENSSVQQFKEEISKRFKSHIDQLVLIFAGKILKDQDTLSQHGIHDGLTVHLVIKTQNR
                     PQDNSAQQTNAPGSTVTSSPAPDSNPTSGSAANSSFGVGGLGGLAGLSSLGLNTTNFS
                     ELQSQMQRQLLSNPEMMVQIMENPFVQSMLSNPDLMRQLIMANPQMQQLIQRNPEISH
                     MLNNPDIMRQTLELARNPAMMQEMMRNQDRALSNLESIPGGYNALRRMYTDIQEPMLN
                     AAQEQFGGNPFASLVSSSSSAEGTQPSRTENRDPLPNPWAPQTSQSSPASGTTGSTTN
                     TMSTSGGTATSTPAGQSTSGPSLVPGAGASMFNTPGMQSLLQQITENPQLMQNMLSAP
                     YMRSMLQSLSQNPDLAAQMMLNNPLFAGNPQLQEQMRQQLPTFLQQMQNPDTLSAMSN
                     PRAMQALLQIQQGLQTLATEAPGLIPGFTPGLAAGNSGGSSGTNAPSTAPSEDTNPQG
                     GTAEPGHQQFIQQMLQALAGVNPQLQSPEVRFQQQLEQLSAMGFLNREANLQALIATG
                     GDINAAIERLLGSQPS"
     exon            371..522
                     /gene="Ubqln1"
                     /gene_synonym="1110046H03Rik; 1810030E05Rik; D13Ertd372e;
                     Da41; Dsk2; Plic-1; Plic1; Xdrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            523..638
                     /gene="Ubqln1"
                     /gene_synonym="1110046H03Rik; 1810030E05Rik; D13Ertd372e;
                     Da41; Dsk2; Plic-1; Plic1; Xdrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            639..901
                     /gene="Ubqln1"
                     /gene_synonym="1110046H03Rik; 1810030E05Rik; D13Ertd372e;
                     Da41; Dsk2; Plic-1; Plic1; Xdrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1060
                     /gene="Ubqln1"
                     /gene_synonym="1110046H03Rik; 1810030E05Rik; D13Ertd372e;
                     Da41; Dsk2; Plic-1; Plic1; Xdrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1304
                     /gene="Ubqln1"
                     /gene_synonym="1110046H03Rik; 1810030E05Rik; D13Ertd372e;
                     Da41; Dsk2; Plic-1; Plic1; Xdrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1447
                     /gene="Ubqln1"
                     /gene_synonym="1110046H03Rik; 1810030E05Rik; D13Ertd372e;
                     Da41; Dsk2; Plic-1; Plic1; Xdrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1531
                     /gene="Ubqln1"
                     /gene_synonym="1110046H03Rik; 1810030E05Rik; D13Ertd372e;
                     Da41; Dsk2; Plic-1; Plic1; Xdrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1647
                     /gene="Ubqln1"
                     /gene_synonym="1110046H03Rik; 1810030E05Rik; D13Ertd372e;
                     Da41; Dsk2; Plic-1; Plic1; Xdrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1813
                     /gene="Ubqln1"
                     /gene_synonym="1110046H03Rik; 1810030E05Rik; D13Ertd372e;
                     Da41; Dsk2; Plic-1; Plic1; Xdrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..3686
                     /gene="Ubqln1"
                     /gene_synonym="1110046H03Rik; 1810030E05Rik; D13Ertd372e;
                     Da41; Dsk2; Plic-1; Plic1; Xdrp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2312..2317
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ubqln1"
                     /gene_synonym="1110046H03Rik; 1810030E05Rik; D13Ertd372e;
                     Da41; Dsk2; Plic-1; Plic1; Xdrp1"
                     /note="hexamer: AATAAA"
     polyA_site      2331
                     /gene="Ubqln1"
                     /gene_synonym="1110046H03Rik; 1810030E05Rik; D13Ertd372e;
                     Da41; Dsk2; Plic-1; Plic1; Xdrp1"
                     /note="major polyA site"
     regulatory      3662..3667
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ubqln1"
                     /gene_synonym="1110046H03Rik; 1810030E05Rik; D13Ertd372e;
                     Da41; Dsk2; Plic-1; Plic1; Xdrp1"
                     /note="hexamer: AATAAA"
     polyA_site      3680
                     /gene="Ubqln1"
                     /gene_synonym="1110046H03Rik; 1810030E05Rik; D13Ertd372e;
                     Da41; Dsk2; Plic-1; Plic1; Xdrp1"
                     /note="major polyA site"
ORIGIN      
        1 agagtgccct gcgcggcgcc ggcgacgagc gtgggggagg tgcgggagga ggaagcggcg
       61 gcgacgcgga gagtccccgc gtccacacgg cagccgatcg cccacccggg gcctgcaccc
      121 gcagcccgcg tccacgcacc ctcggcggcc ccgcagcctg tcacgcctcg cggacccggc
      181 cgcagcccgc agtgtcgcgc tcgcctgagt caccgccatg gccgagagcg cagagagcgg
      241 cggcccaccg ggcgcgcagg acagtgcggc cgacggcggc cccgcagagc ccaagatcat
      301 gaaggtcacg gtgaagacgc ctaaagagaa ggaggagttt gccgtgcccg agaacagctc
      361 ggtccagcag ttcaaagagg aaatctctaa acgtttcaaa tctcatattg accaacttgt
      421 gttgatattt gctggaaaaa ttttaaaaga tcaagatact ctgagtcagc atgggattca
      481 tgatggactt acggttcacc ttgtcatcaa aacacagaac aggccgcaag ataattcagc
      541 tcagcaaaca aatgcccctg gaagcactgt gaccagctca ccagctcccg atagcaaccc
      601 cacgtctggt tctgctgcta acagctcctt tggcgtaggc ggacttggag gacttgcagg
      661 tcttagcagc ttgggtttaa acaccaccaa cttctctgaa ctccagagcc aaatgcagcg
      721 gcaacttttg tctaaccctg aaatgatggt ccagatcatg gaaaatccct ttgtccagag
      781 catgctctca aatcctgacc tgatgcggca attgattatg gccaatccac agatgcaaca
      841 gttgatacag agaaatccag agattagtca tatgcttaat aatccagata taatgagaca
      901 aacactggaa cttgcgagaa atccagcgat gatgcaggaa atgatgagaa accaggaccg
      961 agccttgagc aacctagaaa gtattcctgg gggctataat gccttacggc gcatgtacac
     1021 cgatatccag gagcctatgc tgaatgctgc tcaagaacag tttggtggta atccatttgc
     1081 gtccttagtg agcagttcgt cctcagcaga agggactcag ccttctcgaa cagaaaatag
     1141 ggatccgctc cccaacccgt gggctccgca gacttcccag agctcaccag cctccggtac
     1201 cactggcagc accactaaca ccatgagcac ctctggtggc actgccacca gtacccctgc
     1261 tggacagagc acctcgggcc caagcttggt gcctggcgca ggagctagta tgttcaacac
     1321 ccccggaatg cagagcctgc tgcagcagat aactgagaac ccacagctca tgcagaacat
     1381 gctgtccgcc ccatacatga ggagcatgct gcagtccctg agccagaacc ccgaccttgc
     1441 tgcgcagatg atgctgaata atcccctatt tgctggaaat cctcagcttc aagaacaaat
     1501 gagacaacag ctcccaactt tcctccaaca aatgcagaac cccgacacgc tctcagcgat
     1561 gtcgaatcct agagccatgc aggcgctgct gcagatccag cagggcttgc agacgctggc
     1621 cacagaagct cctggcctca tcccagggtt tactcctggc ttggcagcag gcaattctgg
     1681 aggctcttcc ggaaccaatg cacctagcac tgcacctagt gaagatacga acccccaagg
     1741 gggcactgct gagccaggcc accagcagtt tatccagcag atgctgcagg cccttgcggg
     1801 ggtgaatcct cagctgcaga gtccagaagt cagatttcag caacaactgg aacaactcag
     1861 tgccatggga ttcttgaacc gtgaagcaaa cctgcaagct ctgatagcca cagggggcga
     1921 catcaatgca gcaatcgaaa ggttgctggg ctcccagccg tcatagcagc atctctctat
     1981 cctgagaaaa tgtaatttat ttttgataac ggctcttaaa tctttaaaat aacatgcttt
     2041 atttcattgg gattctgtgc tgttataaag gaaaccaata ggaagtatct ggaggcagag
     2101 tgcagtacga cgggcgggtt tctgtgtctt tttggaacag tgggaatcaa tgtttcttct
     2161 ggttaaggct gctgcatgca tcaaacactt ggcatttatt gtaattttta aaaaaatatc
     2221 accttttcta attgggtgaa caaatttttg tcctgcatct gtccaactaa cttgcttttt
     2281 aaacataacc ctatggtagt aatttatgta gaataaaggc attaaaaagc agatcatttg
     2341 cgcgccccat gatttctggt acaatagtgc ttgttgtgac tttggcatgc actttgcaaa
     2401 tgatgctgta agatttatac tcctgacaat tttgtttatt tgtatacaat acaaattatt
     2461 gcacatttct aggccatcta agcaaaattt ctgtaactaa aaaagtacaa taaggattcc
     2521 taattgtgta gaatcttaca gcatctttga taaacatctc agcagaagtg ccatttagtc
     2581 tgtgtggaaa ataaagaaaa actaactctg gttatctctt tagggacatt taattgtaca
     2641 gacaacataa tgtaacaata tctcagcatt atataatggc tgtaaattac ctttccttgt
     2701 gccgactgga ggagcactgt atcatgctct gatgtgtttg ctggggcgtc ctgctccccg
     2761 taggtgtcgt ctacgcagca ttgagtttat tgaaatgtcg ctttcactgg aagtgcggat
     2821 gtttcggttc taattgccat ataaaagtag agctgtctct tgggtttatc agctttctca
     2881 ttcataggca atacctcgat tttaaatgat tagtgagcca cttgtttctc aagtgtttgg
     2941 ctagttctat taagaaatag ttgaatgtcg tgctgttcgg agcctcagaa gggggtgggg
     3001 gaggggtgaa acagaatcta ttctggattg ggccagcctg aactaggtaa tactggcaat
     3061 taagattctg tgaagattct atgcatatag tagtgtcatt tgggtgaaaa agagccgttt
     3121 taacaatttt gagtacgttt ggctattcta tagcctcttt cttccttccc caaagacgtt
     3181 ctacttgcct aactctcaaa ctgttggggt gatacattcc tttgggacca gttaaaatac
     3241 agcgttaggg tcggtgacat atgtgactgg ctctggttca gtattctctt atcttaggtc
     3301 actgtagtct ctcttgtatg gttgcccaaa attataatgt taaataatct aaagtgagtt
     3361 cagacaagta aaatcaaggg aaatagaagg tgaattctat aacttctgta agttgcttga
     3421 tattaaaagg ttgagaggca ggttggcccc agactgtata cttttctgac actttacctg
     3481 ggaagaaaac atgtacaaag gtcagggtgg aggcatgact gaggaggtcg gcacagcctg
     3541 catgtgtgtg ctctctctgc cttacgcctc agtctgtggt tggaagactt tgtactggtg
     3601 aatggcaata tgcaggtggg gcagtgtcaa aagcagtttg atttattaat ctccaaataa
     3661 caataaatct ccagctttta cacttgaaaa aaa
//
