LOCUS       NM_001255993            3900 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus U box domain containing 5 (Ubox5), transcript variant
            1, mRNA.
ACCESSION   NM_001255993
VERSION     NM_001255993.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3900)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3900)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 3900)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   4  (bases 1 to 3900)
  AUTHORS   Hatakeyama,S., Yada,M., Matsumoto,M., Ishida,N. and Nakayama,K.I.
  TITLE     U box proteins as a new family of ubiquitin-protein ligases
  JOURNAL   J Biol Chem 276 (35), 33111-33120 (2001)
   PUBMED   11435423
REFERENCE   5  (bases 1 to 3900)
  AUTHORS   Pringa,E., Martinez-Noel,G., Muller,U. and Harbers,K.
  TITLE     Interaction of the ring finger-related U-box motif of a nuclear dot
            protein with ubiquitin-conjugating enzymes
  JOURNAL   J Biol Chem 276 (22), 19617-19623 (2001)
   PUBMED   11274149
REFERENCE   6  (bases 1 to 3900)
  AUTHORS   Martinez-Noel,G., Niedenthal,R., Tamura,T. and Harbers,K.
  TITLE     A family of structurally related RING finger proteins interacts
            specifically with the ubiquitin-conjugating enzyme UbcM4
  JOURNAL   FEBS Lett 454 (3), 257-261 (1999)
   PUBMED   10431818
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731707.12, AK158052.1, AK034114.1 and AW060426.1.
            
            Transcript Variant: This variant (1) is the longest transcript.
            Variants 1-3 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK158052.1, AK171070.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AL731707.12        177255-177299       c
            46-430              AK158052.1         4-388
            431-3678            AK034114.1         238-3485
            3679-3900           AW060426.1         1-222               c
FEATURES             Location/Qualifiers
     source          1..3900
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 63.24 cM"
     gene            1..3900
                     /gene="Ubox5"
                     /gene_synonym="1500010O06Rik; C330018L13Rik; Rnf37;
                     Ubce7ip5; Ube7ip5; UIP5"
                     /note="U box domain containing 5"
                     /db_xref="GeneID:140629"
                     /db_xref="MGI:MGI:2154658"
     exon            1..123
                     /gene="Ubox5"
                     /gene_synonym="1500010O06Rik; C330018L13Rik; Rnf37;
                     Ubce7ip5; Ube7ip5; UIP5"
                     /inference="alignment:Splign:2.1.0"
     exon            124..270
                     /gene="Ubox5"
                     /gene_synonym="1500010O06Rik; C330018L13Rik; Rnf37;
                     Ubce7ip5; Ube7ip5; UIP5"
                     /inference="alignment:Splign:2.1.0"
     exon            271..412
                     /gene="Ubox5"
                     /gene_synonym="1500010O06Rik; C330018L13Rik; Rnf37;
                     Ubce7ip5; Ube7ip5; UIP5"
                     /inference="alignment:Splign:2.1.0"
     exon            413..508
                     /gene="Ubox5"
                     /gene_synonym="1500010O06Rik; C330018L13Rik; Rnf37;
                     Ubce7ip5; Ube7ip5; UIP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             455..2074
                     /gene="Ubox5"
                     /gene_synonym="1500010O06Rik; C330018L13Rik; Rnf37;
                     Ubce7ip5; Ube7ip5; UIP5"
                     /EC_number="2.3.2.27"
                     /note="UbcM4-interacting protein 5; U-box
                     domain-containing protein 5; ubiquitin-conjugating enzyme
                     7-interacting protein 5; RING-type E3 ubiquitin
                     transferase RNF37"
                     /codon_start=1
                     /product="RING finger protein 37"
                     /protein_id="NP_001242922.1"
                     /db_xref="CCDS:CCDS16747.1"
                     /db_xref="GeneID:140629"
                     /db_xref="MGI:MGI:2154658"
                     /translation="MVVNLCLPQFRPRIHCNKVSADGYEVENLISEDLIKRSHGFRTE
                     YFIRPPIYVTVSFPFNVEICRVNIDLTTGGYQNVSGLELYTSALSSRVSQDAQDCWTT
                     GPVETSVPDKEAFTLVGKVLLKNQNHVVFSHRGFKARPPFSPMEVTLLSPAVVAQELW
                     NKGALSLSHVAHLKIGITHVTGSGISCIKRLEVWGQPARTCSQEVINSVLLIASESLP
                     QDLDLHAPALPMESDCDPGGQSESQHSPCTLQDMSEVESDVPEEFLDPITLEIMPCPM
                     LLPSGKVIDQSTLEKCNLSEAAWGRVPSDPFTGLAFTPQSQPLPHPSLKARIDRFLLQ
                     HSISGCRLLGRAQTPSAMTPSVITLPSRKRKTEQAEHSSHYSLGMSASSSATSPLFSP
                     TTSEPTAKKMKATSELGLTDMDCSAGPVSHEQKLAQSLEIALTSTLGSMPSFTARLTK
                     GQLQLGTRGSSACRRPASSSEHPRSVSGPECASCKQAFSSYSTNEPVYQLPCGHLLCR
                     PCLSEKQRSQPMMCTACRQPVTSQDVLRVHF"
     exon            509..1706
                     /gene="Ubox5"
                     /gene_synonym="1500010O06Rik; C330018L13Rik; Rnf37;
                     Ubce7ip5; Ube7ip5; UIP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1865
                     /gene="Ubox5"
                     /gene_synonym="1500010O06Rik; C330018L13Rik; Rnf37;
                     Ubce7ip5; Ube7ip5; UIP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..3884
                     /gene="Ubox5"
                     /gene_synonym="1500010O06Rik; C330018L13Rik; Rnf37;
                     Ubce7ip5; Ube7ip5; UIP5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2527..2532
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ubox5"
                     /gene_synonym="1500010O06Rik; C330018L13Rik; Rnf37;
                     Ubce7ip5; Ube7ip5; UIP5"
                     /note="hexamer: AATAAA"
     polyA_site      2550
                     /gene="Ubox5"
                     /gene_synonym="1500010O06Rik; C330018L13Rik; Rnf37;
                     Ubce7ip5; Ube7ip5; UIP5"
                     /note="major polyA site"
     regulatory      2979..2984
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ubox5"
                     /gene_synonym="1500010O06Rik; C330018L13Rik; Rnf37;
                     Ubce7ip5; Ube7ip5; UIP5"
                     /note="hexamer: ATTAAA"
     polyA_site      3005
                     /gene="Ubox5"
                     /gene_synonym="1500010O06Rik; C330018L13Rik; Rnf37;
                     Ubce7ip5; Ube7ip5; UIP5"
     regulatory      3859..3864
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ubox5"
                     /gene_synonym="1500010O06Rik; C330018L13Rik; Rnf37;
                     Ubce7ip5; Ube7ip5; UIP5"
                     /note="hexamer: AATAAA"
     polyA_site      3884
                     /gene="Ubox5"
                     /gene_synonym="1500010O06Rik; C330018L13Rik; Rnf37;
                     Ubce7ip5; Ube7ip5; UIP5"
ORIGIN      
        1 aagcggaagg tgagggccgc tggccggaag tgggttgtgg agcggttgat gcaggagtct
       61 gtgcattgac ttacccgggg cggcccggga ctggagttag ggagctgcct tcgcgggctt
      121 cagtgctgga ggaggccaga agagggcgtt ggatctcctg ggacttgaat taaggttgat
      181 tgtgagccac agtgtgagcg ctggaaatca aaccccaatc ctctggaaga gcagccagta
      241 ctcttaaaca ctgagcaatc tctccagcca gtgaggatcc catttaaact ctgtgaaagc
      301 tatcaggtat gggatacaat ctgccacagt ccctaaagat accagatcga aggcaagagg
      361 taacactgag gctgacgatg aagataattt aatgtggatt ccttccaact caggctgctt
      421 ctgatgcttg gaagctattg ttccagttac taagatggta gtaaatcttt gcctcccaca
      481 gttcagacca agaattcact gcaacaaggt gtcagctgat ggttacgaag tagaaaatct
      541 catctctgaa gacctcataa aaagaagcca tggctttagg acagagtatt tcattagacc
      601 tccaatctat gtgacagttt cctttccctt taatgtggaa atctgtaggg ttaatataga
      661 tctcacaact gggggatatc agaatgtctc tggcctggaa ttatatacat ctgccttatc
      721 tagcagagtc tctcaggatg cccaggactg ctggactaca ggcccggtgg agacatctgt
      781 cccagacaag gaggccttca ccttggtagg caaagtctta ctgaaaaacc agaaccatgt
      841 ggtgttcagc cacaggggct tcaaggccag gccacctttt agcccgatgg aagtcactct
      901 cctctctcct gctgttgtag cccaggaact ctggaataaa ggggctcttt cccttagcca
      961 tgtggcccac ctcaagatcg gcatcaccca tgtgacgggc agtggcatct cttgcatcaa
     1021 gcgtttagag gtgtggggtc agccagccag gacctgctct caggaggtga taaatagtgt
     1081 cttgttgata gcctcagaaa gcctgcctca ggacttggat ctgcatgctc cagccttgcc
     1141 catggagagt gactgtgacc ctgggggtca gtctgagagc cagcactctc cctgtacctt
     1201 acaggacatg tctgaggtgg aaagtgacgt tccagaggag ttcctggatc ctatcaccct
     1261 ggagatcatg ccatgcccca tgctgctgcc ctcaggcaag gtcattgacc agagcactct
     1321 ggagaagtgt aacctcagtg aagctgcttg gggccgagtg cccagtgacc ctttcacagg
     1381 gctagccttt actccacagt cccagcccct ccctcatcct tccctgaaag cccggatcga
     1441 ccggttccta ctccagcact ctatttcagg ctgccgcctg cttgggagag cacagactcc
     1501 atcagcaatg accccttctg tcattaccct gccctcaagg aaaaggaaga cagagcaggc
     1561 tgaacacagc tcacactaca gccttggcat gagtgcgtct tcctctgcca caagcccttt
     1621 attctcacct actacctcag agccaactgc caagaagatg aaagccacca gtgagcttgg
     1681 cctgacggac atggactgtt cagcaggtcc agtgtcccat gagcagaagc tggcgcaaag
     1741 tctggaaatt gccctgactt ctacccttgg ctccatgcct tccttcactg cccggctcac
     1801 caaagggcag ctccagctgg gcacaagagg gagcagtgct tgcaggaggc cagcctccag
     1861 ctccgagcat ccaaggagtg tttctggccc agagtgtgcc tcctgcaaac aagcattttc
     1921 ttcctactcc acaaatgagc ctgtgtacca gctgccctgt ggtcaccttc tgtgccgacc
     1981 ctgcctgagt gagaagcaac gttcccagcc catgatgtgc acagcctgtc ggcagccagt
     2041 caccagccag gatgtgctgc gggtccattt ctgagtgatg agcctcaact ggagaagccc
     2101 cattttgggg gagacctgaa ggtggaggaa gcaagaacag gaccccagtg cctctgttct
     2161 ctcttgggct tgaatacctc atggtgtgtt atggagactg ggtagggaca tcccactcct
     2221 gcttaggcaa caacaggata ataaagccat agggctgggc tggggaagac atccctactc
     2281 tccctggccc accttgtcac ttcccaacca gagccagccc tcactggtca ggagcactcc
     2341 cctgtgcccc atgttatctg catacaacct tctaatggag ctttgtggat ggagctcaat
     2401 agactgactt gggacctcac acagccttct ctgcctcatg gtcactcaga agtggaccat
     2461 ggtaggggct gttaagcaca tgagttagcc atgtgtaccc ccacctctgc agacacttgc
     2521 agccttaata aagtgacagt tgacattcaa caaggattcc tcctagcaca cagaacagaa
     2581 cagccatatg cagttgctgc taccggataa gcaagggttc agatgtcttc agtgtgggtg
     2641 tgccagtgcc aagggagggc aagcagcttc catcaggcca ggtgccagag tatgtctggc
     2701 tgctcctgga gtcactctcc aagggagagg attcatgttc catatgtaac ccacatcagg
     2761 aaaacacttg cttatagaaa aggcttttaa caaattctgt atgtgtgcag gcacgtgtgt
     2821 gccctggtgt acctatggaa gtcagtgttc caggggtcag ctcactcttt ccaactatgt
     2881 ggctcccaaa acctcaggtc atcagcagtg tggcagtctc ctctaccctc tgaaccacct
     2941 cctcggatcc cataggctac attttttttc cttccaaaat taaacagtat ggagcctcaa
     3001 agaaattgat tgcctattgg cttgaaagag cttccagcca gtagaaggat acctgcacag
     3061 gtcctcacgc tgtcccgttc ccttccaggc atgacctgct ctgtcttgag ataaatcaca
     3121 gccccttgag ctacatgttg tctcccctgg ttgcccagga ctcagtcctg agagagaatc
     3181 agctttcaga gttcccagga aatctctcca tagaggtagc caatacggga atgccacctc
     3241 cttcctccta cacgccacca gtgcctgttg tgcttcagcc tttgtatgag acaccaggat
     3301 ctgcatggat aggccacttg cactgcctgg tggctcctgc acaccccact ctatgcctgc
     3361 gcctcccttc taagtggtgt gttcttagcc catgcaacta cagagggctt gctttggggg
     3421 ttgacaccta cccataacct gtcacggtct ctggagtaac ccacttccca ctcagccttt
     3481 acaccttgat gtgagtacca ggggccatcc ctgcccccca ccaagaaccc ccaggctgct
     3541 gcccctctgc agctctacca gaggtacccg gcctactctg ctggaaaact aggtctggga
     3601 ggccctgggg tgacctggag tccagggtgg ggggaaccac acccacaccg taaatgtgat
     3661 taagttttcc cttaaagatc tgacccccac cccatggaag tgctcttttc cttcatccgc
     3721 taccagaatt gttgtaatct tccctagaat acatgagctg ggcgtgatgt aagtttgtaa
     3781 atccaaacat ctaaagaact gctgtgagtt caaggtcagc ctgggccaca tagcaaactc
     3841 ttttctcaaa gacactgaaa taaaaatata tttggcccag tggaaaaaaa aaaaaaaaaa
//
