LOCUS       NM_177185              14671 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ubinuclein 2 (Ubn2), mRNA.
ACCESSION   NM_177185
VERSION     NM_177185.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 14671)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 14671)
  AUTHORS   Xiong,C., Wen,Z., Yu,J., Chen,J., Liu,C.P., Zhang,X., Chen,P.,
            Xu,R.M. and Li,G.
  TITLE     UBN1/2 of HIRA complex is responsible for recognition and
            deposition of H3.3 at cis-regulatory elements of genes in mouse ES
            cells
  JOURNAL   BMC Biol 16 (1), 110 (2018)
   PUBMED   30285846
  REMARK    GeneRIF: This study demonstrates that the UBN1 or UBN2 subunit is
            mainly responsible for specific recognition and direct binding of
            H3.3 by the HIRA complex.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 14671)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   4  (bases 1 to 14671)
  AUTHORS   Jensen,P., Magdaleno,S., Lehman,K.M., Rice,D.S., Lavallie,E.R.,
            Collins-Racie,L., McCoy,J.M. and Curran,T.
  TITLE     A neurogenomics approach to gene expression analysis in the
            developing brain
  JOURNAL   Brain Res Mol Brain Res 132 (2), 116-127 (2004)
   PUBMED   15582152
REFERENCE   5  (bases 1 to 14671)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   6  (bases 1 to 14671)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   7  (bases 1 to 14671)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 14671)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ172473.1, BC051458.1, AK051609.1, AC124762.4 and CF545710.1.
            
            On Oct 27, 2007 this sequence version replaced NM_177185.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051458.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                CJ172473.1         4-28
            26-2852             BC051458.1         1-2827
            2853-4485           AK051609.1         2226-3858
            4486-14320          AC124762.4         62752-72586         c
            14321-14671         CF545710.1         22-372
FEATURES             Location/Qualifiers
     source          1..14671
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 17.79 cM"
     gene            1..14671
                     /gene="Ubn2"
                     /gene_synonym="2900060J04Rik; 6030408G03Rik;
                     D130059P03Rik; mKIAA2030"
                     /note="ubinuclein 2"
                     /db_xref="GeneID:320538"
                     /db_xref="MGI:MGI:2444236"
     exon            1..674
                     /gene="Ubn2"
                     /gene_synonym="2900060J04Rik; 6030408G03Rik;
                     D130059P03Rik; mKIAA2030"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..4193
                     /gene="Ubn2"
                     /gene_synonym="2900060J04Rik; 6030408G03Rik;
                     D130059P03Rik; mKIAA2030"
                     /codon_start=1
                     /product="ubinuclein-2"
                     /protein_id="NP_796159.3"
                     /db_xref="CCDS:CCDS39461.1"
                     /db_xref="GeneID:320538"
                     /db_xref="MGI:MGI:2444236"
                     /translation="MAEPRRVAFISLSPVRRREADFAGAEREPPRLEPQPYREPARAE
                     PAPRADAQPPARDKPLPQREVSRAEPPMALQREPPRPEPPPPPLPLQTPPPRESASRA
                     EPPPRPPKETVRLELVLKDPTDESCVEFSYPELLLCGEQRKKLVHTEDPFTDEHKERQ
                     EVEMLAKKFEMKYGGKARKHRKDRLQDLIDIGFGYDETDPFIDNSEAYDELVPASLTT
                     KYGGFYINTGTLQFRQASDTEEDDFTDNQKHKPPKVPKIKEDDIEVKKRKRKEEGEKE
                     KKPRKKVPKQLGVVALNSHKSEKKKKRYKDSLSLAAMIRKFQKEKDALKKESTPKVPV
                     TPSSSSLPKPPCVTTALGDDIPDLGLNSADPDLPIFVSTNEHELFQEAENALEMLDDF
                     DFDRLLDATSDGSPLSESGGENGNTTHPTFPSQVVPKVVPTLPEGLPVLLEKRIEDLR
                     VAAKLFDEEGRKKFFTQDMNNILLDIELQLQELGPVIRSGVYSHLEAFVPCNKETLVK
                     RLKKLHLNVQDDRLREPLQKLKLAVSNVMPEQLFKYQEDCQARSQAKCAKLQADEERE
                     KNGSDDDDDEKPGKRVIGPRKKFHWDDTIRTLLCNLVEIKLGCYELEPNKSQSAEDYL
                     KSFMETEVKPLWPKGWMQARMLFKESRSVHNHLTSAPAKKKVIPASKPKVKECSPKKD
                     PKAPASVVASGGGPSTSSSTSIVASASSSSAPAQETICLDDSLDEDLSFPSASLDLVS
                     EALAVINNGNKGPSVGSRLNVPTTKPRPGLREEKLASIMSKLPLATPKKLDSTQTAHS
                     SSLIAGHTGPVPKKPQDLAHTGISSGLIAGSSIQNPKVSLEPLPARLLQQGLQRSSQI
                     HASSSSQTHVSSSQAQAAASSHALGTSEAQDASSLTQVTKVHQHSAVQQNYVSPLQAT
                     ISKSQTNPVVKLSNNPQLSCSSQLLKTSDKPLMYRLPLSTPSPGNGSQGPHPLVSRTA
                     PSTTTSSNYLAKAMVSQISTQGFKSPFSMAASPKLAASPKPATSPKPLPSPKPSVSPK
                     PSLSAKPSISTKQISKSNPAPKPAVCPSSSSPNTLVAQSSHSTSNNPVHKQPSGMNIS
                     RQSPTLNLLPSNRTSGLPTTKTLQAPSKLTNSSSTGTAGKNSLSGIPMNVPASRGSNL
                     NSSGANRTSLSGGTGSGTQGATKPLSTPHRPTSASGSSVVTASVQSTAGASLLANASP
                     LTLMTSPLSVTNQTVTPFGMLGGLVPVTMPFQFPLELLGFGTDTAGVTATSGSTSAAL
                     HHSLTQNLLKSLQPGAQHAAALPHSPLPAHLQQAFNDGGQSKGDTKLPRKPQ"
     exon            675..767
                     /gene="Ubn2"
                     /gene_synonym="2900060J04Rik; 6030408G03Rik;
                     D130059P03Rik; mKIAA2030"
                     /inference="alignment:Splign:2.1.0"
     exon            768..869
                     /gene="Ubn2"
                     /gene_synonym="2900060J04Rik; 6030408G03Rik;
                     D130059P03Rik; mKIAA2030"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1007
                     /gene="Ubn2"
                     /gene_synonym="2900060J04Rik; 6030408G03Rik;
                     D130059P03Rik; mKIAA2030"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1111
                     /gene="Ubn2"
                     /gene_synonym="2900060J04Rik; 6030408G03Rik;
                     D130059P03Rik; mKIAA2030"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1601
                     /gene="Ubn2"
                     /gene_synonym="2900060J04Rik; 6030408G03Rik;
                     D130059P03Rik; mKIAA2030"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1672
                     /gene="Ubn2"
                     /gene_synonym="2900060J04Rik; 6030408G03Rik;
                     D130059P03Rik; mKIAA2030"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1802
                     /gene="Ubn2"
                     /gene_synonym="2900060J04Rik; 6030408G03Rik;
                     D130059P03Rik; mKIAA2030"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1921
                     /gene="Ubn2"
                     /gene_synonym="2900060J04Rik; 6030408G03Rik;
                     D130059P03Rik; mKIAA2030"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2035
                     /gene="Ubn2"
                     /gene_synonym="2900060J04Rik; 6030408G03Rik;
                     D130059P03Rik; mKIAA2030"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2179
                     /gene="Ubn2"
                     /gene_synonym="2900060J04Rik; 6030408G03Rik;
                     D130059P03Rik; mKIAA2030"
                     /inference="alignment:Splign:2.1.0"
     exon            2180..2230
                     /gene="Ubn2"
                     /gene_synonym="2900060J04Rik; 6030408G03Rik;
                     D130059P03Rik; mKIAA2030"
                     /inference="alignment:Splign:2.1.0"
     exon            2231..2273
                     /gene="Ubn2"
                     /gene_synonym="2900060J04Rik; 6030408G03Rik;
                     D130059P03Rik; mKIAA2030"
                     /inference="alignment:Splign:2.1.0"
     exon            2274..3821
                     /gene="Ubn2"
                     /gene_synonym="2900060J04Rik; 6030408G03Rik;
                     D130059P03Rik; mKIAA2030"
                     /inference="alignment:Splign:2.1.0"
     exon            3822..4053
                     /gene="Ubn2"
                     /gene_synonym="2900060J04Rik; 6030408G03Rik;
                     D130059P03Rik; mKIAA2030"
                     /inference="alignment:Splign:2.1.0"
     exon            4054..4143
                     /gene="Ubn2"
                     /gene_synonym="2900060J04Rik; 6030408G03Rik;
                     D130059P03Rik; mKIAA2030"
                     /inference="alignment:Splign:2.1.0"
     exon            4144..14669
                     /gene="Ubn2"
                     /gene_synonym="2900060J04Rik; 6030408G03Rik;
                     D130059P03Rik; mKIAA2030"
                     /inference="alignment:Splign:2.1.0"
     regulatory      14647..14652
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ubn2"
                     /gene_synonym="2900060J04Rik; 6030408G03Rik;
                     D130059P03Rik; mKIAA2030"
                     /note="hexamer: AATAAA"
     polyA_site      14669
                     /gene="Ubn2"
                     /gene_synonym="2900060J04Rik; 6030408G03Rik;
                     D130059P03Rik; mKIAA2030"
                     /note="major polyA site"
ORIGIN      
        1 ctgcttctat ttatgtgggg gatccaacat ggcggctgcg gcgaccctgg cgatggcggt
       61 ggagcccatc agaacgtagt agcggggacg gggacccggt ccgcactcac ggtggcgtcc
      121 gcggggacag ctgagggtgc tggagggaag aaaagtgacg gagagcagaa ggagaggcgg
      181 gcaggcgcgc cgtgcggcgt cgaggcgaga gccggctcga gcgagcgccg agggccagaa
      241 cagtggggat ggcggagccg cgcagagtcg cgttcattag cctgtcaccg gtgaggcgac
      301 gcgaggccga cttcgcgggc gccgagcgcg agcccccccg actggagccg cagccgtacc
      361 gcgagccggc ccgggcggag ccggcccccc gcgctgacgc gcagcccccg gcgcgcgaca
      421 agccgctccc ccagcgcgag gtcagccgcg ccgagccgcc catggcgctg cagcgcgagc
      481 ccccgcggcc cgagccgccg ccgccgccgc tgcccctgca gactccccct ccgcgggagt
      541 cggcttcccg ggcggagccg ccgccgcgac cgccgaagga gacggttcgc ctggagctgg
      601 tgctcaagga ccccacggac gaaagctgcg tggagttcag ctacccggag ctgctgctgt
      661 gcggagaaca acggaagaaa cttgttcata cagaagatcc atttactgat gagcataagg
      721 agaggcaaga agtggaaatg ttggctaaga agtttgaaat gaaatatggt gggaaagccc
      781 gtaaacaccg gaaggatcgg ctacaagatt taattgatat aggctttggc tatgatgaga
      841 cagatccatt tattgataac tcagaggctt atgacgaatt agtccctgct tctctaacaa
      901 caaaatatgg aggcttctat atcaacactg gcactctgca gttccgccag gcttcagaca
      961 ctgaagaaga tgatttcaca gataaccaaa agcacaagcc acccaaggtt cccaaaataa
     1021 aagaagatga tatagaggta aagaagcgga agcggaaaga ggaaggggaa aaagaaaaga
     1081 agccaaggaa aaaagtaccc aagcaactgg gagttgtggc tctcaattca cacaagtctg
     1141 aaaaaaagaa aaagcggtat aaagattccc tttctctggc tgccatgata cggaaatttc
     1201 aaaaagagaa ggatgcattg aagaaggaat ctacccctaa agtcccagtg accccatcat
     1261 cttcctctct gcctaagccc ccttgtgtca caacagccct tggggatgac atcccggact
     1321 taggtctgaa cagtgctgac ccagacctcc ctatttttgt tagcacaaat gaacatgaac
     1381 tgtttcagga agctgaaaat gccctagaga tgctagatga ttttgacttt gacagattac
     1441 tggatgctac ttctgacgga agtcccctct ctgagtcagg gggagaaaat ggaaatacca
     1501 cccatcccac cttcccctct caggttgtgc ccaaggtggt acctacactt ccagagggtc
     1561 tacccgtgct tcttgagaaa cgcattgagg accttcgtgt agctgccaaa ctttttgatg
     1621 aagaaggaag gaaaaaattc tttacacagg atatgaataa tattcttctg gacatcgagt
     1681 tacagctaca agaactaggt cctgtcattc gtagtggtgt ctactcccat cttgaagcat
     1741 ttgtgccatg caataaggaa acactggtaa aacgtctaaa gaagttacac cttaatgttc
     1801 aggatgatcg tttaagagaa cctctacaga agctgaagct ggcagttagc aacgtcatgc
     1861 ctgaacagct gtttaaatac caggaggact gccaggctcg cagtcaagcc aaatgtgcca
     1921 agttgcaagc agatgaagaa cgggaaaaaa atggatccga tgatgatgac gatgagaaac
     1981 cagggaagcg agtcatcggc ccacgaaaga aattccactg ggatgacacc atcagaactt
     2041 tgttatgtaa ccttgttgag atcaaattgg gatgctatga attagagcca aataaaagcc
     2101 agtctgctga ggattatctt aaatccttca tggagacgga ggtgaagcca ctgtggccta
     2161 agggctggat gcaggcaaga atgcttttta aggaaagccg gagtgtgcat aatcatctta
     2221 cttctgctcc ggcaaagaaa aaggtgattc ctgcatcaaa acccaaagtc aaggaatgta
     2281 gccccaaaaa agaccccaaa gctcctgcat ccgtggtggc ttcaggtggc ggtccttcca
     2341 cgagctccag cacatccatc gttgcctcag ccagctctag ctcagcacca gcccaagaaa
     2401 ccatctgcct tgatgactcc ctcgatgaag acctttcttt cccctcagcc tcactggatc
     2461 ttgtatctga agctctagct gtcatcaaca atgggaacaa gggcccctca gttggttcaa
     2521 ggctaaatgt gccaactaca aaacctcgtc caggactgag agaagaaaag ctagcaagta
     2581 tcatgagtaa gttaccactg gctactccca aaaaactaga ttctactcag actgctcact
     2641 catcaagtct tattgctggt cacacggggc cagtaccaaa gaaaccccag gatttagctc
     2701 atactggtat ttcttcaggc cttattgctg gttcttcaat tcagaaccct aaagtttcct
     2761 tagaaccttt gccagccagg ctactccagc aaggactgca aaggtcaagc cagatacatg
     2821 cttcttcctc ttcacagact catgtctcct cctcccaagc ccaagctgct gcctcctctc
     2881 atgctctggg aacatcagag gcccaagatg cttcttcgtt aacacaagtc acaaaggtgc
     2941 accagcactc agctgtccag cagaactatg tgtctccatt gcaagccacc attagtaaat
     3001 cacagaccaa cccagtggtg aaattaagta ataaccccca actttcctgt tcgtcccaac
     3061 tactcaagac ttcagataag ccactgatgt atcgcctccc tttgtctacc ccatcacctg
     3121 gaaatggttc tcaggggccc caccccctag tttctaggac agcaccgagt accactacct
     3181 ccagtaacta tttagccaag gctatggtgt cacaaatctc cacgcagggt ttcaaatctc
     3241 ccttctcaat ggctgcatct cccaaacttg ccgcatctcc caaacctgcc acatctccca
     3301 agcctttgcc ctcacctaag ccttctgttt cacccaagcc ctctctgtca gctaagcctt
     3361 caatatctac taaacagatt tctaaatcca acccagctcc caagcctgct gtatgcccaa
     3421 gttcttctag tccaaacaca ctagtagccc agagtagcca ctccacaagt aacaaccctg
     3481 tccataaaca gcccagtgga atgaacatca gcagacagtc tcccactctg aatttgttgc
     3541 cctcaaatcg cacttctggc cttccgacta caaaaactct tcaggcccct tctaaactaa
     3601 caaactcatc atccactgga actgctggga agaacagctt gagtggaatc ccaatgaatg
     3661 tacctgccag cagaggtagc aaccttaact caagtggagc taataggact agtctatctg
     3721 ggggaacagg aagtggaaca cagggtgcta ctaaaccgtt gtctactcca catagaccaa
     3781 cctctgcctc agggtcttca gtggtaacag ccagtgtgca gtccacagca ggagcatcat
     3841 tattggctaa tgcctcacct ctgactctca tgacatcacc tttgtctgta acaaatcaaa
     3901 ctgtgactcc ttttgggatg ctgggtggcc ttgttccagt gaccatgccc ttccagtttc
     3961 ccttggagct acttggcttt ggaacggaca cagctggagt gacagccacc tcgggatcta
     4021 cctcagcggc tctccatcac agcctaaccc agaatttact aaagagttta cagccaggag
     4081 ctcagcacgc ggcagccctt cctcactctc ctctgcctgc tcacttacag caagcgttta
     4141 acgatggagg ccaaagtaaa ggggacacta agttaccacg gaaacctcag tgactttcca
     4201 gcaaggggga gaggaaccac ttggctggct ggcgggaccg acctgatggg aagtcttggc
     4261 ggtcacaggg ctgctgtttc tgtccatgtt tacatgcttg tcccaagcac tgtggtgagg
     4321 aggaaaagag agaaaatgtt acttgagcaa agccagtgca ggaggaagag atgcttttgt
     4381 gcaaagtcag ggagctttgg tcttttcaaa cccaagcccc catgttaacc aacttaaagc
     4441 agactcagct gtcaaaccca cagaagtgtc aatctgactg tatttaaaaa aaaaaaaaaa
     4501 aaaaaaggaa agaaaagaaa agaaaaggaa aaaaactggg gaagaaggaa ggaagttaag
     4561 aggatttggg taaatggcca tccatcctgg gggttaggtc tgaacactct acagataagt
     4621 gcataataaa agcagctaca agtagaatta gcccagttta aggagactca gtcatgtctg
     4681 tctagtagac agattttcca cagtcagttg catgaggctc tccagacagt tgccgaagag
     4741 tactgtgccc tgaaatgtcc tgagcaaact tgaatcttct ccagtatata gcaggtcccc
     4801 gtgcgagtca gtggcctgaa gatactttag caaagctgct gtgacacagt gatgtgtagt
     4861 actatagctt ctaggttttt aaagtcagga aaaggagcct gtgctcttac gagacaaaat
     4921 gtagataatc cctttttata aaagggtcag tttcaccctc cattcagaag taagtactgc
     4981 actcctttcc acagttcact tgtcatctgg tattgactgg ttaatagtta tttctcgtcc
     5041 tgatatgcag aagtgactgc tcgcattttc tcttgacatg tgcgtctttg ttgttgggct
     5101 gctgctttgc tgctcatctc tcttgcagcc tgccaagaac tgcaaactcc cagttccctc
     5161 cctgcacagt gctctttcac tagcggtact ttaggtgact agagctgttg atataaacag
     5221 gagtgtgcac agcatctgtc tcttcatggg tcaaacaaat agcgtatgta taatagtgga
     5281 ctgtttttca ttctgaagtg gtatttttaa agggatgaag tctaatagga atacggatgt
     5341 gcacaggatg tgcacaaagg accacctgtt ataactatca caatgaagct ttatgaccca
     5401 tgcccagcgc aggatgtttt cagcatttgg gatcttaaaa gttttactat gacttactca
     5461 gaatattaat attcaagtca gcctacagat tataagattc gttaattcta gttttcatat
     5521 gcgaatagag gcaatgaagg gtgtgaaggg gaaaacacaa ttttcttggg atacatttta
     5581 ttttgcctca gctatgtttg tggtgtcctt gaattttaaa cttctgagta ttttcagact
     5641 atccaagaaa aagctctgag tgatacaaat ttagtttata tatggtgaca gactagcctg
     5701 gtaataacaa gattgcttct ataatctcat tacatattac tctgtatcat ttaagtttat
     5761 tcagataaga gtgttaacca gaccccattt tcctttgatg agcaaaagtc ccaagaagcc
     5821 tctaggacta taataaccaa ccgcagacct gctccaattt ttatgcctat aatttgactt
     5881 caaagtttca atggcgtgct taatagcaaa aaagtcaatg aataattgaa agctttagtt
     5941 ccaagaactc gttacagtaa aggaagatga tttttttttt agaagaacat tgaaactaga
     6001 tatgatggcc catgcttgta atcctagaat tcaggaagct gaggcaggaa gatctcaggt
     6061 ttgaggccag cctgaagtat ttagcagcaa gtcccatgct agtctctact ggactaacaa
     6121 tgagagctgt ctgtttccaa ctgtcttatt gtcttttaat gttcaattaa ttaaaaatct
     6181 attggacttc catatcaggt gtccctgaca gcaagttctt caatgtcact tgctgccata
     6241 tgaaaataat ctttaaaaag ttcataaagt tcttcaaaaa actggggccc cttgctccag
     6301 gctccttcgc gcctcttctc cttccggttt ggtgcagaat gggttgtgag ctgtgttttt
     6361 ttctttttgt cctcttttgt tactaacatt tttctttttc tttttttcct ttttcttttt
     6421 taaaataaaa agcatagatt tcccctcctt acccctcctt ttacaatggt ctcttctccg
     6481 ctctaagtcc tcccacttcc tagttcaagt ttcatttgtg ccccgactgc ccccctccct
     6541 gccccattgc attgtttgtg tgcggcacct gcagtagaaa atcccagctc tccaggtcgg
     6601 tctgggagct cctccaccct cctcctgtct caaaaaagaa aaagaaaaaa aaagagagag
     6661 aaaagaaaaa aggaaaacaa acgaaagtaa tcactgatat aatttcttga ctgtagaaat
     6721 ttactttacc aataaaacaa atgaggaggc tatgtaagcc ccagtagata ttttggaaag
     6781 atattgggat gttgcagaga agtttgactt gaatttagca cgttaaggtt catttgaaag
     6841 gtctcttaga gaaacttgat cagctcttac gccagcacca ggaaacttcg tttcacaggc
     6901 ctgcttatac ttcataaatt gctgtactgg ggtgtctgtt gaggaaggca gcctgtactt
     6961 cattttctct acccagagag aagtccatgt gtgttagtgt ctcttcttgc tgatacttgt
     7021 gtatttgtgt atttgcagac acatacatat tcatataaat caatcgatat taaaagtcaa
     7081 acaataattg taggttctta aatccatcga ttctgaacca tgctatacga agacccttga
     7141 tggttctctt tcccatgtca ttttataaga ttaccctggg ctctgagact atgctgtgta
     7201 aaatatatcc tgttttctgt cagtcttgac tccttaagga ctgctgccag atccccagtc
     7261 cagcaaccct ttcatgttat acaagtgaat caaagtcctt tctaaatgta aatacatttc
     7321 tttctatatc ataacattga aaatggtgtc catactttat ggttacctgt ctttacagtt
     7381 tttattacta aacaagcata taagttggtt attttttaac agagacttgc aattcatact
     7441 gtatttttgc acttaaagtc aaattatgtt atttttaaaa tggtgaataa ctggaaagga
     7501 tatctataga gcagtgtgta tcactaaaga acgttagcaa catccaaatg cagaagtaaa
     7561 tcagcacacg taggtcccat tcgatggggt ccttgattca ggaatattaa actgtctgtt
     7621 tccaactgtc ttatctttga aattgccttc actgatgtga tgtctaagct gttactgtat
     7681 ataaaggtga tcctcagtat tcacaagcaa taacagtcag cagcgctgtc ctcgggcagc
     7741 agtgctggac cacagctgga gactgtttgc gagccaagtg tcatgctcac tcagagcctc
     7801 caaagtaaat gcaagcaata atctctacta aaatcaaatt atagttcttc tcctgcttct
     7861 gagaacaaag agtgaaaatc atgattttaa aacaatctgg agaaaaggtt tggagaaaag
     7921 aagccaagtt aatgtataat aacaaagtcc tgatattttg aagaaatcaa gaagattcaa
     7981 ttagtacatt ctttcatgcc caccacccct ttgatggatg ttattagccc aaattatctt
     8041 gttttgtgtc ataaacaata aataaggctt atttgggtcc cagcactggg gaaagaactg
     8101 ggcatatacc tgtgggtata tattgactgt gggtttgaca cctgcttgga aacagcttat
     8161 tgaaagtgat cttaatccag aatatttttt cccaaagcag atctaaattg tttactatgc
     8221 agagatggaa agggtaggca cccctattct ctctcctctt gttgtcctct cccacagccc
     8281 ttcccacctc tccttgattc aagactttct aaaatgaaaa tcctactgtt attgcgactg
     8341 ccattggtta tgagaactct gttctttggg aatgtctcta gaactcattg tcctacttgc
     8401 tgctacattg gaagatgatc tttgcctgtg ttggctgact ttaactgctt tatttgtagg
     8461 agactttgtc atgtcctttg accctgtgta gaagaactag ggtactttac tttaggagtg
     8521 tactataaaa gcacactggt cctcgtattg ttagagaagt ttgggatttg ttccccttgt
     8581 tggtttttgt tttgttttat ttttcaaatt gaaagtagaa gaaagaagtc tatagtccag
     8641 gccggacttg agcactgccc tgtgcttcag cacggtgctt ctgctgaccc acgttctctg
     8701 aagggcactt tgatttctag ttgtgcatgt gcggctcttt gtttggtttt gctttcaggg
     8761 tgcttttggt tttgtaaaaa caaagcagag aaaagtacag tagtagataa atgatcacaa
     8821 acatgttatg caattttatt ttataaagtt ttaagggaaa agtttatctc gttgtaaata
     8881 agttcttatc tctggtaaaa tgcttatatt actcctctaa accatgctca attcaggcct
     8941 ttgtctttgt taagtgcctt ttatttcttt ctttttctcc ctcttttgaa actttcaaac
     9001 accctcaagt acagactgat gaagtcaggg gattcaggag aaagaatctg agccttgcca
     9061 aaatcatgtc atgtaataat tctcttcctt ctgctttgtg tgtgtggaca caagtatgag
     9121 gtacacagcg tgtatgaaac caggagcagc tgtgccatgg caatccttct aagcactgcc
     9181 ctgttgacat tgcagaactt ctgccttgtt tattccattg ctttgagttg attcagatgg
     9241 gcagattggg aagtagtctt tgcacatgat gctggcttcc ctttctgaat atctgtagaa
     9301 gttaatatat atgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtatatat
     9361 atatatatgt agggcattat atatataaag catatgtgtt ggttattgca aacataataa
     9421 actctgtgga ctccttgact atttctggat gtaatccact tctctctacc cctcaaatct
     9481 ttcagtagta gtgtgtgaga aagcatcagg ataacaagag catttgttgg tcgaggtgat
     9541 acgatgccct atgcagacaa gattcagtac tagtgctaga accatggggt ggtgtctgaa
     9601 tacactttgg aggaggttgg cactcatgtc aatattaaaa gacgttttct tctggaaaat
     9661 gatcttgaaa ttgtatatct gaaacgtcaa taaacttaga tttttagaca gtgaggaaac
     9721 acttgtataa tcaggacgta cttgagaaat gttcagtctg tttattgcca gatgatcaga
     9781 tttgctctga tttcatgatt gtttaaatgt ctttcctgag caaaataaaa taactttcag
     9841 tatctaagac ttgagggggg ggttctgttt tgtttttgtt tttagatgta acatgttgaa
     9901 aaagactaag ttgaactgat cctctgtata tctacaaagg accccctttt aagtaaaatt
     9961 ttagttgaaa aaggagactt gtggctaaaa gaagaggttc ctgtagcaaa gctgttgtta
    10021 gccagcttag gatcagtagt gagtgttaat tcctaaacta ctttatctag ggggaagtca
    10081 tttaaccttt gtgcctcaga ttacccatga gacaattggg tataataata atcacctacc
    10141 tcccagggat atcagagact ttactatttc aaaaatattt tgtttttcta aaacattcta
    10201 tataattata gtattatctt cctgcagagg ttgaaaaaaa caaatgtttt tcttatagtg
    10261 gatataaaga gcaccctatg gtctttaagt taaaaaaaat cactggaatt ttaatttaga
    10321 tgtatatttg atatttaaac ataccatatt tgttgtgtgg tataattatt agtttcagat
    10381 taaatcaaag gggaatgaac actaagtttc ttaactatca atagattttt taaagctttt
    10441 atgatgttat tacttgtgtg atatttgcaa aggttgtgaa agtaaagtta gataaagttt
    10501 gaattatgga taaatgatcc tgaaagttta tagcctcctt tgtctacatt ctgaatctaa
    10561 tttccttgca gtacttgcct ggtgatggaa aactaatttt ttacctttct aagagtaagt
    10621 cagatcctgg catacgactc ctgcatcagt aggactctcc acctttgcct gggggataag
    10681 gcatgagcag cctacactag ggcggctgtg cgttctttta actttgtatt tcatgcttct
    10741 tcagccagag ccatcaactg ttcgggttgt agtaaaatgg gaggaagatc gacaggattc
    10801 actccctagc tagggcagag gtaaagatgg tcaggataga aggaaatatg atttcccaaa
    10861 ctcctgggag gaaattagca tcattttatc ttcccctcca ggcatgcaca ctaagtagta
    10921 atccataaca tttttctctt taaaacgata acaacaggaa caaatgggta ctacagtttt
    10981 tgttagggct gagtagtgca tgtgagagtg ggggcgggag gggggtagtc taaatgacag
    11041 cgaatattca gggtcagaga gagtggagtg cagggtgttg aggagcaatt actcagctca
    11101 ggtgagttag gaggtagcac tgggctgaag cagccagcac atctgggctg acccagaact
    11161 ggctcagacc tagtcattct ctagtccttc taaaatcatt tttgggattt ttgttgattt
    11221 ttttttctct ccagtagcct ctgaatatca gctatgcaga taagcatatg cttcgttttc
    11281 cacattatat tcctattcat tgttcaataa catgttaaga ttaacccaaa tgaatgtgtg
    11341 tgtttcctct agagaagagt aacagaagcc taaaataaat atcatctgtt ttcctttgcc
    11401 ctaaaatgtg aactttccat aaaacgctag ctgaagatcc tttgctcatg cagacctaga
    11461 gttgatgtta tggatgtgtt tgcactttta tgatagtgtc acctcgtgta atgctgagag
    11521 gcttaggtta gtgttcagga tgacagagct gcagacttgg gctctgatta aaattagttt
    11581 caaatatcaa tgttgaattt gtcttcattt ctttcagtct tcagtcttgc ctttggtgtg
    11641 agctcttaag ttcccacttg ctccactaca gtataaatta cctgttgtta tatctaggga
    11701 gagaaagtga attgtttcca tatcctcttc tcccttactt tgccatctgc tctcagttcc
    11761 catcaagtta gtgtaaagat agtgtgggga gagtttcatc ttagtggagg atacatatat
    11821 atatagagag agtttagtgg aaataccttt gagtagcctg atgctaaatg acacttttct
    11881 tatgcacact caacgtacca tttgctttaa ggtggctatt tgtgatctcc ttgtgttgtg
    11941 atgtttctac ttgtctgtct ttcctatgta tttccatttc atagcagcta gtattcaaac
    12001 tttgtataca ttttacactg ctacccaaac tagtcagtga cgtgttttga agttttcatg
    12061 gtacaaatta aggttctata catagtgtag aacttggtgg tcactgatga ctggggtttc
    12121 ttctcttttc atttatattc aataaataaa tagatttcat aggctgagag tctgtctcac
    12181 tgggcactct tgcccagcat gtacgtaagc tagagctcca cacagcagtg cacagtaaca
    12241 gtaagtagac ttcattttta catagcctgg gataccagtg tattttacat agcctgggat
    12301 accagtgtat tttacatagc ctgggatacc agtgtatttt acatagcctg ggataccagt
    12361 gtattttaag attcttcaga agaaatgcag attttcatta ggggctcaca gcagtctgcc
    12421 ttgctgactg ttttcataca gactccttac aacagagctc ttttgccaag gtctgagcca
    12481 accagatcat tgaatcctag ttaggaccta agtcctaatt ttaggttcct caaaagaaaa
    12541 acattacttg ccccgacttt gctacaatat tctggatttg tttgtttgtt tgtttgctaa
    12601 atctggttgt tagatccttg ttaatagtgc tctggttaga attcagttaa ggttatttgt
    12661 ctgagataac acgagagtca gcagcagtcc agactagcca ctgtgtgtgt gataatctgt
    12721 gctgaagttt ccacaccaga ttgtattttc tgtacttaga accatagact ttcctcctgt
    12781 tatacttatc tctgctgttt acagaaacgt tatgccctac tagaaaattc actagcaaaa
    12841 ttaccaagga tttgccccca tttgggctag aaatataaaa agaaaaaaaa tatttttctt
    12901 agttgacaaa agtatttggt ttaaatagtt agaaagttga gccagctttg gtcagttttc
    12961 ctggcatttt ggctctgact ccatcataga ttgcgtgtac actttgacat gtgttcatca
    13021 gggaccctct cccagtaaag attggttttc ctcccacaca gctttcagga cagagagcca
    13081 agcttttcag tgacctgttt tcagctgtct ttgaaagact atcttattct agaaaatgct
    13141 ggcgtgctaa actgttcttg gaagagagtg tgctagtttg accctcctca tggtgtctct
    13201 tgtcctgtta aacttatcag acttcaagga aaggaagaga aatctctggt gaattttgtg
    13261 ccccaaataa tgaacttaag tctaaccaag gtgactaaga gatgggtgtt ttctctctct
    13321 actcgtgagc aaggtttatt tatggttgta agacttacca tggaactgca gacctatttg
    13381 cccagaaaat aagagtcaga attttagtca tgttaagcac agatttcgaa ccctttggta
    13441 aagttagata aggggagact tttgtttagt agcagaagga aaaataatta tttatacagt
    13501 gagtatccac cctgcaaagc cacttcccag tatggaagca gctcctcttt agtcccttct
    13561 gccctacaca gatgctacca tgtttgcaag ccagtctcca agaaggagcc gaggagttga
    13621 tggtccttta gaggagaggc ctcagttact gggttgcatc tgcttgtagg aaagtgtgtt
    13681 tgctaacttg aaggaatata tgctgtactt caaataagtg tgtgacttaa tgctttggga
    13741 ttttttttcc ctctaaaact ggacctgaac acagctttga gttggtattt gtaataatct
    13801 caggacccga aagattgtag catttagtgt gtcttaaaaa ttatgtactg taccagccat
    13861 ggagttttgt aaatatacct gtctcccttt ttttgtatta ttttagtaaa caataaataa
    13921 ataaataaat ttaataaaag ggggtgatga tgatgtgtgt gtttgtgtgt gtgtgtgact
    13981 gactctgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtggct cttttggagg caaactggtg
    14041 cttgttgaat ttctagttca gttcagcagg aatatagaca aactgctgct gttgaccctt
    14101 acaatgagca aggaggaggt ccttcatttt gccctctggt ggttcatgta gtactagcaa
    14161 aatggaagtc aggagctaaa ctcttctcct ctggccatat tgcctttgtg ttcttggtct
    14221 agctccaaca ttctttgacc tctggcatta aagcttccac actttgaaga ttcctggttt
    14281 tagagctctt aaaactttcc taagagagag agagagagaa aaaggggggg ctgattataa
    14341 aataaataaa aagcaacaaa agagcctcac atttcatagg accgctggtg aattttagat
    14401 atttccaaac atgcatctga gaacttatta aactagcccc acagtgcact cctcagtgcg
    14461 gggatgtctg tgttcatttt gctttgcgac agccttgttc atattccagg tgtaactagc
    14521 aaacctgttt taaaatgaga gccttattcg attcagtgta gatgtttcct ggctatcctc
    14581 caagacagga cctttttaca tgagtgagtt tttctttttg tatatgttaa tgtgtttgtt
    14641 gtattaaata aagaggaatg taaatattaa a
//
