LOCUS       NM_024475               2155 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus ubiquitin-like domain containing CTD phosphatase 1
            (Ublcp1), mRNA.
ACCESSION   NM_024475 XM_006514923 XM_920524 XM_977350 XM_983275
VERSION     NM_024475.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2155)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2155)
  AUTHORS   Soueid,J., Hamze,Z., Bedran,J., Chahrour,M. and Boustany,R.M.
  TITLE     A novel autism-associated UBLCP1 mutation impacts proteasome
            regulation/activity
  JOURNAL   Transl Psychiatry 13 (1), 404 (2023)
   PUBMED   38129378
  REMARK    GeneRIF: A novel autism-associated UBLCP1 mutation impacts
            proteasome regulation/activity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2155)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 2155)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 2155)
  AUTHORS   Sasaki,N., Nagaoka,S., Itoh,M., Izawa,M., Konno,H., Carninci,P.,
            Yoshiki,A., Kusakabe,M., Moriuchi,T., Muramatsu,M., Okazaki,Y. and
            Hayashizaki,Y.
  TITLE     Characterization of gene expression in mouse blastocyst using
            single-pass sequencing of 3995 clones
  JOURNAL   Genomics 49 (2), 167-179 (1998)
   PUBMED   9598303
  REMARK    Erratum:[Genomics 1998 Dec 15;54(3):583]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ061422.1, AK147744.1 and BQ177022.1.
            
            On or before Jan 5, 2014 this sequence version replaced
            XM_006514923.1, NM_024475.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147744.1, AK043952.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                CJ061422.1         4-56
            54-1876             AK147744.1         2-1824
            1877-2155           BQ177022.1         1-279               c
FEATURES             Location/Qualifiers
     source          1..2155
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 25.94 cM"
     gene            1..2155
                     /gene="Ublcp1"
                     /gene_synonym="4930527B16Rik; 8430435I17Rik"
                     /note="ubiquitin-like domain containing CTD phosphatase 1"
                     /db_xref="GeneID:79560"
                     /db_xref="MGI:MGI:1933105"
     exon            1..121
                     /gene="Ublcp1"
                     /gene_synonym="4930527B16Rik; 8430435I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            122..318
                     /gene="Ublcp1"
                     /gene_synonym="4930527B16Rik; 8430435I17Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..1121
                     /gene="Ublcp1"
                     /gene_synonym="4930527B16Rik; 8430435I17Rik"
                     /EC_number="3.1.3.16"
                     /note="nuclear proteasome inhibitor UBLCP1"
                     /codon_start=1
                     /product="ubiquitin-like domain-containing CTD phosphatase
                     1"
                     /protein_id="NP_077795.2"
                     /db_xref="CCDS:CCDS24564.1"
                     /db_xref="GeneID:79560"
                     /db_xref="MGI:MGI:1933105"
                     /translation="MALPIIVKWGGQEYSVTTLSEDDTVLDLKQFLKTLTGVLPERQK
                     LLGLKVKGKPAENDVKLGALKLKPNTKIMMMGTREESLEDVLCPPPDNDDVINDFDIE
                     DEVVEVENREENLLKVSRRVKEYKVEVLNPPREGKKLLVLDVDYTLFDHRSCAETGVE
                     LMRPYLHEFLTSAYEDYDIVIWSATNMKWIEAKMKELGVSTNANYKITFMLDSAAMIT
                     VHTPRRGLIDVKPLGVIWGKFSEFYSKKNTIMFDDIGRNFLMNPQNGLKIRPFMKAHL
                     NRDKDKELVKLTQYLKEIAKLDDFLELNHKYWERYLSKKQGQ"
     exon            319..410
                     /gene="Ublcp1"
                     /gene_synonym="4930527B16Rik; 8430435I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            411..496
                     /gene="Ublcp1"
                     /gene_synonym="4930527B16Rik; 8430435I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            497..612
                     /gene="Ublcp1"
                     /gene_synonym="4930527B16Rik; 8430435I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            613..711
                     /gene="Ublcp1"
                     /gene_synonym="4930527B16Rik; 8430435I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            712..749
                     /gene="Ublcp1"
                     /gene_synonym="4930527B16Rik; 8430435I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            750..848
                     /gene="Ublcp1"
                     /gene_synonym="4930527B16Rik; 8430435I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            849..965
                     /gene="Ublcp1"
                     /gene_synonym="4930527B16Rik; 8430435I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1093
                     /gene="Ublcp1"
                     /gene_synonym="4930527B16Rik; 8430435I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..2138
                     /gene="Ublcp1"
                     /gene_synonym="4930527B16Rik; 8430435I17Rik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1377
                     /gene="Ublcp1"
                     /gene_synonym="4930527B16Rik; 8430435I17Rik"
     regulatory      2116..2121
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ublcp1"
                     /gene_synonym="4930527B16Rik; 8430435I17Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2138
                     /gene="Ublcp1"
                     /gene_synonym="4930527B16Rik; 8430435I17Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggtctcaacc acactttccg gtccgcccgc cggttccggt cccgcccctc gcttccggtc
       61 tccttaggtt ccgctgcggc cggctttttc gtccgctgta gctggttccg ccgcgctcca
      121 ggtgttttgt tcctacagaa agtcctgctt catatgcgtg aagaatggca ctccccatca
      181 tagtgaaatg gggtgggcag gagtactcag tgaccacgct ctcagaagat gatactgtgc
      241 tggatcttaa acagttcctc aagaccctta cgggagtgct cccagaacgc cagaagttac
      301 tagggctcaa agttaaaggc aaacctgcag aaaatgatgt taagcttgga gctctcaaac
      361 tgaaaccaaa tactaaaatc atgatgatgg gaactcgaga ggagagcttg gaagatgtct
      421 tatgtcctcc tcctgacaat gatgatgtca tcaatgattt tgacattgaa gatgaagtag
      481 ttgaagtaga aaatagggag gaaaacctcc tgaaggtctc tcgcagagtc aaggagtaca
      541 aggtggaggt gctgaaccct ccccgggagg gcaagaagct cctggtgctg gatgttgact
      601 atacactgtt tgatcatagg tcttgtgcag agactggggt agagctaatg agaccatatc
      661 ttcatgaatt tctaacatct gcatatgaag attatgacat tgttatttgg tctgcaacaa
      721 atatgaagtg gattgaagct aaaatgaaag agctgggcgt gagcacaaat gccaactata
      781 agattacctt catgctggac agtgcggcca tgatcactgt gcacacgccc cggagagggc
      841 tcattgacgt gaagcctctt ggtgtcattt ggggaaagtt ttctgaattc tacagcaaaa
      901 agaacaccat tatgtttgat gatataggaa gaaattttct aatgaatcca caaaatggac
      961 tgaagataag gcctttcatg aaagctcatc taaaccgtga taaagacaag gaactggtga
     1021 agctcactca gtacctcaag gagatcgcta agcttgatga cttcttggag ctgaatcaca
     1081 agtactggga gaggtatcta tcaaagaagc aaggacagta gttagcagtt acactcagag
     1141 ttgaagatcc ggaggtctgt ggacctctgt ttctttgcta ggcattacca cggctgtgct
     1201 ggacactgaa gcagatgcca gcctgcctag ctgtggtctt ccaatgcttt gtaaacaaag
     1261 tgctaaacaa acaaacaaac aaaaagttct cttccctcta tgttaattta ctcttgaaga
     1321 attgttctct ggcattaatt tttgaggtgt ttcccaaatc ctctaaaaat ggaaaaagga
     1381 aaggaaaatg aaaaaaggag aaaaatatat ctacgattgc catcttgtga ctttggaaat
     1441 gagttttgtc ttatgctttt ctgcttttgt ctccttgtat aatcatctgc ctgagtctga
     1501 gaccaaatct gtcttcaaac tagctagtgc tttccccctt aaaaccaaaa gcagcaccaa
     1561 aaaccccaga ccagcttcta agtaacgacc tggtttgtta tgctgaaaac tcgcaagagt
     1621 tgtccttcct tgtcagagtt tctctcctgc agtctactca gaagatcctg aagctgtgtt
     1681 gtgtcagtgc tccttaagaa tgaaggacat ctgcgtggta aggctgtgcc ctacatgaca
     1741 gggacaggac aagcagactg aaataacaca gcaggacaag gccgagtaga agcacttctg
     1801 cctaaaacta gtcatgagca cagcttacca cagtagtaaa aaggcaccat caccaactcg
     1861 actctcagaa gcatggatag catctctgcc tactccagtc gggtgtcatt gtaactgcta
     1921 acaccgttgc agcaaacatc tagccataag attaaaaata cctgatactt gcaatgctta
     1981 agcctgcaaa tatgtatgtg actgttgttt tatgttgaca gtattgcttt atacagttct
     2041 tgtattgaaa ggaattgctc cttttaaatg aacaggtgta cattgttctt atgggactat
     2101 ttcagtggtg taaataataa atatcttttc ttaaaacaaa aaaaaaaaaa aaaaa
//
