LOCUS       NM_025401               1958 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus ubiquitin-like 5 (Ubl5), transcript variant 2, mRNA.
ACCESSION   NM_025401
VERSION     NM_025401.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1958)
  AUTHORS   Tscherner,A.K., McClatchie,T., Macaulay,A.D. and Baltz,J.M.
  TITLE     Relationship of quantitative reverse transcription polymerase chain
            reaction (RT-PCR) to RNA Sequencing (RNAseq) transcriptome
            identifies mouse preimplantation embryo reference genesdagger
  JOURNAL   Biol Reprod 109 (5), 601-617 (2023)
   PUBMED   37669129
REFERENCE   2  (bases 1 to 1958)
  AUTHORS   Wang,W., Hawkridge,A.M., Ma,Y., Zhang,B., Mangrum,J.B.,
            Hassan,Z.H., He,T., Blat,S., Guo,C., Zhou,H., Liu,J., Wang,X.Y. and
            Fang,X.
  TITLE     Ubiquitin-like protein 5 is a novel player in the UPR-PERK arm and
            ER stress-induced cell death
  JOURNAL   J Biol Chem 299 (7), 104915 (2023)
   PUBMED   37315790
  REMARK    GeneRIF: Ubiquitin-like protein 5 is a novel player in the UPR-PERK
            arm and ER stress-induced cell death.
REFERENCE   3  (bases 1 to 1958)
  AUTHORS   Zou,J., Ma,W., Li,J., Littlejohn,R., Zhou,H., Kim,I.M.,
            Fulton,D.J.R., Chen,W., Weintraub,N.L., Zhou,J. and Su,H.
  TITLE     Neddylation mediates ventricular chamber maturation through
            repression of Hippo signaling
  JOURNAL   Proc Natl Acad Sci U S A 115 (17), E4101-E4110 (2018)
   PUBMED   29632206
REFERENCE   4  (bases 1 to 1958)
  AUTHORS   Hatanaka,K., Ikegami,K., Takagi,H. and Setou,M.
  TITLE     Hypo-osmotic shock induces nuclear export and proteasome-dependent
            decrease of UBL5
  JOURNAL   Biochem Biophys Res Commun 350 (3), 610-615 (2006)
   PUBMED   17026961
  REMARK    GeneRIF: This report is the first to describe changes in the
            intracellular and subcellular localization of UBL5 in response to
            hypo-osmotic conditions.
REFERENCE   5  (bases 1 to 1958)
  AUTHORS   Brailoiu,G.C., Dun,S.L., Chi,M., Ohsawa,M., Chang,J.K., Yang,J. and
            Dun,N.J.
  TITLE     Beacon/ubiquitin-like 5-immunoreactivity in the hypothalamus and
            pituitary of the mouse
  JOURNAL   Brain Res 984 (1-2), 215-223 (2003)
   PUBMED   12932856
  REMARK    GeneRIF: findings report of the presence and distribution of
            ubiquitin-like 5 in the mouse hypothalamus and pituitary
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK051149.1 and BU705105.1.
            
            On Feb 24, 2018 this sequence version replaced NM_025401.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and uses
            an alternate in-frame splice site in the 3' coding region compared
            to variant 1. It encodes isoform 2, which is shorter than isoform
            1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU705105.1, AK051149.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1921              AK051149.1         20-1940
            1922-1958           BU705105.1         433-469
FEATURES             Location/Qualifiers
     source          1..1958
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 7.6 cM"
     gene            1..1958
                     /gene="Ubl5"
                     /gene_synonym="1110030M22Rik; beacon; Ubl5a"
                     /note="ubiquitin-like 5"
                     /db_xref="GeneID:66177"
                     /db_xref="MGI:MGI:1913427"
     exon            1..1558
                     /gene="Ubl5"
                     /gene_synonym="1110030M22Rik; beacon; Ubl5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1625
                     /gene="Ubl5"
                     /gene_synonym="1110030M22Rik; beacon; Ubl5a"
                     /inference="alignment:Splign:2.1.0"
     CDS             1570..1791
                     /gene="Ubl5"
                     /gene_synonym="1110030M22Rik; beacon; Ubl5a"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ubiquitin-like protein 5"
                     /codon_start=1
                     /product="ubiquitin-like protein 5 isoform 2"
                     /protein_id="NP_079677.1"
                     /db_xref="CCDS:CCDS52733.1"
                     /db_xref="GeneID:66177"
                     /db_xref="MGI:MGI:1913427"
                     /translation="MIEVVCNDRLGKKVRVKCNTDDTIGDLKKLIAAQTGTRWNKIVL
                     KKWYTIFKDHVSLGDYEIHDGMNLELYYQ"
     exon            1626..1709
                     /gene="Ubl5"
                     /gene_synonym="1110030M22Rik; beacon; Ubl5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1747
                     /gene="Ubl5"
                     /gene_synonym="1110030M22Rik; beacon; Ubl5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1924
                     /gene="Ubl5"
                     /gene_synonym="1110030M22Rik; beacon; Ubl5a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1890..1895
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ubl5"
                     /gene_synonym="1110030M22Rik; beacon; Ubl5a"
                     /note="hexamer: AATAAA"
     polyA_site      1922
                     /gene="Ubl5"
                     /gene_synonym="1110030M22Rik; beacon; Ubl5a"
                     /note="major polyA site"
ORIGIN      
        1 agtggcgtgc ggaggtttgg cttgtgctgg aaaaggctta gggttactgc caaggcagag
       61 atcagcctgc gaccagaccg tatgtatacc caggaggcat gacttgagca gggaaaagtt
      121 aacagagcaa caaacccaga aaccatgact tgtgtgggaa ggggctcaag gactagggat
      181 cctaattgcg cctgaagact aaacttgtaa aacctagctt aggcggaaca aggtccgata
      241 taggggatgg aatcaagttt ggaatggctg ggcgacaaag ggacaggctg ggagacttat
      301 gactggaaga atggataaga gcagcgacgg gggccctaaa agcatcgctg gagacagaaa
      361 caagagctaa accaggaact gggtgtgcag ctcagtggga gagcctttgg ctggtaagca
      421 tgcttagcag gccctaggtt cgacctccaa cactaaaaca aataccaaaa caaaacaaga
      481 aaaacaaacc ccaccacttt tcttgtatgt atgccaagag acttaaagcc tgagaagttt
      541 tttttcgaga cggaaacgaa tccggtaaag cctgagaagt cttttcagga cggaaacgag
      601 gcattgggga gactggaaca tatctaagca ctaaagacac agaacaggac ttcattcgaa
      661 actgaaaggt gtgactggga tgggagtgag gggccagcag gacggccaag ccagggaggc
      721 gtggccacag ccgcaataga aagcaagaat aatgcctttt gctgcctacg cataaggatt
      781 aaattttgta taagtcgtat taggtaagca caaggcgctg ggtaagactt ttctttttct
      841 tgagtcaata tatgcttacc ttgctaagaa tcctgtctgc taagaagaaa tcgctcaata
      901 gaggcaaaac tggttgaatt taagaaggga ttcctctccc accagctctc gcgattcttt
      961 aatctggaac aagattaaag aatcaaagca aaagctcttt ccccgtatgc tatttccaac
     1021 atcttcgcag gcaggacacg gacacgcgga gtggtacgca acatgcatgg cctctcaacc
     1081 aggatccgac ttagttttca tcaactgcag cctgcacccc tggagtctct gaaacggtca
     1141 ctacgaccag gggcggggaa gcaagcacag ggtttgaggc tgagctttga atgaaagcag
     1201 aaagccacag gccctgcatg actccatttc ggcacacctg cagccgggat tccgcggtag
     1261 gaggattgtc tggcttggga gtagtcgagc accccgccgc tgagatcctt taggtttctt
     1321 ccatgatgaa ggaatctcca acaccagttc caacgtccgc tgtaaatcca ttcttagcaa
     1381 gtcccagctc atccacactg cgcaacagaa tcgcaaatcc tagcccggaa cccggaagca
     1441 cctaagggcc ggtggttccg ttatatcact tccgcttcct gtttgcaggc ttaactccgg
     1501 ccggggttcc tcgctcgagc tacgagttgt gtcgtcgata ggttcgagga tattggagct
     1561 ccagccacaa tgattgaggt ggtttgcaac gaccgtctcg gaaagaaagt ccgcgttaag
     1621 tgcaacaccg atgacaccat cggcgacttg aagaaactga tagctgctca aactggcacc
     1681 cgctggaaca agatcgttct taaaaagtgg tacacgattt ttaaggacca cgtgtctctg
     1741 ggagattatg aaatccacga tgggatgaac ctggagcttt attaccagta gagggggatt
     1801 ccttctcctc ctcgccctgc tctgccctgc cctcctctcc catcctcatc tgacactggt
     1861 gtagatggtc atttttaaca gttcacatga ataaaaactt ggctgctgct ttgctgctgt
     1921 cataaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
