LOCUS       NM_145405               2334 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus ubiquitin-like 4A (Ubl4a), transcript variant 1, mRNA.
ACCESSION   NM_145405
VERSION     NM_145405.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2334)
  AUTHORS   Yu,C., Diao,R., Khan,R., Deng,C., Ma,H., Chang,Z., Jiang,X. and
            Shi,Q.
  TITLE     The Dispensable Roles of X-Linked Ubl4a and Its Autosomal
            Counterpart Ubl4b in Spermatogenesis Represent a New Evolutionary
            Type of X-Derived Retrogenes
  JOURNAL   Front Genet 12, 689902 (2021)
   PUBMED   34249105
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2334)
  AUTHORS   Zhang,H., Zhao,Y., Yao,Q., Ye,Z., Manas,A. and Xiang,J.
  TITLE     Ubl4A is critical for mitochondrial fusion process under nutrient
            deprivation stress
  JOURNAL   PLoS One 15 (11), e0242700 (2020)
   PUBMED   33211772
  REMARK    GeneRIF: Ubl4A is critical for mitochondrial fusion process under
            nutrient deprivation stress.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2334)
  AUTHORS   Peng,S.J., Yao,R.R., Yu,S.S., Chen,H.Y., Pang,X., Zhang,Y. and
            Zhang,J.
  TITLE     UBL4A Augments Innate Immunity by Promoting the K63-Linked
            Ubiquitination of TRAF6
  JOURNAL   J Immunol 203 (7), 1943-1951 (2019)
   PUBMED   31451677
  REMARK    GeneRIF: a novel positive feedback regulation of UBL4A in innate
            immune response combating virus invasion by enhancing the
            K63-linked ubiquitination of TRAF6.
REFERENCE   4  (bases 1 to 2334)
  AUTHORS   Fu,Y., Liu,S., Wang,Y., Ren,F., Fan,X., Liang,J., Liu,C., Li,J.,
            Ju,Y. and Chang,Z.
  TITLE     GdX/UBL4A-knockout mice resist collagen-induced arthritis by
            balancing the population of Th1/Th17 and regulatory T cells
  JOURNAL   FASEB J 33 (7), 8375-8385 (2019)
   PUBMED   31002527
  REMARK    GeneRIF: These findings suggested that GdX functions as an
            important regulator of Th1 or Th17 and Treg cell balance during the
            inflammatory responses.
REFERENCE   5  (bases 1 to 2334)
  AUTHORS   Liu,C., Zhou,Y., Li,M., Wang,Y., Yang,L., Yang,S., Feng,Y.,
            Wang,Y., Wang,Y., Ren,F., Li,J., Dong,Z., Chin,Y.E., Fu,X., Wu,L.
            and Chang,Z.
  TITLE     Absence of GdX/UBL4A Protects against Inflammatory Diseases by
            Regulating NF-small ka, CyrillicB Signaling in Macrophages and
            Dendritic Cells
  JOURNAL   Theranostics 9 (5), 1369-1384 (2019)
   PUBMED   30867837
  REMARK    GeneRIF: This study provides a mechanism by which NF-kappaB
            signaling is positively regulated by an adaptor protein GdX in
            dendritic cells or macrophages to maintain the innate immune
            response.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2334)
  AUTHORS   Derry,J.M. and Barnard,P.J.
  TITLE     Physical linkage of the A-raf-1, properdin, synapsin I, and TIMP
            genes on the human and mouse X chromosomes
  JOURNAL   Genomics 12 (4), 632-638 (1992)
   PUBMED   1572636
REFERENCE   7  (bases 1 to 2334)
  AUTHORS   Taketo,M., Howard,T.A. and Seldin,M.F.
  TITLE     Mapping of recombinant retrovirus integration sites that cause
            expression of the viral genome in murine embryonal carcinoma cells
  JOURNAL   Mamm Genome 2 (4), 240-245 (1992)
   PUBMED   1543915
REFERENCE   8  (bases 1 to 2334)
  AUTHORS   Faust,C.J. and Herman,G.E.
  TITLE     Physical mapping of the loci Gabra3, DXPas8, CamL1, and Rsvp in a
            region of the mouse X chromosome homologous to human Xq28
  JOURNAL   Genomics 11 (1), 154-164 (1991)
   PUBMED   1684949
REFERENCE   9  (bases 1 to 2334)
  AUTHORS   Herman,G.E., Berry,M., Munro,E., Craig,I.W. and Levy,E.R.
  TITLE     The construction of human somatic cell hybrids containing portions
            of the mouse X chromosome and their use to generate DNA probes via
            interspersed repetitive sequence polymerase chain reaction
  JOURNAL   Genomics 10 (4), 961-970 (1991)
   PUBMED   1916827
REFERENCE   10 (bases 1 to 2334)
  AUTHORS   Herman,G.E., Faust,C.J., Darlison,M.G. and Barnard,E.A.
  TITLE     Genetic mapping of the mouse X chromosome in the region homologous
            to human Xq27-Xq28
  JOURNAL   Genomics 9 (4), 670-677 (1991)
   PUBMED   1674728
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY273712.1, BM932729.1, AK048689.1 and BM900115.1.
            
            On Jan 5, 2012 this sequence version replaced NM_145405.1.
            
            Transcript Variant: This variant (1) represents the longer,
            protein-coding transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BF160166.1, SRR1660813.27275.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               BY273712.1         2-108
            108-646             BM932729.1         82-620
            647-2313            AK048689.1         484-2150
            2314-2334           BM900115.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..2334
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 38.0 cM"
     gene            1..2334
                     /gene="Ubl4a"
                     /gene_synonym="DXHXS254E; DXS254E; DXS254Eh; Gdx; Ubl4"
                     /note="ubiquitin-like 4A"
                     /db_xref="GeneID:27643"
                     /db_xref="MGI:MGI:95049"
     exon            1..133
                     /gene="Ubl4a"
                     /gene_synonym="DXHXS254E; DXS254E; DXS254Eh; Gdx; Ubl4"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..559
                     /gene="Ubl4a"
                     /gene_synonym="DXHXS254E; DXS254E; DXS254Eh; Gdx; Ubl4"
                     /note="ubiquitin-like protein GDX; housekeeping protein
                     DXS254E; ubiquitin-like 4"
                     /codon_start=1
                     /product="ubiquitin-like protein 4A"
                     /protein_id="NP_663380.1"
                     /db_xref="CCDS:CCDS30230.1"
                     /db_xref="GeneID:27643"
                     /db_xref="MGI:MGI:95049"
                     /translation="MQLTVKALQGRECSLQVAEDELVSTLKHLVSDKLNVPVRQQRLL
                     FKGKALADEKRLSDYNIGPNSKLNLVVKPLEKVLLEEGSAHRLVDSPATPIWQLISKV
                     LARHFSVADASRVLEQLQRDYDRSLSRLTLDDIERLASRFLHPEVTEAMEKGFCK"
     exon            134..239
                     /gene="Ubl4a"
                     /gene_synonym="DXHXS254E; DXS254E; DXS254Eh; Gdx; Ubl4"
                     /inference="alignment:Splign:2.1.0"
     exon            240..448
                     /gene="Ubl4a"
                     /gene_synonym="DXHXS254E; DXS254E; DXS254Eh; Gdx; Ubl4"
                     /inference="alignment:Splign:2.1.0"
     exon            449..2317
                     /gene="Ubl4a"
                     /gene_synonym="DXHXS254E; DXS254E; DXS254Eh; Gdx; Ubl4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      612..617
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ubl4a"
                     /gene_synonym="DXHXS254E; DXS254E; DXS254Eh; Gdx; Ubl4"
                     /note="hexamer: ATTAAA"
     polyA_site      634
                     /gene="Ubl4a"
                     /gene_synonym="DXHXS254E; DXS254E; DXS254Eh; Gdx; Ubl4"
                     /note="major polyA site"
     regulatory      2293..2298
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ubl4a"
                     /gene_synonym="DXHXS254E; DXS254E; DXS254Eh; Gdx; Ubl4"
                     /note="hexamer: AATAAA"
     polyA_site      2317
                     /gene="Ubl4a"
                     /gene_synonym="DXHXS254E; DXS254E; DXS254Eh; Gdx; Ubl4"
ORIGIN      
        1 ggcggcgggc ggttccgggg cggcggcgcg cggcagggga ccgttggtgt ttgcgttggc
       61 cgtagtggac tgggccgtgg acaccatgca gctgaccgtg aaggcgctcc agggccggga
      121 atgtagccta caggtggcgg aggacgagct agtgtctaca ctgaagcacc tggtctcgga
      181 taagctgaat gtccctgtgc gccagcaacg tctgctgttc aagggcaagg ccctagcaga
      241 tgaaaaacga ctgtcagatt acaacattgg gcccaattct aagctcaacc tagttgttaa
      301 gcctttggag aaggtgctac tggaagaagg gtctgcccac agactggtcg actccccagc
      361 cacccccatc tggcagctga tctccaaagt cctggcccgt cacttcagtg tagcagatgc
      421 cagcagggtc ctggaacaac tacagaggga ttatgacagg tccttgagcc gcctaacact
      481 ggatgacatc gaacgtttgg ccagccgctt tctacaccct gaagtgactg aggctatgga
      541 aaaagggttc tgcaaatagc attctgggat tgtggggaga aatcccaggt caggccacag
      601 ctgcatgttg cattaaatgt gttctcatgt cgcagtttgg ctcatagtga taataatagc
      661 tggtatgtat ccagctcttg ctaggtgcta ggtactcaaa gtacatggcc tgagttctct
      721 tctgcctccc acagcaaagt tgaggctgca ctgtagagac acctagcaat ggcttgggac
      781 agacagggtc caagtctagc cagcctatag aagtgcctct gtaggagaaa gagtgtgctg
      841 ttttcagaga tgggtcttag tattcccatt tagcccactc agcatacacc ctcaaaagac
      901 tccctcagga aaccactagt tcctgtcacc tgccctctgg tgtgtccctt ggcaaatctc
      961 tataggaggc caagtgttag ctatccaggg cccctccact gctgcagcca gtgtgctctt
     1021 gaataacaag caggttaagg ggctggagga tcagaaagat accccagctc catcatagtt
     1081 tgagtcatgt ttctatgcca ctttggtccc caaccaaagt gaatctgtcc catgttaggc
     1141 actcctctga cctgaataag tttcctttct cctttatcag ttcaaggtgg gagtctttgc
     1201 tctcatcacc tgcagttcca ccttgtgttc agaaagcaaa agtgaagtga tagccaagca
     1261 tgggccacta gatggagtat cctgggcctt tgtagcatag ctcttctctg gagcacccta
     1321 tttgcttggc tctttctgga agtaggtctc acccatgagg gacaacaggt gactcagaaa
     1381 ggcagtgtca caactagaac actctgcctt ggtctcctta tccagtgctc acccacagta
     1441 tgaaatggat gcttcctctg ccacctgtat acaggggctt ttactttgca caccttcatt
     1501 gcttaagaag aaactcaggg tgctgagaaa gatatgtatg ctgaaggctg tgattcctct
     1561 ttttattgta cctatgcctg ggtgctaaag gtcatgtaag gactagttcc tttgaggagg
     1621 accccctggg agcagtcaag ctggaagata gctacctgca agacactact gtccctctac
     1681 ttttgccagg aaagccactc tactatgaat gttattgggg ctacacttgc ctttcttgcc
     1741 caagggcctc ctgcatagac cttgtcggtc aaatcttgag tccttgtaca gaaatgatag
     1801 aggcctgagg gggtgtgcag gtgatagacc ctggtactcc taagacctgg ggtatcatat
     1861 cagggacctg cttgtgaaca tgtgtataga gtgccagctc agataataag cttaccagtg
     1921 accttgttca ctttgagtca gggaacgtat ttgtaaaatt aacactaaag atgcatgtga
     1981 gtcatttcac caaaaggaac tctattaata agctagactg cttttggttt ccagtaattg
     2041 gtttaaaaac acagtaaatt tactggctta taaagctgaa aaagcctagg agtactggca
     2101 gtggatgaac aatttcacca aacatccagc ttttttcctg cctccctctg aattctccag
     2161 gatctgcttc accctcacca ccaccacttc caaggatcaa agctgtctac agctccatca
     2221 aaacctttca ttcactgcca atgaggagca ctttctttct gtagcatagc ttctgtctca
     2281 gatgccccag caaataaatg ctgtctctta ttggtcaaaa aaaaaaaaaa aaaa
//
