LOCUS       NM_011908               2667 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus ubiquitin-like 3 (Ubl3), transcript variant 1, mRNA.
ACCESSION   NM_011908 XM_991016 XM_991044 XM_991073 XM_991097
VERSION     NM_011908.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2667)
  AUTHORS   Liu,H., Wilson,K.R., Firth,A.M., Macri,C., Schriek,P., Blum,A.B.,
            Villar,J., Wormald,S., Shambrook,M., Xu,B., Lim,H.J.,
            McWilliam,H.E.G., Hill,A.F., Edgington-Mitchell,L.E., Caminschi,I.,
            Lahoud,M.H., Segura,E., Herold,M.J., Villadangos,J.A. and
            Mintern,J.D.
  TITLE     Ubiquitin-like protein 3 (UBL3) is required for MARCH
            ubiquitination of major histocompatibility complex class II and
            CD86
  JOURNAL   Nat Commun 13 (1), 1934 (2022)
   PUBMED   35411049
  REMARK    GeneRIF: Ubiquitin-like protein 3 (UBL3) is required for MARCH
            ubiquitination of major histocompatibility complex class II and
            CD86.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2667)
  AUTHORS   Ageta,H., Ageta-Ishihara,N., Hitachi,K., Karayel,O., Onouchi,T.,
            Yamaguchi,H., Kahyo,T., Hatanaka,K., Ikegami,K., Yoshioka,Y.,
            Nakamura,K., Kosaka,N., Nakatani,M., Uezumi,A., Ide,T.,
            Tsutsumi,Y., Sugimura,H., Kinoshita,M., Ochiya,T., Mann,M.,
            Setou,M. and Tsuchida,K.
  TITLE     UBL3 modification influences protein sorting to small extracellular
            vesicles
  JOURNAL   Nat Commun 9 (1), 3936 (2018)
   PUBMED   30258067
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2667)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   4  (bases 1 to 2667)
  AUTHORS   Downes,B.P., Saracco,S.A., Lee,S.S., Crowell,D.N. and Vierstra,R.D.
  TITLE     MUBs, a family of ubiquitin-fold proteins that are plasma
            membrane-anchored by prenylation
  JOURNAL   J Biol Chem 281 (37), 27145-27157 (2006)
   PUBMED   16831869
REFERENCE   5  (bases 1 to 2667)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   6  (bases 1 to 2667)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 2667)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   8  (bases 1 to 2667)
  AUTHORS   Chadwick,B.P., Kidd,T., Sgouros,J., Ish-Horowicz,D. and
            Frischauf,A.M.
  TITLE     Cloning, mapping and expression of UBL3, a novel ubiquitin-like
            gene
  JOURNAL   Gene 233 (1-2), 189-195 (1999)
   PUBMED   10375635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK794503.1, BU059122.1, AK145952.1, DV661495.1 and AV226728.2.
            
            On Mar 24, 2007 this sequence version replaced NM_011908.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Variants 1 and 2
            both encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF044222.1, AK145952.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               CK794503.1         1-125
            126-279             BU059122.1         45-198
            280-323             CK794503.1         282-325
            324-671             AK145952.1         2-349
            672-1901            AK145952.1         351-1580
            1902-2167           DV661495.1         273-538
            2168-2635           AK145952.1         1848-2315
            2636-2667           AV226728.2         646-677
FEATURES             Location/Qualifiers
     source          1..2667
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 88.66 cM"
     gene            1..2667
                     /gene="Ubl3"
                     /gene_synonym="HCG; mmMUB; MUB"
                     /note="ubiquitin-like 3"
                     /db_xref="GeneID:24109"
                     /db_xref="MGI:MGI:1344373"
     exon            1..836
                     /gene="Ubl3"
                     /gene_synonym="HCG; mmMUB; MUB"
                     /inference="alignment:Splign:2.1.0"
     CDS             810..1163
                     /gene="Ubl3"
                     /gene_synonym="HCG; mmMUB; MUB"
                     /note="isoform a is encoded by transcript variant 1;
                     ubiquitin-like protein 3; protein HCG-1; membrane-anchored
                     ubiquitin-fold protein"
                     /codon_start=1
                     /product="ubiquitin-like protein 3 isoform a"
                     /protein_id="NP_036038.1"
                     /db_xref="CCDS:CCDS39403.1"
                     /db_xref="GeneID:24109"
                     /db_xref="MGI:MGI:1344373"
                     /translation="MSSHVPADMINLRLILVSGKTKEFLFSPNDSASDIAKHVYDNWP
                     MDWEEEQVSSPNILRLIYQGRFLHGNVTLGALKLPFGKTTVMHLVARETLPEPNSQGQ
                     RNREKTGESNCCVIL"
     exon            837..945
                     /gene="Ubl3"
                     /gene_synonym="HCG; mmMUB; MUB"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1032
                     /gene="Ubl3"
                     /gene_synonym="HCG; mmMUB; MUB"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1110
                     /gene="Ubl3"
                     /gene_synonym="HCG; mmMUB; MUB"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..2667
                     /gene="Ubl3"
                     /gene_synonym="HCG; mmMUB; MUB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1301..1306
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ubl3"
                     /gene_synonym="HCG; mmMUB; MUB"
                     /note="hexamer: AGTAAA"
     polyA_site      1320
                     /gene="Ubl3"
                     /gene_synonym="HCG; mmMUB; MUB"
                     /note="major polyA site"
     regulatory      2638..2643
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ubl3"
                     /gene_synonym="HCG; mmMUB; MUB"
                     /note="hexamer: AATAAA"
     polyA_site      2656
                     /gene="Ubl3"
                     /gene_synonym="HCG; mmMUB; MUB"
                     /note="major polyA site"
ORIGIN      
        1 ttgggctgag gcgatgacag gaggcggccg gggcgtgtgg gattgagaag tggaggagga
       61 ggcggagagt cagggctctg agggggagct gttcccaagc taagggagga gcccccggaa
      121 gacgctgcgg aaggcaggca gcgaggcgga ggcggccgga gcccagacgc gatgcggccc
      181 gaccggcgcg gctgcgctga ggcgcccgcg gcctgagccc ccccggcgct gcgctcggtt
      241 cggctcggcc cagttcggct cggctcggct cggcggctgg cgaggtcgat gcccttgagc
      301 gcggctgcgc gcagcccggc tgtgcggccc cgcggcgcgc gctgagcttc tcggcggccc
      361 cggccgcttt cagctcggcg ctcgatgtgt agccacatag ttatctgtac acttcgtcgc
      421 cggggcttta atgaggacct gagtcgcgag cgcgtgtgaa tcaccgcctg ggccggggaa
      481 agaggacggc gcatttaacc ccctcccacc ccgctccatg tccgtgtgtc actcggctct
      541 gtccacctgg cgcggcgggt cctggagctg ctactgctgc tgacgatcgg ctcccctcgc
      601 gcctctcgcc ccagaagctc ttgtgctccc acgtaacttc tacttttttt tttaattttt
      661 attttttttt tcatttttgg gaaaagctca gcacaaaccg atcagaattg tgaaggttct
      721 tttttatttt ttccgtagtt ccagcacttc tgctcttgct ttttgttttg ttttctgcgt
      781 aaacctctgg cccactctca aaaggcaaga tgtccagtca tgtcccggcg gatatgatta
      841 atttgcgcct catcttggtg agtgggaaga cgaaagagtt cctcttctcc ccaaacgact
      901 ctgcctctga catcgcaaag cacgtgtatg acaactggcc catggactgg gaagaagagc
      961 aggtcagcag cccaaacatt cttcgactca tttatcaagg cagatttcta catggaaacg
     1021 tcaccctagg agcattaaaa cttccttttg gcaaaacaac agtgatgcat ttggtggcca
     1081 gagagaccct gccagagccc aactcacaag gtcagagaaa tcgggagaaa actggtgaga
     1141 gcaactgctg tgtgatcctg tagcgtcgcc agcacagatg tggcagtttg ttggcactgc
     1201 ggggacagag gagactcagc agcttccaac acctgtagga cagtcgccag cacatccgtg
     1261 ggactgaatc actcatgaac tctgtcatct cctctcacaa agtaaaaaga accaagaaca
     1321 ctttcagtgt ggtcctttat tccttatatc tgtgtgtgtg ttgagcagtc tgaagtgcac
     1381 agtggtcccc aggggacgca gcaagtctct ctgcagacac cggtggccct gctgccgcag
     1441 agactcctcc ctccgcagaa gtctgaaggc aagtgctgca agtacaattt gcactaaaaa
     1501 taattattat tttcctcatc acataatctg cacgtgtctg tggcgcccag ttctcctgtg
     1561 tgtagtccac cctggaggac accaatcatc ggtggagtaa atacgaggct ggtcagccag
     1621 ggggacagga aggaatctta cgtgctgggt gacttctacc aaagtcggcc gcagtggctg
     1681 tcctcacagg atatcaaact gggcaagact gttgtcactg cagcaagtga gaagccatgc
     1741 ctgctgctcc cagcgctctg tagagggtgc ccctgctgcc ggcccacacc gaggggcggc
     1801 aggatgaccc aagccttaat gtggaggggc cgtcactgtg cagaactggt gggaagcctg
     1861 agtggcagat atcagaagat cggaagcctg cgccatcact catcgaaccg tgccgggttg
     1921 cactcattca ctagagcaga gggatctttt aaagtctcca gatgctaatt ttgttacttt
     1981 ctgtagtttg cattcggaat cagtgcttgc aattgtatta aaatcacaag ctgagtttta
     2041 aggcatacat gatcaatagc accactctta tttttaccaa taatttaaag attgatatgc
     2101 tataaataaa caatttgcac agcactaaag catgagctaa tttcatctaa acctgtaaaa
     2161 aaaaaaagat tttatatttt tttttcactg ggaagaaatc ttcctggatg aaattacaaa
     2221 tatgtgtaga ttatatttaa taaaaaagac ataataaaat atctaactgt agaacacaaa
     2281 tatagattgg cgtgtagcat tataaaccag tattccatat caataacttt atccagcctt
     2341 ttgaaagatg aagttgcaga ctccgttgtg ttctgtattt aacgagggct cctggccctc
     2401 tgcagcatca gatgtaaatg gtctctaagg tcatccttgt ttcaatgcaa tcaggttact
     2461 ttattcattg ttaatgcttt gaggaaggaa gaggctttat atgcagtaga tctacgaaaa
     2521 tattgttcat actgatcaga attaaatttg tatagaacag agttttaaaa tgaatgtaaa
     2581 tagcactaaa ccttttcttt ctgcagcctg tccttaatag atttcttctg taaactaaat
     2641 aaaaaaaaaa acaaaacatt gtagtgc
//
