LOCUS       NM_027873               2997 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus UbiA prenyltransferase domain containing 1 (Ubiad1),
            mRNA.
ACCESSION   NM_027873 XM_001005574
VERSION     NM_027873.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2997)
  AUTHORS   Tosi,G., Paoli,A., Zuccolotto,G., Turco,E., Simonato,M., Tosoni,D.,
            Tucci,F., Lugato,P., Giomo,M., Elvassore,N., Rosato,A., Cogo,P.,
            Pece,S. and Santoro,M.M.
  TITLE     Cancer cell stiffening via CoQ10 and UBIAD1 regulates ECM signaling
            and ferroptosis in breast cancer
  JOURNAL   Nat Commun 15 (1), 8214 (2024)
   PUBMED   39294175
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2997)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2997)
  AUTHORS   Zheng,H., Tu,R., Chen,C. and Hu,Z.
  TITLE     UBIAD1 protects against oxygen-glucose deprivation/reoxygenation
            injury via nNOS/NO pathway
  JOURNAL   Zhong Nan Da Xue Xue Bao Yi Xue Ban 47 (10), 1332-1344 (2022)
   PUBMED   36411684
  REMARK    GeneRIF: UBIAD1 protects against oxygen-glucose
            deprivation/reoxygenation injury via nNOS/NO pathway.
REFERENCE   4  (bases 1 to 2997)
  AUTHORS   Jo,Y., Kim,S.S., Garland,K., Fuentes,I., DiCarlo,L.M., Ellis,J.L.,
            Fu,X., Booth,S.L., Evers,B.M. and DeBose-Boyd,R.A.
  TITLE     Enhanced ER-associated degradation of HMG CoA reductase causes
            embryonic lethality associated with Ubiad1 deficiency
  JOURNAL   Elife 9, e54841 (2020)
   PUBMED   32118581
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2997)
  AUTHORS   Nakagawa,K., Fujiwara,K., Nishimura,A., Murakami,C., Kawamoto,K.,
            Ichinose,C., Kunitou,Y., Suhara,Y., Okano,T. and Hasegawa,H.
  TITLE     UBIAD1 Plays an Essential Role in the Survival of Pancreatic Acinar
            Cells
  JOURNAL   Int J Mol Sci 20 (8), 1971 (2019)
   PUBMED   31013667
  REMARK    GeneRIF: These results indicate that UBIAD1 is essential for
            maintaining the survival of pancreatic acinar cells in the
            pancreas.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2997)
  AUTHORS   Huang,Y. and Hu,Z.
  TITLE     UBIAD1 protects against oxygen-glucose
            deprivation/reperfusion-induced multiple subcellular organelles
            injury through PI3K/AKT pathway in N2A cells
  JOURNAL   J Cell Physiol 233 (9), 7480-7496 (2018)
   PUBMED   29663377
  REMARK    GeneRIF: UBIAD1 protects against oxygen-glucose
            deprivation/reperfusion-induced multiple subcellular organelles
            injury through PI3K/AKT Pathway.
REFERENCE   7  (bases 1 to 2997)
  AUTHORS   Dong,F., Jin,X., Boettler,M.A., Sciulli,H., Abu-Asab,M., Del
            Greco,C., Wang,S., Hu,Y.C., Campos,M.M., Jackson,S.N., Muller,L.,
            Woods,A.S., Combs,C.A., Zhang,J., Nickerson,M.L., Kruth,H.S.,
            Weiss,J.S. and Kao,W.W.
  TITLE     A Mouse Model of Schnyder Corneal Dystrophy with the N100S Point
            Mutation
  JOURNAL   Sci Rep 8 (1), 10219 (2018)
   PUBMED   29977031
  REMARK    GeneRIF: The Ubiad1(N100S) mouse provides a promising animal model
            of schnyder corneal dystrophy (SCD) revealing that mitochondrial
            dysfunction is a prominent component of the disease. The different
            phenotype in human and mouse may due to difference in cholesterol
            metabolism between species.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2997)
  AUTHORS   Nakagawa,K., Sawada,N., Hirota,Y., Uchino,Y., Suhara,Y.,
            Hasegawa,T., Amizuka,N., Okamoto,T., Tsugawa,N., Kamao,M.,
            Funahashi,N. and Okano,T.
  TITLE     Vitamin K2 biosynthetic enzyme, UBIAD1 is essential for embryonic
            development of mice
  JOURNAL   PLoS One 9 (8), e104078 (2014)
   PUBMED   25127365
  REMARK    GeneRIF: UBIAD1 is responsible for vitamin K2 synthesis but may not
            be responsible for CoQ9 synthesis in mice.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2997)
  AUTHORS   Nakagawa,K., Hirota,Y., Sawada,N., Yuge,N., Watanabe,M., Uchino,Y.,
            Okuda,N., Shimomura,Y., Suhara,Y. and Okano,T.
  TITLE     Identification of UBIAD1 as a novel human menaquinone-4
            biosynthetic enzyme
  JOURNAL   Nature 468 (7320), 117-121 (2010)
   PUBMED   20953171
REFERENCE   10 (bases 1 to 2997)
  AUTHORS   Stover,C.M., Lynch,N.J., Hanson,S.J., Windbichler,M., Gregory,S.G.
            and Schwaeble,W.J.
  TITLE     Organization of the MASP2 locus and its expression profile in mouse
            and rat
  JOURNAL   Mamm Genome 15 (11), 887-900 (2004)
   PUBMED   15672593
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731654.7, AK004550.1 and BE948698.1.
            
            On May 4, 2018 this sequence version replaced NM_027873.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC015303.1, AK004550.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AL731654.7         13792-13800         c
            10-2979             AK004550.1         1-2970
            2980-2997           BE948698.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..2997
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 78.76 cM"
     gene            1..2997
                     /gene="Ubiad1"
                     /gene_synonym="1200002M06Rik; Tere1"
                     /note="UbiA prenyltransferase domain containing 1"
                     /db_xref="GeneID:71707"
                     /db_xref="MGI:MGI:1918957"
     exon            1..833
                     /gene="Ubiad1"
                     /gene_synonym="1200002M06Rik; Tere1"
                     /inference="alignment:Splign:2.1.0"
     CDS             311..1321
                     /gene="Ubiad1"
                     /gene_synonym="1200002M06Rik; Tere1"
                     /EC_number="2.5.1.39"
                     /note="transitional epithelia response protein"
                     /codon_start=1
                     /product="ubiA prenyltransferase domain-containing protein
                     1"
                     /protein_id="NP_082149.1"
                     /db_xref="CCDS:CCDS18936.1"
                     /db_xref="GeneID:71707"
                     /db_xref="MGI:MGI:1918957"
                     /translation="MAAVQAPGEKINILAGETAKVGDPQKNEWPEQDRLPERSWRHKC
                     ASYVLALRPWSFSASLTPVALGSALAYRSQGVLDPRLLLGCAVAVLAVHGAGNLVNTY
                     YDFSKGIDHKKSDDRTLVDRILEPQDVVRFGVFLYTLGCVCAACLYYLSALKLEHLAL
                     IYFGGLSGSFLYTGGIGFKYVALGDLVILITFGPLAVMFAYAVQVGSLAIFPLIYAIP
                     LALSTEAILHSNNTRDMESDREAGIVTLAILIGPTFSYVLYNTLLFVPYLIFTILATH
                     CSISLALPLLTIPMAFSLERQFRSQAFNKLPQRTAKLNLLLGLFYVFGIILAPAGSLP
                     RL"
     exon            834..2981
                     /gene="Ubiad1"
                     /gene_synonym="1200002M06Rik; Tere1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2961..2966
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ubiad1"
                     /gene_synonym="1200002M06Rik; Tere1"
                     /note="hexamer: ATTAAA"
     polyA_site      2981
                     /gene="Ubiad1"
                     /gene_synonym="1200002M06Rik; Tere1"
                     /note="major polyA site"
ORIGIN      
        1 gaggccgacg cacaagatgg cggcgccgtc cgcccgatag gggttgcggg ctgaggcggg
       61 ttattgagtt gtggcacggg ggaagcgacc ccagacaggc ttcgctcagg tgacaggtgg
      121 gcgggcagcg ccgctggccc cgtggcggtg catggcctgg ttgctgtctt cagttttccc
      181 cgcctcccaa accctgaccg ggggcggaac cagagaaagg tcaggccagg ctgtcccgcc
      241 tgtctccgtc ctggggcggt ccccttgagt ggctcacttt tagaattgac tttagccacg
      301 tgtagcttcc atggctgcgg tacaggcccc gggggagaag attaatatcc tggcaggaga
      361 gacagccaag gtcggggacc cgcagaagaa cgaatggccc gagcaggaca ggcttcccga
      421 acgatcctgg aggcacaagt gcgcctccta cgtgttggcc ctgaggccct ggagcttcag
      481 tgcctcactc acccctgtgg ccctgggcag tgccttggcc tacaggtctc agggtgtcct
      541 ggatcccagg ctgttgttgg gttgtgcagt ggctgtcctg gctgtacacg gggccggcaa
      601 tttggtcaac acatactatg acttttccaa gggcattgac cacaaaaaga gtgatgacag
      661 aactttggtg gacagaattc tggagcccca ggatgttgtt cgatttggag tcttcctcta
      721 caccttgggc tgcgtctgtg ctgcttgcct ctactacctg tccgctctga aattggaaca
      781 cttggctctc atctacttcg gaggcctgtc tggctccttt ctctacacag gaggaattgg
      841 attcaagtat gtggccctgg gagacctcgt catcctcatc actttcggcc cgctggctgt
      901 gatgtttgcc tacgctgtcc aggtgggatc cctggccatc ttccctctaa tctacgccat
      961 ccctctggcc ctcagcacgg aggccattct ccattccaac aacaccaggg acatggaatc
     1021 tgaccgagag gctggcatcg tcacgctggc catcctcatt gggcccacct tctcctatgt
     1081 cctctataac acactgctct ttgtgcccta cctaatcttt accatcctgg ccacgcactg
     1141 cagcatcagc ctggcactgc ccctgctcac catccccatg gccttctccc ttgagaggca
     1201 gttccgcagc caggccttca acaagctgcc ccagaggaca gccaagctca acctcctgct
     1261 ggggcttttc tatgtctttg gcatcatcct ggcaccagca ggcagcctgc ccagactctg
     1321 aggagaccag caactcccac cacagcacag cccctcctca ggcagtgcag aagccagaga
     1381 ctgagaaggg gtgccactgg ccagggtggg tgcacagcat aggctgcaaa ctcctgaact
     1441 tgtgtgttgg gattatcttc ctaaagataa cctgctcgtg atttgtgttc catgttacag
     1501 ggaaaccctg aagccactct agtgtcgttc ctgtgttatt tataatctcc actagagggt
     1561 gtcatcaggc cactttagga tggaaagtcc atctccccct tgtcctagac agaatgccct
     1621 gacagtttgt gaaggagctg tgtcccaaaa gagccatagt aactaggcat ggtactgacc
     1681 cgttaccttg gcacgtagga aattgtacta attggtgcca ggccccattt atacagagcg
     1741 cttgtcccct gaatgtgctg cctgctagag aagggccctc attagcaagg agtgctcctg
     1801 gctttttgtg tagttggtgg ttcagatgtt tctgtccttt atgtctccct tcgatcctcg
     1861 ccactgtgga ggaaagtgtc agatcaccct gtagcaagac agttaagcct ggggcggctg
     1921 agaaaagcac tctgctttca gtaaaacatg gcatggtggc tgagggagct gcttccctct
     1981 gtagactcca ctaggaaggc agtgattctg ggacctgaag tggcagtggg atgggcgttt
     2041 aaagcccaaa gggctttgtc ccctcccagc tgcctcccct ggtattcctc ttgcctaccc
     2101 aggatctctg tccctccgtc tgtttccagt gccagactgt gggcaacagc aacacatgag
     2161 tcaaggacac ttacccctct ccacagagcc acaagatggg caaatcaggg accttctgaa
     2221 tgtatgagtc agtggacagc agtcctggcc acactcagct ggaatgtgag gccctgccag
     2281 agaaagaact atgagcacgg gtccttcatc tctctgtgct ctgatgcctt gttcagaatg
     2341 tggcttcagt gaggtcacac ccaaaggacc agaggtgtct cgctgtcttc tgtaccctct
     2401 ctgagtataa catcttgcat ggagatgatc ataccatctc cagtgtgctt tactctgatc
     2461 agctgccctg aagggggctg caggctctta gcctgcagaa aaccaccttg agttagcact
     2521 gggtcacttc cttaggaaaa catatttaaa tattgcccag agttcctctg tagtcagggt
     2581 ggtttgtcta ccagagtccc agagcttgaa tcagggtcca gaatcctagg aacaggatgt
     2641 tctttcctgt tctccccagc gtgctgggtt tgtacgtctg gtgcttttga gtgtcctgcc
     2701 tgtgacccta gcttggggct gatagttgtc acccagagcc tggaggacca atgactctca
     2761 ctgttcataa ggcgggcctg acacgtggct accctcatca gaactgtgtc agctgctaca
     2821 ctgagctctg gtgcagattt taaatgccta tttttatata ccatccccag aggccatatt
     2881 tggtgccaca ttttgtatac agaccaccat aatttgtatt atgtctcctg attcaatgaa
     2941 ggtttcctgt agatttgcta attaaaataa gagaaaacgt aaaaaaaaaa aaaaaaa
//
