LOCUS       NM_001404869            6368 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus ubiquitination factor E4B (Ube4b), transcript variant
            3, mRNA.
ACCESSION   NM_001404869 XM_036164290
VERSION     NM_001404869.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6368)
  AUTHORS   Jin,S., Chen,X., Zheng,H., Cai,W., Lin,X., Kong,X., Ni,Y., Ye,J.,
            Li,X., Shen,L., Guo,B., Abdelrahman,Z., Zhou,S., Mao,S., Wang,Y.,
            Yao,C., Gu,X., Yu,B., Wang,Z. and Wang,X.
  TITLE     Downregulation of UBE4B promotes CNS axon regrowth and functional
            recovery after stroke
  JOURNAL   iScience 26 (1), 105885 (2022)
   PUBMED   36654858
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6368)
  AUTHORS   Kong,X., Shu,X., Wang,J., Liu,D., Ni,Y., Zhao,W., Wang,L., Gao,Z.,
            Chen,J., Yang,B., Guo,X. and Wang,Z.
  TITLE     Fine-tuning of mTOR signaling by the UBE4B-KLHL22 E3 ubiquitin
            ligase cascade in brain development
  JOURNAL   Development 149 (24) (2022)
   PUBMED   36440598
  REMARK    GeneRIF: Fine-tuning of mTOR signaling by the UBE4B-KLHL22 E3
            ubiquitin ligase cascade in brain development.
REFERENCE   3  (bases 1 to 6368)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6368)
  AUTHORS   Starita,L.M., Pruneda,J.N., Lo,R.S., Fowler,D.M., Kim,H.J.,
            Hiatt,J.B., Shendure,J., Brzovic,P.S., Fields,S. and Klevit,R.E.
  TITLE     Activity-enhancing mutations in an E3 ubiquitin ligase identified
            by high-throughput mutagenesis
  JOURNAL   Proc Natl Acad Sci U S A 110 (14), E1263-E1272 (2013)
   PUBMED   23509263
REFERENCE   5  (bases 1 to 6368)
  AUTHORS   Hunter,C.S., Dixit,S., Cohen,T., Ediger,B., Wilcox,C., Ferreira,M.,
            Westphal,H., Stein,R. and May,C.L.
  TITLE     Islet alpha-, beta-, and delta-cell development is controlled by
            the Ldb1 coregulator, acting primarily with the islet-1
            transcription factor
  JOURNAL   Diabetes 62 (3), 875-886 (2013)
   PUBMED   23193182
REFERENCE   6  (bases 1 to 6368)
  AUTHORS   Wang,M., Wu,Y., Culver,D.G. and Glass,J.D.
  TITLE     The gene for slow Wallerian degeneration (Wld(s)) is also
            protective against vincristine neuropathy
  JOURNAL   Neurobiol Dis 8 (1), 155-161 (2001)
   PUBMED   11162249
REFERENCE   7  (bases 1 to 6368)
  AUTHORS   Conforti,L., Tarlton,A., Mack,T.G., Mi,W., Buckmaster,E.A.,
            Wagner,D., Perry,V.H. and Coleman,M.P.
  TITLE     A Ufd2/D4Cole1e chimeric protein and overexpression of Rbp7 in the
            slow Wallerian degeneration (WldS) mouse
  JOURNAL   Proc Natl Acad Sci U S A 97 (21), 11377-11382 (2000)
   PUBMED   11027338
REFERENCE   8  (bases 1 to 6368)
  AUTHORS   Meyer,H.H., Shorter,J.G., Seemann,J., Pappin,D. and Warren,G.
  TITLE     A complex of mammalian ufd1 and npl4 links the AAA-ATPase, p97, to
            ubiquitin and nuclear transport pathways
  JOURNAL   EMBO J 19 (10), 2181-2192 (2000)
   PUBMED   10811609
REFERENCE   9  (bases 1 to 6368)
  AUTHORS   Coleman,M.P., Conforti,L., Buckmaster,E.A., Tarlton,A., Ewing,R.M.,
            Brown,M.C., Lyon,M.F. and Perry,V.H.
  TITLE     An 85-kb tandem triplication in the slow Wallerian degeneration
            (Wlds) mouse
  JOURNAL   Proc Natl Acad Sci U S A 95 (17), 9985-9990 (1998)
   PUBMED   9707587
REFERENCE   10 (bases 1 to 6368)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL606973.29.
            
            On Apr 15, 2022 this sequence version replaced XM_036164290.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223971.5534.1,
                                           SRR10223970.7149.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-737               AL606973.29        181047-181783       c
            738-924             AL606973.29        153764-153950       c
            925-1060            AL606973.29        142246-142381       c
            1061-1148           AL606973.29        140290-140377       c
            1149-1293           AL606973.29        138903-139047       c
            1294-1522           AL606973.29        136348-136576       c
            1523-2260           AL606973.29        135199-135936       c
            2261-2398           AL606973.29        134437-134574       c
            2399-2540           AL606973.29        127993-128134       c
            2541-2641           AL606973.29        126324-126424       c
            2642-2756           AL606973.29        123466-123580       c
            2757-2840           AL606973.29        120619-120702       c
            2841-2897           AL606973.29        116449-116505       c
            2898-3014           AL606973.29        115625-115741       c
            3015-3113           AL606973.29        115443-115541       c
            3114-3227           AL606973.29        114362-114475       c
            3228-3426           AL606973.29        112790-112988       c
            3427-3565           AL606973.29        110583-110721       c
            3566-3665           AL606973.29        108093-108192       c
            3666-3793           AL606973.29        106623-106750       c
            3794-3892           AL606973.29        105823-105921       c
            3893-4128           AL606973.29        103092-103327       c
            4129-4255           AL606973.29        99680-99806         c
            4256-4400           AL606973.29        98044-98188         c
            4401-4535           AL606973.29        92550-92684         c
            4536-4727           AL606973.29        90277-90468         c
            4728-4902           AL606973.29        86488-86662         c
            4903-5049           AL606973.29        85356-85502         c
            5050-6368           AL606973.29        83584-84902         c
FEATURES             Location/Qualifiers
     source          1..6368
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 79.08 cM"
     gene            1..6368
                     /gene="Ube4b"
                     /gene_synonym="4930551I19Rik; 4933406G05Rik; D4Bwg0973e;
                     mKIAA0684; UFD2; UFD2a; Ufd2p"
                     /note="ubiquitination factor E4B"
                     /db_xref="GeneID:63958"
                     /db_xref="MGI:MGI:1927086"
     exon            1..737
                     /gene="Ube4b"
                     /gene_synonym="4930551I19Rik; 4933406G05Rik; D4Bwg0973e;
                     mKIAA0684; UFD2; UFD2a; Ufd2p"
                     /inference="alignment:Splign:2.1.0"
     CDS             714..5111
                     /gene="Ube4b"
                     /gene_synonym="4930551I19Rik; 4933406G05Rik; D4Bwg0973e;
                     mKIAA0684; UFD2; UFD2a; Ufd2p"
                     /EC_number="2.3.2.27"
                     /note="isoform 3 is encoded by transcript variant 3;
                     ubiquitin conjugation factor E4 B; ubiquitin fusion
                     degradation protein 2; ubiquitination factor E4B, UFD2
                     homolog; RING-type E3 ubiquitin transferase E4 B"
                     /codon_start=1
                     /product="ubiquitin conjugation factor E4 B isoform 3"
                     /protein_id="NP_001391798.1"
                     /db_xref="GeneID:63958"
                     /db_xref="MGI:MGI:1927086"
                     /translation="MEELSADEIRRRRLARLAGGQTSQPTTPLTSPQRENPPGPPIAA
                     SAPGPSQSLGLNVHNMTPATSPIGAAGVAHRSQSSEGVSSLSSSPSNSLETQSQSLSR
                     SQSMDIDGVSCEKSMSQVDVDSGIENMEVDENDRREKRSLSDKEPSSGPEVSEEQALQ
                     LVCKIFRVSWKDRDRDVIFLSSLSAQFKQNPKEVFSDFKDLIGQILMEVLMMSTQTRD
                     ENPFASLTATSQPIATAARSPDRNLMLNTGSSSGTSPMFCNMGSFSTSSLSSLYETSP
                     APSASLWSFVPALSPSFALPSHPAPQAAMPSQSLSPHGVAPQAAVPSQSLSPHGVAPQ
                     AAVPSQSLSPHGVAPQVAVPSQSLSTHGVAPQAAVPSQSLSTHGVAPQAAVPSQSLST
                     HGVAPQVAVPSQSLSTHGVAPQAAVPSPPLSPHSTASGNAAGSQPSSPRYRPYTVTHP
                     WGSSPCPTPRSSILASSPGFPSHASSPRAVPASSSRQRPRSRVPAFPPASPSAASRRP
                     SSLRISPSMSNSPFSFLFLELSGDSSDDDEEEDEEELDEGGGDDDFSYVQFGSSLGAS
                     GGASNWDSYSDHFTIETCKETDMLNYLIECFDRVGIEEKKAPKMCSQPAVSQLLSNIR
                     SQCISHTALVLQGSLTQPRSLQQPSFLVPYMLCRNLPYGFIQELVRTTHQDEEVFKQI
                     FIPILQGLALAAKECSLESDYFKYPLMALGELCETKFGKTHPMCNLVASLPLWLPKSL
                     SPGSGRELQRLSYLGAFFSFSVFAEDDAKVVEKYFSGPAITLENTRVVSQSLQHYLEL
                     GRQELFKILHSILLNGETREAALSYMAALVNANMKKAQMQADDRLVSTDGFMLNLLWV
                     LQQLSTKIKLETVDPTYIFHPRCRITLPNDETRINATMEDVNERLTELYGDQPPFSEP
                     KFPTECFFLTLHAHHLSILPSCRRYIRRLRAIRELNRTVEDLKNNESQWKDSPLATRH
                     REMLKRCKTQLKKLVRCKACADAGLLDESFLRRCLNFYGLLIQLMLRILDPAYPDVTL
                     PLNSEVPKVFAALPEFYVEDVAEFLFFIVQYSPQVLYEPCTQDIVMFLVVMLCNQNYI
                     RNPYLVAKLVEVMFMTNPSVQPRTQKFFEMIENHPLSTKLLVPSLMKFYTDVEHTGAT
                     SEFYDKFTIRYHISTIFKSLWQNIAHHGTFMEEFNSGKQFVRYINMLINDTTFLLDES
                     LESLKRIHEVQEEMKNKEQWDQLPRDQQQARQSQLAQDERVSRSYLALATETVDMFHL
                     LTKQVQKPFLRPELGPRLAAMLNFNLQQLCGPKCRDLKVENPEKYGFEPKKLLDQLTD
                     IYLQLDCARFAKAIADDQRSYSKELFEEVISKMRKAGIKSTIAIEKFKLLAEKVEEIV
                     AKNARAEIDYSDAPDEFRDPLMDTLMTDPVRLPSGTVMDRSIILRHLLNSPTDPFNRQ
                     MLTESMLEPVPELKEQIQAWMREKQSSDH"
     exon            738..924
                     /gene="Ube4b"
                     /gene_synonym="4930551I19Rik; 4933406G05Rik; D4Bwg0973e;
                     mKIAA0684; UFD2; UFD2a; Ufd2p"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1060
                     /gene="Ube4b"
                     /gene_synonym="4930551I19Rik; 4933406G05Rik; D4Bwg0973e;
                     mKIAA0684; UFD2; UFD2a; Ufd2p"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1148
                     /gene="Ube4b"
                     /gene_synonym="4930551I19Rik; 4933406G05Rik; D4Bwg0973e;
                     mKIAA0684; UFD2; UFD2a; Ufd2p"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1293
                     /gene="Ube4b"
                     /gene_synonym="4930551I19Rik; 4933406G05Rik; D4Bwg0973e;
                     mKIAA0684; UFD2; UFD2a; Ufd2p"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1522
                     /gene="Ube4b"
                     /gene_synonym="4930551I19Rik; 4933406G05Rik; D4Bwg0973e;
                     mKIAA0684; UFD2; UFD2a; Ufd2p"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..2260
                     /gene="Ube4b"
                     /gene_synonym="4930551I19Rik; 4933406G05Rik; D4Bwg0973e;
                     mKIAA0684; UFD2; UFD2a; Ufd2p"
                     /inference="alignment:Splign:2.1.0"
     exon            2261..2398
                     /gene="Ube4b"
                     /gene_synonym="4930551I19Rik; 4933406G05Rik; D4Bwg0973e;
                     mKIAA0684; UFD2; UFD2a; Ufd2p"
                     /inference="alignment:Splign:2.1.0"
     exon            2399..2540
                     /gene="Ube4b"
                     /gene_synonym="4930551I19Rik; 4933406G05Rik; D4Bwg0973e;
                     mKIAA0684; UFD2; UFD2a; Ufd2p"
                     /inference="alignment:Splign:2.1.0"
     exon            2541..2641
                     /gene="Ube4b"
                     /gene_synonym="4930551I19Rik; 4933406G05Rik; D4Bwg0973e;
                     mKIAA0684; UFD2; UFD2a; Ufd2p"
                     /inference="alignment:Splign:2.1.0"
     exon            2642..2756
                     /gene="Ube4b"
                     /gene_synonym="4930551I19Rik; 4933406G05Rik; D4Bwg0973e;
                     mKIAA0684; UFD2; UFD2a; Ufd2p"
                     /inference="alignment:Splign:2.1.0"
     exon            2757..2840
                     /gene="Ube4b"
                     /gene_synonym="4930551I19Rik; 4933406G05Rik; D4Bwg0973e;
                     mKIAA0684; UFD2; UFD2a; Ufd2p"
                     /inference="alignment:Splign:2.1.0"
     exon            2841..2897
                     /gene="Ube4b"
                     /gene_synonym="4930551I19Rik; 4933406G05Rik; D4Bwg0973e;
                     mKIAA0684; UFD2; UFD2a; Ufd2p"
                     /inference="alignment:Splign:2.1.0"
     exon            2898..3014
                     /gene="Ube4b"
                     /gene_synonym="4930551I19Rik; 4933406G05Rik; D4Bwg0973e;
                     mKIAA0684; UFD2; UFD2a; Ufd2p"
                     /inference="alignment:Splign:2.1.0"
     exon            3015..3113
                     /gene="Ube4b"
                     /gene_synonym="4930551I19Rik; 4933406G05Rik; D4Bwg0973e;
                     mKIAA0684; UFD2; UFD2a; Ufd2p"
                     /inference="alignment:Splign:2.1.0"
     exon            3114..3227
                     /gene="Ube4b"
                     /gene_synonym="4930551I19Rik; 4933406G05Rik; D4Bwg0973e;
                     mKIAA0684; UFD2; UFD2a; Ufd2p"
                     /inference="alignment:Splign:2.1.0"
     exon            3228..3426
                     /gene="Ube4b"
                     /gene_synonym="4930551I19Rik; 4933406G05Rik; D4Bwg0973e;
                     mKIAA0684; UFD2; UFD2a; Ufd2p"
                     /inference="alignment:Splign:2.1.0"
     exon            3427..3565
                     /gene="Ube4b"
                     /gene_synonym="4930551I19Rik; 4933406G05Rik; D4Bwg0973e;
                     mKIAA0684; UFD2; UFD2a; Ufd2p"
                     /inference="alignment:Splign:2.1.0"
     exon            3566..3665
                     /gene="Ube4b"
                     /gene_synonym="4930551I19Rik; 4933406G05Rik; D4Bwg0973e;
                     mKIAA0684; UFD2; UFD2a; Ufd2p"
                     /inference="alignment:Splign:2.1.0"
     exon            3666..3793
                     /gene="Ube4b"
                     /gene_synonym="4930551I19Rik; 4933406G05Rik; D4Bwg0973e;
                     mKIAA0684; UFD2; UFD2a; Ufd2p"
                     /inference="alignment:Splign:2.1.0"
     exon            3794..3892
                     /gene="Ube4b"
                     /gene_synonym="4930551I19Rik; 4933406G05Rik; D4Bwg0973e;
                     mKIAA0684; UFD2; UFD2a; Ufd2p"
                     /inference="alignment:Splign:2.1.0"
     exon            3893..4128
                     /gene="Ube4b"
                     /gene_synonym="4930551I19Rik; 4933406G05Rik; D4Bwg0973e;
                     mKIAA0684; UFD2; UFD2a; Ufd2p"
                     /inference="alignment:Splign:2.1.0"
     exon            4129..4255
                     /gene="Ube4b"
                     /gene_synonym="4930551I19Rik; 4933406G05Rik; D4Bwg0973e;
                     mKIAA0684; UFD2; UFD2a; Ufd2p"
                     /inference="alignment:Splign:2.1.0"
     exon            4256..4400
                     /gene="Ube4b"
                     /gene_synonym="4930551I19Rik; 4933406G05Rik; D4Bwg0973e;
                     mKIAA0684; UFD2; UFD2a; Ufd2p"
                     /inference="alignment:Splign:2.1.0"
     exon            4401..4535
                     /gene="Ube4b"
                     /gene_synonym="4930551I19Rik; 4933406G05Rik; D4Bwg0973e;
                     mKIAA0684; UFD2; UFD2a; Ufd2p"
                     /inference="alignment:Splign:2.1.0"
     exon            4536..4727
                     /gene="Ube4b"
                     /gene_synonym="4930551I19Rik; 4933406G05Rik; D4Bwg0973e;
                     mKIAA0684; UFD2; UFD2a; Ufd2p"
                     /inference="alignment:Splign:2.1.0"
     exon            4728..4902
                     /gene="Ube4b"
                     /gene_synonym="4930551I19Rik; 4933406G05Rik; D4Bwg0973e;
                     mKIAA0684; UFD2; UFD2a; Ufd2p"
                     /inference="alignment:Splign:2.1.0"
     exon            4903..5049
                     /gene="Ube4b"
                     /gene_synonym="4930551I19Rik; 4933406G05Rik; D4Bwg0973e;
                     mKIAA0684; UFD2; UFD2a; Ufd2p"
                     /inference="alignment:Splign:2.1.0"
     exon            5050..6368
                     /gene="Ube4b"
                     /gene_synonym="4930551I19Rik; 4933406G05Rik; D4Bwg0973e;
                     mKIAA0684; UFD2; UFD2a; Ufd2p"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6344..6349
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ube4b"
                     /gene_synonym="4930551I19Rik; 4933406G05Rik; D4Bwg0973e;
                     mKIAA0684; UFD2; UFD2a; Ufd2p"
                     /note="hexamer: AATAAA"
     polyA_site      6368
                     /gene="Ube4b"
                     /gene_synonym="4930551I19Rik; 4933406G05Rik; D4Bwg0973e;
                     mKIAA0684; UFD2; UFD2a; Ufd2p"
                     /note="major polyA site"
ORIGIN      
        1 cccctttcaa agatggccgc cctgttgttt tgatgaataa ttcttggtgg ggcgaggggg
       61 taagagtagg gttggagggg taggaggatt tacgcttcca gcgagggctt cgccagtccc
      121 gtccctcccc tgccccccac cggggttctc gcgtggaggc ggggcgagcc tggcctgctt
      181 ttagagggga ggggcttccc ggtccggtgc tgggctctgc ctgggctgct gtagggtcgc
      241 cgcgcctcgg gggcatccag tgtgcagtgg agctgttccc gcctgggccc aggggtggga
      301 cccggagcag ggtctgcggg agaaaaaaac gcagctgccg cgtcaccgcc acgaagacac
      361 ggcgcgcagc gggcacgagc cgagctggag accgcgccgc ccgccctggg taacctggga
      421 agctgagggg agtcagtggc gcctggagag gaccccatag cggtggccgt ggccagaggc
      481 ggcagctctg ggcgcttgct gctggaggag gctgcggcgg tgcgagcggc cgaagccaag
      541 gcgattcagt gcctcgtgtt cttagttttt aacctctgac tatgcaattc tgaaacctcc
      601 cccattgggg gaccagacag cccgatagat accttccact cttcctttgc tcccgccctg
      661 gtctcaagaa ctgaaggatc tctctaacgc ctttcaccat taagaggaaa gcgatggagg
      721 agctgagcgc tgacgagatt cgacggaggc gcctggcacg acttgctggt ggacagacct
      781 cccagccgac caccccgctt acatctcccc agagggagaa ccctccggga cctccaatag
      841 ctgcatcagc cccaggcccc tcccagagtc ttggtctcaa tgtccacaac atgaccccag
      901 ctacctcccc cataggtgca gcaggagttg cccatcggag ccagagcagc gaaggcgtca
      961 gttctctcag cagctcacct tccaacagcc ttgagacaca gtctcagtcc ctctcccgtt
     1021 cccagagcat ggatattgac ggtgtctcct gtgagaaaag catgtcccag gtggatgtgg
     1081 attcgggaat tgagaatatg gaggtggacg agaacgaccg aagagaaaaa cggagcctga
     1141 gtgacaagga gccttcttca ggtcctgagg tgtctgaaga gcaagcctta cagctggtct
     1201 gtaagatctt ccgtgtctcc tggaaggacc gcgacagaga tgtcatcttc ctttcttctc
     1261 tctctgcgca gtttaaacag aacccaaaag aagtgttctc tgattttaag gatctgattg
     1321 gccagatttt aatggaagta ctgatgatgt caactcagac acgagatgaa aatccatttg
     1381 ccagtctgac agccacatcc cagcccatcg ccacggcagc tcggtcacca gaccgcaatc
     1441 tcatgctgaa cactggctcc agttcaggaa caagccccat gttctgcaac atgggctcct
     1501 tcagcaccag ctcgttgtct agcctctatg aaacgagccc cgccccctct gccagtttat
     1561 ggagttttgt gccagcgctc agcccatcct ttgccttacc ttcccaccca gccccacagg
     1621 cggctatgcc ttcccagtcc cttagccccc atggtgtagc cccacaggcg gctgtgcctt
     1681 cccagtccct cagcccccat ggtgtagccc cgcaggcggc tgtgccttcc cagtccctca
     1741 gcccccatgg tgtagcccca caggtggctg tgccttccca gtccctcagc acccatggtg
     1801 tagccccgca ggcagctgtg ccttcccagt ccctcagcac ccatggtgta gccccgcagg
     1861 cggctgtgcc ttcccagtcc ctcagcaccc atggtgtagc cccgcaggtg gctgtgcctt
     1921 cccagtccct cagcacccat ggtgtagccc cgcaggcggc tgtgccttcc ccacccctca
     1981 gccctcatag tacagcttct ggaaatgctg ccggaagcca gccctcatcc ccgaggtatc
     2041 ggccctatac tgtcacgcac ccttgggggt cttcaccttg ccccacccca cgatcctcca
     2101 ttctggctag ctccccaggc ttcccttccc acgcaagtag tccccgggct gtacctgcca
     2161 gctcctccag acagaggccc cgcagcaggg tccccgcctt cccacctgcc tcgcccagtg
     2221 ccgccagcag acgtccctcc tccctgcgga tctctcctag tatgtccaac agccctttct
     2281 ccttcctctt cctcgaactt tctggggaca gtagtgatga tgatgaagaa gaagatgagg
     2341 aggagttgga tgaaggtggt ggtgatgatg atttttctta tgtccagttt gggtccagtt
     2401 tgggagcctc tggtggagca agtaactggg attcgtacag tgaccatttc accattgaaa
     2461 cctgcaaaga gacggacatg ctgaactacc tcatcgagtg ttttgaccga gttggaatag
     2521 aggaaaaaaa agcaccaaag atgtgcagcc agccagcagt cagccagctt ctgagcaaca
     2581 tccgctcgca gtgcatctcc cacaccgcac tagtgctaca aggttccctc acacagccca
     2641 ggtccttgca acagccatcc ttcctcgtgc cgtacatgct ctgcaggaac ctcccgtacg
     2701 gcttcattca agagctggtg aggaccactc accaggatga agaggtgttc aagcagatct
     2761 ttatccccat tttacaaggc ctggcgctgg ctgccaaaga gtgctccttg gaaagcgact
     2821 actttaagta ccccctcatg gcactgggtg aactctgtga aaccaagttt gggaagacac
     2881 accctatgtg caatttggtc gcttctttac ccctgtggtt gccgaagtcc ttaagccctg
     2941 gttctgggcg ggagctgcag agactctcct acttaggggc cttctttagc ttctcagtct
     3001 tcgcagagga cgatgcaaag gtggttgaga aatacttctc agggcctgcc attaccctgg
     3061 agaacacacg cgtggtcagc cagtcactac agcattacct ggagctggga cggcaagaac
     3121 ttttcaagat tctacatagt attttgttaa atggcgaaac tcgtgaagcg gctctcagct
     3181 acatggcggc ccttgtcaat gccaacatga agaaagccca gatgcaggca gatgatcggt
     3241 tggtgtctac agacgggttt atgctgaatc tcctttgggt cctgcagcag ctaagtacaa
     3301 aaatcaagtt agaaacagtt gaccccactt acatattcca cccaagatgt cggatcactc
     3361 tcccgaatga tgagacacgg ataaatgcaa cgatggagga tgtgaatgag cggctgacag
     3421 agctctatgg tgatcagcct ccattttctg agccaaaatt ccctacggaa tgtttctttc
     3481 tcaccctgca tgctcatcac ctctctattc tgcctagttg tcgtcgctac attcgccgac
     3541 ttcgagccat ccgcgagctc aatagaaccg tggaagattt gaaaaataat gaaagccagt
     3601 ggaaagattc cccactggcc accagacacc gtgaaatgct gaagcgctgt aaaactcagc
     3661 ttaagaaact ggtacggtgc aaggcctgtg ctgacgctgg cttacttgac gagagcttcc
     3721 taagaagatg cctgaatttt tatggccttc tcattcagct gatgctgcgc atcctggacc
     3781 ctgcatatcc tgacgtaaca ctgcctttga attcagaagt ccccaaggta tttgcagcat
     3841 tgcctgagtt ttatgtcgaa gatgttgctg aatttttatt ttttattgta caatactctc
     3901 ctcaggtgct ttatgagccc tgcactcagg acattgtcat gttcctcgtt gtgatgctgt
     3961 gcaaccagaa ctacatccga aacccttacc tagtggccaa gctggtggag gtcatgttca
     4021 tgaccaaccc ttctgtccag ccgagaactc agaagttctt tgagatgatt gagaaccatc
     4081 ctctctctac caaactgctg gtgccgtccc tcatgaagtt ctatacagat gtcgagcata
     4141 ctggagccac cagcgagttc tatgacaagt tcacaattcg ctatcacatt agcactattt
     4201 ttaaaagcct ttggcaaaac atagctcacc atggcacctt catggaggag ttcaattctg
     4261 gaaagcagtt cgttcggtat atcaatatgc taataaatga cacgaccttt ttactggacg
     4321 aaagtctgga gtctctgaag cggatccatg aagtgcaaga agagatgaag aacaaagaac
     4381 agtgggacca gctgcctcgg gatcagcagc aggcccggca gtctcagctt gctcaggacg
     4441 agcgtgtttc ccgttcttat cttgccctgg caactgaaac cgtggacatg ttccatctcc
     4501 tcaccaagca agtccagaag ccgttcctga ggccagagct tggtccccga ttagcagcca
     4561 tgctgaactt taacctgcag cagctctgcg gacccaagtg ccgggacctg aaagttgaaa
     4621 acccagagaa gtatggtttt gagccaaaga agctgttgga ccaactgaca gatatttatt
     4681 tacaattgga ctgtgctcgc tttgctaaag ccatcgccga tgaccagcga tcctacagca
     4741 aggaactgtt tgaagaagtc atttcaaaga tgcggaaggc gggaatcaaa tccaccatcg
     4801 caatagagaa gtttaaactt cttgcagaga aagtggagga aatcgtggca aagaatgcgc
     4861 gggcagaaat agactacagc gatgccccgg acgagttcag agaccctctg atggacaccc
     4921 tgatgaccga tcccgtgaga ctgccctctg gcaccgtcat ggaccgttct atcatcctgc
     4981 ggcatctgct caactccccc accgacccct tcaaccgcca gatgctgact gagagcatgc
     5041 tggagccagt gccagagcta aaggagcaga ttcaggcctg gatgagagag aaacagagca
     5101 gtgaccactg aggccccatc gctcctccgc tggaagccgc cacgccagcc agccaggccg
     5161 cagcagcatc tgcctcgagg ctgcagctcc agcctgtaac cagatgtggc cagatcctga
     5221 gagcccaccc gtgtgaccaa acagtggaga tctgagggga tgacgagaag aggattcctg
     5281 tacatatatt taagtgacaa cagtcaaagc ttgagggacg agtttacgat ggcttgtgta
     5341 gtaaagcgca cccttcgcct gtcgctacct ggggctgtgg cagcggaagt gtttagtgac
     5401 aagtgggtct gggcagcttc ccctgagctt acgttttgtt ttgttttgtt ttttcgatgt
     5461 gaatagagaa ctcggacatt ttgctgctaa acaatctccc ctccctcacc ctacttgcac
     5521 tgctgtgggt tttttaaaga gaaacagaac cagactcctt tcccggccct ccaaacatgt
     5581 attctgtgcg ataacttgtg cctgcgacaa gtgttaatct tgggatcgta tttttatatc
     5641 atattcacat acttgttttt ttaattggtg ttagatgaca tgattaataa aaaaggcaag
     5701 atattttcag aatttgaatt tcagtttttt tttcttttga aatagccctt ttaaattttt
     5761 ttattataaa caaaatgaag agaaccctgt gagcctggtc cttctagcaa ccctcagtta
     5821 agatcctgag ggacaggtgc agcagcagct ggctggagtg gatcaggact cctgtgactc
     5881 gtggggctcg ggggaggtga ggggtgtgtt tggttttttg ttgttttgtt gttttgtttt
     5941 aatcctatgt gacaattcca actatgcggt taccctctga ggataagttc ctcagcccgg
     6001 ggttctttta tatgctgtgt ccttttgggg tttgacctta ccaaagcaaa gaaacaaaaa
     6061 acaaaaaaaa caaaaaaaaa aaagggtgca agaaatgtgg aaatctgtct gcttgtttac
     6121 atggcccgac aacaccacct aggcgcacgc gagcagaagc cctctctgta ttaccgctcc
     6181 ctacgcaaca tacttgaatt cttgagttcc ctttggggtg agaaaggatt tgaaaccata
     6241 aagtgtttta aagaaatgaa ctcttcagaa acagacttcc tcctcttttc ctttctcctc
     6301 tgctccacag cctgtgctct gttcagttcc caacacaatc gacaataaac ggtgatgccc
     6361 attcggaa
//
