LOCUS       NM_133907               5033 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus ubiquitin protein ligase E3C (Ube3c), mRNA.
ACCESSION   NM_133907
VERSION     NM_133907.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5033)
  AUTHORS   Godoy-Corchuelo,J.M., Ali,Z., Brito Armas,J.M., Martins-Bach,A.B.,
            Garcia-Toledo,I., Fernandez-Beltran,L.C., Lopez-Carbonero,J.I.,
            Bascunana,P., Spring,S., Jimenez-Coca,I., Munoz de Bustillo
            Alfaro,R.A., Sanchez-Barrena,M.J., Nair,R.R., Nieman,B.J.,
            Lerch,J.P., Miller,K.L., Ozdinler,H.P., Fisher,E.M.C.,
            Cunningham,T.J., Acevedo-Arozena,A. and Corrochano,S.
  TITLE     TDP-43-M323K causes abnormal brain development and progressive
            cognitive and motor deficits associated with mislocalised and
            increased levels of TDP-43
  JOURNAL   Neurobiol Dis 193, 106437 (2024)
   PUBMED   38367882
  REMARK    Erratum:[Neurobiol Dis. 2024 Nov;202:106708. doi:
            10.1016/j.nbd.2024.106708.. PMID: 39462744]
REFERENCE   2  (bases 1 to 5033)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5033)
  AUTHORS   Wang,Y., Liu,M., Liu,X. and Guo,X.
  TITLE     LINC00963-FOSB-mediated transcription activation of UBE3C enhances
            radioresistance of breast cancer cells by inducing
            ubiquitination-dependent protein degradation of TP73
  JOURNAL   J Transl Med 21 (1), 321 (2023)
   PUBMED   37173692
  REMARK    GeneRIF: LINC00963-FOSB-mediated transcription activation of UBE3C
            enhances radioresistance of breast cancer cells by inducing
            ubiquitination-dependent protein degradation of TP73.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5033)
  AUTHORS   Fratta,P., Sivakumar,P., Humphrey,J., Lo,K., Ricketts,T.,
            Oliveira,H., Brito-Armas,J.M., Kalmar,B., Ule,A., Yu,Y., Birsa,N.,
            Bodo,C., Collins,T., Conicella,A.E., Mejia Maza,A.,
            Marrero-Gagliardi,A., Stewart,M., Mianne,J., Corrochano,S.,
            Emmett,W., Codner,G., Groves,M., Fukumura,R., Gondo,Y., Lythgoe,M.,
            Pauws,E., Peskett,E., Stanier,P., Teboul,L., Hallegger,M.,
            Calvo,A., Chio,A., Isaacs,A.M., Fawzi,N.L., Wang,E., Housman,D.E.,
            Baralle,F., Greensmith,L., Buratti,E., Plagnol,V., Fisher,E.M. and
            Acevedo-Arozena,A.
  TITLE     Mice with endogenous TDP-43 mutations exhibit gain of splicing
            function and characteristics of amyotrophic lateral sclerosis
  JOURNAL   EMBO J 37 (11) (2018)
   PUBMED   29764981
REFERENCE   5  (bases 1 to 5033)
  AUTHORS   Kuo,C.L. and Goldberg,A.L.
  TITLE     Ubiquitinated proteins promote the association of proteasomes with
            the deubiquitinating enzyme Usp14 and the ubiquitin ligase Ube3c
  JOURNAL   Proc Natl Acad Sci U S A 114 (17), E3404-E3413 (2017)
   PUBMED   28396413
  REMARK    GeneRIF: Usp14 and Ube3c cycle together on and off proteasomes, and
            the presence of ubiquitinated substrates promotes their
            association. This mechanism enables proteasome activity to adapt to
            the supply of substrates.
REFERENCE   6  (bases 1 to 5033)
  AUTHORS   Mu,X., Fu,X., Beremand,P.D., Thomas,T.L. and Klein,W.H.
  TITLE     Gene regulation logic in retinal ganglion cell development: Isl1
            defines a critical branch distinct from but overlapping with Pou4f2
  JOURNAL   Proc Natl Acad Sci U S A 105 (19), 6942-6947 (2008)
   PUBMED   18460603
REFERENCE   7  (bases 1 to 5033)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   8  (bases 1 to 5033)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   9  (bases 1 to 5033)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 5033)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC104548.6,
            AC169627.2 and AC122782.8.
            
            On May 1, 2007 this sequence version replaced NM_133907.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK046056.1, AK122187.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-339               AC104548.6         153558-153896
            340-393             AC104548.6         171591-171644
            394-468             AC104548.6         174204-174278
            469-615             AC104548.6         175126-175272
            616-731             AC104548.6         181385-181500
            732-889             AC104548.6         183175-183332
            890-1043            AC104548.6         184957-185110
            1044-1264           AC104548.6         185448-185668
            1265-1416           AC104548.6         186512-186663
            1417-1604           AC104548.6         191223-191410
            1605-1691           AC104548.6         199224-199310
            1692-1849           AC104548.6         203544-203701
            1850-2082           AC104548.6         203871-204103
            2083-2187           AC169627.2         5224-5328
            2188-2275           AC169627.2         6782-6869
            2276-2373           AC169627.2         9663-9760
            2374-2506           AC169627.2         11670-11802
            2507-2754           AC169627.2         20442-20689
            2755-2967           AC169627.2         32242-32454
            2968-3156           AC169627.2         37495-37683
            3157-3223           AC169627.2         37808-37874
            3224-3354           AC169627.2         41946-42076
            3355-5033           AC122782.8         21072-22750
FEATURES             Location/Qualifiers
     source          1..5033
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 15.12 cM"
     gene            1..5033
                     /gene="Ube3c"
                     /gene_synonym="mKIAA0010; RAUL"
                     /note="ubiquitin protein ligase E3C"
                     /db_xref="GeneID:100763"
                     /db_xref="MGI:MGI:2140998"
     exon            1..339
                     /gene="Ube3c"
                     /gene_synonym="mKIAA0010; RAUL"
                     /inference="alignment:Splign:2.1.0"
     CDS             274..3525
                     /gene="Ube3c"
                     /gene_synonym="mKIAA0010; RAUL"
                     /EC_number="2.3.2.26"
                     /note="HECT-type ubiquitin transferase E3C; RTA-associated
                     ubiquitin ligase"
                     /codon_start=1
                     /product="ubiquitin-protein ligase E3C"
                     /protein_id="NP_598668.1"
                     /db_xref="CCDS:CCDS39042.1"
                     /db_xref="GeneID:100763"
                     /db_xref="MGI:MGI:2140998"
                     /translation="MFSFEGDFKTRPKVSLGGASRKEEKASLLHRTQEERRKREEERR
                     RLKNAVIIQSFIRGYRDRKQQYFIQRSAFDQCTDSAQPGGTFCLADGPNLTLLVRQLL
                     FFYKQSEDSKRLIWLYQNLIKHSSLFVKQLDGSERLTCLFQIKRLMSLCCRLLQNCSD
                     DSLNVALPMRMLEVFTSENTYLPVLQDSSYVVSVIEQILHYMVHSGYYRSLYLLINSK
                     LPSSIEYSDLSRVPIAKILLENVLKPLHFTYSSCPEASRHQVFSAFTEEFLGAPFTDQ
                     IFHFVIPAFADAQTVFPYEPFLNALLLLESQSSKRCSGVPWLFYFVLTVGENYLGALS
                     EDGLLVYLRVLQTFLSQLPASPTGTGCPDSTSDSEDDNEETDQPNSPEDGRVSAPYIT
                     EECLRKLDTKQQTNTLLNLVWRDSASEEVFTRMASICHTLMVQHRMMVPKVRLLYSLA
                     FNARFLRHLWFLISSMTTQMITGSMVPLLQLISRGSPMSFEDSSRIIPLFYLFSSLFS
                     HSLISIHDNEFFGDPIEVVGQRQSSMMPFTLEELILLSRCLRDACLGIIKLAYPETKP
                     EVREEYVTAFQSIGVTTNSEMQQCIQMEQKRWVQLFKVITNLVKMLKSRDTRRNFCPP
                     NHWLSEQEDIKADKVTQLYVPASRHVWRFRRMGRIGPLQSTLEVGLESLPLSVSEERQ
                     LAILTELPFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGINVTIRRNYIYEDAYDKL
                     SPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEG
                     LLYPNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDI
                     HHLASLDPEVYRNLLFLKSYEEDVEELGLNFTVVNNDLGEAQVVELKFGGKDIPVTGA
                     NRIAYIHLVADYRLNKQIRPHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPVS
                     LEDLKSFTNYSGGYSADHPVIKIFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELY
                     PAFCIHNGGSDLERLPTASTCMNLLKLPEFYDEALLRSKLLYAIECAAGFELS"
     exon            340..393
                     /gene="Ube3c"
                     /gene_synonym="mKIAA0010; RAUL"
                     /inference="alignment:Splign:2.1.0"
     exon            394..468
                     /gene="Ube3c"
                     /gene_synonym="mKIAA0010; RAUL"
                     /inference="alignment:Splign:2.1.0"
     exon            469..615
                     /gene="Ube3c"
                     /gene_synonym="mKIAA0010; RAUL"
                     /inference="alignment:Splign:2.1.0"
     exon            616..731
                     /gene="Ube3c"
                     /gene_synonym="mKIAA0010; RAUL"
                     /inference="alignment:Splign:2.1.0"
     exon            732..889
                     /gene="Ube3c"
                     /gene_synonym="mKIAA0010; RAUL"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1043
                     /gene="Ube3c"
                     /gene_synonym="mKIAA0010; RAUL"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1264
                     /gene="Ube3c"
                     /gene_synonym="mKIAA0010; RAUL"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1416
                     /gene="Ube3c"
                     /gene_synonym="mKIAA0010; RAUL"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1604
                     /gene="Ube3c"
                     /gene_synonym="mKIAA0010; RAUL"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1691
                     /gene="Ube3c"
                     /gene_synonym="mKIAA0010; RAUL"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1849
                     /gene="Ube3c"
                     /gene_synonym="mKIAA0010; RAUL"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..2082
                     /gene="Ube3c"
                     /gene_synonym="mKIAA0010; RAUL"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2187
                     /gene="Ube3c"
                     /gene_synonym="mKIAA0010; RAUL"
                     /inference="alignment:Splign:2.1.0"
     exon            2188..2275
                     /gene="Ube3c"
                     /gene_synonym="mKIAA0010; RAUL"
                     /inference="alignment:Splign:2.1.0"
     exon            2276..2373
                     /gene="Ube3c"
                     /gene_synonym="mKIAA0010; RAUL"
                     /inference="alignment:Splign:2.1.0"
     exon            2374..2506
                     /gene="Ube3c"
                     /gene_synonym="mKIAA0010; RAUL"
                     /inference="alignment:Splign:2.1.0"
     exon            2507..2754
                     /gene="Ube3c"
                     /gene_synonym="mKIAA0010; RAUL"
                     /inference="alignment:Splign:2.1.0"
     exon            2755..2967
                     /gene="Ube3c"
                     /gene_synonym="mKIAA0010; RAUL"
                     /inference="alignment:Splign:2.1.0"
     exon            2968..3156
                     /gene="Ube3c"
                     /gene_synonym="mKIAA0010; RAUL"
                     /inference="alignment:Splign:2.1.0"
     exon            3157..3223
                     /gene="Ube3c"
                     /gene_synonym="mKIAA0010; RAUL"
                     /inference="alignment:Splign:2.1.0"
     exon            3224..3354
                     /gene="Ube3c"
                     /gene_synonym="mKIAA0010; RAUL"
                     /inference="alignment:Splign:2.1.0"
     exon            3355..5033
                     /gene="Ube3c"
                     /gene_synonym="mKIAA0010; RAUL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4277..4282
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ube3c"
                     /gene_synonym="mKIAA0010; RAUL"
                     /note="hexamer: ATTAAA"
     polyA_site      4297
                     /gene="Ube3c"
                     /gene_synonym="mKIAA0010; RAUL"
                     /note="major polyA site"
     regulatory      4762..4767
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ube3c"
                     /gene_synonym="mKIAA0010; RAUL"
                     /note="hexamer: AATAAA"
     polyA_site      4781
                     /gene="Ube3c"
                     /gene_synonym="mKIAA0010; RAUL"
     regulatory      5006..5011
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ube3c"
                     /gene_synonym="mKIAA0010; RAUL"
                     /note="hexamer: ATTAAA"
     polyA_site      5023
                     /gene="Ube3c"
                     /gene_synonym="mKIAA0010; RAUL"
                     /note="major polyA site"
ORIGIN      
        1 accatcttgg tacctacggc agcgcggtgc aggcgcgagt cggggcgtcc ctcgcttgac
       61 ggtggcgcgc tgtggataaa taagcagcgg ggacaggccg gcctccagcg tcgccgcgct
      121 cgcgcccgcg tgcagggcgg agagcgctga gcctcggggg gggcggcgcg ggacagcgag
      181 gccgcgaccc tgccgggccc cgcccagccc gccgggcccg cccccggccg ctccgctgcc
      241 tgccgggccg cgcagatggg ataagcggcg aagatgttca gcttcgaagg cgacttcaag
      301 acaaggccca aagtgtctct cggtggcgcg agcaggaagg aagaaaaggc ttctctttta
      361 catcgcactc aggaagaaag acgcaagaga gaggaagaaa ggcgaagatt gaaaaatgca
      421 gtaataatcc aatcttttat ccgaggctat agagacagaa aacaacaata cttcatccaa
      481 agaagcgcgt ttgaccaatg cactgactcg gctcagcctg gtggtacctt ctgccttgct
      541 gatggtccca accttaccct cttggtaagg cagcttctgt tcttttacaa gcagagtgaa
      601 gactccaaac gtttgatatg gctttatcag aacttaatta aacacagctc tctgtttgtc
      661 aagcaattgg atggatcaga gagactgaca tgcttatttc aaataaagag gttgatgagc
      721 ctctgttgca ggttgctgca aaactgtagt gatgacagtc tgaatgttgc acttccaatg
      781 cgaatgcttg aggtgtttac atctgagaat acatacttgc ctgttttaca agattctagc
      841 tatgtggtgt cagtgattga acaaattttg cactacatgg ttcacagtgg atattataga
      901 tctctctact tgttgattaa tagcaagctt ccatcaagta ttgaatattc tgatttatct
      961 cgagttccta tagcaaaaat tttgctggag aatgtcctaa aaccattgca ctttacgtat
     1021 agctcctgtc ctgaagcctc aaggcatcaa gttttctcag ccttcacaga ggagtttctg
     1081 ggagcacctt ttaccgatca aatttttcat ttcgtcattc cggcctttgc agatgcacaa
     1141 actgtgttcc cttatgagcc ctttctcaat gcattgttgt tacttgagag tcaaagttca
     1201 aaacggtgta gtggagtgcc atggctcttc tattttgttt taactgttgg cgagaattat
     1261 ttaggagcac tctctgagga tggtctactg gtttatctgc gagtgcttca gaccttcctc
     1321 tctcagctac ctgcttcacc cactggtaca ggctgtcctg attccaccag tgactctgag
     1381 gacgataacg aggagactga ccaacccaac agccctgagg atggcagggt gtcagcccca
     1441 tatattactg aagagtgtct gagaaaactg gatacgaagc agcaaaccaa caccctgctg
     1501 aacctggtgt ggagggactc ggccagtgag gaggtcttca caaggatggc ttctatctgc
     1561 cacacattga tggtgcagca ccgaatgatg gtgcccaaag tcaggcttct ctacagttta
     1621 gccttcaatg ccaggttttt gaggcatctt tggtttctca tctcttcaat gacaacacag
     1681 atgatcacag gatctatggt gccattgctt cagttgatat cgcggggttc gcccatgtct
     1741 tttgaagatt ctagtcgaat catcccactc ttttacctct tcagctcctt gttcagtcat
     1801 tcgctgatct ccatacatga caatgaattt tttggtgacc ccatagaagt tgtaggtcag
     1861 agacaatcat ccatgatgcc tttcactctg gaggagttaa tcctgctgtc acgatgcctt
     1921 cgagatgcct gcttggggat catcaagcta gcatacccgg aaacaaagcc agaagttcgg
     1981 gaagaatatg tcaccgcatt tcagagtatt ggggtcacta ctaattctga gatgcagcag
     2041 tgcatacaaa tggaacagaa gcgatgggtt cagctgttca aggttatcac caacctagtg
     2101 aaaatgctga agtctagaga cacgaggaga aatttctgtc ctccaaacca ctggctgtca
     2161 gaacaagagg atatcaaagc agataaagtt acccagctct atgtacctgc atctagacat
     2221 gtgtggcgat tccggaggat gggcaggatt ggcccactgc agtccaccct ggaggtgggt
     2281 ctggagtcct tacccctgtc tgtgtctgag gaacgacagc ttgccatcct gacagaactg
     2341 ccttttgtgg ttccatttga ggagcgagtg aagatctttc aaaggttgat ttatgctgat
     2401 aagcaagaag ttcaaggcga tggtccattt ctggatggaa tcaatgttac tataaggaga
     2461 aattatattt atgaagatgc ttatgacaaa ctttctccag aaaatgagcc tgatttgaaa
     2521 aaacggatcc gggtgcactt gctcaatgcc catggcctgg atgaagctgg catcgatggt
     2581 ggtggtattt tcagagagtt tttaaatgaa ctactgaaat ctggatttaa ccccaaccag
     2641 ggcttcttta agactactaa tgaagggctt ctatacccca acccagctgc tcagatgctt
     2701 gtgggagatt ctttcgcaag gcattactac ttcctaggca gaatgcttgg aaaggctctg
     2761 tatgaaaaca tgttggtgga gctacccttt gctggctttt tcctgtccaa gctactggga
     2821 accagtgcag atgtggacat tcaccatctt gcctcattgg accccgaagt ctacaggaac
     2881 ctgcttttcc tcaagagcta tgaggaggat gtggaggaac tgggactgaa ctttactgtg
     2941 gtgaacaatg acctgggaga agcccaggtg gttgaactaa aatttggtgg aaaagacatc
     3001 ccggtaactg gggccaaccg aattgcctac atccacctgg tggctgacta ccggctgaac
     3061 aagcagatcc gaccgcattg cctagctttc cgccagggcc tggccaatgt tgtgagccta
     3121 gagtggctcc gaatgtttga ccaacaggaa attcaggtat taatttctgg tgcacaagtt
     3181 cctgtaagtc tggaggacct aaaatccttt acaaactatt cagggggcta ttctgccgat
     3241 catcctgtca ttaaaatctt ttggagagtt gtagaaggtt tcactgacga agaaaagcgc
     3301 aagttgctca agtttgtaac aagttgctct cgcccccctc tcctgggttt caaggagcta
     3361 taccctgcgt tttgcattca caatggaggc tctgaccttg agcggctacc tacagccagc
     3421 acctgcatga acctgctgaa gctcccagag ttttatgatg aagccctgct gcgaagcaag
     3481 ctgctgtatg ccattgagtg tgctgctggc tttgagctga gctgaattga gcccagagaa
     3541 cttgatctca cccaaaggca gccagcacct accagaccca agagagcact caggcaggac
     3601 cctcagctct cctcaggcct tctatctggc atctctccct ttctaatttt ttttttagat
     3661 gattttatcg tgacatagtc acatacatag atggacattg cttttcacat aacctagcta
     3721 ttgttatgtg ctatgtggct ggtttagtaa ttttgccaag aagagcacag gttttagaat
     3781 agtggcaact cagtgaaatt aaccaaagat gaagctttgg ccttgctgac ccagtttata
     3841 tcccttcttg ggtcaggcac cagtatctgc atacagaatc tggggctgat acacagagcc
     3901 aagccactgc ttctcatgtg gttgattgtt tacaagccta attgtaaaaa ctgaaggcat
     3961 ttttcctgct gccttttccc aaagtggtta ggtttggaaa atggataaca ctagtattat
     4021 tttatttgtg ctttttaagc catgtccccc aggtgggaat cgcatgcttg tcttcagact
     4081 cctactgacc tgcctcatga ggtttggaca tggctgtgtg ggttgaggtg actgctgccc
     4141 tcattgctct ttgcctgtct ctgctttatg cctggaaagc tttccaggag gtggaggaga
     4201 agggtcctta cacttcctga ggtaccgtgt cacctgcagt gagttggcaa ctggggatgt
     4261 gggcactgca gcttttatta aagtcatttg aaccaaagtg gcgggctgcg tctctccgtg
     4321 atccatatgc cctcctagcc tggctgtgcc catcatcttg cgcatcttgg ggggacttat
     4381 cccaggcctc agcacctctg ctttctgccg ctgtcttgat aagaagacag catccctggc
     4441 atctgccagg gaagagcatc aggccaggtg attctcactt gggcacttta tcagggtcaa
     4501 acttgttgcc agttgacctc agcctctgca aacaaagcag ggaagcatct gagaggctag
     4561 catacaagga tcatcatgga gctggtgagg actccagact ctgcttctcg tctaagtcca
     4621 gcatctgtgc ctggaggctc tttgtgctgt tggagttagg tgaacagaat tagcaatata
     4681 cttttaaatg tgggaaaact gaatgacact tttaagacaa tgacaattat cagacaaaat
     4741 gtataatttc ttaatttgaa taataaagta tttaaatgct atttgtagtc ttgatacata
     4801 ggaagaaata gcatttatcc ttgattttgt tttttgtttg gggatgttta tattgaatgt
     4861 cctacatctt tttatgagtt aatttgtgta ttagtgtttt agaattgaag tatctgagac
     4921 tggagataaa ttggcagttt gtattttttt tctgttggct cttctgagct tatttatttg
     4981 tacatcctaa tgggtgaata tttacattaa atcttttccc caagattgtg ttg
//
