LOCUS       NM_054093               5181 bp    mRNA    linear   ROD 26-SEP-2023
DEFINITION  Mus musculus ubiquitin protein ligase E3B (Ube3b), transcript
            variant 1, mRNA.
ACCESSION   NM_054093
VERSION     NM_054093.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5181)
  AUTHORS   Katsube S, Koganezawa N, Hanamura K, Cuthill KJ, Tarabykin V,
            Ambrozkiewicz MC and Kawabe H.
  TITLE     The murine ortholog of Kaufman oculocerebrofacial syndrome gene
            Ube3b is crucial for the maintenance of the excitatory synapses in
            the young adult stage
  JOURNAL   Neurosci Lett 797, 137059 (2023)
   PUBMED   36623761
  REMARK    GeneRIF: The murine ortholog of Kaufman oculocerebrofacial syndrome
            gene Ube3b is crucial for the maintenance of the excitatory
            synapses in the young adult stage.
REFERENCE   2  (bases 1 to 5181)
  AUTHORS   Ambrozkiewicz MC, Borisova E, Schwark M, Ripamonti S, Schaub T,
            Smorodchenko A, Weber AI, Rhee HJ, Altas B, Yilmaz R, Mueller S,
            Piepkorn L, Horan ST, Straussberg R, Zaqout S, Jahn O, Dere E,
            Rosario M, Boehm-Sturm P, Borck G, Willig KI, Rhee J, Tarabykin V
            and Kawabe H.
  TITLE     The murine ortholog of Kaufman oculocerebrofacial syndrome protein
            Ube3b regulates synapse number by ubiquitinating Ppp3cc
  JOURNAL   Mol Psychiatry 26 (6), 1980-1995 (2021)
   PUBMED   32249816
  REMARK    GeneRIF: The murine ortholog of Kaufman oculocerebrofacial syndrome
            protein Ube3b regulates synapse number by ubiquitinating Ppp3cc.
REFERENCE   3  (bases 1 to 5181)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5181)
  AUTHORS   Cheon S, Kaur K, Nijem N, Tuncay IO, Kumar P, Dean M, Juusola J,
            Guillen-Sacoto MJ, Bedoukian E, Ierardi-Curto L, Kaplan P, Schaefer
            GB, Mishra P and Chahrour MH.
  TITLE     The ubiquitin ligase UBE3B, disrupted in intellectual disability
            and absent speech, regulates metabolic pathways by targeting BCKDK
  JOURNAL   Proc Natl Acad Sci U S A 116 (9), 3662-3667 (2019)
   PUBMED   30808755
REFERENCE   5  (bases 1 to 5181)
  AUTHORS   Basel-Vanagaite L, Dallapiccola B, Ramirez-Solis R, Segref A,
            Thiele H, Edwards A, Arends MJ, Miro X, White JK, Desir J,
            Abramowicz M, Dentici ML, Lepri F, Hofmann K, Har-Zahav A, Ryder E,
            Karp NA, Estabel J, Gerdin AK, Podrini C, Ingham NJ, Altmuller J,
            Nurnberg G, Frommolt P, Abdelhak S, Pasmanik-Chor M, Konen O,
            Kelley RI, Shohat M, Nurnberg P, Flint J, Steel KP, Hoppe T,
            Kubisch C, Adams DJ and Borck G.
  TITLE     Deficiency for the ubiquitin ligase UBE3B in a
            blepharophimosis-ptosis-intellectual-disability syndrome
  JOURNAL   Am J Hum Genet 91 (6), 998-1010 (2012)
   PUBMED   23200864
  REMARK    GeneRIF: Our data reveal the pleiotropic effects of UBE3B
            deficiency and reinforce the physiological importance of
            ubiquitination in neuronal development and function in mammals.
REFERENCE   6  (bases 1 to 5181)
  AUTHORS   Gong TW, Huang L, Warner SJ and Lomax MI.
  TITLE     Characterization of the human UBE3B gene: structure, expression,
            evolution, and alternative splicing
  JOURNAL   Genomics 82 (2), 143-152 (2003)
   PUBMED   12837265
REFERENCE   7  (bases 1 to 5181)
  AUTHORS   Lomax MI, Huang L, Cho Y, Gong TL and Altschuler RA.
  TITLE     Differential display and gene arrays to examine auditory plasticity
  JOURNAL   Hear Res 147 (1-2), 293-302 (2000)
   PUBMED   10962193
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132102.3.
            
            [WARNING] On Oct 5, 2023 this sequence was replaced by NM_054093.4.
            
            On Sep 13, 2016 this sequence version replaced NM_054093.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023956.1, SRR1660813.59773.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-356               AC132102.3         133542-133897       c
            357-444             AC132102.3         130115-130202       c
            445-629             AC132102.3         127239-127423       c
            630-750             AC132102.3         127016-127136       c
            751-810             AC132102.3         125735-125794       c
            811-915             AC132102.3         125348-125452       c
            916-1012            AC132102.3         124031-124127       c
            1013-1098           AC132102.3         122334-122419       c
            1099-1181           AC132102.3         121358-121440       c
            1182-1287           AC132102.3         116004-116109       c
            1288-1408           AC132102.3         115635-115755       c
            1409-1586           AC132102.3         114550-114727       c
            1587-1756           AC132102.3         113080-113249       c
            1757-1924           AC132102.3         111828-111995       c
            1925-2096           AC132102.3         109806-109977       c
            2097-2215           AC132102.3         108227-108345       c
            2216-2330           AC132102.3         107657-107771       c
            2331-2430           AC132102.3         106874-106973       c
            2431-2550           AC132102.3         106301-106420       c
            2551-2727           AC132102.3         103322-103498       c
            2728-2838           AC132102.3         103103-103213       c
            2839-2976           AC132102.3         102214-102351       c
            2977-3042           AC132102.3         102030-102095       c
            3043-3101           AC132102.3         101608-101666       c
            3102-3284           AC132102.3         99133-99315         c
            3285-3396           AC132102.3         98829-98940         c
            3397-3489           AC132102.3         95887-95979         c
            3490-5181           AC132102.3         93348-95039         c
FEATURES             Location/Qualifiers
     source          1..5181
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 55.99 cM"
     gene            1..5181
                     /gene="Ube3b"
                     /note="ubiquitin protein ligase E3B"
                     /db_xref="GeneID:117146"
                     /db_xref="MGI:MGI:1891295"
     exon            1..356
                     /gene="Ube3b"
                     /inference="alignment:Splign:2.1.0"
     exon            357..444
                     /gene="Ube3b"
                     /inference="alignment:Splign:2.1.0"
     exon            445..629
                     /gene="Ube3b"
                     /inference="alignment:Splign:2.1.0"
     CDS             469..3681
                     /gene="Ube3b"
                     /EC_number="2.3.2.26"
                     /note="isoform 1 is encoded by transcript variant 1;
                     HECT-type ubiquitin transferase E3B"
                     /codon_start=1
                     /product="ubiquitin-protein ligase E3B isoform 1"
                     /protein_id="NP_473434.2"
                     /db_xref="CCDS:CCDS19564.1"
                     /db_xref="GeneID:117146"
                     /db_xref="MGI:MGI:1891295"
                     /translation="MFTVSQTSRAWFIDRARQAREERLVQKERERSAVTIQALVRSFL
                     CRRRLHRDIRKEIDEFFSADESGSSKRSALCIFKIARRLLFICKTTEDSERLEKLCRS
                     ILNSMDAENEPKVWYVSLALSKDLTLLWIKQIKSILWHCCELLGQLKPEILQDSRLIT
                     LYLTMLVTFTDTSTWKILRGKGESLRPALNHICANIMGHLNQRGLYSVLQVLLTRGLA
                     RPRPCLSKGMLTAAFSLALRPVVAAQFSDNLMRPFIIHVMSVPALVAHLSTVAPERLG
                     VLESHDMLRKFIVFLRDRDRCRDACESLEGCHTLCLMGNLLHLGSLSLRLLEEEMDGF
                     VSALTQMLCYCQKYVAQKKSNLTHWHPVLGWFSQPVDYGLNDSMYLITKQLQFLWAVP
                     LIRILFSDILSRKLLEHAEPAPVQPQPSSPQTVLPVKSLLKRAFQKSASVRNILRPVG
                     GRRVDSAEVRKVCNICVLYQTSLTTLTQIRLQILTGLTYLDDLLPKLWAFICELGPHG
                     GLKLFLECLNNDTGESKQLLAMLMLFCDCSRHLITILDDIEVYEEQISFKLEELVTIS
                     SFLNSFVFKMIWDGIVENAKGETLELFQSVHGWLMVLYERDCRRRFAPEDHWLRRDLK
                     PGVLFQELDKDRRRAQLVLQHIPHVVPHKNRVLLFRNMVIKEKEKLGLVETSSASPHV
                     THITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEI
                     IKRVFDPALNLFKTTSGDERLYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDVPF
                     ASFFLSQMLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDIADLGLTLSYDEDVM
                     GQLVCHELVPGGKTIPVTDENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWI
                     RMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPEERA
                     MFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGG
                     RLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFELS"
     exon            630..750
                     /gene="Ube3b"
                     /inference="alignment:Splign:2.1.0"
     exon            751..810
                     /gene="Ube3b"
                     /inference="alignment:Splign:2.1.0"
     exon            811..915
                     /gene="Ube3b"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1012
                     /gene="Ube3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1098
                     /gene="Ube3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1181
                     /gene="Ube3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1287
                     /gene="Ube3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1408
                     /gene="Ube3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1586
                     /gene="Ube3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1756
                     /gene="Ube3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1924
                     /gene="Ube3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..2096
                     /gene="Ube3b"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2215
                     /gene="Ube3b"
                     /inference="alignment:Splign:2.1.0"
     exon            2216..2330
                     /gene="Ube3b"
                     /inference="alignment:Splign:2.1.0"
     exon            2331..2430
                     /gene="Ube3b"
                     /inference="alignment:Splign:2.1.0"
     exon            2431..2550
                     /gene="Ube3b"
                     /inference="alignment:Splign:2.1.0"
     exon            2551..2727
                     /gene="Ube3b"
                     /inference="alignment:Splign:2.1.0"
     exon            2728..2838
                     /gene="Ube3b"
                     /inference="alignment:Splign:2.1.0"
     exon            2839..2976
                     /gene="Ube3b"
                     /inference="alignment:Splign:2.1.0"
     exon            2977..3042
                     /gene="Ube3b"
                     /inference="alignment:Splign:2.1.0"
     exon            3043..3101
                     /gene="Ube3b"
                     /inference="alignment:Splign:2.1.0"
     exon            3102..3284
                     /gene="Ube3b"
                     /inference="alignment:Splign:2.1.0"
     exon            3285..3396
                     /gene="Ube3b"
                     /inference="alignment:Splign:2.1.0"
     exon            3397..3489
                     /gene="Ube3b"
                     /inference="alignment:Splign:2.1.0"
     exon            3490..5181
                     /gene="Ube3b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggggaact ctttttatca accgttcccg cctccccttg gccgagtcag gcgtttagtc
       61 ccacttctgg atgtttgttt ctcctttccg tctgctaaag aagatgacaa gaggaaagga
      121 gtcctcacct cctccatggg caaagaagca gtgcggaact gttgtttccc ggaactgaat
      181 aattgcttgc ttcccaagag gtgttcggag cacaacaccc ggggcaagat ggcggccggg
      241 cttcggccgc tgccccgggg ctggcggacc tcggggggat cgggctaagg cggcggtcgc
      301 tgcggcccgg accccgagtg cggggcctcg aacggataaa gatctccgga ctgcgggcca
      361 gaaaacccaa ctcctcggaa gccagaggct gcaggaggtc actgatggtc acctagcatc
      421 tccgctgcac aggcaggtcc tcaggcttcg tcgtgtcagt ttgcaaacat gttcactgta
      481 tctcagacct ccagagcatg gttcatcgac agagcccggc aggcacgaga agagaggctg
      541 gtgcagaagg agcgggagcg ctcagcggtg acgatccagg ccctagtccg cagtttcctc
      601 tgccggaggc gactgcacag agacatcagg aaagagattg atgagttttt tagtgctgat
      661 gagtctgggt ccagtaaaag aagtgcactt tgtattttta agattgccag gagactgctg
      721 tttatatgca aaactaccga ggacagcgag agactggaga agttgtgtcg aagcatcctg
      781 aacagcatgg atgccgagaa tgagccaaag gtgtggtacg tgtccctggc tctctccaag
      841 gacctcacgc tgctgtggat taagcagatc aagagcatcc tgtggcactg ctgtgagctt
      901 ctggggcagc tcaagccaga gatcttacag gactccaggc tcatcacgct gtacctcacc
      961 atgcttgtga ccttcacaga cacttcaaca tggaagattc tccggggaaa aggtgagagc
     1021 cttcggccag ccctgaacca catttgcgca aatataatgg gccatctcaa ccagcgtgga
     1081 ctttactctg tattgcaggt actgctgacc cgaggcctgg ccaggccccg gccctgtctg
     1141 tccaaaggca tgttaacagc agccttctct ctggccctgc gccctgtggt tgctgcgcag
     1201 ttctcagaca atcttatgcg accattcatc atccacgtca tgtcggtacc tgctctcgtg
     1261 gctcatctca gcaccgtggc ccctgagcgc ctcggcgttt tagagtccca tgacatgctt
     1321 cgtaaattca tcgtcttcct gagagataga gaccgatgcc gcgatgcttg tgagagttta
     1381 gaaggctgcc ataccctgtg tctcatgggc aatctcctgc acttgggctc cctcagcctc
     1441 aggctgttag aggaagagat ggatgggttt gtgagcgcgc tcacgcagat gctgtgctac
     1501 tgtcagaagt acgtggctca gaagaagtcc aacctgaccc actggcaccc tgtgctcggc
     1561 tggttttccc aacctgtgga ttacggcctc aatgattcca tgtacctgat caccaagcag
     1621 ctgcagttcc tgtgggcggt gcctctcatc cgcattctct tcagtgacat cctgagcagg
     1681 aagctgctgg agcatgcaga gccggccccg gtgcaaccgc agccgtcctc accgcagacg
     1741 gtgctccccg tgaagagcct cctcaagcgt gcgtttcaga agtcggcttc ggttcggaac
     1801 atcctcaggc ctgttggggg ccgccgtgtc gactccgctg aggtgcggaa ggtctgcaac
     1861 atttgcgtgc tctaccagac ctcgctgacg accctcaccc agatccgcct gcagatcctc
     1921 acaggtctta cgtacctgga tgacctgctg cccaagctct gggcgtttat ctgtgagctg
     1981 gggccccacg gcgggctcaa gctcttcctg gagtgcctga acaatgacac tggagagtcc
     2041 aagcagctcc tggccatgct gatgctcttc tgtgactgtt cccggcacct catcaccatc
     2101 ctcgatgaca ttgaagttta tgaagaacag atctccttca agctggaaga gctggtcacc
     2161 atctcctcgt tcctcaattc cttcgtgttt aagatgatct gggacggaat tgtagagaat
     2221 gccaagggtg agaccttgga gctgttccag tccgtccatg gctggctgat ggtgctgtat
     2281 gagcgagact gccgccggcg ctttgctccg gaggaccact ggctacggag ggacctcaag
     2341 cctggtgtgc tcttccagga gctcgacaag gaccgaagga gggctcagct ggtcctgcag
     2401 cacatccccc acgtcgtgcc tcacaagaac agagttcttc tgttccggaa catggttatc
     2461 aaggagaaag agaagctggg gcttgtggag accagctctg cctctcctca cgtcacccac
     2521 atcaccatcc gaaggtcccg gatgttggag gacggctacg aacagctccg gcagctttcc
     2581 cagcatgcca tgaagggtgt gatccgagtg aagtttgtca acgacctcgg ggtggacgag
     2641 gctgggattg accaggatgg tgtcttcaag gagtttctgg aagagatcat caagagggtg
     2701 tttgaccccg cactcaacct gttcaagaca accagcgggg atgagcggct gtacccatca
     2761 cccacgtcct acattcacga gaattacctg cagctcttcg agtttgtggg gaagatgctg
     2821 ggaaaggcag tgtatgaggg gatcgtggta gatgtgccct ttgcctcctt cttcctgagc
     2881 cagatgctcg ggcaccacca cagcgtcttc tacagctccg tggatgagct tccctccctg
     2941 gactcggagt tttataaaaa cctcacctcc atcaagcgct acgatggaga catcgcagac
     3001 ctcgggctga cgctgtctta cgatgaagac gtcatgggtc agctcgtctg ccacgaactg
     3061 gttcccggag ggaagaccat cccggttaca gatgagaaca aaattagcta catccatctg
     3121 atggcgcatt tccgaatgca cactcaaatt aaaaaccaga cagctgctct tatcagtggc
     3181 ttccgttcca tcatcaagcc cgagtggatc cgaatgttct ctacccctga gcttcagcgc
     3241 ctcatctccg gggacaacgc tgagatagat ctggaagact taaagaagca cacagtgtac
     3301 tacggtggct ttcatgggag ccacagggtc atcatctggc tctgggatat cctggcttcc
     3361 gacttcacgc ctgaagaaag agccatgttc ctgaagtttg tgaccagctg ctcccggccc
     3421 ccgctcctag gattcgccta cctcaagcct ccgttctcca tccgctgtgt ggaagtatca
     3481 gatgaccagg acactgggga taccctgggc agcgtcctca ggggcttctt caccatccgc
     3541 aagagggagc caggggggcg tctgcccaca tcttccactt gcttcaacct gcttaagctg
     3601 cccaactaca gcaagaagag cgtactgcga gagaaactac gctatgccat cagcatgaac
     3661 acgggctttg agctctccta acacagcctg gtctcgctac cacagagccc ccaggagtgt
     3721 ggccagggta cccacagccc tcagaccctc tcaatagcca tgagacaccc aaggttgggg
     3781 atgctacaca gtgccctcca tgcactgggg acagagggct gatgaaaata accccccagt
     3841 tctgccctgt ggggcctgag acctgggcct agtgattaca gagcaactcc tggagattct
     3901 gtgaggcttt cttctcttgc cctctgagga ggacacaagg cctgtgcctg tgagctcctc
     3961 cttccgttct gaaaactcag gtacggcctc gccaagcctc tatgcacagc aaagtccctg
     4021 cctctaccct gtccacagtg gcctcttccc aggcaaccaa gcccagctcc tgccagggag
     4081 gccactgagc acagtcaggg tctctcctat agggatccag gtggtccaca ccacagccct
     4141 ccttcccaag tcctcagcag gccacgctgt cagggaaccc ttgctgtcag cccctggcct
     4201 gtgcatcagt gtcctagctt gggaaagaaa cccatcgttc ccctggagaa cagcccattt
     4261 ctggagtacc cagagcctgc tcgctctggg catctgcccc ctattcacct tacggagaac
     4321 cacatgagac cctacctaca gtgcccagcc gcctgggcag tactttattc cagggacttc
     4381 agagtccgtc cttttgcact gacaggccct gggagctgag gatacgtccc acacatctca
     4441 tctccacacc gcctctgttg gcgcttgctc ttttgtctgg gacctcattc tcttttccca
     4501 cacactgcgc tcctgggccc tccctttccc catttccctt aagaactttc tccagattca
     4561 ggatgttgag gcagaggccc agggcttagt aacctgctag tagccacttg tctcctgcct
     4621 catcaggttc ttgtctccct cccaccctga tggaggagtc ctggcccctc ctccactccg
     4681 tggagccagc ttagggctac agcgctcaaa gcaagaaaac gccttcccca aggagcctgc
     4741 acagtgggaa gtggccgtgc cctgttctca ctttagcaaa gatcttgggc tggagcatgg
     4801 ggtaggccca ggaaagcccc tggggttctg gaaggtggct ccagcttcac gtctgccaac
     4861 catgtgtgtt cccagcttgc ccgcagagcc ctgtgccccg tgcacagcct gcacaggtaa
     4921 cacagagcct gagagttaca gcgggcacac gggagagtta gttgtaagca ccgatatcaa
     4981 cttgacccct ttgtctttga cctagggctg tctgtcggtc acctagagtc tgcttcccgg
     5041 cagttatgtc atagctgctg tttgatgaca tctcagcagc tcctggtggc gccagaagga
     5101 agcaggggtt tttgtttttg taggtaactc gtggactaag acttgtcagg gctttattaa
     5161 atttgtactt gagcacacga c
//
