LOCUS       NM_172300               3974 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus ubiquitin-conjugating enzyme E2Z (Ube2z), mRNA.
ACCESSION   NM_172300
VERSION     NM_172300.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3974)
  AUTHORS   Lee,P.C., Dodart,J.C., Aron,L., Finley,L.W., Bronson,R.T.,
            Haigis,M.C., Yankner,B.A. and Harper,J.W.
  TITLE     Altered social behavior and neuronal development in mice lacking
            the Uba6-Use1 ubiquitin transfer system
  JOURNAL   Mol Cell 50 (2), 172-184 (2013)
   PUBMED   23499007
REFERENCE   2  (bases 1 to 3974)
  AUTHORS   Mohlke,K.L., Purkayastha,A.A., Westrick,R.J. and Ginsburg,D.
  TITLE     Comparative mapping of distal murine chromosome 11 and human
            17q21.3 in a region containing a modifying locus for murine plasma
            von Willebrand factor level
  JOURNAL   Genomics 54 (1), 19-30 (1998)
   PUBMED   9806826
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA317477.1, AK153328.1 and AL603682.36.
            
            On Jul 26, 2006 this sequence version replaced NM_172300.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK149770.1, AK077793.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-269               CA317477.1         25-293
            270-2908            AK153328.1         1-2639
            2909-3974           AL603682.36        71711-72776         c
FEATURES             Location/Qualifiers
     source          1..3974
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 59.28 cM"
     gene            1..3974
                     /gene="Ube2z"
                     /gene_synonym="C030047H17Rik; D11Moh35"
                     /note="ubiquitin-conjugating enzyme E2Z"
                     /db_xref="GeneID:268470"
                     /db_xref="MGI:MGI:1343160"
     exon            1..413
                     /gene="Ube2z"
                     /gene_synonym="C030047H17Rik; D11Moh35"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1161
                     /gene="Ube2z"
                     /gene_synonym="C030047H17Rik; D11Moh35"
                     /EC_number="2.3.2.23"
                     /note="use1; ubiquitin-protein ligase Z; ubiquitin carrier
                     protein Z; uba6-specific E2 conjugating enzyme 1; E2
                     ubiquitin-conjugating enzyme Z; ubiquitin-conjugating
                     enzyme E2Z (putative)"
                     /codon_start=1
                     /product="ubiquitin-conjugating enzyme E2 Z"
                     /protein_id="NP_758504.3"
                     /db_xref="CCDS:CCDS36289.1"
                     /db_xref="GeneID:268470"
                     /db_xref="MGI:MGI:1343160"
                     /translation="MAESPTEEAATATAGAGAAGPGSSGVAGVVGVSGSGGGFGPPFL
                     PDVWAAAAAAGGAGGPGSGLAPLPGLPPSAAAHGAALLSHWDPTLSSDWDGERTAPQC
                     LLRIKRDIMSIYKEPPPGMFVVPDTVDMTKIHALITGPFDTPYEGGFFLFVFRCPPDY
                     PIHPPRVKLMTTGNNTVRFNPNFYRNGKVCLSILGTWTGPAWSPAQSISSVLISIQSL
                     MTENPYHNEPGFEQERHPGDSKNYNECIRHETIRVAVCDMMEGKCPCPEPLRGVMEKS
                     FLEYYDFYEVACKDRLHLQGQTMQDPFGEKRGHFDYQSLLMRLGLIRQKVLERLHNEN
                     AEMDSDSSSSGTETDLHGSLRV"
     exon            414..486
                     /gene="Ube2z"
                     /gene_synonym="C030047H17Rik; D11Moh35"
                     /inference="alignment:Splign:2.1.0"
     exon            487..674
                     /gene="Ube2z"
                     /gene_synonym="C030047H17Rik; D11Moh35"
                     /inference="alignment:Splign:2.1.0"
     exon            675..786
                     /gene="Ube2z"
                     /gene_synonym="C030047H17Rik; D11Moh35"
                     /inference="alignment:Splign:2.1.0"
     exon            787..899
                     /gene="Ube2z"
                     /gene_synonym="C030047H17Rik; D11Moh35"
                     /inference="alignment:Splign:2.1.0"
     exon            900..990
                     /gene="Ube2z"
                     /gene_synonym="C030047H17Rik; D11Moh35"
                     /inference="alignment:Splign:2.1.0"
     exon            991..3974
                     /gene="Ube2z"
                     /gene_synonym="C030047H17Rik; D11Moh35"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2891..2896
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ube2z"
                     /gene_synonym="C030047H17Rik; D11Moh35"
                     /note="hexamer: AATAAA"
     polyA_site      2912
                     /gene="Ube2z"
                     /gene_synonym="C030047H17Rik; D11Moh35"
                     /note="major polyA site"
     regulatory      3950..3955
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ube2z"
                     /gene_synonym="C030047H17Rik; D11Moh35"
                     /note="hexamer: AATAAA"
     polyA_site      3974
                     /gene="Ube2z"
                     /gene_synonym="C030047H17Rik; D11Moh35"
ORIGIN      
        1 gacactctgg cccggctctc ggtggtgcgg gagcagcggc cgctctggtc ggcggacgtg
       61 ctgctgagca gtcccggaag cgaagcagcg atggcggaga gtccgactga ggaggcggcg
      121 acggcgacgg ctggcgccgg ggcggcgggc ccagggtcga gtggtgttgc cggtgtggtc
      181 ggcgttagcg ggagcggcgg cgggttcggg ccgccttttc tgccggatgt gtgggcggcg
      241 gcggcggcgg cgggcggggc cgggggaccg gggagcggcc tggctccgct gccaggactc
      301 ccgccctcgg ccgctgccca cggggccgcg ctgcttagcc attgggaccc cacgctcagc
      361 tcggactggg acggcgagcg aaccgcgcca cagtgtctac ttcggattaa gcgggatatc
      421 atgtccattt ataaggagcc tcctccagga atgttcgttg tgcccgacac tgttgacatg
      481 actaagattc atgctttgat cacaggccca tttgacactc cttatgaagg gggtttcttc
      541 ctgttcgtct ttcggtgtcc acctgactat cccatccacc cacctcgggt caaactgatg
      601 acaacgggca ataacacagt gaggtttaac cccaacttct accgcaatgg gaaagtctgc
      661 ttgagtattc taggtacgtg gactggccct gcctggagcc cagcccagag catctcttct
      721 gtgcttatct ccatccagtc cctgatgact gagaatccct accacaacga accaggcttt
      781 gaacaggaaa gacatccagg agacagcaaa aactataatg aatgtatccg gcacgagacc
      841 atcagggttg cagtctgtga catgatggag ggcaagtgcc cctgccctga acccctacgg
      901 ggagtgatgg agaagtcctt cctggagtat tatgacttct atgaggtggc ctgcaaagat
      961 cgcctgcatc ttcaaggcca aactatgcag gacccttttg gagagaagcg gggccacttt
     1021 gactaccagt ccctcttgat gcgcctcgga ctgattcgac agaaagtgct ggaaaggctc
     1081 cataatgaaa atgctgaaat ggactctgat agcagctcct ctgggacaga gacagacctt
     1141 catgggagcc tgagggtcta gaccctgctc ccctgcccct cccccaactc gagagtccca
     1201 gcagagcccc tcccctcgcc ccagggacgg agaggcactg tgcatctccc ttcaaaggtg
     1261 tccgcaaggt ggcaagaagc aagcaagctc aaccccaggg ggtgggggtg gggctggtcc
     1321 cagtctgacc tctttggtgc tggagcacct agggcaacag tcaatcctgg atcagggcca
     1381 gggtactttt gtgaaagtac ctggagtgat ggcctctggc aaagctaaac aaccaacaca
     1441 cctctctgca gggccagcta attagggata ggagaagaca gaaaatgaga acccaagagg
     1501 gagcatgccc aagtggttta tagggatatc tgggagtttg ggtgggggtg ctgtccatga
     1561 cacttaagca gtctggttgg ttatctgttt gtcttcagtc ttgaagcagg gcttcccaac
     1621 acccttttct tcccctcccc tatttcccat gggccagcat aactttgttt ttcctaattt
     1681 atatagtcac tgttctagac agaccaaaga caaggaacag tggtggagtc tgggctgctg
     1741 atcagtaagc tttacctagc acctgagcac cttctccctc acaccatttc ctccgaattt
     1801 taggttacag gtagaaggta agccagctgg aactgagccc aggtctctgt gaagtctgca
     1861 tgggcgtcag gaagctgctc actgtgtccc cacaatcact gatttgaaag gttcccagca
     1921 caggcagctg cagcctgtgt gggatttgag ccactacata aaatagtctc ttacagattg
     1981 tcctgaatag tagtcaatga gggtggtttt cttggggtgg agcacggtaa gactaatgct
     2041 agtccctatt ttgtttagct gttacgtctg tagtccctgt cctcccttct gtcctacccc
     2101 catccctggg gatttgtgag catggacagc caatggctcg agggattgtg gctgggactc
     2161 tggagacttc tccctttatc tttccctctt tgtcactgga gctgttcctt tctttgaatt
     2221 tagctacagt gacccttcag ctggttgagt aaggatatgt gttttcagtg gctctgggtt
     2281 agaagaacct atccttccca ggttgataca gttcacactt ttcagggttg ctgttctggc
     2341 ttccagtgga tggttagtga tccacatgat acaggccttc tggtcagtgt ccagccctga
     2401 gaaatggaga gagccacctg ccctgcccgc tgctataaag gtctctgact tgtggatcat
     2461 gggactccct tgcagagata gggagaagat agggcacaaa gagggacctc ttgggagggc
     2521 agaaagcaga gaactggaca gggacaggtc acttggggag cagttttgtt ttggctacat
     2581 ggtggctggg tcatgtggag gtttgaaagg ggactctgct tccaatttcc ctcttccatt
     2641 cccagagcta gtccagggct gaggatgcct ttggtctgtg ggtccagtgt tgtctgtcat
     2701 ccattaagtg ttcccacttt caagtgacaa tcttctcctt ggccctgcca tggggcagag
     2761 catgtccggc atagcagcct gacttttatg ccctggtttt aagttgagga aatatatgca
     2821 caggagtcaa agagatgtct ttatatctga ctgtacataa atgaagtttt ctttttttcc
     2881 tttttggtgc aataaagttt gttttggcag aaggaggaag cgcctgtggg tgtgggaggg
     2941 tttgtgtaaa gaaacggagt cacctgggcc aacctgtcag gaaggagttt tttggcagct
     3001 gagtagatgc atctgtggaa agaactactt gtggtgggtt ccctatcatt tggaagtgca
     3061 gggctatact ctcagcagtc aatgacagaa caactaaccc tgagtggata ccaaaagtag
     3121 ctttcaagat tgggcgtgag catgtcctgt gagggcagat gggagtcaag atgggcccag
     3181 gctacaggat gtcagtgtgg aaaagccact gtatttgtgt ccagatattg acccagcaca
     3241 gatctgacaa gcttgtaaga ctgggttata aactctaaaa agccttgttt ccattaccat
     3301 ctcattcaaa tgctgtgaga gaattttgct ttctaacaga aggtgtttcc tcttgattga
     3361 tcatgagtgc agaaagaaat aaccagtgca tgttctgtcc tgccagcctg tactgtgagt
     3421 gcaatgatag ggtaacgtgg gctagtagag cctggctcta gctttggcac tgcctctggc
     3481 attcactccc ctttgagcca gataactgct taagacggtt gctgtaagga caaatggaca
     3541 gtgtatataa aagaacaggg taggtactca gcaattcccc accttgacct ggtcaggaaa
     3601 cagtaaggaa tttggacaaa ttactgaact gcagtggaac tgttccagtt aagtgcaccg
     3661 cttgctttcc tctacctaac accagacttc agtttccttc acatagaaga ctgcaagaca
     3721 agtcacagag caaagtctgc tagggtggaa aggaaatgag gaagagcttg aattggtgaa
     3781 gtggtgactt gtttcacagc tataataagg ctagccacaa gaagctacat cttggcccag
     3841 ccctgagtct agatgtttta cacaagtcat tttacatgtt gctcaggtta tcctcactgg
     3901 ataaaagagg cttcctccaa aacagatgaa atgtgaaggc acttctaaaa ataaatactg
     3961 ggggaacaaa aaaa
//
