LOCUS       NM_023585               5892 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus ubiquitin-conjugating enzyme E2 variant 2 (Ube2v2),
            transcript variant 1, mRNA.
ACCESSION   NM_023585 XM_203673
VERSION     NM_023585.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5892)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5892)
  AUTHORS   Mural,R.V., Liu,Y., Rosebrock,T.R., Brady,J.J., Hamera,S.,
            Connor,R.A., Martin,G.B. and Zeng,L.
  TITLE     The tomato Fni3 lysine-63-specific ubiquitin-conjugating enzyme and
            suv ubiquitin E2 variant positively regulate plant immunity
  JOURNAL   Plant Cell 25 (9), 3615-3631 (2013)
   PUBMED   24076975
REFERENCE   3  (bases 1 to 5892)
  AUTHORS   Min,L.J., Mogi,M., Iwanami,J., Li,J.M., Sakata,A., Fujita,T.,
            Tsukuda,K., Iwai,M. and Horiuchi,M.
  TITLE     Angiotensin II type 2 receptor deletion enhances vascular
            senescence by methyl methanesulfonate sensitive 2 inhibition
  JOURNAL   Hypertension 51 (5), 1339-1344 (2008)
   PUBMED   18362223
  REMARK    GeneRIF: Ang II type 2 receptor signaling attenuates DNA damage and
            consequent vascular senescence at least in part through methyl
            methanesulfonate sensitive 2 (MMS2) transactivation.
REFERENCE   4  (bases 1 to 5892)
  AUTHORS   Wen,R., Torres-Acosta,J.A., Pastushok,L., Lai,X., Pelzer,L.,
            Wang,H. and Xiao,W.
  TITLE     Arabidopsis UEV1D promotes Lysine-63-linked polyubiquitination and
            is involved in DNA damage response
  JOURNAL   Plant Cell 20 (1), 213-227 (2008)
   PUBMED   18178771
REFERENCE   5  (bases 1 to 5892)
  AUTHORS   Ashley,C., Pastushok,L., McKenna,S., Ellison,M.J. and Xiao,W.
  TITLE     Roles of mouse UBC13 in DNA postreplication repair and Lys63-linked
            ubiquitination
  JOURNAL   Gene 285 (1-2), 183-191 (2002)
   PUBMED   12039045
REFERENCE   6  (bases 1 to 5892)
  AUTHORS   Franko,J., Ashley,C. and Xiao,W.
  TITLE     Molecular cloning and functional characterization of two murine
            cDNAs which encode Ubc variants involved in DNA repair and
            mutagenesis
  JOURNAL   Biochim Biophys Acta 1519 (1-2), 70-77 (2001)
   PUBMED   11406273
REFERENCE   7  (bases 1 to 5892)
  AUTHORS   JACKSON,B.R. and DANIEL,W.H.
  TITLE     Recurrent carcinoma of the rectum, surgical treatment
  JOURNAL   Calif Med 91 (3), 149-150 (1959)
   PUBMED   14406273
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY025619.1, AK028472.1 and CT010522.7.
            
            On Apr 15, 2009 this sequence version replaced NM_023585.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033016.1, AK031233.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                BY025619.1         8-35
            29-3307             AK028472.1         3-3281
            3308-5892           CT010522.7         87726-90310
FEATURES             Location/Qualifiers
     source          1..5892
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 10.09 cM"
     gene            1..5892
                     /gene="Ube2v2"
                     /gene_synonym="1110021H13Rik; 4632410D19Rik;
                     5730524P06Rik; 6820402M05; MMS2"
                     /note="ubiquitin-conjugating enzyme E2 variant 2"
                     /db_xref="GeneID:70620"
                     /db_xref="MGI:MGI:1917870"
     exon            1..59
                     /gene="Ube2v2"
                     /gene_synonym="1110021H13Rik; 4632410D19Rik;
                     5730524P06Rik; 6820402M05; MMS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..481
                     /gene="Ube2v2"
                     /gene_synonym="1110021H13Rik; 4632410D19Rik;
                     5730524P06Rik; 6820402M05; MMS2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     methyl methanesulfonate sensitive 2; ubc-like protein
                     MMS2"
                     /codon_start=1
                     /product="ubiquitin-conjugating enzyme E2 variant 2
                     isoform 1"
                     /protein_id="NP_076074.2"
                     /db_xref="CCDS:CCDS37265.1"
                     /db_xref="GeneID:70620"
                     /db_xref="MGI:MGI:1917870"
                     /translation="MAVSTGVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLT
                     RWTGMIIGPPRTNYENRIYSLKVECGSKYPEAPPSVRFVTKINMNGINNSSGMVDARS
                     IPVLAKWQNSYSIKVILQELRRLMMSKENMKLPQPPEGQTYNN"
     exon            60..208
                     /gene="Ube2v2"
                     /gene_synonym="1110021H13Rik; 4632410D19Rik;
                     5730524P06Rik; 6820402M05; MMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            209..334
                     /gene="Ube2v2"
                     /gene_synonym="1110021H13Rik; 4632410D19Rik;
                     5730524P06Rik; 6820402M05; MMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            335..5892
                     /gene="Ube2v2"
                     /gene_synonym="1110021H13Rik; 4632410D19Rik;
                     5730524P06Rik; 6820402M05; MMS2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1181..1186
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ube2v2"
                     /gene_synonym="1110021H13Rik; 4632410D19Rik;
                     5730524P06Rik; 6820402M05; MMS2"
                     /note="hexamer: AATAAA"
     polyA_site      1206
                     /gene="Ube2v2"
                     /gene_synonym="1110021H13Rik; 4632410D19Rik;
                     5730524P06Rik; 6820402M05; MMS2"
                     /note="major polyA site"
     regulatory      3292..3297
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ube2v2"
                     /gene_synonym="1110021H13Rik; 4632410D19Rik;
                     5730524P06Rik; 6820402M05; MMS2"
                     /note="hexamer: AATAAA"
     polyA_site      3312
                     /gene="Ube2v2"
                     /gene_synonym="1110021H13Rik; 4632410D19Rik;
                     5730524P06Rik; 6820402M05; MMS2"
                     /note="major polyA site"
     regulatory      3404..3409
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ube2v2"
                     /gene_synonym="1110021H13Rik; 4632410D19Rik;
                     5730524P06Rik; 6820402M05; MMS2"
                     /note="hexamer: AATAAA"
     polyA_site      3436
                     /gene="Ube2v2"
                     /gene_synonym="1110021H13Rik; 4632410D19Rik;
                     5730524P06Rik; 6820402M05; MMS2"
                     /note="major polyA site"
     regulatory      4180..4185
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ube2v2"
                     /gene_synonym="1110021H13Rik; 4632410D19Rik;
                     5730524P06Rik; 6820402M05; MMS2"
                     /note="hexamer: AATAAA"
     polyA_site      4202
                     /gene="Ube2v2"
                     /gene_synonym="1110021H13Rik; 4632410D19Rik;
                     5730524P06Rik; 6820402M05; MMS2"
     regulatory      4782..4787
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ube2v2"
                     /gene_synonym="1110021H13Rik; 4632410D19Rik;
                     5730524P06Rik; 6820402M05; MMS2"
                     /note="hexamer: AATAAA"
     polyA_site      4808
                     /gene="Ube2v2"
                     /gene_synonym="1110021H13Rik; 4632410D19Rik;
                     5730524P06Rik; 6820402M05; MMS2"
ORIGIN      
        1 gttgacgccc tgcgtgcggt ggtgcgtctg gtagcaggag aagatggcgg tctccacagg
       61 agttaaagtt cctcgtaatt ttcgcttgtt ggaagaactt gaagaaggac aaaaaggagt
      121 aggtgatggt actgttagct ggggccttga agatgatgaa gacatgacac ttacaaggtg
      181 gacaggcatg attattgggc caccaaggac aaactatgaa aacagaatat atagcctgaa
      241 agtagaatgt ggatctaaat acccagaagc tcctccatca gttagatttg taacaaaaat
      301 taatatgaat gggatcaata attccagtgg aatggtggat gcacggagca taccagtatt
      361 agcaaaatgg caaaattcct atagcattaa agtcatactt caagagctaa gacgtcttat
      421 gatgtccaaa gaaaatatga agcttccaca gcctccagaa ggacagacgt acaacaacta
      481 actttagtgg atctcaaact tgtcttaaat cagcaacctt ctactcatgt taatgtcttg
      541 attaaatatc accatgcaca atacccacac aataagtaaa agaattgcag ctggtaaaca
      601 tgacctggac agttgtaaga atatatttaa tatatgtaca cctattatgt tttcaggtaa
      661 caagagacgt gcagcacaat ttttctttct attaaagcac tgtcatttaa acatgaacct
      721 gaagtactca aaatggagtt caggctttca agacaaaagc atgacaaaag agtgtcatgt
      781 ggccatggaa acatttgttt ttctggaaag taaagtctca agaaggaaga acagaaatgg
      841 catgctttat catatttaga gctgcagttg gaattgttta aagtagcaga tacaatgact
      901 agtcaacaat tgtgttaatt cttgaagcgg tgtgggtgct gactactatt agtacaaaca
      961 taggttcagg attgttttga tacctgtatt tataataaaa ggtgttgggg ttttgaattt
     1021 ctgttaaaag ctgttcccgt ttgttacatg taacagacat aataatttgt ttacagtctt
     1081 tgtttagtaa aacatgctta gatgttttaa gtgaagtcaa caaaaaggaa ataggtgtat
     1141 ggatatgtga ttttgagatg aaagttagtc ttaaaatgta aataaaatat ggaatgtgtc
     1201 ttaagagact gtgctatttc tgttacattg atatatgcta tggtagccat atcatggtag
     1261 caaaattggg agttattaag ctaggcatgg taatggcaga ggcaggcgat tacaagttcc
     1321 tggccagcct gggctagtac ataagactgc aattaaaaca aaataagaaa tactgtgaga
     1381 ctatcaaaga ctttcattga aattctattc tatatgccta tgtttggaac ttacagagca
     1441 cttgttgtga caccgtacat gctcagttta atttcttcgc acaaagaggt atctcagtta
     1501 ctatatttca aattttattt catcataggc aatattaaaa aagatctttg cattttagca
     1561 gtttttgtag ctacaaactg caaattattc agtactcatt taattttttc ttgtgacatt
     1621 ttaatttttc tgtaaagctt tggttcatta caattgactg aattgaagac tttcctcccc
     1681 tatctttaat tttttttttg ttatttagtg tgtgtgtgcg cagtgtgtgt ggtgggggga
     1741 tgtgtgcgcg cgcatacgtg tgtgtacttg tgtgaagatc agaggttacc tttggagtgt
     1801 tggttcttgc cttcactttc ctgtgtgtta ctgatgtcga actctgatca ccatgtacca
     1861 tgcgtgtcaa caagggccct cactgcagag ccatctcatt ggttcctctt ctaagaacaa
     1921 cggaagttaa ttttatcatt ccactctgtt tactttaaca aatatgtgtc tgaagttgaa
     1981 agtttatttt tattctttta tcaaattgac agtttaattg tcaaaataaa aaaatgagat
     2041 gttcaaactt tgcatataaa gaaagtaaag ggaacagcat gactagtata ctgattactt
     2101 ttggttactt ttatagcaag gataggtttc ttgacatata cttggtgtgt tttgattaag
     2161 ctgtttaaaa gttaatgttt ttttagtcat taaactagtt tgtctagaca ttatcatcac
     2221 tgttgtagtt tgaaagaggg taccactgta taacctatga tggcttcaaa cttgcacaat
     2281 tatttctgtc tcagcctccc aagtactagt tcaggtgtac accatgtcca gcataagtgg
     2341 actcatttta aatgagctag tctaattatc aacaaacttc ctttattcgt gttttgtgtg
     2401 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgttgggtgc atgcagaggc cttaggtggt
     2461 atctggagtc tctcttaatt gttctttcac tttatagtgt cagacagtgt ttttaaatga
     2521 agcccagagc tcactgatgc agctagactt gctaatcagc ttgctataga aatagatccc
     2581 cctgcctctg ctttccaagg ctggaattat agccttacct gttattttat gtgggttctg
     2641 ggaatcggat ctccaacaag cattttcaac cattgagcca tctcagcccc tcaaagatgt
     2701 tctaaatatt taaccacata gaacatacac ataacatttt ccatgtgtaa ttgattaaag
     2761 tagacttaaa tgaaatatac taatatttaa tgattaaaga ttacattcaa ttgcattgac
     2821 agtatagagt cattaccagt tcttttctgc cttgaaaatg tgtcttgtga tacttggagc
     2881 tagtaagtgt tgggatgctt ttgatagcct ttggtagaat ctggtacttt ggtctcatgt
     2941 tgtctttgta tatgccactg tgagagttct ctcctccacc caaggctgtt tgtcagagcc
     3001 cagcctattt aaaaaaaacc cctttcttgt ttaagggatt gtggatctta gcataaatct
     3061 atgagtcagt taacagattt ccaaagcaaa atccattttg catgtaacag ttatatatga
     3121 ttatctaaga ttgatgaaat tttagagtta atagagcctc ttttaaataa aagcaaatct
     3181 tcttttgtaa agtgactagg attgcaggaa tgtggtataa atagactaga aatttgcctt
     3241 agaaacttgt ttcaagagat tttaaagtat gacccttgat gactatatgt taataaaagt
     3301 taaaaagtaa aattcttgtt ccagtaggtc cctgttatac tttaatggct ttaactattt
     3361 gttattttca gaattggtaa ttttttatta tttgttaatt taaaataaag ttattgcact
     3421 tgtttaggga tctgtatata cttttctaga atttttgtaa caaacattgg gtctgtcaca
     3481 ggcagtcttt tgggtgtgaa aacaaaacct gtaattttac attgaccttt ataaaaacta
     3541 ttttactcaa catttgggta tgtgaataaa tagggacttt agtttgattt atcaggacaa
     3601 gtacttcacc aagactgact tccatcatcg aagtgttctt caacattaga atgcatgtga
     3661 agttgatatt tgaaaattta gagcattgtt gaaaaccact cttaataggt ttgatgttta
     3721 tggctttagg ccattctcat aagttcagtc aaaatcatgt cagcttccta aatgagttta
     3781 aaaccatata ttcttgcatg cttacaagga ttttggaaac tacttaagga atcttacagt
     3841 ttttttcctt tataagaata gtttttaggt atttgtatac agagctacaa tattattgat
     3901 tattgggaag gatagcagac acagatctta cttttctgat aagtagcaat acactttcat
     3961 tgcttcagtt tgaccagttt ttgttcagtt gtaatgcctc aagattttgg aaagatgtac
     4021 atgttttctg aactagaaac accatgaaaa ggaataaaca caagtggtag gaacacaagt
     4081 gattaactta cattcagtac cgagcttact aaaaagcagg gagtccacag gaatagaatt
     4141 tctaaagtta atgttctttg gagaagttac caaagactga ataaactttt tctctaaaac
     4201 tatattttgt gtgtgcctgt gactgtgcat ttgcatgcct gtgtgcattc atttatgagt
     4261 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtat gtgtgtgtgg ccaaagaaca
     4321 acttaggaat ttgttcgcac cttgcactgt gtgaggggtt gaactcaggt catctggctt
     4381 agatgcaagt atctttaccc actgaaccat cttgcttgtc ccaggggaat ctgatactga
     4441 acatattgga tgtttaggaa gttttctgga attttgaaaa gatacactgt aagtattttc
     4501 tgaaaagaaa actaataaag gtatttgttg atacaggaaa taaaaatgaa gaccattttg
     4561 taaaatcaag gagtttgaaa aactcataga atgagttaca tgatttaaaa agccattagc
     4621 aggctggagg agtgagcctg atgtcttgtt tggatatgca gacgccatgt agaaagcggg
     4681 acagtgtagt atgtgagtaa tcccaacatg tctctaccag caggtgtggg gagacagaac
     4741 ttttaaaagc aaccgctggt tgctgtggtg tttatatctt caataaaagg tgtgcagcta
     4801 agaaataagg gttttgcccc atctcatttt tccatataat ttaaaaatac tgcggtaggt
     4861 tcccccttct aagtttatga gatcaatgat aaaagctgaa tcaatctctc tctctctctc
     4921 tgtctgtctg tctcaagaga tttatttatt tcatgtatgt gagtacactg tcattgtctt
     4981 tagacacacc aggagaggac atcggatccc cattacagat ggctgtgagc caccatgtag
     5041 ttgctgggaa ttgaactcag gacctctagg aagagcagtc agtgtgggaa tcacttgtct
     5101 acctacttcc cacggacaga atcaacattg cccagaattt ccccagtctt agctaactgt
     5161 actgtgagat gaatatttgc ttaattggga aaatgaaggc tcttaaagta cagtgccttg
     5221 ggttacagtt gcatttatta ctttccataa ttgaagtttt ctataaactt tccataggtt
     5281 attactgcta gcctctatac tgacaaatgt tggcagttgc cccttagcca cttcagattc
     5341 tgcctgtact aaagttgtca acaactgttg taggttaaaa gtacaggttc ctcccacctc
     5401 agcttggacc tatctctctt tttttctttt tttctttttg agacagggtt tctctgtgta
     5461 gccctggctg tcttggaact cactttgtag accaggctgg cctcgaactc agaaatccgc
     5521 ctgcctctgc ctcccaagtg ctgcgattaa aggcgtgcgc caccacgtct ggcttttatc
     5581 tcatattttt aatccattct ttgagtaaat cattttaaaa acagaattct ttattctctc
     5641 agggttagtt actcgttttt gaacatgagt ttttttttct ttaagtaatg tcttcatttg
     5701 caatgaattt atctcgttct aaaatttgca tacttccagt agggttcttt tggttgtagc
     5761 atttggccag ttttagtgaa tgttacccct ggagaatgtt tacttttatg caattgcttg
     5821 cttttataca atgtttgctt ttatgcaagc cccaattttt ggctaccaat aaagtagaag
     5881 atattctaag gt
//
