LOCUS       NM_026024               1134 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus ubiquitin-conjugating enzyme E2T (Ube2t), transcript
            variant 1, mRNA.
ACCESSION   NM_026024 XM_915091
VERSION     NM_026024.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1134)
  AUTHORS   Wang,Y., Gao,G., Wei,X., Zhang,Y. and Yu,J.
  TITLE     UBE2T Promotes Temozolomide Resistance of Glioblastoma Through
            Regulating the Wnt/beta-Catenin Signaling Pathway
  JOURNAL   Drug Des Devel Ther 17, 1357-1369 (2023)
   PUBMED   37181827
  REMARK    GeneRIF: UBE2T Promotes Temozolomide Resistance of Glioblastoma
            Through Regulating the Wnt/beta-Catenin Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1134)
  AUTHORS   Yu,Y., Xu,W., Wen,C., Zhao,S., Li,G., Liu,R., Chen,Z.J., Qin,Y.,
            Ma,J., Yang,Y. and Zhao,S.
  TITLE     UBE2T resolves transcription-replication conflicts and protects
            common fragile sites in primordial germ cells
  JOURNAL   Cell Mol Life Sci 80 (4), 92 (2023)
   PUBMED   36928776
  REMARK    GeneRIF: UBE2T resolves transcription-replication conflicts and
            protects common fragile sites in primordial germ cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1134)
  AUTHORS   Tao,X., Wu,X., Zhou,P., Yu,X., Zhao,C., Peng,X., Zhang,K., Shen,L.,
            Peng,J. and Yang,L.
  TITLE     UBE2T promotes glioblastoma malignancy through
            ubiquitination-mediated degradation of RPL6
  JOURNAL   Cancer Sci 114 (2), 521-532 (2023)
   PUBMED   36156329
  REMARK    GeneRIF: UBE2T promotes glioblastoma malignancy through
            ubiquitination-mediated degradation of RPL6.
REFERENCE   4  (bases 1 to 1134)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1134)
  AUTHORS   Ulmke,P.A., Sakib,M.S., Ditte,P., Sokpor,G., Kerimoglu,C., Pham,L.,
            Xie,Y., Mao,X., Rosenbusch,J., Teichmann,U., Nguyen,H.P.,
            Fischer,A., Eichele,G., Staiger,J.F. and Tuoc,T.
  TITLE     Molecular Profiling Reveals Involvement of ESCO2 in Intermediate
            Progenitor Cell Maintenance in the Developing Mouse Cortex
  JOURNAL   Stem Cell Reports 16 (4), 968-984 (2021)
   PUBMED   33798452
REFERENCE   6  (bases 1 to 1134)
  AUTHORS   Zhao,L.W., Zhu,Y.Z., Chen,H., Wu,Y.W., Pi,S.B., Chen,L., Shen,L.
            and Fan,H.Y.
  TITLE     PABPN1L mediates cytoplasmic mRNA decay as a placeholder during the
            maternal-to-zygotic transition
  JOURNAL   EMBO Rep 21 (8), e49956 (2020)
   PUBMED   32558204
REFERENCE   7  (bases 1 to 1134)
  AUTHORS   Lewandowski,J.P., Du,F., Zhang,S., Powell,M.B., Falkenstein,K.N.,
            Ji,H. and Vokes,S.A.
  TITLE     Spatiotemporal regulation of GLI target genes in the mammalian limb
            bud
  JOURNAL   Dev Biol 406 (1), 92-103 (2015)
   PUBMED   26238476
REFERENCE   8  (bases 1 to 1134)
  AUTHORS   Hao,J., Xu,A., Xie,X., Hao,J., Tian,T., Gao,S., Xiao,X. and He,D.
  TITLE     Elevated expression of UBE2T in lung cancer tumors and cell lines
  JOURNAL   Tumour Biol 29 (3), 195-203 (2008)
   PUBMED   18667844
  REMARK    GeneRIF: Overexpression of UBE2T in NIH3T3 cells significantly
            promoted colony formation in mouse cell cultures.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB872310.1, AK012565.1 and BY576015.1.
            
            On May 10, 2013 this sequence version replaced NM_026024.2.
            
            Transcript Variant: This variant (1) represents the longer variant.
            Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK166098.1, AK021213.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                BB872310.1         2-43
            43-1113             AK012565.1         2-1072
            1114-1134           BY576015.1         399-419
FEATURES             Location/Qualifiers
     source          1..1134
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 58.24 cM"
     gene            1..1134
                     /gene="Ube2t"
                     /gene_synonym="2700084L22Rik"
                     /note="ubiquitin-conjugating enzyme E2T"
                     /db_xref="GeneID:67196"
                     /db_xref="MGI:MGI:1914446"
     exon            1..222
                     /gene="Ube2t"
                     /gene_synonym="2700084L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            223..394
                     /gene="Ube2t"
                     /gene_synonym="2700084L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            395..464
                     /gene="Ube2t"
                     /gene_synonym="2700084L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            465..570
                     /gene="Ube2t"
                     /gene_synonym="2700084L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            571..669
                     /gene="Ube2t"
                     /gene_synonym="2700084L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            670..753
                     /gene="Ube2t"
                     /gene_synonym="2700084L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            754..1134
                     /gene="Ube2t"
                     /gene_synonym="2700084L22Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1095..1100
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ube2t"
                     /gene_synonym="2700084L22Rik"
                     /note="hexamer: AATAAA"
     regulatory      1099..1104
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ube2t"
                     /gene_synonym="2700084L22Rik"
                     /note="hexamer: AATAAT"
     polyA_site      1113
                     /gene="Ube2t"
                     /gene_synonym="2700084L22Rik"
     polyA_site      1116
                     /gene="Ube2t"
                     /gene_synonym="2700084L22Rik"
                     /note="major polyA site"
ORIGIN      
        1 aacggtctcc gcggttccgc gtgagcacag cagaggcgcg ccgcggtaag tggggctgct
       61 gacgggtgct gcgagtgcca cctgagggaa cgagcccgag gtcacggaga gtctggggaa
      121 ggagtcccgt ttctacccga gcggccctgg gaggaacacg gcggggagag cgaaccgccc
      181 tgggcgcgcc aaggctacct ccagcatctg ccacctaccc agtacacccc cgccagacct
      241 cagtgtggaa cagtgaactg tttctggttc ctttcacttg agatcatgca gagagcctca
      301 cgcctgaaga aggaactgca catgctagcc atcgaacctc ccccgggcat cacgtgctgg
      361 caggaaaagg atcaagtggc tgatttgcga gctcaaatac taggtggagc taatacacct
      421 tatgagaaag gtgttttcac actggaagtt atcattcctg agaggtaccc atttgaacct
      481 ccacaggtcc gatttctaac tccaatctat catccaaaca ttgattctag tggaaggatt
      541 tgtctagata ttctcaaatt gccaccaaag ggtgcatgga gaccatccct caacattgcc
      601 actgtattga cctctattca gctgctcatg gcagaaccca atcctgatga cccactaatg
      661 gctgacattt cttcagaatt taaatataac aagatagctt ttctcaagaa agccaagcag
      721 tggacagagg ctcatgcaag acagaaacaa aaggctgatg aagaggagct aggcacctca
      781 tcagaagttg gtgactctga ggaaagccat tccacacaga aaaggaaggc caggccatta
      841 ggaggaatgg aaaaaaagtt ttcccctgac gttcagagag tctatcctgg tccctcttag
      901 ttacggcagt ctgtgtcaag gtggtctctt ttgcttgctt cttttaaatg ttttcctttg
      961 tatttgatga caaatgtttg tatccttaca aaagaccttg tatgtttacg aattctgcca
     1021 tgcagcgatt ctttaaggat agtttgtttt atttatcttg tacatatgta tttagaaaac
     1081 ttttaaactt gaaaaataaa taatacttaa tgttaagtgt gtgtttatat gaaa
//
