LOCUS       NM_133777                988 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus ubiquitin-conjugating enzyme E2S (Ube2s), mRNA.
ACCESSION   NM_133777
VERSION     NM_133777.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 988)
  AUTHORS   Sun,S.M., Zhao,B.W., Li,Y.Y., Liu,H.Y., Xu,Y.H., Yang,X.M.,
            Guo,J.N., Ouyang,Y.C., Weng,C.J., Guan,Y.C., Sun,Q.Y. and Wang,Z.B.
  TITLE     Loss of UBE2S causes meiosis I arrest with normal spindle assembly
            checkpoint dynamics in mouse oocytes
  JOURNAL   Development 151 (6) (2024)
   PUBMED   38546043
  REMARK    GeneRIF: Loss of UBE2S causes meiosis I arrest with normal spindle
            assembly checkpoint dynamics in mouse oocytes.
REFERENCE   2  (bases 1 to 988)
  AUTHORS   Zhang,S., You,X., Zheng,Y., Shen,Y., Xiong,X. and Sun,Y.
  TITLE     The UBE2C/CDH1/DEPTOR axis is an oncogene and tumor suppressor
            cascade in lung cancer cells
  JOURNAL   J Clin Invest 133 (4), e162434 (2023)
   PUBMED   36548081
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 988)
  AUTHORS   Huang,L., Liu,H., Zhang,K., Meng,Q., Hu,L., Zhang,Y., Xiang,Z.,
            Li,J., Yang,Y., Chen,Y., Cui,S., Tang,H., Pei,H., Bu,Z. and Weng,C.
  TITLE     Ubiquitin-Conjugating Enzyme 2S Enhances Viral Replication by
            Inhibiting Type I IFN Production through Recruiting USP15 to
            Deubiquitinate TBK1
  JOURNAL   Cell Rep 32 (7), 108044 (2020)
   PUBMED   32814047
  REMARK    GeneRIF: Ubiquitin-Conjugating Enzyme 2S Enhances Viral Replication
            by Inhibiting Type I IFN Production through Recruiting USP15 to
            Deubiquitinate TBK1.
REFERENCE   4  (bases 1 to 988)
  AUTHORS   Chen,X., Wang,C., Yang,P., Shi,L. and Wang,H.
  TITLE     Ube2s-stabilized beta-catenin protects against myocardial
            ischemia/reperfusion injury by activating HIF-1alpha signaling
  JOURNAL   Aging (Albany NY) 12 (7), 5716-5732 (2020)
   PUBMED   32250966
  REMARK    GeneRIF: Ube2s-stabilized beta-catenin protects against myocardial
            ischemia/reperfusion injury by activating HIF-1alpha signaling.
REFERENCE   5  (bases 1 to 988)
  AUTHORS   Wang,J., Zhang,Y., Hou,J., Qian,X., Zhang,H., Zhang,Z., Li,M.,
            Wang,R., Liao,K., Wang,Y., Li,Z., Zhong,D., Wan,P., Dong,L.,
            Liu,F., Wang,X., Wan,Y., Xiao,W. and Zhang,W.W.
  TITLE     Ube2s regulates Sox2 stability and mouse ES cell maintenance
  JOURNAL   Cell Death Differ 23 (3), 393-404 (2016)
   PUBMED   26292759
  REMARK    GeneRIF: Besides its role in fine-tuning the precise level of Sox2,
            Ube2s reinforces the self-renewing and pluripotent state of
            embryonic stem cells.
REFERENCE   6  (bases 1 to 988)
  AUTHORS   Ben-Eliezer,I., Pomerantz,Y., Galiani,D., Nevo,N. and Dekel,N.
  TITLE     Appropriate expression of Ube2C and Ube2S controls the progression
            of the first meiotic division
  JOURNAL   FASEB J 29 (11), 4670-4681 (2015)
   PUBMED   26207029
  REMARK    GeneRIF: alongside their canonical function in protein degradation,
            Ube2C and -S also control the extrusion of the first polar body.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC162034.6.
            
            On Nov 17, 2006 this sequence version replaced NM_133777.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083323.1, BI647226.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN01164134,
                                           SAMN01164135 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-178               AC162034.6         156658-156835       c
            179-326             AC162034.6         155904-156051       c
            327-517             AC162034.6         154917-155107       c
            518-988             AC162034.6         152509-152979       c
FEATURES             Location/Qualifiers
     source          1..988
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 2.78 cM"
     gene            1..988
                     /gene="Ube2s"
                     /gene_synonym="0910001J09Rik; 6720465F12Rik; E2-EPF"
                     /note="ubiquitin-conjugating enzyme E2S"
                     /db_xref="GeneID:77891"
                     /db_xref="MGI:MGI:1925141"
     exon            1..178
                     /gene="Ube2s"
                     /gene_synonym="0910001J09Rik; 6720465F12Rik; E2-EPF"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..847
                     /gene="Ube2s"
                     /gene_synonym="0910001J09Rik; 6720465F12Rik; E2-EPF"
                     /EC_number="2.3.2.23"
                     /note="E2-EPF5; ubiquitin-protein ligase S; ubiquitin
                     carrier protein S; ubiquitin-conjugating enzyme E2-24 kDa;
                     ubiquitin-conjugating enzyme E2-EPF5; E2
                     ubiquitin-conjugating enzyme S"
                     /codon_start=1
                     /product="ubiquitin-conjugating enzyme E2 S"
                     /protein_id="NP_598538.1"
                     /db_xref="CCDS:CCDS39743.1"
                     /db_xref="GeneID:77891"
                     /db_xref="MGI:MGI:1925141"
                     /translation="MNSNVENLPPHIIRLVYKEVTTLTADPPDGIKVFPNEEDLTDLQ
                     VTIEGPEGTPYAGGLFRMKLLLGKDFPASPPKGYFLTKIFHPNVGPNGEICVNVLKRD
                     WTAELGIRHVLLTIKCLLIHPNPESALNEEAGRLLLENYEEYAARARLLTEIHGGACS
                     TSSGRAEATQDLASGASASSADPMIPGVLGGAEGPMAKKHAGERDKKLAAKKKLDKKR
                     ALRRL"
     exon            179..326
                     /gene="Ube2s"
                     /gene_synonym="0910001J09Rik; 6720465F12Rik; E2-EPF"
                     /inference="alignment:Splign:2.1.0"
     exon            327..517
                     /gene="Ube2s"
                     /gene_synonym="0910001J09Rik; 6720465F12Rik; E2-EPF"
                     /inference="alignment:Splign:2.1.0"
     exon            518..988
                     /gene="Ube2s"
                     /gene_synonym="0910001J09Rik; 6720465F12Rik; E2-EPF"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagacgtaac gttgtgagcg tttcgtagcg gacgtcggaa ttagtgggag cggagtgggg
       61 cctcgggggc ctcgctaggg ccacagcggc cggcagttgg gccccccgcc ccggccggcg
      121 gtccgaggag tgcaggaagg gggccggggg gacccgcccc cggccggctg aagtcatgaa
      181 ctccaatgtg gagaatctgc cgccccacat catccgccta gtgtacaagg aggtgacaac
      241 actgacggca gacccacctg atggcattaa agtcttcccc aatgaggagg atctcacaga
      301 cctgcaggtt accatcgagg gccctgaagg gactccctat gctggaggtc tgttccgtat
      361 gaagctccta ctggggaagg acttccctgc ctccccaccc aagggctact tcctgactaa
      421 aatcttccac ccaaatgtgg gccccaatgg cgagatctgt gtcaatgtgc tcaagaggga
      481 ctggacggct gaattgggca tacgacatgt gctgctgacc atcaagtgcc tgctgatcca
      541 ccctaaccca gagtctgcac tcaatgagga ggcaggccgc ctgcttttgg agaattatga
      601 agagtatgct gcccgggccc gtctgctcac agaaatccat gggggtgcat gcagcaccag
      661 cagcgggagg gctgaggcta cccaagacct ggccagtggg gcttcagcct cctctgctga
      721 ccctatgatc ccaggggtcc tagggggagc tgagggtccc atggccaaga aacatgcagg
      781 tgagcgagat aagaagctgg cagccaagaa aaagttggac aagaagcgag cactgaggcg
      841 actgtagtgg ggctctttct ccttccctcc cttctgtccc ctcccactct gtctctaagt
      901 tatttaaatt atggctgggg tgggggaggg agttgggggg ggcaccagaa cctggatttg
      961 gttttctaaa taaaaagttg gaaaagca
//
